* Cold Embrace can render the extra attack speed from Overcharge meaningless.
* Splinter Blast and Winter's Curse are very affective against Io, as it has to stay close to its tethered hero.

* Cold Embrace mitigates Primal Roar's single-target initiation on allies.
* Winter's Curse can turn Beastmaster's summons and Inner Beast against his teammate.
Additional:
* Beastmaster's summons and Inner Beast are very useful to attack his cursed teammate.
* Cold Embrace effectively mitigates Primal Roar's single-target initiation on allies.

* Lightning Storm will usually hit both Io and his Tethered target since both will be close enough for the lightning to jump. It can then be followed up by Split Earth.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and his Tethered target.
Additional:
* Io is a hero who needs to be close to it's tethered target to make it effective, and that's where Leshrac gets the advantage thanks to many of his area-of-effect abilities.
* Lightning Storm will usually hit both Io and its tethered target since both will be close enough for the lightning to jump.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to both, Io and its tethered target.

* Heroes who summon multiple units that are not spell immune. Nature's Prophet,Lycan,Beastmaster

* Burning Barrage and Searing Arrows allow Clinkz to quickly kill Io due to its low armor.
* Clinkz iz a hero that very often goes for Orchid Malevolence, and its upgrade Bloodthorn. And if Clinkz has it, he will be able to silence Io and prevent him from escaping wit either Tether or Relocate.

* Having many summons out will cause Echo Slam to deal extra damage.

* Lich's Chain Frost forces Io to either give up providing buff to his ally with Tether or suffer devastating damage with his tethered ally.
* Lich can easily use Sinister Gaze to disable Io from getting away with Tether or Relocate.

* Aphotic Shield effectively nullifies Primal Roar's single-target initiation on allies.
* Even being initiated by Primal Roar, Borrowed Time can make Abaddon extremely difficult to kill.
Additional:
* Primal Roar can be instantly dispelled by Aphotic Shield.
* The debuffs from Wild Axes and Poison from Call of the Wild: Boar can also be dispelled by Aphotic Shield.

* Living Armor can be used to save a hero from a Relocate gank.

* Frostbite kills boars instantly on the laning stage leading to either experience lead or disabling Beastmaster from using Boar
* Crystal Nova nukes and slows down the attack and movement speed of Beastmaster's summons.
* Freezing Field grants improved self armor, nukes and slows down Beastmaster and his summons.

* False Promise effectively nullifies Primal Roar's single-target initiation on allies.
* Purifying Flames kills Beastmaster's Hawk instantly and Boar with two casts.

* Chen can take control of the Boar from Call of the wild Boar at any time.

* Disruptor can always Glimpse back Io or his target after he Relocated nearby.
* Even better, thanks to the indicator on the ground, you can even preemptively drop Static Storm and Kinetic Field on the spot they will relocate to.
* Thunder Strike and Glimpse are also good tools to bring back an Io that Tethered away in the fog of war.
Additional:
* Glimpse directly negates Relocate.

* Lucent Beam can be used to cancel both, Tether and Relocate.
* Like with Leshrac's Diabolic Edict, Lightning Storm and Pulse Nova abilities. Luna's Moon Glaives and Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with Aghanim's Scepter.

* Ice Blast prevents Io from healing an ally with Tether and prevents healing from Overcharge
* Io is a common Mekansm builder which is useless if he is affected by Ice Blast.
Additional:
* Ice Blast prevents Io from healing the target.

* Charge of Darkness can be used to escape or counter-initiate against a Relocate gank.
* Greater Bash and Nether Strike is devastating due to Io's low armor, and can even knock it away from tethered target.

* Fireblast is a good tool to interrupt Io during its escapes through Tether.
* Ignite can be one of the few spells with enough total damage to out-trade the sustained healing Io provides for its fellow laner.
* However, picking other supports that focus less on the laning phase is generally a better choice against Io.

* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Additional:
* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.

* Illuminate clears Beastmaster's summons and is effective against his push.

* Grimstroke can catch Io and his ally easily with SoulBind as Io has a tendency to tether himself with an ally frequently.
* Io is highly vulnerable to disables. Hence, Grimstroke's Phantom's Embrace is a great ability to hinder Io's potential.
Additional:
* Soulbind can target both Io and its Tethered ally, allowing Grimstroke and his team to target both with single target spells. Should Io try to Relocate, Phantom's Embrace can stop its channel to prevent escape.

* Reactive Armor is very effective against Beastmaster's summons during laning stage and entire game.
* Timbersaw can quickly clear Beastmaster's summons with his nukes.

* Untouchable negates Inner Beast's attack speed bonus, making her hard to kill even if stunned by Primal Roar.
* Enchantress can also take control of Beastmaster's summons.
Additional:
* Enchant can control Beastmaster's boars, mitigating his effectiveness during the laning stage and teamfights.

* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.

* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper

* Heroes with strong dispels can remove Primal Roar's stun: Abaddon, Slark, Oracle.

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Heroes with summoned units don't fare well against Dawnbreaker. (Phantom Lancer ,Beastmaster ,Lycan)

* Fragile heroes: Bounty Hunter has decent nuking capabilities with Shiruken Toss and Jinada thus making fragile heroes easy picks for ganking. Few examples of such heroes are:Crystal Maiden, Pugna, Skywrath Mage, Io, Witch Doctor, etc.

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Heroes with AoE abilities are a bane to Beastmaster's summons: Storm Spirit, Magnus, Pangolier.

* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.

* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: Bane, Beastmaster, Bloodseeker, Clockwerk, Doom, Shadow Shaman.

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.

* Squishy heroes (Io, Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.

* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.

* Take Aim and Assassinate allow Sniper to reach Io even if it stays in the backline.

* Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.

* Phantom Strike allows Phantom Assassin jump directly to Io.
* Coup de Grace can make a short work of Io's low health and armor.