* Untouchable makes it near impossible to stack Burning Spears.
* Impetus' pure damage puts an instant end to Huskar's low-health brinkmanship.

* Huskar is often at low health, providing large Thirst bonuses to Bloodseeker.
* Life Break can trigger Rupture's damage.
* A self applied Bloodrage together with Blademail means it's almost suicidal for Huskar to jump on Bloodseeker with Life Break
Additional:
* Huskar is often at low health, providing large Thirst bonuses.
* Life Break triggers Rupture's damage.

* Skeleton Walk is not enough to outrun Bloodseeker, and is detected by Thirst.
Additional:
* Thirst reveals Clinkz if he tries to escape with Skeleton Walk with low health. It also allows Bloodseeker to match or exceed Clinkz's speed.
* Rupture negates the mobility provided by Skeleton Walk in any attempt to escape or reposition in fights.
* Bloodseeker can easily build items to counter Clinkz, including Talisman of Evasion upgrades, Blade Mail, and armor items.

* Untouchable prevents Clinkz from harassing Enchantress in lane by lowering his attack speed.
* Nature's Attendants helps Enchantress to sustain from Clinkz' harrass in Lane.

* Sniper is suspectible to being ganked by Bloodseeker, who can easily kill Sniper due to his lack of mobility and escape mechanisms.
* Even if Sniper builds mobility items, Bloodseeker can prevent and even punish Sniper from/for using them with Rupture; Sniper is forced to stand still with Shadow Blade, while Hurricane Pike and Blink Dagger deals damage if he attempts to use them while Ruptured.
Additional:
* Sniper's lack of mobility and escape mechanisms makes him one of the easier heroes for Bloodseeker to gank.

* Range-reliant heroes: Sniper, Drow Ranger

* Heroes that can maintain vision on Monkey King can see when he uses Tree Dance: Bloodseeker, Treant Protector with Eyes In The Forest, Sniper, Weaver

* Impetus pure damage ignores the extra armor granted from Wukong's Command.
* Enchant can dispel Monkey King's Jingu Mastery bonuses.
* Untouchable makes it hard for Monkey King to land Jingu Mastery stacks.
* Sproink allows Enchantress to escape from Wukong's Command.

* Rupture deals extra damage to Magnus during Skewer or Force Staff, preventing him from escaping or counter-initiating, forcing him to invest on a Linken's Sphere.

* Heroes that have an escape that doesn't disjoint projectiles: Mirana, Faceless Void, Magnus

* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.
Additional:
* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.

* He relies heavily on right clicks making Untouchable very effective against him.
* If he tries to run away Impetus will do huge amounts of damage.
Additional:
* She can Enchant one of the wolves to her side.
* Untouchable still slows Lycan's attack speed.

* Enchant dispels Overpower.
* Enchant's slow can help kite Ursa in fights and also in lane.
* Enchantress can out harass Ursa in lane by using her long attack range and Untouchable, as well as out sustaining him with Nature's Attendants.

* Thirst provides constant sight and speed to Bloodseeker, allows him to catch up a fleeing Pangolier through all of his mobility.
* Rupture is a great threat to Pangolier, causes him to take heavy damage if he uses Swashbuckle and especially Rolling Thunder, forcing him to stop his ultimate prematurely, or keep rolling to his death.
Additional:
* Rupture works through Rolling Thunder and Swashbuckle, greatly reducing Pangolier's mobility.

* Untouchable greatly reduces Chemical Rage's attack speed advantage.

* Since Untouchable pierce Spell immunity, Lifestealer cannot burst her down even with Rage ; meaning she can heal herself back to full HP.

* Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.

* Bloodseeker's Rupture can turn Bounty Hunter's mobility against him, and prevents him from escaping with Shadow Walk due to the potentially heavy damage.
* Thirst can prevent Bounty Hunter from escaping with Shadow Walk should Bounty Hunter's health become low enough.

