* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Additional:
* Level 4 Mana Burn burns 38,5% of Medusa's mana every 4 seconds if Medusa only increases her mana pool with intelligence. Additionally, 60% of the Mana Burn damage gets mitigated by Mana Shield, burning even more mana.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.

* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has Manta Style.
* Anti-Mage effectively avoids Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* Anti-Mage's Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with Blink, burning her mana or forcing her to use Stone Gaze.
* Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.

* If Meat Hook is used before Blink, Anti-Mage may be able to escape Pudge's grasp by blinking safety.
* Counterspell grants Anti-Mage a large degree of magic resistance, a damage type Pudge is highly reliant on to secure kills. This make Anti-Mage a bad target for Pudge.
* Mana Break can quickly drains Pudge's low supply of mana, which may render Meat Hook & Dismember unusable and making him a prime target for Mana Void.

* Mana Burn completely drains Pudge's little mana which may render Meat Hook & Dismember unusable.
* Impale and Spiked Carapace used to cancel Dismember if timed perfectly.
* Vendetta grants Nyx Assassin invisibility and a high degree of mobility for a long time, which can make Nyx a difficult target to hook. In addition, it also scouts out Pudge's location and surprising him with his attack, Impale and Mana Burn.

* Blink allows Anti-Mage to get on top of Lina and deal damage with his Mana Break.
* Counterspell makes Anti-Mage tanky against Lina's heavy magic damage.
* Mana Void is very strong against Lina, who has a high mana pool and quickly depletes it during fights.

* Mana Burn does tons of damage against Lina because of her high intelligence. The mana burn also prevents Lina from casting her full combo.
* Spiked Carapace can easily be used to counter Lina's abilities because of their long cast animation, and could probably kill Lina outright if Laguna Blade is reflected.

* Because Queen of Pain's spells cost a decent amount of mana, Anti-Mage can easily use Mana Void if she spams her spells recklessly.
* Anti-Mage has similar mobility through Blink, which can allow him to catch up with her.
* Counterspell will reduce the damage done by Shadow Strike and Scream of Pain.

* A good Nyx can reflect Queen of Pain's Sonic Wave with his Spiked Carapace, or even initiate a gank on her in Vendetta while she farms a creep wave with Scream of Pain.
* Her strength to intelligence ratio is bad enough that he should be able to kill her without even requiring a Dagon, provided he can get his full combo off.

* Mana Break reduces Snapfire's already low mana pool.
* Blink allows Anti-Mage to avoid being hit by Lil' Shredder and Mortimer Kisses.
* Counterspell can be used immediately after Blinking onto Snapfire to reflect her Scatterblast response.

* Spiked Carapace stops Snapfire's Mortimer Kisses.
* Snapfire's low armor and agility gain means that Vendetta will deal a decent amount of damage.

* Mana Burn can instantly deplete Tidehunter's low mana pool, especially in the early game, potentially preventing Tidehunter from casting Ravage.
* Ravage's travel time allows Nyx Assassin to easily stun Tidehunter with Spiked Carapace.
* Vendetta offers a very rare break effect, which fully disables Kraken Shell and makes Tidehunter susceptible to follow-up disables.

* Both Gush and Ravage do little damage against Counterspell.
* Blink helps Anti-Mage escape through Anchor Smash.
* Tidehunter's small mana pool can be eated by Mana Break, preventing to spam his abilities and ignores the protection from Kraken Shell.
Additional:
* Mana Break quickly burns Tidehunter's mana pool, preventing him from spamming his abilities, and Kraken Shell does not mitigate the bonus damage component.
* Blink allows Anti-Mage to enter combat quickly and safely after Ravage.

* Due to Pugna's incredible intelligence growth and terrible strength growth, Nyx should always be able to take you out with his combo, with or without an added Dagon. Mana Burn will deal a large amount of damage in particular, especially in the late game.
* Spiked Carapace is also a great tool versus Pugna. A good player will wait for you in Vendetta until you farm a creep wave with Nether Blast and reflect it back at you as their initiation and setup for Impale.
Additional:
* Nether Blast's animation makes it easy to time Spiked Carapace for a stun.
* Pugna has the largest intelligence gain in the game, making him a prime target for Mana Burn.
* Pugna needs to channel Life Drain, making him easy to hit with Impale.

