* Rupture deals extra damage to Magnus during Skewer or Force Staff, preventing him from escaping or counter-initiating, forcing him to invest on a Linken's Sphere.

* If Luna can use Eclipse in anticipation, Magnus will be killed before he can even manages to cast Reverse Polarity.
* Aghanim's Scepter upgraded Eclipse is a very good counter-initiation tool against Magnus when he casts Reverse Polarity, granted as long as Luna can cast it from safe distance.

* Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.

* Lucent Beam can cancel Tether and Relocate.
* Moon Glaives and Eclipse make short work of Io and its tethered ally.

* Blood Rite prevents Queen of Pain from escaping with Blink.
* Blink will trigger the extra damage from Rupture.
Additional:
* Bloodrage is the best tool to pop her spell block talent or her Linken's Sphere, following up with Rupture.
* Blood Rite silences her, preventing her from initiating or escaping.
* With Thirst, even if she Blinks away, Bloodseeker can catch right up to her.
* Rupture will heavily damage Queen of Pain if she tries to Blink away.
* She is, however, one of the few heroes who can avoid the damage from Rupture if she does it correctly.

* Aggressively blinking is not going to end well against Luna, because Queen of Pain will be an easy target for Lucent Beam & Eclipse.
* Queen of Pain's HP is abysmal, so Luna can quickly kill Queen of Pain as soon as she initiates with Blink.

* Rupture can turn Bounty Hunter's mobility against him, and prevents him from escaping with Shadow Walk due to the potentially heavy damage.
* Thirst can prevent Bounty Hunter from escaping with Shadow Walk should Bounty Hunter's health become low enough, as it provides True Sight.

* Even though Luna is the kind of hero that Bounty Hunter can handle due to Shadow Walk rendering him safe from Eclipse, smart Luna will always buy Dust of Appearance, allowing her to provide vision on him to her team, and possibly, kill Bounty Hunter with Eclipse.
Additional:
* Even though Luna is the kind of hero that Bounty Hunter can handle due to Shadow Walk rendering him safe from Eclipse, smart Luna will always buy Dust of Appearance, allowing her to provide vision on him to her team, and possibly, kill Bounty Hunter with Eclipse.

* Without Black King Bar and if not caught in it, Luna will be able to cancel Enigma's Black Hole from safe distance with her Lucent Beam.
* Moon Glaives combined with Lunar Blessing can make a short work of Enigma's Eidolons.
* If used in anticipation, Eclipse will often kill Enigma before he even gets a chance to use Black Hole to disable Luna.
* Luna has stronger laning presence than Enigma thanks to her Moon Glaives and low mana cost of her abilities, diminishing Enigma's laning presence by a lot.

* Blood Rite can flush Enigma out of position and potentially force him to activate his spell immunity prematurely, before pulling off a Black Hole combo.
* Bloodseeker can find an Enigma out of position and Rupture him, making it difficult to initiate properly in a team fight, as it pierces through Black King Bar

* Thirst detects Riki whenever his health is low.
* Rupture does large damage when Riki uses Blink Strike.

* Luna can push very fast with Moon Glaives, which is something Riki cannot deal with well.
* Luna is naturally very fast, making it hard for Riki to trap her in Smoke Cloud.
* Even though Riki can evade Eclipse with his invisibility, smart Luna will always buy Dust of Appearance, providing vision on Riki to her allies and herself.

* Illusion heroes like the aforementioned Phantom Lancer or Naga Siren, or heroes that tend to buy Manta Style, like Luna or Juggernaut, will give Slardar a hard time, as his damage is single-targeted.

* Bloodseeker's Rupture forces Slardar to stay still during fights, preventing Slardar from using Guardian sprint to move in and out of fights. This takes away the ability to initiate and re-initiate with Slithereen Crush's low cooldown. Due to the increased move speed from Guardian Sprint, Slardar can lose health at about 160% the rate of normal heroes while under Rupture. Bloodseeker's Thirst also gives him enough move speed so that he's one of the few heroes who can outrun or catch up to a Slardar during Guardian Sprint.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Although he can avoid Eclipse with Rage and Infest, Luna's physical damage can be enough to deal with him.
* Manta Style is a common pick on Luna, which can help her dispel Open Wounds. In addition, Lifestealer is not good against illusions created by Manta Style.

