* Thirst provides constant sight and speed to Bloodseeker, allows him to catch up a fleeing Pangolier through all of his mobility.
* Rupture is a great threat to Pangolier, causes him to take heavy damage if he uses Swashbuckle and especially Rolling Thunder, forcing him to stop his ultimate prematurely, or keep rolling to his death.
Additional:
* Rupture works through Rolling Thunder and Swashbuckle, greatly reducing Pangolier's mobility.

* Soulbind ignores spell immunity, forcing Pangolier to roll in place during his ultimate as well as anchoring the other victim to his vicinity.

* Shukuchi will trigger extra damage from Rupture.
* Shukuchi's invisibility is detected by Thirst.
* Time Lapse cannot dispel Rupture, preventing Weaver from escaping ganks.
Additional:
* Rupture is particularly crippling against Weaver, who relies on high movement speed from Shukuchi to fight and escape, and it cannot be dispelled by Time Lapse.
* Thirst detects Weaver through Shukuchi whenever his health is low.
* Blood Rite combined with Rupture forces Weaver to either take damage from the latter, or to get silenced for a long duration.

* Phantom's Embrace and Soulbind prevent Weaver from using Shukuchi or Time Lapse to escape.
* Ink Swell discourages Weaver from moving through and damaging allies with Shukuchi.

* Grimstroke can catch Io and his ally easily with SoulBind as Io has a tendency to tether himself with an ally frequently.
* Io is highly vulnerable to disables. Hence, Grimstroke's Phantom's Embrace is a great ability to hinder Io's potential.
Additional:
* Soulbind can target both Io and its Tethered ally, allowing Grimstroke and his team to target both with single target spells. Should Io try to Relocate, Phantom's Embrace can stop its channel to prevent escape.

* Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.

* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.
Additional:
* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.

* Stroke of Fate deals more damage when it hits more targets which makes it very effective in dealing with Lycan and his units.
* Soulbind prevents lycan from running away and makes him very easy to deal with.

* Bloodseeker's Rupture deals great damage against Timbersaw should he tried escaping with Timber Chain.

Additional:
* Rupture and Blood Rite locks down Timbersaw, preventing him from escaping with Timber Chain. However, Timbersaw may reflect a good deal of damage with Blade Mail.

* Timbersaw relies heavily on his abilities so Phantom's Embrace's silence makes it more difficult for him.
* Timbersaw cannot use Return Chakram or attack the phantom during Phantom's Embrace, forcing him to take full damage and refreshes Phantom's Embrace's cooldown.

* Rupture turns Windranger's mobility against her.
Additional:
* Windrun triggers the damage from Rupture.

* Windranger heavily relies on her abilities for any form of tactical advantage and damage. A well timed silence will make her useless: Puck,Silencer, Death Prophet, Skywrath Mage, Drow Ranger, Earth Spirit, Grimstroke.

* Blood Rite can flush Enigma out of position and potentially force him to activate his spell immunity prematurely, before pulling off a Black Hole combo.
* Bloodseeker can find an Enigma out of position and Rupture him, making it difficult to initiate properly in a team fight, as it pierces through Black King Bar

* Heroes with powerful channeling abilities are easily interrupted by Phantom's Embrace: Bane, Pudge, Witch Doctor, Crystal Maiden, Enigma.

* Blood Rite prevents Anti-Mage from escaping with Blink.
* Blink will trigger the damage from Rupture.
* Both Blood Rite & Rupture are pure damage which can bypass Counterspell.

* Phantom's Embrace stops Anti-Mage from Blinking away. However, it can be reflected back by Counterspell if quick enough.
* Soulbind stops Blink and lets allies cast abilities on the tethered target to avoid Counterspell. It cannot be reflected by Counterspell.

* Heroes with long-lasting, undispellable debuffs will pinpoint the true Naga Siren: Spirit Breaker, Bloodseeker.

* Heroes who are reliant on illusions or summons: Chaos Knight, Broodmother, Naga Siren.

* Rupture deals extra damage to Magnus during Skewer or Force Staff, preventing him from escaping or counter-initiating, forcing him to invest on a Linken's Sphere.

* Every Meepo clone adds to Thirst's bonuses.
* Bloodseeker can chase down retreating clones when Meepo tries to cycle weaker clones away from combat.

* Phantom's Embrace silences Viscous Nasal Goo and Quill Spray.
* Ink Swell stuns Bristleback and gets allies in position faster with increased movement speed to attack his front, countering his passive ability.

* Grimstroke's Soulbind will always reliably connect onto both of them if they are close together.

* Terrorblade's lack of escape mechanisms makes it hard for him to escape both Ink Swell and Stroke of Fate.
* Phantom's Embrace's silence will also prevent him from casting Sunder to save himself.

