* Pudge is particularly susceptible to Bristleback's Viscous Nasal Goo and Quill Spray due to his naturally low armor and poor agility gain.
* Bristleback, in combination with his strength gain, high health, common itemization for magic resistance and damage reduction from Bristleback makes him a poor target for Pudge.
Additional:
* Bristleback is one of the hardest heroes to gank with a Meat Hook and Dismember combo, and attempts to do so sometimes backfire on Pudge.

* Phantasm's illusions make it difficult to land Meat Hook and Dismember.
* Chaos Bolt is a comparatively low cooldown tool to interrupt Dismember.
* Chaos Strike's lifesteal offsets Rot's damage.

* Chaos Bolt and Reality Rift makes Tiny's low mobility non existent.
* Chaos Strike means Chaos Knight will most likely survive longer in a duel between the two because Tiny has much lower attack speed.
* Chaos Knight has a 3.2 strength growth, making him one of the most tanky heroes and a very difficult target for Tiny to burst.

* Tiny's nonexistent armor in the early game makes him very vulnerable to Quill Spray's large amounts of physical damage.
* Bristleback decreases Tiny's high burst damage against Bristleback.
* Viscous Nasal Goo can slow Tiny to a crawl and allows Bristleback to easily kite him with his high movement speed and Quill Spray's long range, as Tiny has no ability to escape.

* Chaos Bolt can stun Huskar when he jump in with Life break, giving 4 seconds maximum for Chaos Knight to deliver a beatdown.
* Reality Rift further reduces Huskar's low armor, boosting Chaos Knight's damage even more.
* Berserker's Blood offer no protection against Chaos Strike, which deal physical damage.
* Phantasm can be used to dispel the disarm from Inner Fire.
* Although Huskar can use this to disarm the illusion instead, buying himself some times.
Additional:
* Huskar's low armor and movement speed make an easy target for Chaos Knight to initiate on with Reality Rift and Chaos Bolt.
* Beside Inner Fire, Huskar has no reliable area of effect ability to clear Phantasm illusions.
* Huskar likes to fight at low health to benefit from his Berserker's Blood, thus vulnerable to Chaos Knight's high burst physical damage.

* Bristleback's tankiness and Bristleback allow him to outlast Burning Spears' damage-over-time at almost any point in the game. In addition, if Huskar chooses to cast Life Break on Bristleback, Bristleback can simply turn around before it hits and receive little damage.
* Viscous Nasal Goo will reduce Huskar's low armor even further, and Quill Spray and Warpath will tear him down extremely quickly.
Additional:
* The damage from Burning Spear can be reduced by turning away from Huskar.
* Bristleback can bait Huskar into using Life Break on him, then turn around and receive very little damage.

* Reality Rift lets Chaos Knight bypass the Spirit Bear and jump onto Lone Druid.
* The Spirit Bear's lack of scaling means it dies quickly to Chaos Knight during the late-game.

* Lone Druid and The Spirit Bear cannot burst down Bristleback due to Bristleback
* Bristleback can easily run to Lone Druid without any hesitation, with Viscous Nasal Goo to reduce armor and slow the Spirit Bear or Lone Druid and Quill Spray can deal damage to both Lone Druid and the Spirit Bear at the same time

* Chaos Knight's Level 20 Talent: Reality Rift Pierces Spell Immunity allows for quick bursting down of Lifestealer during his Rage.
* Lifestealer has no way of dealing with Chaos Knight's illusions.
Additional:
* Level 20 talent allows Reality Rift to bypass spell immunity provided by Rage, thus negating the advantage Lifestealer has in his kit.
* The fact that Lifestealer lacks wave clearing and reliable lockdown makes it difficult to fight Chaos Knight's illusions.
* Feast is largely negated by Chaos Knight's high burst damage from Chaos Strike.

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar {Hero ID:Terrorblade}

* Bristleback's Viscous Nasal Goo can catch and slow Bounty Hunter. Warpath and Quill Spray can defeat him quickly due to his small HP pool when compared to Bristleback's.

* Phantasm dispels Track, and the illusions make it difficult to Track the real Chaos Knight.
* Bounty Hunter is fragile and can easily be killed by Chaos Knight and Phantasm's illusions.

* Chaos Knight can dispel Flux with Phantasm.
* Chaos Knight can use Reality Rift to pull Arc Warden out of Magnetic Field.
* Once Chaos Knight jumps on Arc Warden with Reality Rift, Arc Warden struggles to escape due to low mobility.