* Nether Swap triggers extra damage from Rupture.
* Blood Rite sets up while Vengeful Spirit using her Nether Swap within a timed correctly.

* Bloodseeker natural attack, run and turn speed outpaces viper's and makes viper easy pickings for Bloodseekers top

* Blood Rite prevents Anti-Mage from escaping with Blink.
* Blink will trigger the damage from Rupture.
* Both Blood Rite & Rupture are pure damage which can bypass Counterspell.

* Provided Luna is able to cast it in time, Eclipse can help win a Duel from Legion Commander.
* If Luna isn't the target, she can easily use Lucent Beam and Eclipse to win the fight for the ally.
Additional:
* A well-timed Eclipse before a Duel usually prevents Legion Commander from winning Duels, if Luna is the target.
* Meanwhile, when Luna is not a target, Eclipse and Lucent Beam can also help an ally win a Duel against Legion Commander.
* However, skilled Legion Commander players will always have a Black King Bar or Aghanim's Scepter handy since both abilities do not pierce through spell immunity.

* Luna has Moon Glaives and Lunar Blessing to help her destroy Tombstone, and this becomes more effective if Luna is equipped with Manta Style.
* Defending with Zombies from Tombstone against Luna is not a good idea because Eclipse will strike only Undying.

* If Thirst activated, Lich doesn't slow Bloodseeker.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Thirst or forces Bloodseeker to build Blade Mail can cause Lich to accidentally kill himself with Chain Frost.
* Even Lich builds Glimmer Cape or Force Staff are suicidal item against Bloodseeker when he is affected by Rupture.

* Huskar is often at low health, providing large Thirst bonuses to Bloodseeker.
* Life Break can trigger Rupture's damage.
* A self applied Bloodrage together with Blademail means it's almost suicidal for Huskar to jump on Bloodseeker with Life Break
Additional:
* Huskar is often at low health, providing large Thirst bonuses.
* Life Break triggers Rupture's damage.

* Rupture turns Windranger's mobility against her.
Additional:
* Windrun triggers the damage from Rupture.

* Lucent Beam allows Luna to easily cancel Freezing Field.
* Without Black King Bar protection, Lucent Beam and Eclipse can make a short work out of Crystal Maiden's abysmal health.
* Skilled Luna will always buy Dust of Appearance, allowing her team to have a vision on Crystal Maiden while invisible and during channeling Freezing Field.

* Thirst provides constant sight and speed to Bloodseeker, allows him to catch up a fleeing Pangolier through all of his mobility.
* Rupture is a great threat to Pangolier, causes him to take heavy damage if he uses Swashbuckle and especially Rolling Thunder, forcing him to stop his ultimate prematurely, or keep rolling to his death.
Additional:
* Rupture works through Rolling Thunder and Swashbuckle, greatly reducing Pangolier's mobility.

* Rupture will fully damage Void Spirit during his ultimate, removing his main escape mechanic during fights and his way to disrupt them heavily.
* Blood Rite will force Void Spirit to use Dissimilate or Astral Step or be silenced. In the latter's case, it can be dangerous when combined with Rupture.

* Life Drain will be always canceled by Lucent Beam if Pugna does not have Black King Bar.
* Decrepify can be suicide against Luna due to Lucent Beam and Eclipse.
* Nether Ward is rather weak against Luna since she does not have abilities that cost a lot of mana.
Additional:
* Luna can shrug off most damage taken from Nether Ward as she only has two castable skills with average mana cost.
* Luna can deal constant damage to Pugna through the low-cooldown Lucent Beam and her right clicks.
* Lucent Beam's considerable range can reliably cancel Pugna's Life Drain.
* Luna is a common Black King Bar carrier, which totally nullifies Pugna's damage output.
* If Pugna uses Decrepify on himself to avoid Luna's right click, she can burst him down with Lucent Beam and Eclipse.

