* Lightning Storm will usually hit both Io and his Tethered target since both will be close enough for the lightning to jump. It can then be followed up by Split Earth.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and his Tethered target.
Additional:
* Io is a hero who needs to be close to it's tethered target to make it effective, and that's where Leshrac gets the advantage thanks to many of his area-of-effect abilities.
* Lightning Storm will usually hit both Io and its tethered target since both will be close enough for the lightning to jump.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to both, Io and its tethered target.

* Leshrac's AoE abilities make quick work of Chen's creep army.

* Ice Blast prevents Io from healing an ally with Tether and prevents healing from Overcharge
* Io is a common Mekansm builder which is useless if he is affected by Ice Blast.
Additional:
* Ice Blast prevents Io from healing the target.

* Ice Blast prevents healing from Hand of God.
Additional:
* Ice Blast prevents Divine Favor and Hand of God from healing his allies or himself.

* Sticky Napalm slows Chen and his creeps and Flamebreak and Firefly can deal heavy damage to them.
* Flaming Lasso can pull Chen away from his creeps toward Batrider's team, often to certain death.
Additional:
* Sticky Napalm slows Chen and amplifies Batrider's damage.
* Flamebreak and Firefly can deal heavy damage to Chen and his creeps.
* Flaming Lasso pulls Chen away from his creeps, often to certain death.

* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Additional:
* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.

* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper

* Chen is basically Riki's natural prey: he has little HP, low armor and relies on his persuaded creeps to fight, which in most situations will not save Chen from Riki. Just be wary of {U:Centaur Conqueror}, who can stun Riki outside of Smoke Screen and ruin his attempt at Chen's life.

* Burning Barrage and Searing Arrows allow Clinkz to quickly kill Io due to its low armor.
* Clinkz iz a hero that very often goes for Orchid Malevolence, and its upgrade Bloodthorn. And if Clinkz has it, he will be able to silence Io and prevent him from escaping wit either Tether or Relocate.

* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: Lifestealer, Doom, Mirana, Clinkz.

* Jakiro's damage over time force Chen to use Hand of God prematurely, potentially wasting chance to save his allies during teamfight.
* Macropyre can also disrupt Chen's jungling work.
Additional:
* Liquid Fire and Dual Breath can clear Chen's creeps, and kill his allies before he uses Hand of God.
* Macropyre can quickly clear Chen's creeps and deal intense damage to his allies.

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Silence will prevent Chen from activating Hand of God.
* Crypt Swarm and Exorcism can clear Chen's creeps and heavily damage Chen.
* Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Lucent Beam can be used to cancel both, Tether and Relocate.
* Like with Leshrac's Diabolic Edict, Lightning Storm and Pulse Nova abilities. Luna's Moon Glaives and Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with Aghanim's Scepter.

* Moon Glaives can easily clear Chen's creeps while Eclipse can kill Chen's allies before he can react.
Additional:
* Luna's Moon Glaives and Lunar Blessing can easily kill Chen's creeps.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. However, Chen can convert enemy summons with Holy Persuasion, as long as they don't bunch up.

* Heroes with low armor and little mobility, like Huskar, Io, etc. will also have an unfortunate fate.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. However, Chen can convert enemy summons with Holy Persuasion, as long as they don't bunch up.

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Fragile heroes: Bounty Hunter has decent nuking capabilities with Shiruken Toss and Jinada thus making fragile heroes easy picks for ganking. Few examples of such heroes are:Crystal Maiden, Pugna, Skywrath Mage, Io, Witch Doctor, etc.

* Invisibility heroes can sneak past Chen's creeps and pick him off: Nyx Assassin, Weaver, Bounty Hunter Riki.

* Heroes with summons can find their summons eliminated easily by Lina, like Broodmother, Nature's Prophet, and Chen.

Additional:
* Lina's high damage burst from Dragon Slave, Light Strike Array and Laguna Blade can easily kill Chen's allies or Chen himself before he can use Hand of God.

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Chen's low mobility and lack of AoE abilities makes him an easy target for Broodmother and her Spiderlings.
* Broodmother can easily pick off Chen's creeps with Spawn Spiderlings, and by ambushing them through terrain in her web.
Additional:
* Chen has no area-of-effect spells to deal with Broodmother's spiderlings and must rely on his creeps to take care of them.
* Spawn Spiderlings can kill Chen's creeps and spawn spiderlings in their place.
* Spin Web allows Broodmother to disrupt Chen's jungling.

* Echo Slam will deal immense damage due to the amount of creeps Chen will have.
* Fissure and Enchant Totem deal large amounts of AOE damage, wearing down non-ancient creeps that Chen converts.

* Lich's Chain Frost forces Io to either give up providing buff to his ally with Tether or suffer devastating damage with his tethered ally.
* Lich can easily use Sinister Gaze to disable Io from getting away with Tether or Relocate.

* Aphotic Shield can nullify Chen's combo, while clearing Chen's creeps simultaneously.

* Living Armor can be used to save a hero from a Relocate gank.