* Rupture will fully damage Void Spirit during his ultimate, removing his main escape mechanic during fights and his way to disrupt them heavily.
* Blood Rite will force Void Spirit to use Dissimilate or Astral Step or be silenced. In the latter's case, it can be dangerous when combined with Rupture.

* Although Blood Rite can be easily avoided, if it does hit, its lengthy silence and pure damage can be a severe punishment for a slow, unobservant, or simply unfortunate Phoenix. His Rupture can turn Icarus Dive into a suicide option, and it cannot be dispelled, meaning even if Phoenix completes a Supernova, choosing to Dive may just cut its health back down. And finally, due to Phoenix's health costs, too much careless ability spamming may just put Phoenix into Bloodseeker's vision, making it a very tempting ganking target.
Additional:
* Phoenix expends health to use its abilities, making it a good target for Thirst.
* Rupture deals heavy damage against Icarus Dive.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

* Spirit Breaker won’t do much harm because of Untouchable and Nature's Attendants. Unless Enchantress is low on HP, Spirit Breaker won’t catch her with mere spells.

* Blood Rite can silence Warlock, which as a spellcaster is bad for him.
* Rupture prevents Warlock from moving without taking damage, which due to his general lack of escapes is bad for him, and when combined with Blood Rite can be a very lethal combo.

* Untouchable makes her heavily reduce Elder Titan's physical damage output on her without Spell Immunity.
* Enchant can purge Astral Spirit's buff without Spell immunity.
* Nature's Attendants can protect her if she survives the full combo and manages to juke around.

* Against her Untouchable, Sven is barely able to hit Enchantress even with his Black King Bar.

* Nether Swap triggers extra damage from Rupture.
* Blood Rite sets up while Vengeful Spirit using her Nether Swap within a timed correctly.

* Rupture can quickly kill Mirana if she tries to Leap away.
* Thirst detects Mirana and her allies during Moonlight Shadow.
Additional:
* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.

* Heroes that have an escape that doesn't disjoint projectiles: Mirana, Faceless Void, Magnus

* Blood Rite can flush Enigma out of position and potentially force him to activate his spell immunity prematurely, before pulling off a Black Hole combo.
* Bloodseeker can find an Enigma out of position and Rupture him, making it difficult to initiate properly in a team fight, as it pierces through Black King Bar

* Heroes with silences : Bloodseeker, Riki, Silencer.

* Heroes with long-lasting, undispellable debuffs will pinpoint the true Naga Siren: Spirit Breaker, Bloodseeker.

* Heroes with good mobility to avoid Jakiro's abilities and with good chase to punish Jakiro from pushing a tower: Bloodseeker, Ember Spirit, Juggernaut, Phantom Assassin, Weaver.

* Heroes that can dominate his illusions or create their own illusions of him: Dark Seer, Morphling, Enchantress, Shadow Demon.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

* Enchantress's Untouchable slows down Meepos attacks and Impetus can deal heavy pure damage to a single meepo, however once Meepo has closed the gap she is an easy target for Poof.

* Every Meepo clone adds to Thirst's bonuses.
* Bloodseeker can chase down retreating clones when Meepo tries to cycle weaker clones away from combat.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

* Bloodseeker's Rupture forces Slardar to stay still during fights, preventing Slardar from using Guardian sprint to move in and out of fights. This takes away the ability to initiate and re-initiate with Slithereen Crush's low cooldown. Due to the increased move speed from Guardian Sprint, Slardar can lose health at about 160% the rate of normal heroes while under Rupture. Bloodseeker's Thirst also gives him enough move speed so that he's one of the few heroes who can outrun or catch up to a Slardar during Guardian Sprint.

* Bloodseeker's Rupture turns Night Stalker mobility against him and Thirst grants movement speed bonus and vision prevents Night Stalker from initiating and re-initiating.

* Range-reliant heroes: Sniper, Drow Ranger

* Thirst prevents Slark from healing with Shadow Dance.
* Rupture will deal damage during Pounce.
* Dark Pact cannot dispel Rupture, preventing Slark from escaping ganks.
Additional:
* Thirst makes Slark visible while at low health, canceling out Shadow Dance's passive. For this reason, Bloodseeker is usually considered the hardest counter to Slark.
* Rupture cannot be dispelled by Dark Pact, and using Pounce while affected by it will cause Slark to take damage.