* Heroes with damage-over-time abilities will not only proc Bristleback's passive continuously, they will also do little harm to him when he is facing away from the source: Venomancer, Arc Warden

Additional:
* Arc Warden has relatively lower armor and mobility, which makes him an easy target to apply Quill Spray and Viscous Nasal Goo stacks.
* Arc Warden also does not like to build a Silver Edge as it takes a long time to build up and may slow down the timings for other important items needed in the game. (eg. an Orchid Malevolence versus a Storm Spirit)
* However, do note that in a game where your team has many jumping capabilities or good passives, like a Tidehunter or Spectre, a Silver Edge becomes incredibly valuable on Arc Warden as not only can he run away from the jumps, he effectively gets 2 breaks, and Bristleback may not be the best pick.

* Bristleback's abilities are nearly useless for Rubick to Spell Steal, as he does not gain the bonuses from Warpath.

* Phantasm removes Glimpse and dispels Thunder Strike. Additionally, the Phantasm illusions make it difficult to use Glimpse and Thunder Strike on the real Chaos Knight.
* Disruptor's lack of mobility, combined with his lack of innate defense, sets him up for a Reality Rift and a beatdown by Chaos Knight and his illusions.

* Quill Spray's constant AoE damage will hit Dark Willow even in Shadow Realm. Its automatic damage will hurt her if she tries to get close and use Bedlam.

* Quill Spray and Bristleback harass Luna more efficiently than she does with Lucent Beam.
* Bristleback withstands Luna’s nukes, and gives lots of damage in return.
* Viscous Nasal Goo and Warpath are enough to outrun a speedy Luna.
* Bristleback tends to be a frequent carrier of Crimson Guard, which is good protection from bouncing glaives.
Additional:
* Multiple instances of damage from Eclipse will trigger Bristleback's passive repeatedly in a short time, dealing tremendous damage to Luna and her teammates.

* Heroes that create illusions: Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress, Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse, but that will require lots of farming for right-click items.

* Dark Pact is minimally effective against Phantasm illusions, and Slark lacks area damage otherwise.
* Pounce can be counteracted by Reality Rift.
* Slark is naturally frail and dies quickly to Chaos Knight's burst damage before he can build Essence Shift stacks.
* Be aware, however, that Shadow Dance can make Slark hard to kill as he can't be targeted during its duration.
Additional:
* Phantasms have enough health to survive Dark Pact, and Slark has no other source of AoE damage to deal with them.

* Sniper is very fragile, along with his low movement speed, make an exceptionally easy target for Chaos Knight to initiate on.
* Sniper has no innate ability to deal with Phantasm or escape a Reality Rift and Chaos Bolt combo.
* In most cases, Sniper likes to stay far in the backline to deal damage, thus he is vulnerable if Chaos Knight manages to jump in the back line, which will usually spell a quick end for Sniper.

* Morphling is mostly a single target damage dealer with low mobility and no wave clear, this leave him vulnerable to Chaos Knight illusion from Phantasm.
* A long duration stun from Chaos Bolt coupled with Reality Rift and high damage output from Phantasm can easily burst down Morphling before he can shifts Agility to Strength.
* Chaos Knight often buys Bloodthorn, rendering Morphling useless for 5 seconds (unless he has Linken's Sphere or Manta Style )

* Reality Rift will disable Drow Ranger's Marksmanship, along with Chaos Bolt he can keep her locked for enough time to be killed.
* Phantasm's illusions are hard for Drow Ranger to deal with as she lacks of AoE damage.

* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.

* Fortune's End cannot dispel Warpath stacks on Bristleback or Quill Spray stacks on allies.
* Bristleback can heavily reduce Oracle's damage output. With it, Oracle may accidentally heal Bristleback with Purifying Flames, especially if Bristleback has bonus magic resistance.

* Chaos Knight's high health pool makes him resistant to Zeus' burst damage. Phantasm can dispel Veil of Discord, a typical item purchased by Zeus.
* Zeus is easily overwhelmed by Chaos Knight's strong illusions, as Arc Lightning is not enough to kill them fast enough to have any impact.
* Zeus' low base armor makes him extremely vulnerable to Chaos Knight's high damage output and armor reduction.

* Wraith King has no form of AoE to clear Chaos Knight's illusions from Phantasm.
* Wraith King is very vulnerable if he reincarnates in the middle of his illusions.

* Phantasm dispels Ignite and makes targeting the real Chaos Knight much harder.