* Pugna only deals magical damage, which Anti-Mage is exceptionally resistant due to Counterspell.
* Anti-Mage can dispel Decrepify with Manta Style.
* Pugna has a very large mana pool. This allows Anti-Mage to constantly deal bonus damage to Pugna with Mana Break and devastate Pugna's entire team with Mana Void.
Additional:
* Since Pugna relies on his teammates for protection, it is fairly common for Anti-Mage to get multiple kills with a single use of his Mana Void on Pugna if he's missing a considerable portion of his mana.
* Pugna's massive mana pool will result in Anti-Mage's Mana Break almost always dealing the bonus damage from the mana burn.
* Counterspell negates a large amount of Pugna's damage, as most of Pugna's damage comes from his spells.
* Blink can be used to get out of a bad situation, and Pugna has no way to prevent him from casting it.

* Because of the high mana cost of Ball Lightning, Storm Spirit is often vulnerable to Mana Void.
* Mana Break diminishes Storm Spirit's mobility with Ball Lightning, and Anti-Mage can catch him with Blink over short distances.
* Almost all of Storm Spirit's damage is magical, which is severely reduced by Counterspell.
* Storm Sprit has a very large mana pool which means Anti-Mage can do large amounts of damage to him with Mana Break and Mana Void.
Additional:
* Mana Break can quickly burn Storm Spirit's mana, preventing him from escaping.
* Blink allows Anti-Mage to catch up to Storm Spirit when he tries to use his Ball Lightning to escape.
* Mana Void deals massive damage to Storm Spirit as well as his teammates, as Storm Spirit depletes his mana pool by using Ball Lightning.
* Counterspell's passive magic resistance reduces much of Storm Spirit's magical damage dealt to Anti-Mage, and the active aspect may even make Storm Spirit disable himself.

* Mana Burn is capable of removing most of Storm Spirit's large mana pool, along with dealing heavy damage and quickly depleting his chances of escaping a gank or fight.
Additional:
* Mana Burn removes much-needed mana for Ball Lightning.
* Spiked Carapace triggers on Static Remnant for an easy stun.

* Nyx Assassin's high burst damage can be the bane of Dark Willow, as her low health makes it difficult to survive long enough to escape through Shadow Realm.
* Spiked Carapace can be triggered by walking deliberately into Bramble Maze, leaving Dark Willow stunned and defenseless.

* Counterspell negates Dark Willow's high magic burst damage. Its active blocks Cursed Crown.
* Blink allows Anti-Mage to dodge Terrorize during its long cast animation, as well as avoiding the obstacles from Bramble Maze. On the other hand, if Anti-Mage gets caught inside Bramble Maze, he's unable to Blink away.
* Dark Willow's chained magic burst requires a lot of mana, setting her up for damaging Mana Voids.

* Impale interrupts Upheaval.
* Nyx Assassin Vendetta allows him to escape from Warlock's Upheaval with maximum move speed.
* Warlock's low health pool and mobility can easily take down by Nyx Assassin's burst damage.

* Mana Break prevents Warlock from casting his spells.
* Blink allows Anti-Mage to escape from Upheaval.
* Counterspell reduces damage from Shadow Word and the {U:Warlock Golem}'s Permanent Immolation.
* Mana Void deals heavy damage after Chaotic Offering and interrupts Upheaval.

* Vendetta disables Vengeance Aura and allows him to attack Vengeful Spirit with Impale and Mana Burn.
* Spiked Carapace is easy to use against a Wave of Terror or Magic Missile.

* Past the mid game, an isolated Vengeful Spirit makes for an easy kill for Anti-Mage.
* Magic Missile is the only disable Vengeful Spirit has against Anti-Mage, but he can either Blink away to disjoint the stun or reflect it back against Vengeful Spirit with Counterspell.
* Nether Swap isn't very effective against Anti-Mage - if used offensively, Anti-Mage can simply blink away to safety, and if used defensively, Blink's low cooldown allows him to persistently chase as well.

