* Ice Blast nullifies the healing from {U:Warlock Golem} and Shadow Word.
* Cold Feet stuns Warlock if he chooses to continue channeling Upheaval.

* Blood Rite can silence Warlock, which as a spellcaster is bad for him.
* Rupture prevents Warlock from moving without taking damage, which due to his general lack of escapes is bad for him, and when combined with Blood Rite can be a very lethal combo.

* Huskar is often at low health, providing large Thirst bonuses.
* Life Break triggers Rupture's damage.
Additional:
* Huskar is often at low health, providing large Thirst bonuses to Bloodseeker.
* Life Break can trigger Rupture's damage.
* A self applied Bloodrage together with Blademail means it's almost suicidal for Huskar to jump on Bloodseeker with Life Break

* Ice Blast prevents Huskar from healing, regeneration, health gained from activating an Armlet of Mordiggian and will kill him when his health dips below a threshold. This makes it very dangerous for him to use his abilities.
Additional:
* Ice Blast prevents Huskar from healing with Berserker's Blood and negates any lifesteal, making him significantly weaker in battle.
* Burning Spear and Life Break cost Huskar his own health, killing him under the effects from Ice Blast.
* Huskar often builds Armlet of Mordiggian which can be deadly during Ice Blast.

* Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.

* Ice Blast prevents Io from healing an ally with Tether and prevents healing from Overcharge
* Io is a common Mekansm builder which is useless if he is affected by Ice Blast.
Additional:
* Ice Blast prevents Io from healing the target.

* Heroes that withstand damage like Timbersaw, Bristleback, Dragon Knight and others will have their durability largely reduced when hit by an Ice Blast due to the risk of shattering.

* Rupture and Blood Rite locks down Timbersaw, preventing him from escaping with Timber Chain. However, Timbersaw may reflect a good deal of damage with Blade Mail.

* Thirst prevents Slark from healing with Shadow Dance.
* Rupture will deal damage during Pounce.
* Dark Pact cannot dispel Rupture, preventing Slark from escaping ganks.
Additional:
* Thirst stops Shadow Dance's passive health regeneration if he is within Thirst's percentage.
* Rupture effectively takes Slark out of battle because he cannot move or pounce, leaving him susceptible to aoe stuns or forced to teleport out of the fight.

* Heroes like Slark, Witch Doctor and others also tend to suffer in Ice Blast's heal denial.

Additional:
* Ice Blast stops Shadow Dance's passive health regeneration, even when Slark is not in vision.

* Every Meepo clone adds to Thirst's bonuses.
* Bloodseeker can chase down retreating clones when Meepo tries to cycle weaker clones away from combat.

* Ice Blast prevents Insatiable Hunger lifesteal, Spin Web regeneration and quickly kills spiderlings.

* Ice Blast prevents healing from Hand of God.
Additional:
* Ice Blast prevents Divine Favor and Hand of God from healing his allies or himself.

* Nether Swap triggers extra damage from Rupture.
* Blood Rite sets up while Vengeful Spirit using her Nether Swap within a timed correctly.

* Cold feet can be used to ensure that the full channel of Freezing Field doesn't go off.

* Cold Feet's debuff affects Death Prophet even while she's affected by Eul's Scepter of Divinity.
* Ice Vortex lowers her magic resistance and her kiting potential.
* Ice Blast prevents Death Prophet from gaining health from Spirit Siphon and Exorcism.
Additional:
* Ice Blast prevents Death Prophet from gaining health from Spirit Siphon and Exorcism.

* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.
Additional:
* Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.

* Sniper's lack of mobility and escape mechanisms makes him one of the easier heroes for Bloodseeker to gank.
Additional:
* Sniper is suspectible to being ganked by Bloodseeker, who can easily kill Sniper due to his lack of mobility and escape mechanisms.
* Even if Sniper builds mobility items, Bloodseeker can prevent and even punish Sniper from/for using them with Rupture; Sniper is forced to stand still with Shadow Blade, while Hurricane Pike and Blink Dagger deals damage if he attempts to use them while Ruptured.

* Blood Rite can flush Enigma out of position and potentially force him to activate his spell immunity prematurely, before pulling off a Black Hole combo.
* Bloodseeker can find an Enigma out of position and Rupture him, making it difficult to initiate properly in a team fight, as it pierces through Black King Bar

* If Thirst activated, Lich doesn't slow Bloodseeker.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Thirst or forces Bloodseeker to build Blade Mail can cause Lich to accidentally kill himself with Chain Frost.
* Even Lich builds Glimmer Cape or Force Staff are suicidal item against Bloodseeker when he is affected by Rupture.

* Ice Blast prevents Lifestealer from lifestealing and healing with Infest in fights.

* Rupture deals extra damage to Magnus during Skewer or Force Staff, preventing him from escaping or counter-initiating, forcing him to invest on a Linken's Sphere.

