* Brain Sap's pure damage ignores stacks of Reactive Armor.
* Nightmare prevents Timbersaw from using Timber Chain, setting him up for chain stuns and burst damage.
* Enfeeble highly reduces regeneration granted by reactive armor.
* Fiend's Grip immobilizes Timbersaw and drains his low mana pool, preventing escape afterwards. It also pierces Black King Bar.
* Bane's multiple disables often force Timbersaw or his teammates to spend gold on a Linken's Sphere.

* Timbersaw is heavily reliant on his abilities for damage and escape, allowing Silencer to effectively disable him and make him useless in both team fights and 1v1 scenarios.
Additional:
* Arcane Curse deals repeated stacks of damage to Timbersaw because he relies on constantly using his abilities.
* Glaives of Wisdom deals pure damage and when cast manually, nearby creeps will not attack silencer, making it an effective harassment tool.
* Although Last Word takes a while to trigger, it will break Timbersaw's ability combo and can be used to silence him.
* Global Silence will silence Timberaw no matter where he is on the map. This can be used to help allies get a kill on him, or prevent Timbersaw from killing someone.

* If Bane is outside Chronosphere, he can use Nightmare or Fiend's Grip to cripple Faceless Void inside.
* Nightmare and Fiend's Grip are long duration disables and can render Time Walk's mobility very unreliable.

* Global Silence has faster cast animation than Chronosphere, making Silencer can silence Faceless Void before he can cast Chronosphere.

* Silencer burns easily through her effective HP from Mana Shield, by taking away her intelligence.
* Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. He can force her to use Manta Style before he has cast Global Silence and Medusa usually does not want to build Black King Bar.

* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* Fiend's Grip leaves Medusa defenseless, if Bane's teammates can cover him or he initiates at the right time by Spell immunity.

* Like any hero with a channeled spell, Last Word is a counter to it.
* Global Silence goes through spell immunity and prevents Witch Doctor from casting his spells.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Fiend's Grip prevents Anti-Mage from Blinking away or using Manta Style. It also pierces spell immunity.
* Nightmare sets Bane's team up for chain disables on Anti-Mage.
* Enfeeble lowers Anti-Mage's status resistance and magic resistance, making him more vulnerable to disables and magic damage.

* Heroes with abilities or items that can silence or disable Anti-Mage for long periods of time will prevent him from Blinking away: Silencer, Shadow Shaman, Grimstroke, Witch Doctor, Riki, Faceless Void, Skywrath Mage, Puck.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Invoker is heavily dependent on his spells, making him useless during Global Silence, as well as interrupting Invoker during his combo.
* Arcane Curse is particularly deadly, because Invoker will continuously lose health if he keeps invoking and casting new spells.
* Last Word will silence Invoker when he casts Invoke, interrupting his combo.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Generally strong against every spellcaster, Puck fully relies on their skill set and is barely a threat when silenced.
* Arcane Curse disables Blink Dagger for quite some time, and is also effective against Puck as it tend to use its spells a lot.
* Glaives of Wisdom can do a lot of damage against Puck due to Puck's low agility gain and armor.
* Last Word can prevent Puck from getting a full combo off, limiting its effectiveness in team fights or ganks.
* Global Silence can take Puck out of fights entirely.

* Silencer's Global Silence will render Zeus useless for 6 seconds in a team fight.
* Arcane Curse will punish Zeus for casting spells, which can cause continuous damage to him should he continue to cast spells.
* Last Word can silence Zeus and prevent him from spamming his spells.
* Silencer often builds Orchid Malevolence (or Bloodthorn) which can be used on spell casters like Zeus, forcing him to invest in a Linken's Sphere.
Additional:
* Zeus' main source of damage is his low cooldown, high damage spells - meaning Last Word and Global Silence will pretty much take him out of the game for the duration.
* Zeus likes to spam his abilities, which makes him vulnerable to Arcane Curse.
* If Zeus dies near Silencer, he will begin to lose intelligence, reducing his mana pool, mana regen, and attack damage. Furthermore, if the game is long and Zeus dies often, the intelligence losses will also reduce his spell damage.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Wraith King, Medusa, Storm Spirit and other mana dependent heroes will have diminished impact on a fight if they survive Fiend's Grip due to its mana steal.