* Shukuchi will trigger extra damage from Rupture.
* Shukuchi's invisibility is detected by Thirst.
* Time Lapse cannot dispel Rupture, preventing Weaver from escaping ganks.
Additional:
* Rupture is particularly crippling against Weaver, who relies on high movement speed from Shukuchi to fight and escape, and it cannot be dispelled by Time Lapse.
* Thirst detects Weaver through Shukuchi whenever his health is low.
* Blood Rite combined with Rupture forces Weaver to either take damage from the latter, or to get silenced for a long duration.

* Blood Rite prevents Queen of Pain from escaping with Blink.
* Blink will trigger the extra damage from Rupture.
Additional:
* Bloodrage is the best tool to pop her spell block talent or her Linken's Sphere, following up with Rupture.
* Blood Rite silences her, preventing her from initiating or escaping.
* With Thirst, even if she Blinks away, Bloodseeker can catch right up to her.
* Rupture will heavily damage Queen of Pain if she tries to Blink away.
* She is, however, one of the few heroes who can avoid the damage from Rupture if she does it correctly.

* If Thirst activated, Lich doesn't slow Bloodseeker.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Thirst or forces Bloodseeker to build Blade Mail can cause Lich to accidentally kill himself with Chain Frost.
* Even Lich builds Glimmer Cape or Force Staff are suicidal item against Bloodseeker when he is affected by Rupture.

* Blood Rite prevents Anti-Mage from escaping with Blink.
* Blink will trigger the damage from Rupture.
* Both Blood Rite & Rupture are pure damage which can bypass Counterspell.

* Bloodseeker natural attack, run and turn speed outpaces viper's and makes viper easy pickings for Bloodseekers top

* Untouchable negates Inner Beast's attack speed bonus, making her hard to kill even if stunned by Primal Roar.
* Enchantress can also take control of Beastmaster's summons.

* Bloodseeker's Rupture deals great damage against Timbersaw should he tried escaping with Timber Chain.

Additional:
* Rupture and Blood Rite locks down Timbersaw, preventing him from escaping with Timber Chain. However, Timbersaw may reflect a good deal of damage with Blade Mail.

* Timbersaw has a difficult time against magical and pure damage: Lina, Leshrac, Enchantress, Queen of Pain

* Bloodseeker's Rupture shows a clear red trail effect on the real Phantom Lancer.
* Heroes with undispellable debuffs will help identify the real Phantom Lancer through visual effects or debuff indicators, provided that it was cast on the real Phantom Lancer to begin with:
* Doom's Doom marks Phantom Lancer with a highly visible effect, and also silences him.
* Bloodseeker's Rupture shows a clear red trail effect on the real Phantom Lancer.
* Ancient Apparition's Ice Blast will only debuff Phantom Lancer and not his illusions.
* Grimstroke's Soulbind is undispellable.
* Shadow Demon's Demonic Purge is undispellable.
* Monkey King's Jingu Mastery is undispellable and puts a big yellow Mark over his head.

* Impetus will deal huge amounts of damage when he uses a Fire Remnant to escape.
* Flame Guard is useless against Impetus.
* Enchant dispels Flame guard.

* Rupture turns Windranger's mobility against her.
Additional:
* Windrun triggers the damage from Rupture.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

Additional:
* Rupture can deal a lot of damage to either a surged Dark Seer or his allies and prevent the target to get into position.

* Thirst detects Riki whenever his health is low.
* Rupture does large damage when Riki uses Blink Strike.

* Enchantress can turn Chen's own creeps against him with Enchant. The creeps still keep the health buff Holy Persuasion granted them.
* Untouchable and Nature's Attendants make her difficult to kill.

* Impetus is not blocked by Guardian Angel. A {U:Satyr Banisher} can also be controlled to dispel Guardian Angel.