* Cold Embrace is no salvation against Lucent Beam and Eclipse.
* Moon Glaives will not hit a hero affected by Winter's Curse, making it weak against allies, but strong versus enemies.
* Luna has better night vision provided by Lunar Blessing than Winter Wyvern when affected by Arctic Burn.
Additional:
* Cold Embrace is no salvation against Lucent Beam and Eclipse.
* Moon Glaives will not hit a hero affected by Winter's Curse, making it weak against allies, but strong versus enemies.
* Luna has better night vision provided by Lunar Blessing than Winter Wyvern when affected by Arctic Burn.

* Although Blood Rite can be easily avoided, if it does hit, its lengthy silence and pure damage can be a severe punishment for a slow, unobservant, or simply unfortunate Phoenix. His Rupture can turn Icarus Dive into a suicide option, and it cannot be dispelled, meaning even if Phoenix completes a Supernova, choosing to Dive may just cut its health back down. And finally, due to Phoenix's health costs, too much careless ability spamming may just put Phoenix into Bloodseeker's vision, making it a very tempting ganking target.
Additional:
* Phoenix expends health to use its abilities, making it a good target for Thirst.
* Rupture deals heavy damage against Icarus Dive.

* Moon Glaives is effective at destroying Familiars and will remove one instance of Gravekeeper's Cloak upon each hit to Visage, leaving him susceptible to damage.

* Blood Rite can silence Warlock, which as a spellcaster is bad for him.
* Rupture prevents Warlock from moving without taking damage, which due to his general lack of escapes is bad for him, and when combined with Blood Rite can be a very lethal combo.

* Skeleton Walk is not enough to outrun Bloodseeker, and is detected by Thirst.
Additional:
* Thirst reveals Clinkz if he tries to escape with Skeleton Walk with low health. It also allows Bloodseeker to match or exceed Clinkz's speed.
* Rupture negates the mobility provided by Skeleton Walk in any attempt to escape or reposition in fights.
* Bloodseeker can easily build items to counter Clinkz, including Talisman of Evasion upgrades, Blade Mail, and armor items.

* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.
Additional:
* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.

* Heroes with high burst damage: Lina, Lion, Luna, Nyx Assassin, Queen of Pain.

* With Dust of Appearance, Luna will be able to use Eclipse on invisible heroes. Be mindful that Slark is exception because he'll be able to remove the debuff with Dark Pact.

* Thirst prevents Slark from healing with Shadow Dance.
* Rupture will deal damage during Pounce.
* Dark Pact cannot dispel Rupture, preventing Slark from escaping ganks.
Additional:
* Thirst makes Slark visible while at low health, canceling out Shadow Dance's passive. For this reason, Bloodseeker is usually considered the hardest counter to Slark.
* Rupture cannot be dispelled by Dark Pact, and using Pounce while affected by it will cause Slark to take damage.

* Luna's Lucent Beams and Eclipse will prevent Earthshaker from initiating or re-initiating.

* Heroes with silences : Bloodseeker, Riki, Silencer.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

* Heroes with good mobility to avoid Jakiro's abilities and with good chase to punish Jakiro from pushing a tower: Bloodseeker, Ember Spirit, Juggernaut, Phantom Assassin, Weaver.

* Bloodseeker's Rupture deals great damage against Timbersaw should he tried escaping with Timber Chain.

Additional:
* Rupture and Blood Rite locks down Timbersaw, preventing him from escaping with Timber Chain. However, Timbersaw may reflect a good deal of damage with Blade Mail.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

Additional:
* Rupture can deal a lot of damage to either a surged Dark Seer or his allies and prevent the target to get into position.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

* Bloodseeker's Rupture turns Night Stalker mobility against him and Thirst grants movement speed bonus and vision prevents Night Stalker from initiating and re-initiating.

* Heroes that can maintain vision on Monkey King can see when he uses Tree Dance: Bloodseeker, Treant Protector with Eyes In The Forest, Sniper, Weaver

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

Additional:
* While Burrowing, Nyx is an easy target for a Blood Rite, although he can at least partially counter it with a well-timed Spiked Carapace.
* Thirst is always a threat to Nyx Assassin, hindering his attempt of escape using Vendetta.
* Rupture also prevents Nyx Assassin from escaping with Vendetta, as it forces him to stay still.