* Silencer's Intelligence Steal can reduce Storm Spirit's damage output if he gets some kills on laning phase.
* Last Word and Global Silence will make Storm Spirit an easy target.
* Global Silence can be used to prevent Storm Spirit from connecting abilities after a Ball Lightning on his targets.

* Arcane Curse punishes Necrophos if tries to spam Death Pulse, increasing the duration of the slow and damage taken over time.
* Last Word heavily damages Necrophos and also silence him for a lenghty duration.
* Glaives of Wisdom will reduce temporarily Necrophos intelligence on each hit dealing hindering his ability to spam Death Pulse, also reducing his attack damage and mana pool; dealing increasing amounts of phisical and pure damage each time. Silencer will permanently steal Necrophos intelligence if killed by him or dies nears him.
* Global Silence turns Necrophos almost useless for a long time, allowing your team to easily dispatch him, since he heavily relies on his spells to survive.

* Heroes who possess abilities that can save targets from being killed by Reaper's Scythe: Abaddon, Bane, Outworld Destroyer, Shadow Demon, Omniknight, etc.

* Last Word or Arcane Curse can be cast from a long range to prevent Enigma's potential initiation.
* Global Silence can interrupt Enigma's Black Hole channeling through Black King Bar and Linken's Sphere, making Silencer one of Enigma's hard counters.
Additional:
* Silencer can easily ruin Enigma's initiation, as Global Silence cancels Black Hole, even through Black King Bar and Linken's Sphere.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Basically, Heroes that heavily rely on abilities for damage or escape, such as Queen of Pain and Storm Spirit.

* Heroes with silences : Bloodseeker, Riki, Silencer.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes with silencing abilities that are not blocked by Linken's Sphere, like Puck's Waning Rift, Death Prophet's Silence or Silencer's Global Silence.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Silences and other types of lockdown that prevent Weaver from using his spells: Silencer, Riki, Lion, Legion Commander, Shadow Shaman, Bane.

* Global Silence stops Snapfire's Mortimer Kisses.
* Last Word can prevent Snapfire from casting additional spells.

* Global Silence and Last Word can prevent Ember Spirit from casting Activate Fire Remnant to escape.
* Glaives of Wisdom also provide high pure damage that is not negated by Flame Guard.
* Arcane Curse is also a potent harassing tool in the laning stage as its cooldown is lower than Flame Guard's.

* Bristleback will not be able to cast Viscous Nasal Goo or Quill Spray while silenced, effectively blocking a major part of the hero's damage and preventing Warpath charges from stacking.
* Arcane Curse slows Bristleback down and lasts longer the more abilities he uses. On the other hand, if he doesn't use any abilities, he will begin to lose Warpath charges.
Additional:
* Arcane Curse stacks every time Bristleback uses an ability, forcing him to stop spamming his abilities, or take heavy health degeneration.
* Glaives of Wisdom steals intelligence both permanently and temporarily, causing mana issues for Bristleback .
* Last Word and Global Silence stops Bristleback from using his abilities altogether.

* Kunkka relies on his powerful AOE spells to turn the tides of teamfights. He cannot use them while silenced.
* Last Word can mess up Kunkka's ability synergy, silencing him in the middle of his strong combo.
* Global Silence can disable Kunkka's spell casting from anywhere on the map, even if Kunkka is spell immune at the time.

* Last Word and Arcane Curse have the range to hit Dark Willow beyond Bramble Maze.
* Global Silence renders Dark Willow useless in teamfights.

* Fiend's Grip and Nightmare are very useful to lock down Void Spirit.
* Brain Sap can be difficult for Void Spirit to deal with in the laning stage.