* Rupture works through Rolling Thunder and Swashbuckle, greatly reducing Pangolier's mobility.
Additional:
* Thirst provides constant sight and speed to Bloodseeker, allows him to catch up a fleeing Pangolier through all of his mobility.
* Rupture is a great threat to Pangolier, causing him to take heavy damage if he uses Swashbuckle and especially Rolling Thunder, forcing him to stop his ultimate prematurely, or keep rolling to his death.

* Rupture ruins her only movement ability, Rebound. Combined with its high movement speed and her being unable to interrupt it once its cast, using it under the effects of Rupture will surely deal incredibly immutable damage, if not kill her.
* As a Strength hero, Marci naturally has high HP. Rupture's initial damage uses her high HP as a catalyst to deal damage depending on her current health, dealing a good amount of damage if she's full HP or forcing her to stop if she's low.
* With Aghanim's Shard, Bloodrage will now deal pure damage and lifesteal based on the opponent's max health. Her high HP as a Strength hero ensures that Bloodseeker will always deal significant attack damage and sustain himself a lot whenever he attacks Marci.
* If Marci doesn't build Black King Bar, Bloodseeker's Blood Rite will prevent her from using all of her spells which she relies quite heavily on. Her only dispel is tied to Unleash which gets disabled, and the spell immunity from her level 20 Sidekick talent doesn't remove it if she tries to save a teammate from being silenced.

* Cold Embrace makes its target immovable, allowing Ancient Apparition to easily land Ice Blast, or a Cold Feet stun.
* Ice Blast also negates healing from Cold Embrace.
Additional:
* Ice Blast disables the healing component of Cold Embrace, making it essentially a 4 second stun on an ally and a perfect setup for Ice Blast.
* If Cold Feet is cast on an Allied hero affected by Cold Embrace, it will almost guarantee the Ally comes out stunned.

* Snapfire is vulnerable while she is casting Mortimer Kisses making her an easy target for the effects of Cold Feet and Ice Blast.
Additional:
* Ice Blast, Cold Feet, and Ice Vortex are easier to land on Snapfire while she channels her Mortimer Kisses.

* Heroes that can maintain vision on Monkey King can see when he uses Tree Dance: Bloodseeker, Treant Protector with Eyes In The Forest, Sniper, Weaver

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

Additional:
* Rupture can deal a lot of damage to either a surged Dark Seer or his allies and prevent the target from getting into position.

* Ice Blast negates healing from Shadow Wave, and lasts longer than Shallow Grave.
Additional:
* Shallow Grave prevents Ice Blast's shatter for up to 5 seconds, but can mostly only delay it as Ice Blast's debuff lasts 10 seconds and prevents Shadow Wave from healing them.

* Bloodseeker's Thirst, Rupture, and huge AoE silence Blood Rite can fare well against Dazzle.

* Heroes with long-lasting, undispellable debuffs will pinpoint the true Naga Siren: Spirit Breaker, Bloodseeker.

* Bloodseeker's Rupture forces Slardar to stay still during fights, preventing Slardar from using Guardian sprint to move in and out of fights. This takes away the ability to initiate and re-initiate with Slithereen Crush's low cooldown. Due to the increased move speed from Guardian Sprint, Slardar can lose health at about 160% the rate of normal heroes while under Rupture. Bloodseeker's Thirst also gives him enough move speed so that he's one of the few heroes who can outrun or catch up to a Slardar during Guardian Sprint.

* Since all of Phoenix's abilities (except for Supernova) have health costs, heroes like Ancient Apparition or Necrophos can turn Phoenix's abilities against it. However, Supernova does completely protect Phoenix from Ice Blast.

* Phoenix expends health to use its abilities, making it a good target for Thirst.
* Rupture deals heavy damage against Icarus Dive.
Additional:
* Although Blood Rite can be easily avoided, if it does hit, its lengthy silence and pure damage can be a severe punishment for a slow, unobservant, or simply unfortunate Phoenix.
* His Rupture can turn Icarus Dive into a suicide option, and it cannot be dispelled, meaning even if Phoenix completes a Supernova, choosing to Dive may just cut its health back down.
* And finally, due to Phoenix's health costs, too much careless ability spamming may just put Phoenix into Bloodseeker's vision through Thirst, making it a very tempting ganking target.

* As a spellcaster, silences will nullify him entirely. Some notable examples are Death Prophet, Drow Ranger, Bloodseeker, Disruptor and many others.
* Doom, as usual, fits this description nicely.

* Heroes with silences : Bloodseeker, Riki, Silencer.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

* Heroes with global abilities can give Legion Commander's opponent an edge in Duels from anywhere on the map: Nature's Prophet, Ancient Apparition, Zeus, Invoker, Treant Protector

* Ancient Apparition's Cold Feet will freeze Clockwerk in place if he stays inside his Power Cogs. His immobility while in his cogs also makes him a very easy target to Ice Vortex and Ice Blast.