* Viscous Nasal Goo can hinder Crystal Maiden's already abysmal mobility, which allows Bristleback (or his teammates) to run her down and kill her.
* Bristleback frequently builds Blade Mail, which can quickly kill Crystal Maiden if her ultimate is used while he is under its effect.
* The passive part of Bristleback will trigger many, many times under the damage from Freezing Field, and as the stacks increase, the damage output from each successive cast (or proc) will eat away at Crystal Maiden's small HP pool.

* Innately fragile heroes will die almost instantly to Reality Rift while Chaos Knight has illusions active: Drow Ranger, Bane, Necrophos, Crystal Maiden.

* Life Drain does not instantly kill the illusions from Phantasm
* Chaos Bolt easily interrupts the channeling from Life Drain
* Reality Rift makes it harder for Pugna to keep his distance
* Nether Ward barely deals any significant damage on Chaos Knight
* The overwhelming damage of Chaos Knight and his illusions will do a quick work on Pugna's poor HP poll, or safely remove the Nether Ward from the battlefield

* The bonus Backstab damage from Cloak and Dagger is rendered irrelevant with Bristleback and hurts Riki more than him because of the passive Quill Spray.
* Riki can still get damaged by Bristleback's Quill Spray while invisible, and it can be hard to deal with in lane.
* Bristleback is not too bothered by Smoke Screen. Though he cannot use Quill Spray manually inside it, it still procs passively when he takes damage from the back. The movement speed from Warpath allows him to get out of the area easily.
* Due to Bristleback's natural tankiness, he is an ideal Gem of True Sight carrier.
* Riki rarely buys Silver Edge to break Bristleback's passive because the invisibility aspect of it is redundant.
Additional:
* Quill Spray will hit Riki even when he is invisible.
* Cloak and Dagger's bonus backstab damage is rendered irrelevant against Bristleback.
* Smoke Screen does not stop Bristleback's passive from activating.
* Due to Bristleback's natural tankiness, he is an ideal Gem of True Sight carrier, directly countering Riki's invisibility.

* Quill Spray usually hits Meepo's clones, although Bristleback cannot turn his back when rooted with Earthbind.

* Chaos Bolt can stun Night Stalker outside of Crippling Fears relatively small radius.
* Reality Rift is a great way to force Night Stalker to fight Chaos Knight, a hero with massive health and damage output. It also forces Night Stalker's Crippling Fear off his primary target.
* Night Stalker doesn't have a lot of ways to deal with multiple targets, which makes him vulnerable to Phantasm illusions unless Night Stalker buys Aghanim's Scepter.

* Quill Spray can be used to kill Lycan's summons.
* Bristleback allows him to stay alive against Lycan while dishing out counter attacks
* He can overpower Lycan with his Warpath instead.
Additional:
* Lycan's wolves deal little damage to Bristleback, and are easily killed by Quill Spray, even when they're invisible.
* Lycan's lack of burst damage makes it very hard for him to kill Bristleback, especially when his back is turned.

* While Blade Fury is on cooldown, Juggernaut can be easily killed by a standard Chaos Bolt & Reality Rift combo.
* Phantasm illusions can tank Omnislash.

* Heroes that have AoE damage: Lina, Keeper of the Light, Timbersaw, Leshrac, Bristleback, Axe

* Phantasm gives Chaos Knight a significant advantage against single-target damage dealers: Lifestealer, Wraith King, Night Stalker, Troll Warlord.

Additional:
* Chaos Knight's tanky illusions easily take advantage of Troll Warlord's lack of AoE damage.
* Chaos Bolt can stun Troll for up to 4 seconds and Reality Rift prevents Troll Warlord from chasing down foes.
* Phantasm increases Chaos Knight's physical damage output up to 4 times and can easily kill Troll Warlord before he has a chance to use Battle Trance or a Black King Bar.

* Heroes with illusions and summons can be hard for Phantom Assassin to deal with, as she lacks any AoE abilities to deal with them without items: Broodmother, Phantom Lancer, Chaos Knight, Naga Siren, Terrorblade.

* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Jakiro, Pugna

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: Bane, Beastmaster, Bloodseeker, Clockwerk, Doom, Shadow Shaman.

* Heroes with illusion and clone abilities may confuse Bloodseeker, causing him to waste time in fights: Phantom Lancer, Chaos Knight, Arc Warden

* Skywrath mage also has a terrible time fighting against anything that isn't a hero. As Mystic Flare only affects heroes, his skills are mostly target-based and he has terrible strength and agility, he can easily be kited or harassed by illusion-based heroes like Chaos Knight and Phantom Lancer, or by Heroes that summon other units like Lone Druid, Lycan and Beastmaster.

