* Refraction negates all of Void Spirit's burst damage.
* Meld quickly burns through Resonant Pulse.

* Rupture will fully damage Void Spirit during his ultimate, removing his main escape mechanic during fights and his way to disrupt them heavily.
* Blood Rite will force Void Spirit to use Dissimilate or Astral Step or be silenced. In the latter's case, it can be dangerous when combined with Rupture.

* Refraction protects against Anti-Mage's low burst damage, and allows her to win most fights against Anti-Mage during the early game.
* Meld's burst damage and armor reduction is often enough to finish off Anti-Mage before he Blinks away.

* Rupture deals damage through Blink, dissuading Anti-Mage from using it. This allows Bloodseeker to get early kills on Anti-Mage, preventing him from snowballing.
* However, Anti-Mage is one of the few heroes who can avoid the damage from Rupture if he does it correctly.
* Blood Rite silences Anti-Mage during teamfights, preventing him from Blinking away.
* Bloodseeker's abilities also deal pure damage, which bypasses Counterspell.
Additional:
* Blood Rite prevents Anti-Mage from escaping with Blink.
* Blink will trigger the damage from Rupture.
* Both Blood Rite & Rupture are pure damage which can bypass Counterspell.

* Sniper is suspectible to being ganked by Bloodseeker, who can easily kill Sniper due to his lack of mobility and escape mechanisms.
* Even if Sniper builds mobility items, Bloodseeker can prevent and even punish Sniper from/for using them with Rupture; Sniper is forced to stand still with Shadow Blade, while Hurricane Pike and Blink Dagger deals damage if he attempts to use them while Ruptured.
Additional:
* Sniper's lack of mobility and escape mechanisms makes him one of the easier heroes for Bloodseeker to gank.

* Heroes with powerful nuke can waste their precious abilites on her Refraction during a ganking attempt or chaos combat: Lich, Lina, Sniper, Outworld Devourer Zeus

* Heroes with powerful nuke can waste their precious abilites on her Refraction during a ganking attempt or chaos combat: Lich, Lina, Sniper, Outworld Devourer Zeus

* If Thirst activated, Lich doesn't slow Bloodseeker.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Thirst or forces Bloodseeker to build Blade Mail can cause Lich to accidentally kill himself with Chain Frost.
* Even Lich builds Glimmer Cape or Force Staff are suicidal item against Bloodseeker when he is affected by Rupture.

* Skeleton Walk is not enough to outrun Bloodseeker, and is detected by Thirst.
Additional:
* Thirst reveals Clinkz if he tries to escape with Skeleton Walk with low health. It also allows Bloodseeker to match or exceed Clinkz's speed.
* Rupture negates the mobility provided by Skeleton Walk in any attempt to escape or reposition in fights.
* Bloodseeker can easily build items to counter Clinkz, including Talisman of Evasion upgrades, Blade Mail, and armor items.

* Fragile carries with no reliable escaping mechanism can be bursted down in no time: Sniper, Drow Ranger, Clinkz

* Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.

* Centaur has nothing to deal with Refraction that will negate all of his burst damage.
* Psionic Traps provide good vision, making for him harder to initiate.

* Shadow Fiend's fragility and lack of a natural escape mechanism makes him a great target for Templar Assassin's Meld.
* Shadow Fiend's burst damage, such as Shadowraze and Requiem of Souls, is easily nullified by her Refraction.

* Rupture deals extra damage to Magnus during Skewer or Force Staff, preventing him from escaping or counter-initiating, forcing him to invest on a Linken's Sphere.

* Her Psionic Traps will usually disable Earthshaker's Blink Dagger prior to a teamfight, preventing him from initiating.
* Refraction blocks all of Earthshaker's abilities.

* Templar Assassin can easily counter Invoker's last hitting process in the early game with Refraction. Refraction also negates the stun from Cold Snap, since it will need to deal damage in order to apply its stun.
* Additionally, Refraction completely blocks damage from Sun Strike should Invoker try to finish her off, provided she activate Refraction beforehand.

* Shukuchi will trigger extra damage from Rupture.
* Shukuchi's invisibility is detected by Thirst.
* Time Lapse cannot dispel Rupture, preventing Weaver from escaping ganks.
Additional:
* Rupture is particularly crippling against Weaver, who relies on high movement speed from Shukuchi to fight and escape, and it cannot be dispelled by Time Lapse.
* Thirst detects Weaver through Shukuchi whenever his health is low.
* Blood Rite combined with Rupture forces Weaver to either take damage from the latter, or to get silenced for a long duration.
* Bloodrage is a good tool to pop Weaver's Linken's Sphere to follow up with Rupture.

* Sven has no easy way to burn Refraction charges and needs help from teammates to kill TA successfully.