* Heroes that can jump on her: Slark, Queen of Pain, Anti-Mage

* Vendetta breaks Untouchable and deals great damage against her.
* Enchantress' lack of mobility makes her a primary target for ganking with Vendetta.
* Spiked Carapace can reflect Impetus and stun Enchantress.
* Mana Burn can deal tremendous damage against her due to being an Intelligence hero.
Additional:
* Vendetta disables Untouchable.
* Spiked Carapace reflects the damage from Impetus.
* Enchantress is a rather squishy hero, making her fall easily to Nyx Assassin's high burst damage.

* Assassinate is easy to reflect with Spiked Carapace for massive damage.
* Shrapnel's area damage can set up an easy stun with Spiked Carapace, especially when combined with Vendetta.
* In the early game, Sniper's low health pool and high intelligence makes him easy prey for Nyx Assassin.

* Heroes with high mobility can approach Sniper: Anti-Mage, Earth Spirit, Io, Nature's Prophet, Pangolier, Puck, Queen of Pain and most notably Riki.

* Anti-Mage's high mobility from Blink and tendency to build Battle Fury makes him strong against split-pushing heroes: Nature's Prophet, Tinker, and Arc Warden.

Additional:
* Tinker is fragile and vulnerable against carries like Anti-Mage.
* Mana Break burns away his mana pool and deals bonus physical damage.
* Tinker's massive mana pool makes Mana Void deal large amount of damage, and can be used to cancel a Boots of Travel teleport even through spell immunity.
* Blink gives Anti-Mage many options, like disjointing Heat Seeking Missiles or leaving March of Machines' area of effect. He can use Blink to wait out of sight for a split pushing Tinker or chase a blinking Tinker into trees.
* Tinker doesn't want any of his spells reflected back at him through Counterspell.

* His whole skillset acts like a counter to Tinker:
* Impale prevents Tinker from blinding Nyx Assassin or fighting back, while giving Nyx' allies time to catch up to Tinker's position.
* Mana Burn generally deals more damage to intelligence based heroes like Tinker
* Spiked Carapace can stun Tinker at a moment of Nyx Assassin's choosing if March of the Machines has been cast. It is also quite easy to time Spiked Carapace against Heat Seeking Missiles.
* Vendetta allows Nyx to approach Tinker in the trees or wait for him in common hiding spots and deal heavy damage to his low armor.
Additional:
* March of the Machines and Heat-Seeking Missile allow easy Spiked Carapace stuns.
* As a fragile hero that relies on mana and intelligence items, Tinker is vulnerable to Mana Burn.
* Nyx Assassin's stuns can interrupt Rearm and leave Tinker helpless.

* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: Lich, Necrophos, Oracle, and Leshrac.

Additional:
* Counterspell severely reduces Leshrac's magical damage.
* Leshrac already burns through his own mana with Pulse Nova, Mana Break will burn through even more.
* Leshrac's high mana pool will increase the amount of damage Mana Void does to him when his mana is low.

* Nyx Assassin's Spiked Carapace will stun Leshrac when hit by any of his AOE abilities.
* Mana Burn deals high damage due to Leshrac's high intelligence gain and burns a large amount of Leshrac's essential mana pool.

* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: Invoker, Silencer, Nyx Assassin, Skywrath Mage, Shadow Shaman, Lion and etc.

* Anti-Mage easily Blinks out of Cold Feet's freeze radius.
Additional:
* Anti-Mage can Blink away from Cold Feet or to build a Manta Style to dispel it.
* Counterspell minimizes the damage Anti-Mage takes from all of Ancient Apparition's abilities.
* Mana Break and Mana Void deal a lot of damage to Ancient Apparition due to his high mana pool.

* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

Additional:
* Nyx Assassin takes advantage of Invoker's massive intelligence gain and mana pool to do tons of damage using Mana Burn, as the spell does more damage based on the target's intelligence.
* Nyx Assassin can simply activate Spiked Carapace while under many Invoker's abilities to stun him.

* Anti-Mage's mobility and magic resistance make him nearly impossible to kill alone.
* Invoker's spells cost a lot of mana, and Invoker himself has a lot of mana. This means Invoker and his team are vulnerable to Mana Void's heavy damage.
* Blink allows Anti-Mage to escape from Invoker's combo if he doesn't have disables.