* Moon Glaives and Lunar Blessing help Luna to tear off Nature's Prophet's treants.
* Luna can easily cancel Teleportation with her Lucent Beam.

* Enchantress has pitiful HP so Lucent Beam and Eclipse can kill her very quickly.
* Moon Glaives allows Luna to clear Enchantress' creeps very efficiently.
Additional:
* Enchantress has pitiful HP, even more pitiful than Luna, so Lucent Beam and Eclipse will often harass and/or kill her through her Untouchable.
* With Moon Glaives, Luna can clear Enchantress's creep wave efficiently.

* Moon Glaives can easily clear Chen's creeps while Eclipse can kill Chen's allies before he can react.
Additional:
* Luna's Moon Glaives and Lunar Blessing can easily kill Chen's creeps.

* Shukuchi will trigger extra damage from Rupture.
* Shukuchi's invisibility is detected by Thirst.
* Time Lapse cannot dispel Rupture, preventing Weaver from escaping ganks.
Additional:
* Rupture is particularly crippling against Weaver, who relies on high movement speed from Shukuchi to fight and escape, and it cannot be dispelled by Time Lapse.
* Thirst detects Weaver through Shukuchi whenever his health is low.
* Blood Rite combined with Rupture forces Weaver to either take damage from the latter, or to get silenced for a long duration.

* Rupture can quickly kill Mirana if she tries to Leap away.
* Thirst detects Mirana and her allies during Moonlight Shadow.
Additional:
* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.

* It is almost impossible for Bane to use Fiend's Grip properly against Luna's allies due to the huge cast range of the Lucent Beam.
Additional:
* Luna's Lucent Beam can be used to disable Bane while he is channeling Fiend's Grip.
* Luna's Eclipse will often be able to kill Bane before he can even act.

* Luna often builds Black King Bar, and none of Tidehunter's spells can bypass spell immunity.
* Lucent Beam and Eclipse deal a lot of magic damage in the early and mid-game, which can bypass Kraken Shell.

* Heroes that can stall pushes: Invoker, Keeper of the Light, Lina, Luna.

* Lucent Beam interrupts Death Ward from a decent range.
* Eclipse kills Witch Doctor during Death Ward, even through Glimmer Cape.

* Every Meepo clone adds to Thirst's bonuses.
* Bloodseeker can chase down retreating clones when Meepo tries to cycle weaker clones away from combat.

* Sniper is suspectible to being ganked by Bloodseeker, who can easily kill Sniper due to his lack of mobility and escape mechanisms.
* Even if Sniper builds mobility items, Bloodseeker can prevent and even punish Sniper from/for using them with Rupture; Sniper is forced to stand still with Shadow Blade, while Hurricane Pike and Blink Dagger deals damage if he attempts to use them while Ruptured.
Additional:
* Sniper's lack of mobility and escape mechanisms makes him one of the easier heroes for Bloodseeker to gank.

* Guardian Angel does not offer protection from Eclipse, though it will negate damage from Moon Glaives.

* Heroes with long-lasting, undispellable debuffs will pinpoint the true Naga Siren: Spirit Breaker, Bloodseeker.

* Lunar Blessing gives allies bonus damage and armor required to endure against Atrophy Aura early on.
* Eclipse can be devastating for Underlord's team when they're grouped up for Dark Rift, it can also be used to intercept arrivals with Dark Rift. And Pit of Malice does not prevent Luna to use it.
* To make things even better, Aghanim's Scepter upgraded Eclipse can finish off Underlord or any of his teammates escape attempts with Dark Rift if timed correctly.
Additional:
* Lunar Blessing gives allies bonus damage required to endure against Atrophy Aura early on.
* Eclipse can be devastating for Underlord's team when they're grouped up for Dark Rift, it can also be used to intercept arrivals with Dark Rift. And Pit of Malice does not prevent Luna from using it.
* To make things even worse, Aghanim's Scepter upgraded Eclipse can finish off Underlord or any of his teammates escape attempts with Dark Rift if timed correctly.