* Fragile supports with low armor are always a good prey, also her Psionic Trap will wear down most attempts to flee with their built-in disables: Silencer, Crystal Maiden, Warlock, Ancient Apparition, Grimstroke, Witch Doctor

* Blood Rite can silence Warlock, which as a spellcaster is bad for him.
* Rupture prevents Warlock from moving without taking damage, which due to his general lack of escapes is bad for him, and when combined with Blood Rite can be a very lethal combo.

* Rupture can quickly kill Mirana if she tries to Leap away.
* Thirst detects Mirana and her allies during Moonlight Shadow.
Additional:
* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.

* As a spellcaster, silences will nullify him entirely. Some notable examples are Death Prophet, Drow Ranger, Bloodseeker, Disruptor and many others.
* Doom, as usual, fits this description nicely.

* Refraction blocks all of Zeus' damage and Zeus has no innate way of removing the instances quickly.
* Meld helps burst down Zeus' small health pool while he's still working through the Refraction instances.
* Psi Blades allow her to harass and zone Zeus in lane.
* Templar Assassin usually buys Blink Dagger, enabling her to quickly close the gap to Zeus' defensive positioning.

* Nether Swap triggers extra damage from Rupture.
* Blood Rite sets up while Vengeful Spirit using her Nether Swap within a timed correctly.

* Heroes that can jump and kill him: Meepo, Clinkz, Templar Assassin

* Fragile supports with low armor are always a good prey, also her Psionic Trap will wear down most attempts to flee with their built-in disables: Silencer, Crystal Maiden, Warlock, Ancient Apparition, Grimstroke, Witch Doctor

* Heroes that can maintain vision on Monkey King can see when he uses Tree Dance: Bloodseeker, Treant Protector with Eyes In The Forest, Sniper, Weaver

* Heroes with powerful nuke can waste their precious abilites on her Refraction during a ganking attempt or chaos combat: Lich, Lina, Sniper, Outworld Devourer Zeus

Additional:
* Refraction blocks most of the damage dealt with Arcane Orb and Sanity's Eclipse if used correctly, and is difficult for Outworld Devourer to deal with.
* If Astral Imprisonment is on cooldown, then an Outworld Devourer slowed by Psionic Trap is an easy kill for Templar Assassin, especially during the laning stage.

* Heroes who can delivers a big chunk of damage in few hits will find themselves struggle against Templar Assassin's Refraction: Sven, Phantom Assassin, Ursa, Wraith King, Lifestealer

* Heroes who can delivers a big chunk of damage in few hits will find themselves struggle against Templar Assassin's Refraction: Sven, Phantom Assassin, Ursa, Wraith King, Lifestealer

Additional:
* Templar Assassin usually places Psionic Traps inside the Roshan Pit (and can teleport herself to the traps with an Aghanim's Scepter), preventing Ursa from killing Roshan without getting noticed by the enemy team.

* Heroes with powerful nuke can waste their precious abilites on her Refraction during a ganking attempt or chaos combat: Lich, Lina, Sniper, Outworld Devourer Zeus

* Heroes who can delivers a big chunk of damage in few hits will find themselves struggle against Templar Assassin's Refraction: Sven, Phantom Assassin, Ursa, Wraith King, Lifestealer

* Powerful physical hitters that can destroy Pangolier during his rolling from afar: Drow Ranger, Sniper, Templar Assassin, Arc Warden

* Thirst provides constant sight and speed to Bloodseeker, allows him to catch up a fleeing Pangolier through all of his mobility.
* Rupture is a great threat to Pangolier, causes him to take heavy damage if he uses Swashbuckle and especially Rolling Thunder, forcing him to stop his ultimate prematurely, or keep rolling to his death.
Additional:
* Rupture works through Rolling Thunder and Swashbuckle, greatly reducing Pangolier's mobility.

* Fragile supports with low armor are always a good prey, also her Psionic Trap will wear down most attempts to flee with their built-in disables: Silencer, Crystal Maiden, Warlock, Ancient Apparition, Grimstroke, Witch Doctor

* Heroes with silences : Bloodseeker, Riki, Silencer.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

Additional:
* While Burrowing, Nyx is an easy target for a Blood Rite, although he can at least partially counter it with a well-timed Spiked Carapace.
* Thirst is always a threat to Nyx Assassin, hindering his attempt of escape using Vendetta.
* Rupture also prevents Nyx Assassin from escaping with Vendetta, as it forces him to stay still.

* Bloodseeker's Rupture deals great damage against Timbersaw should he tried escaping with Timber Chain.

Additional:
* Rupture and Blood Rite locks down Timbersaw, preventing him from escaping with Timber Chain. However, Timbersaw may reflect a good deal of damage with Blade Mail.