* Silencer will most likely disrupt an initiation with his ultimate, Global Silence, prevent escape with his Last Word, and if Phoenix happens to die to him (or near him) enough times, he would sap enough of Phoenix's much needed Intelligence to make him a stronger foe and Phoenix with less mana than it already had.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Silencer's intelligence steal will heavily reduce Outworld Destroyer's damage output, especially if Destroyer dies a lot near Silencer and loses intelligence permanently.
* Global Silence and Last Word will render Outworld Destroyer helpless unless he has an item/ally to dispel silence.
Additional:
* Silencer's Intelligence Steal will heavily reduce Outworld Destroyer's damage output, particularly from Sanity's Eclipse.
* Last Word and Global Silence will take Outworld Destroyer out of the fight unless he has built Black King Bar.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* As Tinker relies heavily on his spells to be effective, Last Word and Global Silence will render him largely useless.
* Arcane Curse effectively prevents Tinker from casting spells during its duration, as he will otherwise suffer heavy damage.
* Glaives of Wisdom deal pure damage, which make quick work of fragile heroes like Tinker.
Additional:
* Silencer can stop Rearm, preventing Tinker from spamming his abilities/items or escaping.

* Crystal Maiden is squishy, is heavily spell reliant, has low base Intelligence, and is naturally slow, making her an ideal target for Silencer.
* Crystal Maiden's Freezing Field has a similar cooldown to Global Silence, therefore, Freezing Field can almost always be canceled to ruin aggressive Crystal Maiden initiations.

* Silencer's Last Word and Global Silence prevents Jakiro from casting any spell.
* A carry Silencer can easily take down a support Jakiro with his Glaives of Wisdom.

* A well-timed Global Silence prevents Dazzle from saving allies with Shallow Grave or Shadow Wave. Items that could dispel the silence are expensive, and difficult for Dazzle to farm from a support role.
* Arcane Curse and Last Word cause long damage over time, which may outlast Shallow Grave.

* Arcane Curse can effectively discourage Undying from casting his spammable abilities in a team fight, as Undying will have to suffer more damage and the slow due to the penalty duration of Arcane Curse.
* Last Word and Global Silence are able to silence Undying for up to 6 seconds, preventing Undying from gaining strength and healing his ally or himself.

* Both Arcane Curse and Last Word punishes casters with spammable spells such as Sand King.
* As a strength caster, Intelligence Steal reduces Sand King's mana pool even more.
* Global Silence silences Sand King, effectively reducing Sand King's initiation and counter-initiation potential. It can also interrupt channeling of Epicenter.

* Being a cast-oriented hero, Ezalor will suffer from all of Silencer's abilities.
* Global Silence is a guaranteed lengthy silence which will render Ezalor useless in a teamfight.
* Arcane Curse and Last Word are good against any caster, since they are extremely potent.
* However, it should be worth mentioning that a smart Ezalor will buy Eul's Scepter of Divinity to dispel Silencer's abilities. Combined with the level 20 talent (Chakra Magic applies a basic dispel), Ezalor can purge Silencer's abilities off allies and himself alike.

* Pugna is very reliant on his abilities for damage. (Just be careful around the Nether Ward)

* After Brewmaster has committed Thunder Clap and Cinder Brew to gank, Bane can use Nightmare on Brewmaster to wait out the debuffs, and might even turn the tables by buying time for allied reinforcements.
* Bane can also prevent Brewmaster from using Primal Split with his long disables.

* Because Warlock's abilities are all active abilities, Silencer can make his impact minimal.
* Arcane Curse prevents Warlock from using his abilities without increasing it's duration, which since all of Warlock's abilities are actives it is very effective against him.
* Last Word can prevent Warlock from casting his Fatal Bonds, Chaotic Offering, and Upheaval combo.
* Global Silence can nullify Warlock's impact in fights by preventing him from casting Fatal Bonds and Chaotic Offering, or by interrupting his Upheaval.

* Lion is extremely dependent on his abilities. Silences like Silencer's Last Word, magic resistance like Oracle's Fate's Edict, and dispels like Legion Commander's Press the Attack all make his abilities less effective.

* Heroes with nukes: Bane, Lich, Lion, Skywrath Mage

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

Additional:
* Nightmare and Fiend's Grip help to control/disable Troll Warlord in team-fights.

* Heroes with spell immunity can still be disabled by Fiend's Grip: Juggernaut, Lifestealer, Pangolier.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Windranger heavily relies on her abilities for any form of tactical advantage and damage. A well timed silence will make her useless: Puck,Silencer, Death Prophet, Skywrath Mage, Drow Ranger, Earth Spirit, Grimstroke.

Additional:
* Silencer's abilities hamper Windranger's effectiveness in battle, preventing her from comboing abilities and escaping using Windrun.