* Heroes that withstand damage like Timbersaw, Bristleback, Dragon Knight and others will have their durability largely reduced when hit by an Ice Blast due to the risk of shattering.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

* Heroes with good mobility to avoid Jakiro's abilities and with good chase to punish Jakiro from pushing a tower: Bloodseeker, Ember Spirit, Juggernaut, Phantom Assassin, Weaver.

* Ice Blast completely nullifies any healing, making Necrophos unable to stay in a teamfight to sustain his teammates (and himself) or deal gradual damage to the enemy, else he be faced with a quick death if focused on.

* Windrun triggers the damage from Rupture.
Additional:
* Rupture turns Windranger's mobility against her.

* Skeleton Walk is not enough to outrun Bloodseeker, and is detected by Thirst.
Additional:
* Thirst reveals Clinkz if he tries to escape with Skeleton Walk with low health. It also allows Bloodseeker to match or exceed Clinkz's speed.
* Rupture negates the mobility provided by Skeleton Walk in any attempt to escape or reposition in fights.
* Bloodseeker can easily build items to counter Clinkz, including Talisman of Evasion upgrades, Blade Mail, and armor items.

* Cold Feet and Ice Vortex both hinder Dragon Knight's movement greatly during teamfights.
* Ice Blast ignores Dragon Knight's armor, disables his health regeneration, and kills him prematurely.

* Blood Rite prevents Queen of Pain from escaping with Blink.
* Blink will trigger the extra damage from Rupture.
Additional:
* Blood Rite silences her, preventing her from initiating or escaping.
* With Thirst, even if she Blinks away, Bloodseeker can catch right up to her.
* Rupture will heavily damage Queen of Pain if she tries to Blink away.
* She is, however, one of the few heroes who can avoid the damage from Rupture if she successfully blink-walks.

* Rupture will fully damage Void Spirit during his ultimate, removing his main escape mechanic during fights and his way to disrupt them heavily.
* Blood Rite will force Void Spirit to use Dissimilate or Astral Step or be silenced. In the latter's case, it can be dangerous when combined with Rupture.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

* Thirst detects Riki whenever his health is low.
* Rupture does large damage when Riki uses Blink Strike.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

Additional:
* While Burrowing, Nyx is an easy target for a Blood Rite, although he can at least partially counter it with a well-timed Spiked Carapace.
* Thirst is always a threat to Nyx Assassin, hindering his attempt of escape using Vendetta.
* Rupture also prevents Nyx Assassin from escaping with Vendetta, as it forces him to stay still.

* Bloodseeker's Rupture turns Night Stalker mobility against him and Thirst grants movement speed bonus and vision prevents Night Stalker from initiating and re-initiating.

* Ice Blast stops Attribute Shift (Strength Gain) from recovering additional health, and using it will even bring Morphling closer to the shatter threshold.
* In lane, Ice Vortex slows Morphling's already poor movement speed to a crawl; this, coupled with the amplification of magic damage, can set up an early kill on Morphling if Ancient Apparition has a suitable lane partner.
Additional:
* Ice Blast stops Morphling from gaining additional health with Attribute Shift.
* Using Attribute Shift would even bring Morphling closer to the shatter threshold.
* In the lane, Ice Vortex slows Morphling's already poor movement speed to a crawl; this, coupled with the amplification of magic damage, can set up an early kill on Morphling if Ancient Apparition has a suitable lane partner.

* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.
Additional:
* Rupture can quickly kill Mirana if she tries to Leap away.
* Thirst detects Mirana and her allies during Moonlight Shadow.

* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.
Additional:
* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

Additional:
* Rupture can turn Bounty Hunter's mobility against him, and prevents him from escaping with Shadow Walk due to the potentially heavy damage.
* Thirst can prevent Bounty Hunter from escaping with Shadow Walk should Bounty Hunter's health become low enough, as it provides True Sight.

* Blood Rite prevents Anti-Mage from escaping with Blink.
* Blink will trigger the damage from Rupture.
* Both Blood Rite & Rupture are pure damage which can bypass Counterspell.

* Ice Blast nullifies Borrowed Time's and Mist Coil's healing.
Additional:
* Ice Blast's nullifies Abaddon healing from Borrowed Time and Mist Coil and it is not dispelled by Aphotic Shield.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

* Shukuchi will trigger extra damage from Rupture.
* Shukuchi's invisibility is detected by Thirst.
* Time Lapse cannot dispel Rupture, preventing Weaver from escaping ganks.
Additional:
* Rupture is particularly crippling against Weaver, who relies on high movement speed from Shukuchi to fight and escape, and it cannot be dispelled by Time Lapse.
* Thirst detects Weaver through Shukuchi whenever his health is low.
* Blood Rite combined with Rupture forces Weaver to either take damage from the latter, or to get silenced for a long duration.