* Silence (and mana burns) will be a persistent problem for Phoenix, as it is heavily reliant on its abilities whether defensively or offensively, so heroes like Death Prophet, Skywrath Mage, and even Nyx Assassin must be closely observed to prevent being shut down by these heroes.
* Hexes are a greater threat to Phoenix as they also disable items, preventing Phoenix from dispelling the debuff on its own.

Additional:
* Spiked Carapace reacts on any of the damage over time from Phoenix's abilities and can interrupt Sun Ray and Icarus Dive.

* Anti-Mage dispels Phoenix's slows with Manta Style.
* Anti-Mage can Blink directly next to Supernova, giving him more time to destroy the egg.

* Enigma's Midnight Pulse damage can be substantially mitigated by Anti-Mage's high magic resistance thanks to Counterspell.
* In the early game, Anti-Mage's Mana Void can cancel a Black Hole until Enigma gets his Black King Bar.
* Should Anti-Mage survive a Black Hole combo, Enigma will have exhausted most of his skills and items, preventing him from defending himself against any counter initiation or a follow-up from a blink escape.

* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Puck, Slark, Nyx Assassin, etc.

Additional:
* Enigma's uncontrollable damage from Malefice and Midnight Pulse make him easy to stun with Spiked Carapace.
* Black Hole can be easily interrupted by Impale or Spiked Carapace.

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Venomancer's damage-over-time abilities do little damage against Counterspell.
* Blink helps Anti-Mage get away from Venomancer's slows.
Additional:
* Counterspell provides magic resistance, diminishing the effectiveness of Venomancer's spells.
* Venomancer's lack of hard disable allows Anti-Mage to use Blink, circumventing the slows Venomancer depends on.

* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: Lich, Necrophos, Oracle, and Leshrac.

* The huge physical damage taken from Vendetta will force Necrophos to use Ghost Shroud, which is good for a followup with Dagon and Ethereal Blade, both of which are common items on Nyx Assassin.
* Using Ghost Shroud also sets Necrophos up for a Mana Burn or Impale.

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Dark Seer's strength lies in his high-mana cost skills. So Mana Break can be a great nuisance for him, since it can reduce his mana and prevent him from casting his spells.
* Mana Void can deal a lot of damage if Dark Seer spent a lot of mana on his abilities.

* Counterspell gives Anti-Mage magic resistance to negate a majority of Skywraith Mage's magical damage.
* Anti-Mage often builds Black King Bar and Manta Style which can dispel Ancient Seal and Concussive Shot.
* Huge mana cost on Mystic Flare means easy target for Mana Void.
* However, Anti-Mage is weak early-game to Ancient Seal until he can dispel silences, but still, Skywrath's solo kill potential is very low.

* Skywrath Mage's low health makes him rather easy prey for Nyx Assassin and his lack of armor generally means he'll take the full brunt of a Vendetta strike.
* Mana Burn is annoying at all stages of the game as it turns Skywrath Mage's high intelligence growth against him.
* Spiked Carapace gives Nyx some degree of protection against Skywrath's spells.

* Anti-Mage's high mobility from Blink and tendency to build Battle Fury makes him strong against split-pushing heroes: Nature's Prophet, Tinker, and Arc Warden.

* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin

* Heroes with high burst damage: Lina, Lion, Luna, Nyx Assassin, Queen of Pain.

* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: Timbersaw, Slark, Shadow Fiend, Clinkz, Bristleback Nyx Assassin, Magnus

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin

* Mana Burn is strong against Keeper of the Light due to his high mana pool.
* Spiked Carapace can be used to reflect Illuminate damage and stun Keeper of the Light.
* Vendetta allows Nyx Assassin to follow Keeper of the Light around if he tries to split-push.

* Mana Break quickly eats away at Bristleback small mana pool, preventing him from spamming Viscous Nasal Goo and Quill Sprays.
* Bristleback has no innate mobility. Bristleback is easily kited by Blink, ignoring the protection from Bristleback.
Additional:
* Mana Break quickly depletes Bristleback's low mana, denying him the ability to spam Quill Spray and Viscous Nasal Goo.
* Bristleback has no way to prevent Anti-Mage from using Blink.

