* Lone Druid and The Spirit Bear cannot burst down Bristleback due to Bristleback
* Bristleback can easily run to Lone Druid without any hesitation, with Viscous Nasal Goo to reduce armor and slow the Spirit Bear or Lone Druid and Quill Spray can deal damage to both Lone Druid and the Spirit Bear at the same time

* Reality Rift lets Chaos Knight bypass the Spirit Bear and jump onto Lone Druid.
* The Spirit Bear's lack of scaling means it dies quickly to Chaos Knight during the late-game.

* Bristleback's abilities are nearly useless for Rubick to Spell Steal, as he does not gain the bonuses from Warpath.
Additional:
* Rubick deals little damage on his own, so Bristleback can simply shrug off all his spells and chase you down with his spells and attacks.
* Quill Spray requires multiple casts and close range to add up stacks. Because Rubick does not stay in the front lines, it's generally not a good spell for him to steal.
* Viscous Nasal Goo will slow Rubick down even further and reduce his armor, making him vulnerable to Quill Spray and the damage bonus from Warpath.

* While Chaos Knight can land far away from Rubick due to Telekinesis, it can be counteracted by Reality Rift.
* Phantasm dispels Fade Bolt's damage reduction debuff.
* Rubick is fragile and can easily be killed by Chaos Knight and Phantasm's illusions, before he retaliates.

* Bristleback is one of the hardest heroes to gank with a Meat Hook and Dismember combo, and attempts to do so sometimes backfire on Pudge.
Additional:
* Pudge is particularly susceptible to Bristleback's Viscous Nasal Goo and Quill Spray due to his naturally low armor & poor agility gain.
* Bristleback, in combination with his strength gain, high health, common itemization for magic resistance and damage reduction from Bristleback makes him a poor target for Pudge.

* Phantasm's illusions make it difficult to land Meat Hook and Dismember.
* Chaos Bolt is a comparatively low cooldown tool to interrupt Dismember.
* Chaos Strike's lifesteal offsets Rot's damage.

* Bristleback need not worry about charging into Magnetic Field, and quickly clearing up Arc Warden's summons and Tempest Double with Quill Spray.
Additional:
* Bristleback activates frequently while he escapes from Arc Warden's Necronomicon army.
* Arc Warden has little armor and mobility, which makes him an easy target to apply Quill Spray and Viscous Nasal Goo stacks.

* Chaos Knight can dispel Flux with Phantasm.
* Chaos Knight can use Reality Rift to pull Arc Warden out of Magnetic Field.
* Once Chaos Knight jumps on Arc Warden with Reality Rift, Arc Warden struggles to escape due to low mobility.

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar

* Chaos Knight's Level 20 Talent: Reality Rift Pierces Spell Immunity allows for quick bursting down of Lifestealer during his Rage.
* Phantasm dispels Open Wounds.
* Lifestealer has no way of dealing with Chaos Knight's illusions.

* Quill Spray and Bristleback harass Luna more efficiently than she does with Lucent Beam.
* Bristleback withstands Luna’s nukes, and gives lots of damage in return.
* Viscous Nasal Goo and Warpath are enough to outrun a speedy Luna.
* Bristleback tends to be a frequent carrier of Crimson Guard, which is good protection from bouncing glaives.
Additional:
* Multiple instances of damage from Eclipse will trigger Bristleback's passive repeatedly in a short time, dealing tremendous damage to Luna and her teammates.
* Luna's damage burst may be high, but it will not be enough for her to take down Bristleback.

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

* Heroes with illusions can overwhelm Huskar, as he has no AoE abilities: Phantom Lancer, Anti-Mage, Arc Warden, Chaos Knight.

* Bristleback's tankiness and Bristleback allow him to outlast Burning Spears' damage-over-time at almost any point in the game. In addition, if Huskar chooses to cast Life Break on Bristleback, Bristleback can simply turn around before it hits and receive little damage.
* Viscous Nasal Goo will reduce Huskar's low armor even further, and Quill Spray and Warpath will tear him down extremely quickly.
Additional:
* The damage from Burning Spear can be reduced by turning away from Huskar.
* Bristleback can bait Huskar into using Life Break on him, then turn around and receive very little damage.

* Phantasm dispels Track, and the illusions make it difficult to Track the real Chaos Knight.
* Bounty Hunter is fragile and can easily be killed by Chaos Knight and Phantasm's illusions.

* Bristleback's Viscous Nasal Goo can catch and slow Bounty Hunter. Warpath and Quill Spray can defeat him quickly due to his small HP pool when compared to Bristleback's.

* Quill Spray usually hits Meepo's clones, although Bristleback cannot turn his back when rooted with Earthbind.

* Chaos Knight's high health pool makes him resistant to Zeus' burst damage. Phantasm can dispel Veil of Discord, a typical item purchased by Zeus.
* Zeus is easily overwhelmed by Chaos Knight's strong illusions, as Arc Lightning is not enough to kill them fast enough to have any impact.
* Zeus' low base armor makes him extremely vulnerable to Chaos Knight's high damage output and armor reduction.

