* Broodmother can destroy Nature's Prophet's treants with Spawn Spiderlings and summon spiderlings in their place.
* Broodmother loves buying Orchid Malevolence, which can prevent Nature's Prophet from escaping with Sprout and Teleportation.
Additional:
* Sprout cannot protect Nature's Prophet if Broodmother puts down a web.
* Nature's Prophet's low mobility means he is defenseless against Incapacitating Bite.
* Spiderlings absorb much of the damage from Wrath of Nature.

* Doom can eats Nature's Prophet's treants with Devour and gains lots of gold.
* Doom usually buys Radiance or using his Scorched Earth deals a lot of damage to Nature's Prophet if they stand close to his Treants, as well as killing all of his Treants and getting lots of gold.
* Doom can pick up several different abilities from neutral creeps using Devour, some of which can be annoying to Nature's Prophet:
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer, Satyr Tormenter and etc. are good examples.
* Doom and a ministun from Infernal Blade's prevents Nature's Prophet from escaping with Sprout and Teleportation.

* Broodmother can kill Invoker easily in the early game with her Spawn Spiderlings and her spiderlings.
* Broodmother is both an Orchid Malevolence and a Nullifier carrier. As she can farm it early, she can kill Invoker easily.

* Doom completely takes Invoker out of a team fight, a hero who relies on using abilities and items to contribute.
Additional:
* Doom is a good way to shut down Invoker, preventing from casting spells and using items for a lengthy time, thus forcing him to invest on Linken's Sphere.

* Heroes with break can disable Untouchable for a while: Doom and Shadow Demon (via Aghanim's Scepter), Viper

* Enchantress is well known for taking control of various summons with her Enchant. However, Broodmother's summons are not a good target for that, because she can swarm up a bunch of her summons with Spawn Spiderlings and Enchantress has no good waveclear (Spawn Spiderlings can also kill creeps controlled with Enchant).
Additional:
* Enchantress' lack of AoE abilities allows Broodmother to swarm her with Spiderlings.
* Spawn Spiderlings can kill enchanted creeps.

* Phantom Assassin's single target abilities make her very helpless against swarms of spiderlings.
* Because Phantom Assassin is always reliant on critical strikes, Broodmother will usually have enough time to use Spin Web to save herself.
* Aside from Spin Web, Incapacitating Bite can cripple her due to being reliant on physical attacks and critical strikes.
Additional:
* Phantom Assassin's single target abilities make her very helpless against swarms of Spiderlings.
* Because Phantom Assassin is always reliant on critical strikes, Broodmother will usually have enough time to use Spin Web to save herself.
* Incapacitating Bite cripples her due to reliant on physical attacks.

* Doom, Disruptor with Aghanim's Scepter, and hex abilities all prevent item usage, which is a severe problem for Phantom Assassin as it prevents her from using Black King Bar, the one item that helps protect her against the aforementioned dangers. Doom and Shadow Demon with Aghanim's Scepter also disables Phantom Assassin's Evasion and Critical Strike, removing much of her damage and survivabaility.

* Scorched Earth can be used to engage Visage while removing Gravekeeper's Cloak charges.
* Infernal Blade will deal tremendous amounts of damage over time due to Visage's high health pool.
* Doom completely nullifies Gravekeeper's Cloak and prevents Visage from casting spells.

* Support heroes with low mobility can be slowed further by Incapacitating Bite, and swarmed by Spiderlings for an easy kill: Shadow Shaman, Visage, Dazzle, Rubick, Lich.

* Doom shuts down Anti-Mage's escape capabilities with Blink. The ability also deals pure damage, which ignores the protection from Counterspell.
* If Doom has Aghanim's Scepter, Infernal Blade can hit Anti-Mage loses his Mana Break and Counterspell, weakening both his offense and defense.
* Doom's low mana pool causes him to take little damage from Mana Void.
Additional:
* Doom prevents Anti-Mage from maneuvering around a fight or escaping from an initiation using Blink. Additionally, Doom deals pure damage, which is not affected by Counterspell. This can quickly whittle away Anti-Mage's naturally poor health pool.
* Be careful when using Doom as a well-timed Counterspell can block and reflect it back against Doom himself.
* An Aghanim's Scepter upgraded Infernal Blade will also disable Mana Break and Counterspell, which makes Anti-Mage significantly less effective in fights and more susceptible to the high magical damage of Doom's abilities and any allies'.