* Heroes with spell immunity can still be disabled by Fiend's Grip: Juggernaut, Lifestealer, Pangolier.

Additional:
* Fiend's Grip can disable Lifestealer through Rage.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: Invoker, Silencer, Nyx Assassin, Skywrath Mage, Shadow Shaman, Lion and etc.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Heroes with silence such as Riki, Silencer, or Night Stalker prevents Skywrath Mage from using his spells.

* With 4 active abilities, Shadow Shaman is weak against silencing foes such as silencer, Drow Ranger and Death Prophet.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

Additional:
* Fiend's Grip pierces spell immunity, rendering Blade Fury nearly useless.

* Arcane Curse discourages Lina from using her abilities, preventing her from building up Fiery Soul stacks.
* Last Word and Global Silence are great against Lina for the same reason, as well as interrupting her combos and preventing her from casting spells.

* Viper's Corrosive Skin is useless against Bane as all of his damaging abilities deal Pure damage.
* Viper has no solutions to cancel Fiend's Grip and in addition, he hates buying disabling items like Eul's Scepter of Divinity.

* Shadow Demon's main source of damage is his low cooldown, high damage spells - meaning Last Word and Global Silence will pretty much take him out of the game for the duration.
* Shadow Demon likes to spam his abilities, which makes him vulnerable to Arcane Curse.
* If Shadow Demon dies near Silencer, he will lose intelligence, reducing his mana pool, mana regen, and attack damage. Furthermore, if the game is long and Shadow Demon dies often, the intelligence losses will also reduce his spell damage.

* Global Silence takes Omniknight out of the fight completely.
* Glaives of Wisdom are a great harass vs Omniknight during the laning stages of the game, since it doesn't aggro creeps & ignores his high base armor. It deals pure damage, which means it can also go through Guardian Angel.
* Silencer's intelligence steal can also cause Omniknight to falter in the early phases as it reduces his ability to use his spells.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Enfeeble greatly reduces Phantom Assassin's burst damage.
* Nightmare and Fiend's Grip can ground Phantom Assassin, who normally blinks around with Phantom Strike, and stop her from outputting damage, even with Black King Bar.
* Phantom Assassin's low health pool early on makes her susceptible to Brain Sap and Fiend's Grip's heavy nuke damage.
Additional:
* Enfeeble greatly reduces Phantom Assassin's damage output, crippling her damage with Coup De Grace, lowering cast range of her abilities, making her unable to harass enemy heroes with Stifling Dagger, or escape/engage with Phantom Strike, and it also reduces any form of health regeneration Phantom Assassin receives.
* Brain Sap deals pure damage against Phantom Assassin and can nuke her down especially in early game.
* Fiend's Grip can disable Phantom Assassin, even through Black King Bar or any source of Spell immunity.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Enfeeble can be used to decrease Shadow Fiend's already abysmal level one damage even further, preventing him from getting farm and Necromastery stacks.
* Brain Sap allows Bane to heavily harass Shadow Fiend.
* Nightmare allows Bane to set up some early ganks onto Shadow Fiend.
* Fiend's Grip enables Bane to completely take Shadow Fiend out of a fight and potentially even kill him, even through Black King Bar.
Additional:
* Enfeeble can be used to decrease Shadow Fiend's already abysmal level one damage even further, preventing him from getting farm and Necromastery stacks.
* Brain Sap allows Bane to heavily harass Shadow Fiend.
* Nightmare allows Bane to set up some early ganks onto Shadow Fiend.
* Fiend's Grip enables Bane to completely take Shadow Fiend out of a fight and potentially even kill him, even through Black King Bar.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Silencer's Global Silence and Doom's Doom makes Earthshaker temporarily useless.

* Wraith King, Medusa, Storm Spirit and other mana dependent heroes will have diminished impact on a fight if they survive Fiend's Grip due to its mana steal.

* Bane can use Nightmare and Fiend's Grip to lock down Ursa early game and in team fights, forcing Ursa to buy a Black King Bar and making him very vulnerable to being kited once his Black King Bar is down to 6 seconds.
* Overall, Bane's potent disables force Ursa to build more defensive items and play more defensively in general.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Heroes with pure damage can kill Huskar when he inevitably gets low on health: Outworld Destroyer, Silencer.