* Mana Break makes Gyrocopter, who has low mana pool, unable to use his abilities that most of his damage output depends on.
* Counterspell negates magical damages from Gyrocopter and it can also reflect Homing Missile back to himself.
* Anti-Mage can easily escape from Gyrocopter's attack range and Call Down with Blink.

* Nyx can walk into Firefly with Spiked Carapace and stun Batrider if he has no Spell Immunity.

* With Vendetta, Nyx Assassin can move closely to Ember Spirit when he's farming with his Flame Guard and use Spiked Carapace with Impale to provide a reliable and long disable.
* Mana Burn is also good, as Ember Spirit relies on his limited mana pool for the early to midgame.
Additional:
* Spiked Carapace can be easily triggered by Flame Guard or Battle Fury, setting up a deadly Impale.

* Counterspell's bonus magic resistance causes the Ethereal Blade and Adaptive Strike combo to deal significantly less damage.
* Counterspell's active component can reflect the Ethereal Blast and Adaptive Strike combo back into Morphling, dealing significant damage or even killing him.
* Mana Break combined with Manta Style can quickly burn away Morphling's mana, leaving him unable to use his spells.

* Ursa can be kited by Blink. Additionally, Anti-Mage can steal Aegis of the Immortal during Roshan attempts through the Pit.
* Anti-Mage usually builds Manta Style, which can dispel Earthshock's slow.
* Anti-Mage can control Ursa's low mana pool via Mana Break.
* Anti-Mage can farm much more quickly than Ursa, allowing Anti-Mage to overpower Ursa once a significant farm advantage is established.

* Mana Break is very effective against Tusk, as he has a very low mana pool.
* Blink allows Anti-Mage to escape from an incoming Snowball.
* Counterspell reflects the Snowball back onto Tusk

* Mana Break quickly eats away at Rubick's low mana pool, preventing Spell Steal abilities from triggering.
* Rubick's complete lack of mobility makes him very easy for Anti-Mage to chase down with Blink.
* Anti-Mage dispels Fade Bolt damage reduction debuff with Manta Style or severly reduced by Counterspell.

* Echo Stomp and Earth Splitter's long cast times give Anti-Mage plenty of time to Blink away.

* Blink can easily break Static Link and Counterspell reflects Static Link on Razor.

* Blink allows Anti-Mage to hunt down Jakiro, who has no way to escape.
* Counterspell protects Anti-Mage against all of Jakiro's magic damage.
* Mana Void is very effective against Jakiro because of his high mana.

* Many of Nyx Assassin's abilities are good against Windranger.
* Impale is great for stunning Windranger and allowing additional disables to be landed.
* Mana Burn is useful against Windranger's decent intelligence growth and also burns some mana, preventing her from using more abilities.
* Spiked Carapace is easy to use against Powershot.
* Vendetta allows Nyx Assassin to sneak up on and deal massive damage to Windranger without giving Windranger a chance to use Windrun to evade it.
* Nyx Assassin's item build allows him to easily deal with Windranger.

* Ogre Magi only deals magical damage, which Anti-Mage is exceptionally resistant due to Counterspell.
* Anti-Mage dispels Ignite with Manta Style.
* Ogre Magi has a very large mana pool which means Anti-Mage can do large amounts of damage to him with Mana Break and Mana Void.

* Crystal Maiden has a very bad movement speed, so Impale is easy to land against her. Furthermore, even while trapped by Frostbite, Nyx Assassin can still cast Impale.
* Crystal Maiden has very low armor, so Vendetta is very effective.
* Nyx Assassin has two ways to stop Freezing Field, provided she doesn't get a Black King Bar. He can pop Spiked Carapace and simply walk into the field, or he can use Impale to interrupt the field, since Crystal Maiden has to channel it.
Additional:
* Spike Carapace easily interrupts Freezing Field.
* Frostbite's damage over time sets up an easy Spiked Carapace stun.
* Crystal Maiden is extremely fragile and dies quickly to Nyx Assassin's burst damage.

* Heroes with large health pools (Pudge) or good innate magic resistance (Anti-Mage) can be very problematic for Crystal Maiden, since even if they are under the effect of her ultimate for the entire duration, the damage output is simply not enough to kill or force them to retreat.