* Fragile supports with low armor are always a good prey, also her Psionic Trap will wear down most attempts to flee with their built-in disables: Silencer, Crystal Maiden, Warlock, Ancient Apparition, Grimstroke, Witch Doctor

* Because Oracle uses few, powerful instances of damage to kill enemies, Templar Assassin's Refraction and Visage's Gravekeeper's Cloak can absorb his burst damage.

* Heroes with invisibility will be detected by Thirst when they have low enough health: Bounty Hunter, Templar Assassin, Riki, Clinkz, Weaver, Treant Protector, Nyx Assassin.

* Bloodseeker's Rupture turns Night Stalker mobility against him and Thirst grants movement speed bonus and vision prevents Night Stalker from initiating and re-initiating.

* Fragile carries with no reliable escaping mechanism can be bursted down in no time: Sniper, Drow Ranger, Clinkz

* Thirst prevents Slark from healing with Shadow Dance.
* Rupture will deal damage during Pounce.
* Dark Pact cannot dispel Rupture, preventing Slark from escaping ganks.
Additional:
* Thirst makes Slark visible while at low health, canceling out Shadow Dance's passive. For this reason, Bloodseeker is usually considered the hardest counter to Slark.
* Rupture cannot be dispelled by Dark Pact, and using Pounce while affected by it will cause Slark to take damage.

* Every Meepo clone adds to Thirst's bonuses.
* Bloodseeker can chase down retreating clones when Meepo tries to cycle weaker clones away from combat.

* Blood Rite prevents Queen of Pain from escaping with Blink.
* Blink will trigger the extra damage from Rupture.
Additional:
* Bloodrage is the best tool to pop her spell block talent or her Linken's Sphere, following up with Rupture.
* Blood Rite silences her, preventing her from initiating or escaping.
* With Thirst, even if she Blinks away, Bloodseeker can catch right up to her.
* Rupture will heavily damage Queen of Pain if she tries to Blink away.
* She is, however, one of the few heroes who can avoid the damage from Rupture if she does it correctly.

* Bloodseeker's Rupture can turn Bounty Hunter's mobility against him, and prevents him from escaping with Shadow Walk due to the potentially heavy damage.
* Thirst can prevent Bounty Hunter from escaping with Shadow Walk should Bounty Hunter's health become low enough.

* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.
Additional:
* Rupture completely negates Lycan's high mobility.
* All of Lycan's summons are good sources of healing with Bloodrage.

* Blood Rite can flush Enigma out of position and potentially force him to activate his spell immunity prematurely, before pulling off a Black Hole combo.
* Bloodseeker can find an Enigma out of position and Rupture him, making it difficult to initiate properly in a team fight, as it pierces through Black King Bar

* Thirst detects Riki whenever his health is low.
* Rupture does large damage when Riki uses Blink Strike.

* Due to Tiny's non-existent agility gain, high physical damage heroes are more effective against him (Clinkz, Phantom Assassin, Templar Assassin, Ursa, Wraith King etc).

* Refraction can be very useful in safely navigating potentially mined choke points and rune spawns.

* Heroes with long-lasting, undispellable debuffs will pinpoint the true Naga Siren: Spirit Breaker, Bloodseeker.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

* Although Blood Rite can be easily avoided, if it does hit, its lengthy silence and pure damage can be a severe punishment for a slow, unobservant, or simply unfortunate Phoenix. His Rupture can turn Icarus Dive into a suicide option, and it cannot be dispelled, meaning even if Phoenix completes a Supernova, choosing to Dive may just cut its health back down. And finally, due to Phoenix's health costs, too much careless ability spamming may just put Phoenix into Bloodseeker's vision, making it a very tempting ganking target.
Additional:
* Phoenix expends health to use its abilities, making it a good target for Thirst.
* Rupture deals heavy damage against Icarus Dive.

* Bloodseeker natural attack, run and turn speed outpaces viper's and makes viper easy pickings for Bloodseekers top

* Rupture turns Windranger's mobility against her.
Additional:
* Windrun triggers the damage from Rupture.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

* Huskar is often at low health, providing large Thirst bonuses to Bloodseeker.
* Life Break can trigger Rupture's damage.
* A self applied Bloodrage together with Blademail means it's almost suicidal for Huskar to jump on Bloodseeker with Life Break
Additional:
* Huskar is often at low health, providing large Thirst bonuses.
* Life Break triggers Rupture's damage.

* Bloodseeker's Rupture forces Slardar to stay still during fights, preventing Slardar from using Guardian sprint to move in and out of fights. This takes away the ability to initiate and re-initiate with Slithereen Crush's low cooldown. Due to the increased move speed from Guardian Sprint, Slardar can lose health at about 160% the rate of normal heroes while under Rupture. Bloodseeker's Thirst also gives him enough move speed that he's one of the few heroes who can outrun or catch up to a Slardar during Sprint.