* Thirst prevents Slark from healing with Shadow Dance.
* Rupture will deal damage during Pounce.
* Dark Pact cannot dispel Rupture, preventing Slark from escaping ganks.
Additional:
* Thirst makes Slark visible while at low health, canceling out Shadow Dance's passive. For this reason, Bloodseeker is usually considered the hardest counter to Slark.
* Rupture cannot be dispelled by Dark Pact, and using Pounce while affected by it will cause Slark to take damage.

* If Thirst activated, Lich doesn't slow Bloodseeker.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Thirst or forces Bloodseeker to build Blade Mail can cause Lich to accidentally kill himself with Chain Frost.
* Even Lich builds Glimmer Cape or Force Staff are suicidal item against Bloodseeker when he is affected by Rupture.

* Phantom's Embrace can silence Crystal Maiden and disrupt Freezing Field's channeling. Her slow movement speed and fragile nature will also make her an easy target for Stroke of Fate and Ink Swell.

* Rupture will fully damage Void Spirit during his ultimate, removing his main escape mechanic during fights and his way to disrupt them heavily.
* Blood Rite will force Void Spirit to use Dissimilate or Astral Step or be silenced. In the latter's case, it can be dangerous when combined with Rupture.

* Blood Rite can silence Warlock, which as a spellcaster is bad for him.
* Rupture prevents Warlock from moving without taking damage, which due to his general lack of escapes is bad for him, and when combined with Blood Rite can be a very lethal combo.

* Bloodseeker's Rupture shows a clear red trail effect on the real Phantom Lancer.
* Heroes with undispellable debuffs will help identify the real Phantom Lancer through visual effects or debuff indicators, provided that it was cast on the real Phantom Lancer to begin with:
* Doom's Doom marks Phantom Lancer with a highly visible effect, and also silences him.
* Bloodseeker's Rupture shows a clear red trail effect on the real Phantom Lancer.
* Ancient Apparition's Ice Blast will only debuff Phantom Lancer and not his illusions.
* Grimstroke's Soulbind is undispellable.
* Shadow Demon's Demonic Purge is undispellable.
* Monkey King's Jingu Mastery is undispellable and puts a big yellow Mark over his head.

* Stroke of Fate clears Phantom Lancer's illusion easily as it deals bonus damage to more targets.
* Ink Swell can be used on an allied hero or Grimstoke himself to stun Phantom Lancer and his illusions.
* Phantom's Embrace and Soulbind have an undispellable debuff that can be used to mark the real Phantom Lancer.
Additional:
* Stroke of Fate's damage increases the more units are hit by it, making it effective against Phantom Lancer's army of illusions.
* Phantom's Embrace and Ink Swell's stun can prevent Phantom Lancer from escaping with Doppelganger if properly timed.
* If he has already used Doppelganger, Soulbind can tie Phantom Lancer to one of his own illusions to keep him in place, or to ensure a kill if Grimstroke's team is unsure which one is the real hero.

* Rupture can quickly kill Mirana if she tries to Leap away.
* Thirst detects Mirana and her allies during Moonlight Shadow.
Additional:
* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.

* Skeleton Walk is not enough to outrun Bloodseeker, and is detected by Thirst.
Additional:
* Thirst reveals Clinkz if he tries to escape with Skeleton Walk with low health. It also allows Bloodseeker to match or exceed Clinkz's speed.
* Rupture negates the mobility provided by Skeleton Walk in any attempt to escape or reposition in fights.
* Bloodseeker can easily build items to counter Clinkz, including Talisman of Evasion upgrades, Blade Mail, and armor items.

* Rupture can turn Bounty Hunter's mobility against him, and prevents him from escaping with Shadow Walk due to the potentially heavy damage.
* Thirst can prevent Bounty Hunter from escaping with Shadow Walk should Bounty Hunter's health become low enough, as it provides True Sight.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

* Heroes with silences : Bloodseeker, Riki, Silencer.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

* Bloodseeker's Rupture forces Slardar to stay still during fights, preventing Slardar from using Guardian sprint to move in and out of fights. This takes away the ability to initiate and re-initiate with Slithereen Crush's low cooldown. Due to the increased move speed from Guardian Sprint, Slardar can lose health at about 160% the rate of normal heroes while under Rupture. Bloodseeker's Thirst also gives him enough move speed so that he's one of the few heroes who can outrun or catch up to a Slardar during Guardian Sprint.