* Heroes with abilities or items that can silence or disable Anti-Mage for long periods of time will prevent him from Blinking away: Silencer, Shadow Shaman, Death Prophet, Clinkz, Riki, Broodmother, Skywrath Mage, Puck

* Heroes that have strong powerspikes early into the game can shut down the Arc Warden before he can fight, such as Broodmother or {Hero ID:Bristleback}.

* Arc Warden relies on items and abilities, as well as his {U:Tempest Double}, to deal damage to enemies. Doom effectively denies that and makes Arc Warden useless in fights.

* Tinker is heavily reliant on casting his spells and Doom can disable all of his abilities and items. An Aghanim's Scepter only makes it harder for Tinker to survive.
Additional:
* Tinker is heavily dependent on active abilities and Doom prevents him from using any of them.

* Doom makes Ursa less disruptive, and it cannot be dispelled with Enrage upgraded with Aghanim's Scepter.
* Aghanim's Scepter upgraded Infernal Blade can break Fury Swipes, negating much of his damage output.

* Doom disables the toggling of Rot and, if cast at the right time, may leave Pudge with a potentially lethal health drain.
* Doom's naturally high health, strength gain and damage output makes him a poor target for Pudge.
* The damage of Doom's Infernal Blade scales with the target's maximum health, which is particularly effective against Pudge due to his naturally high health and further health granted by stacks of Flesh Heap.
Additional:
* Infernal Blade deals high damage to Pudge due to his high strength grow with Flesh Heap.
* Using Doom with timing against Pudge who had just activated Rot would usually kill him.

* Chen has no area-of-effect spells to deal with Broodmother's spiderlings and must rely on his creeps to take care of them.
* Spawn Spiderlings can kill Chen's creeps and spawn spiderlings in their place.
* Spin Web allows Broodmother to disrupt Chen's jungling.
* Incapacitating Bite and Insatiable Hunger let Broodmother easily win fights against Chen.
Additional:
* Chen's low mobility and lack of AoE abilities makes him an easy target for Broodmother and her Spiderlings.
* Broodmother can easily pick off Chen's creeps with Spawn Spiderlings, and by ambushing them through terrain in her web.

* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: Lifestealer, Doom, Mirana, Clinkz.

* Doom can completely shut down Dazzle through Doom, as it prevents him from casting his abilities and, by extension, gaining Bad Juju stacks.

* Support heroes with low mobility can be slowed further by Incapacitating Bite, and swarmed by Spiderlings for an easy kill: Shadow Shaman, Visage, Dazzle, Rubick, Lich.

* Spin Web and Broodmother's auto-attacks allow her to gank Rubick easily before Rubick has a chance to retaliate, especially if Broodmother obtains Orchid Malevolence.
* Broodmother loves buying Diffusal Blade, which drains Rubick's low supply of mana, preventing Rubick from spamming his abilities.
* Though Insatiable Hunger is a great spell to steal, Broodmother's untargetable nature and her low cooldown spells makes it a difficult spell to steal.

* Broodmother relies less on abilities and more on right-clicks.
* Spiderlings can overwhelm Silencer, who has mediocre armor and no escape tool.

* Doom can stop Death Prophet from casting spells, which makes her useless during team fights if she didn't cast Exorcism before the fight. Furthermore, Doom can use Scorched Earth to chase after her.

* Her Spiderlings can harass Luna in lane heavily, as Luna has no AoE abilities to clear Spiderlings.
* Broodmother can knock down towers in the early game quickly, and limit Luna's farming space.

* Chain Frost can bounce to the Spiderlings that Broodmother spawns.

* Faceless Void relies on Time Walk for mobility and survivability but he can be prevented from utilizing it through Doom.
* Doom has a high cooldown duration for every ability except Infernal Blade, so he is not significantly affected by Time Dilation.

* Doom makes Ogre Magi less disruptive.
* Infernal Blade effectively negates Ogre Magi's tankiness.
* With Aghanim's Scepter he can disable Multicast.

* Doom alone can easily pick off Crystal Maiden since she is fairly fragile, even with using only basic attacks, Infernal Blade, and Scorched Earth.
* Doom prevents her from using any abilities in a fight, making her impact negligible.
* Devour allows Doom to acquire a stun, allowing him to cancel Freezing Field without having to use Doom.