* Tombstone's zombies rarely inhibit Anti-Mage, as he can either Blink away or onto the Tombstone and destroy it.

* Mana Break quickly eats away at Wraith King's small mana pool, preventing Reincarnation from triggering.
* Wraith King has no innate mobility. Even with Blink Dagger, Wraith King is easily kited by Blink.
* Anti-Mage can farm much more quickly than Wraith King, allowing Anti-Mage to overpower Wraith King once a significant farm advantage is established.
Additional:
* Mana Break can prevent Wraith King from reincarnating unless Wraith King picks the level 20 talent that removes the mana cost from Reincarnation.
* With Manta Style, his mana burning will triple because illusions can also use Mana Break.

* Anti-Mage Blinks directly into Magnetic Field, bypassing its protection.
* Anti-Mage's high mobility allows him to deal with Tempest Double while it is split-pushing.
* Anti-Mage's Battle Fury cleans up Arc Warden's Necronomicon summons, and Counterspell protects him from Necronomicon Warrior's Last Will.
Additional:
* Arc Warden's high reliance on casting spells leads him to be dependent on mana, which Anti-Mage can easily burn with Mana Break.
* Blink mitigates the threat of Flux slow and allows Anti-Mage to close the distance between himself and Arc Warden.
* Anti-Mage's ability to farm quickly allows him keep up with Arc Warden's farm while also de-pushing the lanes Arc Warden shoves in with Tempest Double.
* Counterspell significantly reduces the effectiveness of Arc Warden's magic damage.

* Spectre cannot chase down Anti-Mage with Spectral Dagger because of Blink, though it still grants her team vision over him.
* Counterspell reduces much of the damage from Dispersion and Spectre's Radiance.
* Anti-Mage usually builds a Manta Style, preventing Spectre from dealing any Desolate damage to him once he summons his illusions.
Additional:
* Spectre has no way to prevent Blink, for escape or initiation. Anti-Mage can easily pick off enemy supports and Spectre cannot do anything about it.
* Mana Break burns through Spectre's low mana pool.
* Manta Style's illusions prevent Desolate's damage.
* Even though Anti-Mage is outcarried by Spectre in the later stages of the game, a competent Anti-Mage with a Battle Fury can easily outfarm and get ahead of Spectre before she can come online.

* Anti-Mage can Blink into or out of Power Cogs, negating Clockwerk's initiation and bypassing his defenses.
Additional:
* Anti-Mage can easily Blink out of Power Cogs, escaping any ganking or initiation attempts.
* Mana Break depletes Clockwerk's much-needed mana.

* Zeus almost exclusively relies on magical damage, which is heavily reduced by Counterspell.
* Zeus' complete lack of mobility makes him very easy for Anti-Mage to chase down with Blink.
* Zeus likes to stand in the back during team fights, but Anti-Mage can easily Blink to close the distance.
Additional:
* Anti-Mage can burn mana, which is a big problem for a spellcaster like Zeus that heavily relies on it.
* Counterspell decreases magical damage taken from Zeus.
* Zeus' high intelligence and mana pool makes him a perfect target for Mana Void.

* Heroes with damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Heroes with considerable mobility can easily escape from a rolling Pangolier: Anti-Mage, Queen of Pain, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, moreover, if a player is familiar with how Rolling Thunder work, they can adjust their movement to avoid it entirely and of course outplay the Pangolier player.

* Mana Break drains Abaddon's mana, preventing him from using Aphotic Shield to zone out enemies in lane.
* Counterspell decreases the amount of damage received from Aphotic Shield and Mist Coil.

* Nyx Assassin might not kill Abaddon with his nuke, but a support Abaddon will struggle to protect an ally from him.

* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: Timbersaw, Slark, Shadow Fiend, Clinkz, Bristleback Nyx Assassin, Magnus

* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: Timbersaw, Slark, Shadow Fiend, Clinkz, Bristleback Nyx Assassin, Magnus

* As a caster, Anti-Mage's Mana Break and Mana Void are highly effective against him.

* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill you, Nyx being particularly deadly. Watch Slark carefully, as he can break either (but not both unless you are making a mistake) of your disables, with Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn you from prey to predator.

* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: Lich, Necrophos, Oracle, and Leshrac.

Additional:
* Although he can be effective against Anti-Mage in an aggro offlane, Lich has a hard time nuking down Anti-Mage in the midgame due to his Counterspell.
* All of Lich's abilities are also targeted, which makes it much harder to disable Anti-Mage.
* In the lategame, Anti-Mage can easily pick off Lich with Blink, and the high mana cost of Chain Frost along with Lich's large mana pool makes him vulnerable to Mana Void.
* Blink allows Anti-Mage to escape Chain Frost.

* Nyx Assassin can reflect Life Break with Spiked Carapace.

* Heroes with illusions can overwhelm Huskar, as he has no AoE abilities: Phantom Lancer, Anti-Mage, Arc Warden, Chaos Knight.

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: Lich, Necrophos, Oracle, and Leshrac.

Additional:
* Oracle has minimal damage potential against Anti-Mage due to Counterspell, and may even have some ability damage reflected at himself.
* Anti-Mage can easily overwhelm Oracle with Mana Break and Mana Void.
* Blink allows Anti-Mage to easily chase and take advantage of Oracle's low mobility.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Nyx Assassin can take advantage of every one of Puck's weaknesses. His entire skill set is very effective in countering Puck.
* Because Illusory Orb is such a slow moving projectile, Nyx Assassin can simply walk into the orb and activate Spiked Carapace, stunning Puck and setting up an easy Impale. This can be circumvented by using Phase Shift while the orb is traveling, however, that means that Puck cannot use Phase Shift to dodge any other skill nor use it to safely blink away from a fight.
* Puck is an intelligence hero that likes to build intelligence items such as Eul's Scepter of Divinity, Scythe of Vyse, and Dagon. This makes Mana Burn that much more deadly against Puck.
* An ill-timed Phase Shift can easily set himself up to be stunned by Impale.
* Puck's low base armor and below average agility gain means he is always susceptible to Vendetta.
Additional:
* Illusory Orb is easy to reflect with Spiked Carapace, either stunning Puck and setting up an easy Impale or forcing a premature Phase Shift.
* Puck is an intelligence hero that tends to build intelligence items, making it vulnerable to Mana Burn.
* An ill-timed Phase Shift can easily set Puck up to be stunned by Impale.
* Puck's low base armor and below average agility gain mean it is always susceptible to Vendetta.

* Thanks to Counterspell Anti-Mage can fight Techies head on and trip multiple mines once the late game hits.

* Silencer is rather squishy and has poor mobility without items, making him an easy target for Nyx.
* Mana Burn will deal increasing damage for each 2 points of intelligence Silencer has stolen, turning Silencer's intelligence steal against him.

* Death Prophet has a high mana pool and due to her heavy reliance on her spells, she will be a prime target for Mana Void.
* Death Prophet has less mobility than Anti-Mage due to Blink.

* Spiked Carapace allows Nyx to get an easy long-duration stun on Weaver once he uses Shukuchi, and then he can follow up with Impale.
* Vendetta works as a great setup for both Impale and Spiked Carapace and can deal decent damage to Weaver. Additionally he can neutralize The Swarm beetles due to his invisibility duration.

* Outworld Devourer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Devourer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed Sanity's Eclipse or well timed Spiked Carapace can deal a lot of damage to Outworld Devourer and stun him, unless Outworld Devourer used Black King Bar beforehand.
Additional:
* Outworld Devourer's high mana pool, high intelligence, and low health makes him a prime target for Mana Burn.
* If timed correctly, Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Devourer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned; if used on any other target, Nyx can come and stand close to it and use it to reflect the damage.

* Heroes with break abilities: Nyx Assassin, Shadow Demon (with Aghanim's Scepter), Viper.

* Nyx Assassin has a lot of burst damage from his Impale, Mana Burn, Dagon, and the bonus damage from Vendetta. All of this damage is enough to kill Drow Ranger.
* Nyx Assassin is usually invisible most of the time thanks to his ability Vendetta, which allows him to gank Drow Ranger easily.

* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: Timbersaw, Slark, Shadow Fiend, Clinkz, Bristleback Nyx Assassin, Magnus