* Reality Rift will disable Drow Ranger's Marksmanship, along with Chaos Bolt he can keep her locked for enough time to be killed.
* Phantasm's illusions are hard for Drow Ranger to deal with as she lacks of AoE damage.

* The bonus Backstab damage from Cloak and Dagger is rendered irrelevant with Bristleback and hurts Riki more than him because of the passive Quill Spray.
* Riki still gets damaged by Bristleback's Quill Spray while invisible, and it can be hard to deal with in lane.
* Bristleback is not too bothered by Smoke Screen. Though he cannot use Quill Spray manually inside it, it still procs passively when he takes damage from the back. The movement speed from Warpath allows him to get out of the area easily.
* Due to Bristleback's natural tankiness, he is an ideal Gem of True Sight carrier.
* Riki rarely buys Silver Edge to break Bristleback's passive because the invisibility aspect of it is redundant.
Additional:
* Quill Spray will hit Riki even when he is invisible.
* Cloak and Dagger's bonus backstab damage is rendered irrelevant against Bristleback.
* Smoke Screen does not stop Bristleback's passive from activating.
* Due to Bristleback's natural tankiness, he is an ideal Gem of True Sight carrier, directly countering Riki's invisibility.

* Dark Pact is minimally effective against Phantasm illusions, and Slark lacks area damage otherwise.
* Pounce can be counteracted by Reality Rift.
* Slark is naturally frail and dies quickly to Chaos Knight's burst damage before he can build Essence Shift stacks.
* Be aware, however, that Shadow Dance can make Slark hard to kill as he can't be targeted during its duration.
Additional:
* Phantasms have enough health to survive Dark Pact, and Slark has no other source of AoE damage to deal with them.

* Phantasm's illusions can be used to push towers and force Techies to detonate Remote Mines.
* Phantasm's illusions can be used to sweep Proximity Mines and Stasis Traps.
* Chaos Knight can easily kill a lone Techies before they Blast Off!.

* Innately fragile heroes will die almost instantly to Reality Rift while Chaos Knight has illusions active: Drow Ranger, Bane, Necrophos, Crystal Maiden.

* Viscous Nasal Goo can hinder Crystal Maiden's already abysmal mobility, which allows Bristleback (or his teammates) to run her down and kill her.
* Bristleback frequently builds Blade Mail, which can quickly kill Crystal Maiden if her ultimate is used while he is under its effect.
* The passive part of Bristleback will trigger many, many times under the damage from Freezing Field, and as the stacks increase, the damage output from each successive cast (or proc) will eat away at Crystal Maiden's small HP pool.

* Fortune's End cannot dispel Warpath stacks on Bristleback or Quill Spray stacks on allies.
* Bristleback can heavily reduce Oracle's damage output. With it, Oracle may accidentally heal Bristleback with Purifying Flames, especially if Bristleback has bonus magic resistance.

* Phantasm dispels Ignite and makes targeting the real Chaos Knight much harder.

* Wraith King has no form of AoE to clear Chaos Knight's illusions from Phantasm.
* Wraith King is very vulnerable if he reincarnates in the middle of his illusions.

* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.

* Chaos Knight's tanky illusions easily take advantage of Troll Warlord's lack of AoE damage.
* Chaos Bolt can stun Troll for up to 4 seconds and Reality Rift prevents Troll Warlord from chasing down foes.
* Phantasm increases Chaos Knight's physical damage output up to 4 times and can easily kill Troll Warlord before he has a chance to use Battle Trance or a Black King Bar.

* Quill Spray's constant AoE damage will hit Dark Willow even in Shadow Realm. Its automatic damage will hurt her if she tries to get close and use Bedlam.

* While Blade Fury is on cooldown, Juggernaut can easily killed by a standard Chaos Bolt & Reality Rift combo.
* Phantasm illusions can tank Omnislash.

* Reality Rift pulls out Night Stalker while he tries to escape or chase.
* Night Stalker doesn't have a lot of ways to deal with multiple targets, which makes him vulnerable to Phantasm illusions from early to mid game, until Night Stalker buys Aghanim's Scepter.

* Lycan's wolves deal little damage to Bristleback, and are easily killed by Quill Spray, even when they're invisible.
* Lycan's lack of burst damage makes it very hard for him to kill Bristleback, especially when his back is turned.
Additional:
* Quill Spray can be used to kill Lycan's summons.
* Bristleback allows him to stay alive against Lycan while dishing out counter attacks
* He can overpower Lycan with his Warpath instead.

* Heroes that have AoE damage: Lina, Keeper of the Light, Timbersaw, Leshrac, Bristleback, Axe

* Heroes with illusions and summons can be hard for Phantom Assassin to deal with, as she lacks any AoE abilities to deal with them: Broodmother, Phantom Lancer, Chaos Knight.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Heroes who relies on illusions and summons (Beastmaster, Chaos Knight, etc.).