* Doom pierces spell immunity and can prevent Enigma from casting any spells or using items until the duration of the spell depletes, as well as damaging him over time. This can however, be blocked by a Linken's Sphere.
* An Enigma with a Helm of the Dominator can potentially feed his dominated creeps to Doom's Devour, giving Doom the abilities and benefits instead.

* Spiderlings melt away Living Armor almost instantly.
* The vision from Eyes In The Forest may prove dangerous for Broodmother, however.

* Infernal Blade's damage is calculated by percentage of maximum health, meaning that it will hurt Spectre more than most normal attacks, negating some of her tankiness.
* With Aghanim's Scepter Dispersion and Desloate are disabled.
* Doom can pick up several different abilities from neutral creeps using Devour, some of which can be annoying to Spectre.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom makes Spectre less disruptive.

* Scorched Earth deals damage to Clinkz during Skeleton Walk.
* Doom shuts down Clinkz entirely, as it prevents him from casting any of his spells and contributing a large amount of damage in teamfights.

* Heroes with blind of some sort can be a bad choice for Monkey King to go on: Broodmother, Riki, Keeper of the Light.

* Heroes with silencing abilities can be particularly deadly when Slark is trying to escape: Silencer, Death Prophet, Puck, Doom

* Heroes with summons like Broodmother,Enigma, Invoker, Nature's Prophet, Lycan, Visage;or illusions, like Naga Siren, Phantom Lancer, Terrorblade are effective at keeping the choke points and rune spawns safe from Proximity mines in the early game.

* Support heroes with low mobility can be slowed further by Incapacitating Bite, and swarmed by Spiderlings for an easy kill: Shadow Shaman, Visage, Dazzle, Rubick, Lich.

* Heroes with abilities that break Berserker's Blood, lowering Huskar's attack speed and health regeneration: Doom, Shadow Demon, Viper.

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Heroes with illusions and summons can swarm Bane, who has no area abilities: Broodmother, Chaos Knight, Nature's Prophet, Phantom Lancer, Terrorblade

* Heroes with illusions and summons can manfight Night Stalker: Terrorblade, Beastmaster, Broodmother.

* Sniper is completely helpless against Incapacitating Bite, and can be seriously damaged by Spiderlings in lane.

* Doom will make Abaddon unable to use Mist Coil, Aphotic Shield, and the active component of Borrowed Time, which means his allies could be easily disabled or killed.
* Infernal Blade upgraded with Aghanim's Scepter can break Curse of Avernus and the passive component of Borrowed Time. It also deals high damage due to Abaddon's high health.

* A well-timed Doom prevents Nyx Assassin escaping with Vendetta and does not allow him to disengage with Spiked Carapace.
* Doom's high HP easily shrug off Nyx Assassin's burst damage and fend him off.

* Doom turns Omniknight into a walking creep, or completely takes out his buffed cores, also removing Guardian Angel in the process.
* Doom has access to Satyr Banisher's Purge, which allows him to remove Guardian Angel.
Additional:
* Doom applies a basic dispel upon cast, so it can remove Guardian Angel.
* Casting Doom on Omniknight will prevent him from healing allies with Purification, or casting buffs like Heavenly Grace and Guardian Angel.

* Infernal Blade does damage based on percentage health, and is useful against high health pool hero like Underlord
* Doom can prevent Underlord from spamming his abilities and most important is prevent him from using Dark Rift to escape

* Infernal Blade deals scaling damage and is useful against high health targets such as Bristleback. With Aghanim's Scepter, it also breaks Bristleback's passive, rendering him more vulnerable.
* Doom disables Bristleback's low cooldown abilities, preventing him from triggering Warpath. Its pure damage also penetrates Bristleback.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Bristleback.
* If Doom gets an Aghanim's Scepter, he can disable Bristleback, taking away much of his durability.
* Doom prevents Bristleback from casting his two low cooldown abilities, which then prevents him from utilizing Warpath.

* Any heroes with silences can negate the majority of Outworld Devourer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .

* Broodmother's Insatiable Hunger and Troll Warlord's Battle Trance can nullify Sunder.

* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, after an Incapacitating Bite she will get her swarmed in no time.
* Medusa usual do not build a BKB to benefit from Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away mana.
Additional:
* Incapacitating Bite will give Medusa a dire time to clear horde of small spiderlings or retaliate Broodmother herself.
* Spin Web will allow broodmother to pick her own fights and sometimes slip away to ambush Medusa.