* Heroes with illusions and summons can swarm Bane, who has no area abilities: Broodmother, Chaos Knight, Nature's Prophet, Phantom Lancer, Terrorblade.

Additional:
* Phantasm's illusions make it difficult for Bane to target Chaos Knight with Nightmare, Enfeeble, and Fiend's Grip.
* Chaos Bolt is a comparatively low cooldown tool to interrupt Fiend's Grip.
* Nightmare can be transferred by Phantasm illusions.

* Heroes who relies on illusions and summons (Beastmaster, Chaos Knight, etc.).

* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: Bane, Beastmaster, Bloodseeker, Clockwerk, Doom, Shadow Shaman.

* Heroes with damage-over-time abilities will not only proc Bristleback's passive continuously, they will also do little harm to him when he is facing away from the source: Venomancer, Arc Warden

* Warlock is a very strong hero when positioned correctly, and his long cast range helps him with this. However, some Heroes might disrupt or sneakily pass through his allies and deal with him, preventing him from doing his job. Such heroes include Chaos Knight, Spirit Breaker, Riki, and more.

* Single-target disablers will have difficulty locking down a Chaos Knight with Phantasm active: Bane, Beastmaster, Bloodseeker, Clockwerk, Doom, Shadow Shaman.

* Heroes that can overwhelm Visage by sheer number like Chaos Knight, Meepo, Terrorblade and Phantom Lancer.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. However, Chen can convert enemy summons with Holy Persuasion, as long as they don't bunch up.

* Quill Spray will hit Sand King inside Sand Storm, damaging him and putting Sand King's Blink Dagger on cooldown, preventing him from escaping.
* Epicenter's numerous damage ticks will trigger Bristleback's passive repeatedly during teamfights.

* Bristleback reduces most of Broodmother's and her spiderlings' damage.
* Quill Spray will hit any spiders in its proximity, hindering Broodmother's fighting and farming capabilities.
Additional:
* Quill Spray destroys spiderlings, and hits Broodmother even when she's regenerating in her webs. This makes Bristleback one of her hardest counters in lane.

* Heroes who can summon illusions and summons because Terrorblade has no abilities to deal with multiple enemies at once: Shadow Shaman, Naga Siren, Broodmother, Lycan, Enigma, Chaos Knight, Phantom Lancer, Shadow Demon, Dark Seer, Nature's Prophet, Invoker, Morphling, Grimstroke with Aghanim's Scepter.

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Chaos Knight, Lone Druid, Meepo and Arc Warden can be hard targets since Shadow Demon's spells are ill-suited to fight many enemies at once.

* Viscous Nasal Goo slows down Dragon Knight and lowers armor, locking him down and making him more vulnerable.

* Razor has no way to deal with Chaos Knight's multiple illusions from Phantasm.

* Macropyre's frequent damage ticks causes Bristleback to activate repeatedly, resulting in free damage as long as Bristleback faces away from Jakiro.

* Ursa has no way to clear illusion quickly, making him vulnerable to Chaos bolt and Phantasm combo.
* Reality Rift can quickly relocate or reinitiate on Ursa once the duration of Enrage is over.
* Phantasm can be used to dispel Earthshock's slow. Manta Style is another item that counter Ursa greatly.
* Ursa has low mobility, once jumped on by Reality Rift, Ursa struggles to escape.
Additional:
* Ursa cannot effectively fight against Phantasm's illusions with his single-target damage.
* Chaos Bolt's potentially long stun with Chaos Bolt gives Ursa little opportunity to Enrage.

* Bristleback's tankiness and damage reduction from the rear makes him very hard for Phantom Lancer to chase and finish off, due to his lack of burst damage.
* Quill Spray destroys Phantom Lancer's illusions.
* Bristleback's passive costs no mana, meaning that it will continue to trigger even if Phantom Lancer drains Bristleback's mana with Diffusal Blade.
Additional:
* Bristleback's tankiness and damage reduction from the rear makes him very hard for Phantom Lancer to chase and finish off, due to his lack of burst damage.
* Quill Spray quickly destroys Phantom Lancer's illusions.
* Bristleback's passive costs no mana, meaning that it will continue to trigger even if Phantom Lancer drains Bristleback's mana with Diffusal Blade.

* Bristleback's constant harass from Quill Spray will greatly hurt his laning.
* However, assuming Bristleback's back is not turned on Enigma, Midnight Pulse will shred through Bristleback's tankiness. Combined with Aghanim's scepter, Bristleback is just as squishy as any other hero and his tankiness is severely mitigated.