* Chaos Knight with Phantasm
* Heroes that can dodge Glimpse:
* Puck with Phase Shift
* Riki with Tricks of the Trade
* Phantom Lancer with Doppelganger
* Ember Spirit with Sleight of Fist and Activate Fire Remnant
* Chaos Knight with Phantasm
* Naga Siren with Mirror Image
* Tusk with Snowball
* Juggernaut with Omnislash
* Brewmaster with Primal Split
* Lifestealer with Infest
* Phoenix with Supernova

Additional:
* Phantasm removes Glimpse and dispels Thunder Strike. Additionally, the Phantasm illusions make it difficult to use Glimpse and Thunder Strike on the real Chaos Knight.
* Disruptor's lack of mobility, combined with his lack of innate defense, sets him up for a Reality Rift and a beatdown by Chaos Knight and his illusions.

* Heroes with damage-over-time abilities will not only proc Bristleback's passive continuously, they will also do little harm to him when he is facing away from the source: Venomancer, Arc Warden

* Skywrath mage also has a terrible time fighting against anything that isn't a hero. As Mystic Flare only affects heroes, his skills are mostly target-based and he has terrible strength and agility, he can easily be kited or harassed by illusion-based heroes like Chaos Knight and Phantom Lancer, or by Heroes that summon other units like Lone Druid, Lycan and Beastmaster.

* Warlock is a very strong hero when positioned correctly, and his long cast range helps him with this. However, some Heroes might disrupt or sneakily pass through your allies and deal with you, preventing you from doing your job. Such heroes include Chaos Knight, Spirit Breaker, Riki, and some others.

* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Pugna

* Heroes with illusion and clone abilities may confuse Bloodseeker, causing him to waste time in fights: Phantom Lancer, Chaos Knight, Arc Warden

* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: Bane, Beastmaster, Bloodseeker, Clockwerk, Doom, Shadow Shaman.

* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: Bane, Beastmaster, Bloodseeker, Clockwerk, Doom, Shadow Shaman.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. However, Chen can convert enemy summons with Holy Persuasion, as long as they don't bunch up.

* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: Bane, Beastmaster, Bloodseeker, Clockwerk, Doom, Shadow Shaman.

* Heroes with illusions and summons can swarm Bane, who has no area abilities: Broodmother, Chaos Knight, Nature's Prophet, Phantom Lancer, Terrorblade

Additional:
* Phantasm's illusions make it difficult for Bane to target Chaos Knight with Nightmare, Brain Sap and Fiend's Grip.
* Chaos Bolt is a comparatively low cooldown tool to interrupt Fiend's Grip.
* Nightmare can be transferred by Phantasm illusions.

* Heroes that can overwhelm Visage by sheer number like Chaos Knight, Meepo, Terrorblade and Phantom Lancer.

* Bristleback decreases Tiny's high burst damage against Bristleback.
* Tiny's high damage will also proc Bristleback multiple times.
* Viscous Nasal Goo can help counteract the bonus armor granted by Grow.

* Quill Spray will hit Sand King inside Sand Storm, damaging him and putting Sand King's Blink Dagger on cooldown, preventing him from escaping.
* Epicenter's numerous damage ticks will trigger Bristleback's passive repeatedly during teamfights.

* Quill Spray destroys spiderlings, and hits Broodmother even when she's regenerating in her webs. This makes Bristleback one of her hardest counters in lane.
Additional:
* Bristleback reduces most of Broodmother's and her spiderlings' damage.
* Quill Spray will hit any spiders in its proximity, hindering Broodmother's fighting and farming capabilities.

* Viper has no response to the standard initiation combo of Reality Rift into Chaos Bolt.
* Phantasm can eliminate Viper almost instantly with its damage output.
Additional:
* As Viper focuses on single-target damage, he has trouble fighting off Phantasm illusions.
* Reality Rift counteracts Viper's slows and reduces his durability.

* Chaos Knight, Lone Druid, Meepo and Arc Warden can be hard targets since Shadow Demon's spells are ill-suited to fight many enemies at once.

* Viscous Nasal Goo slows down Dragon Knight and lowers armor, locking him down and making him more vulnerable.

* Casting Phantasm before a fight minimizes the disruption from Global Silence.
* Because Chaos Knight generally relies on attack damage, Silencer's spells won't be as effective against him.

* Macropyre's frequent damage ticks causes Bristleback to activate repeatedly, resulting in free damage as long as Bristleback faces away from Jakiro.

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Bristleback's tankiness and damage reduction from the rear makes him very hard for Phantom Lancer to chase and finish off, due to his lack of burst damage.
* Quill Spray destroys Phantom Lancer's illusions.
* Bristleback's passive costs no mana, meaning that it will continue to trigger even if Phantom Lancer drains Bristleback's mana with Diffusal Blade.
Additional:
* Quill Spray cleans up Phantom Lancer's illusions in no time.
* Phantom Lancer's complete lack of burst damage makes it nearly impossible for him to kill Bristleback during chases.

* Razor has no way to deal with Chaos Knight's multiple illusions from Phantasm.

* Bristleback's tankiness can enable him to chase Enigma out of a teamfight, making it difficult to initiate with a Black Hole.