* Heroes with plenty of summons, such as Broodmother or Nature's Prophet can have their minions soak up most of your Paralyzing Cask.

* Infernal Blade deals scaling damage and is useful against high HP targets such as Elder Titan.
* Doom has very low base armor and naturally high HP, so he isn't significantly affected by Natural Order.

* Doom has several disable abilities to choose from jungle creeps (e.g. War Stomp, Ensnare) to deal with Shadow Fiend who lacks escape abilities.
* When Doom combines creep abilities with Scorched Earth, Infernal Blade, and Doom, Shadow Fiend most likely will die as he cannot use Shadowraze and Requiem of Souls to protect himself, and also cannot even flee by using Shadow Blade or Blink Dagger.
* Although Shadow Fiend has a high physical damage output, Doom has a large health pool to survive it, meaning Doom's combo with high magical damage output will shutdown Shadow Fiend first.
* Doom usually buys Radiance to improve his damage, making his nuke combo more deadly to Shadow Fiend. The blind also prevents Shadow Fiend from landing his attacks often.

* Infernal Blade's damage is calculated by percentage of maximum health, meaning that it will hurt Axe more than most normal attacks, negating some of his tankiness. With Aghanim's Scepter, Counter Helix is also disabled, making him effectively useless for a lengthy duration.
* Doom can pick up several different abilities from neutral creeps using Devour, some of which can be annoying to Axe.
* Mud Golem, Dark Troll Summoner, Harpy Stormcrafter, Satyr Mindstealer or Satyr Tormenter are good examples.
* Doom makes Axe less disruptive, preventing him from using his skills or items.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Axe.
* Doom has low attack speed because of his high Base-Attack-Time, poor agility gain and limited attack-speed granting items which are commonly built. This means Doom will trigger Counter Helix less often and thus is an unideal target for initiation.
* Doom has naturally high HP so it takes longer for Doom to be brought down to the killing threshold of Culling Blade.
* Axe is highly reliant on his abilities and items to be effective during a fight. Without the usage of Berserker's Call and Blink Dagger, Axe offers very little in the way of damage.

* Doom shuts down Timbersaw completely, negating his mobility and preventing him from doing any damage.
* Infernal Blade can stun Timbersaw several times in a fight, potentially interrupting Timber Chain. It also breaks Reactive Armor's passive bonuses from Aghanim's Scepter.
Additional:
* Infernal Blade deals scaling damage and is useful against high HP targets such as Timbersaw.
* Timbersaw is extremely reliant on his abilities to be effective during a teamfight - both for mobility, damage and crowd control. Timbersaw offers very little impactful right-click damage, and thus Doom is particularly crippling against this hero.
* Additionally, when upgraded with Aghanim's Scepter, Infernal Blade breaks Reactive Armor, which effectively removes the durability which Timbersaw is commonly known for.

* Viper's lack of escape and durability means he can be ran over in a laning stage by Spiderlings.
* Broodmother can bring Viper down quickly with Insatiable Hunger activated.

* Illusion-based and multi-unit heroes can take advantage of Chaos Knight's lack of area damage: Naga Siren, Phantom Lancer, Meepo, Broodmother

* Doom is effective against every hero, and Void Spirit is no exception. Being unable to cast spells or items during fights for 16 seconds nullifies his impact entirely.
* Doom has a very versatile build and can consume creeps which has abilities that can stun or provide additional magic resistance.
* Doom's high strength gain and versatility in items can be effective against Void Spirit's magical damage.

* Infernal Blade deals scaling damage and is useful against high HP targets such as Tidehunter.
* If Doom gets an Aghanim's Scepter, he can also disable Kraken Shell, reducing his survivability and tankiness.
* Doom prevents Tidehunter from casting his Gush, Anchor Smash and Ravage, making him useless in team fights.

* Doom prevents Storm Spirit from using all of his abilities and items, rendering Storm Spirit useless in a fight.

* Oracle cannot easily deal with swarms of units, making him weak against heroes like Phantom Lancer or Broodmother.

* Broodmother can easily clear Wraith King's skeletons with Spawn Spiderlings and summon spiderlings in their place.
* With Diffusal Blade, Broodmother can prevent Wraith King from reincarnating unless the level 20 talent is chosen.

* Drow Ranger's lack of mobility makes her easy prey for Broodmother and her Spiderlings.