* Heroes that can maintain vision on Monkey King can see when he uses Tree Dance: Bloodseeker, Treant Protector with Eyes In The Forest, Sniper, Weaver

* Heroes with good mobility to avoid Jakiro's abilities and with good chase to punish Jakiro from pushing a tower: Bloodseeker, Ember Spirit, Juggernaut, Phantom Assassin, Weaver.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

* Hard-hitters who relies mostly on raw stats or good passive and therefore make a perfect target for Dark Portrait: Naga Siren, Faceless Void, Terrorblade, Luna, Anti-Mage

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

Additional:
* Rupture can deal a lot of damage to either a surged Dark Seer or his allies and prevent the target to get into position.

* Heroes who rely heavily on melee attacks and lack early spell immunity are easily blocked and interrupted by Ink Swell: Lycan, Ursa, Troll Warlord.

* Bloodseeker's Rupture turns Night Stalker mobility against him and Thirst grants movement speed bonus and vision prevents Night Stalker from initiating and re-initiating.

* Heroes with area of effect abilities that increase in power based on the number of units struck: Legion Commander, Grimstroke.

Additional:
* Stroke of Fate can deal heavy damage to Broodmother and her spiders, and with enough spiders it can kill her instantly.
* Phantom's Embrace provides vision on Broodmother when she's fleeing into the trees.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

Additional:
* While Burrowing, Nyx is an easy target for a Blood Rite, although he can at least partially counter it with a well-timed Spiked Carapace.
* Thirst is always a threat to Nyx Assassin, hindering his attempt of escape using Vendetta.
* Rupture also prevents Nyx Assassin from escaping with Vendetta, as it forces him to stay still.

* Heroes with powerful channeling abilities are easily interrupted by Phantom's Embrace: Bane, Pudge, Witch Doctor, Crystal Maiden, Enigma.

* Blood Rite prevents Queen of Pain from escaping with Blink.
* Blink will trigger the extra damage from Rupture.
Additional:
* Bloodrage is the best tool to pop her spell block talent or her Linken's Sphere, following up with Rupture.
* Blood Rite silences her, preventing her from initiating or escaping.
* With Thirst, even if she Blinks away, Bloodseeker can catch right up to her.
* Rupture will heavily damage Queen of Pain if she tries to Blink away.
* She is, however, one of the few heroes who can avoid the damage from Rupture if she does it correctly.

* Ghost Shroud amplifies damage taken from all of Grimstroke's abilities. Necrophos is particularly vulnerable to Ink Swell and Phantom's Embrace while in Ghost Shroud.
* Death Pulse works against Necrophos in lane by keeping his creeps alive and add damage to Stroke of Fate.

* Soulbind pierces spell immunity and prevents Faceless Void from escaping with Time Walk.

* Nether Swap triggers extra damage from Rupture.
* Blood Rite sets up while Vengeful Spirit using her Nether Swap within a timed correctly.

* As a spellcaster, silences will nullify him entirely. Some notable examples are Death Prophet, Drow Ranger, Bloodseeker, Disruptor and many others.
* Doom, as usual, fits this description nicely.

* Thirst detects Riki whenever his health is low.
* Rupture does large damage when Riki uses Blink Strike.

* Sniper is suspectible to being ganked by Bloodseeker, who can easily kill Sniper due to his lack of mobility and escape mechanisms.
* Even if Sniper builds mobility items, Bloodseeker can prevent and even punish Sniper from/for using them with Rupture; Sniper is forced to stand still with Shadow Blade, while Hurricane Pike and Blink Dagger deals damage if he attempts to use them while Ruptured.
Additional:
* Sniper's lack of mobility and escape mechanisms makes him one of the easier heroes for Bloodseeker to gank.

* Although Blood Rite can be easily avoided, if it does hit, its lengthy silence and pure damage can be a severe punishment for a slow, unobservant, or simply unfortunate Phoenix. His Rupture can turn Icarus Dive into a suicide option, and it cannot be dispelled, meaning even if Phoenix completes a Supernova, choosing to Dive may just cut its health back down. And finally, due to Phoenix's health costs, too much careless ability spamming may just put Phoenix into Bloodseeker's vision, making it a very tempting ganking target.
Additional:
* Phoenix expends health to use its abilities, making it a good target for Thirst.
* Rupture deals heavy damage against Icarus Dive.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

* Heroes who are reliant on illusions or summons: Chaos Knight, Broodmother, Naga Siren.

* Huskar is often at low health, providing large Thirst bonuses to Bloodseeker.
* Life Break can trigger Rupture's damage.
* A self applied Bloodrage together with Blademail means it's almost suicidal for Huskar to jump on Bloodseeker with Life Break
Additional:
* Huskar is often at low health, providing large Thirst bonuses.
* Life Break triggers Rupture's damage.