* Chen's fragility and low mobility make him an enticing Duel target.
* Overwhelming Odds and Moment of Courage can take advantage of converted creeps' numbers.
* With enough damage from Duel stacks, Legion Commander can also often kill any of Chen's unfortunate allies before he can use Hand of God.
Additional:
* Chen's frailty and low mobility make him an enticing Duel target.
* Overwhelming Odds and Moment of Courage can take advantage of converted creeps' numbers.
* With enough damage from Duel stacks, Legion Commander can also often kill any of Chen's unfortunate allies before he can use Hand of God.

* Duel is very effective against Io due to its low health and armor.

* Elder Titan's Astral Spirit ability gives him bonus damage for each converted creep it passes through.
* Echo Stomp and Earth Splitter will often kill him or any of his allies quickly before he has time to use Hand of God.

* Disruptor can always Glimpse back Io or his target after he Relocated nearby.
* Even better, thanks to the indicator on the ground, you can even preemptively drop Static Storm and Kinetic Field on the spot they will relocate to.
* Thunder Strike and Glimpse are also good tools to bring back an Io that Tethered away in the fog of war.
Additional:
* Glimpse directly negates Relocate.

* Great Cleave quickly destroys Chen's creeps in team fights, before they have a chance to do much.
Additional:
* Storm Hammer locks down Chen and his converted creeps.
* Great Cleave and God's Strength can destroy Chen and his creeps quickly.
* Warcry minimizes damage taken from creeps' attacks.

* Dark Seer's Vacuum and Ion Shell can clear a wave of Chen's Creeps effectively.

* Cold Embrace can render the extra attack speed from Overcharge meaningless.
* Splinter Blast and Winter's Curse are very affective against Io, as it has to stay close to its tethered hero.

* Charge of Darkness can be used to escape or counter-initiate against a Relocate gank.
* Greater Bash and Nether Strike is devastating due to Io's low armor, and can even knock it away from tethered target.

* Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.

* Burrowstrike and Sand Storm will deal a large amount of damage to Chen's creeps.
* Caustic Finale will quickly clear Chen's creeps at low health.

* Fireblast is a good tool to interrupt Io during its escapes through Tether.
* Ignite can be one of the few spells with enough total damage to out-trade the sustained healing Io provides for its fellow laner.
* However, picking other supports that focus less on the laning phase is generally a better choice against Io.

* Mortimer Kisses will quickly destroy Chen's creeps and might waste Hand of God.

* Heartstopper Aura can do a decent damage overtime to Chen's High-Health-Creep Army, and Chen does not have any source of burst damage to Necrophos.
* Necrophos can purchase a Spirit Vessel to provide an AOE debuff that reduce the healing from Divine Favor and Hand of God.

* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.

* Razor's Plasma Field and the passive from Eye of the Storm can damage and clear Chen's creep army.
* Chen has no escape mechanisms, making him easy prey for Static Link.
* Eye of the Storm will strike Chen's creeps around Razor.

* Monkey King can kill Chen or any of his allies with his physical damage burst from Boundless Strike and Jingu Mastery before he can use Hand of God.
* None of the neutral creeps have any abilities to destroy trees, which makes Chen susceptible for ganks with Tree Dance and Primal Spring.

* Phantom Strike allows Phantom Assassin jump directly to Io.
* Coup de Grace can make a short work of Io's low health and armor.

* Grimstroke can catch Io and his ally easily with SoulBind as Io has a tendency to tether himself with an ally frequently.
* Io is highly vulnerable to disables. Hence, Grimstroke's Phantom's Embrace is a great ability to hinder Io's potential.
Additional:
* Soulbind can target both Io and its Tethered ally, allowing Grimstroke and his team to target both with single target spells. Should Io try to Relocate, Phantom's Embrace can stop its channel to prevent escape.

* With Timber Chain, Timbersaw can slow, catch up with, or escape from Chen and his creeps.
* Chakram can clear Chen's creeps and slow him.
* Attacks from multiple creeps quickly build Reactive Armor stacks.

* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. However, Chen can convert enemy summons with Holy Persuasion, as long as they don't bunch up.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. However, Chen can convert enemy summons with Holy Persuasion, as long as they don't bunch up.

Additional:
* Naga Siren can make landing Chen's combo very hard due to her being an illusion hero.
* Ensnare will prevent Chen from activating Hand of God.

* Mirana can instantly kill creeps with Sacred Arrow, making her decent at crippling the armies of Chen or Enchantress.

* Heroes with damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Heroes like Enchantress and Chen, or heroes that make use of Helm of the Dominator are weak to Crystal Maiden, as Frostbite can do wonders against Enchant, Holy Persuasion, or dominated creeps. Careful though, as an army of carefully controlled creeps (Enchantress and Chen) can hold many stuns that will cancel Freezing Field.

Additional:
* Frostbite roots and disarms your creeps for 10 seconds.
* Crystal Maiden has a lot of AOE damage between Crystal Nova and Freezing Field to clear your creeps out side and during team fights.

* Hand of God has a long cooldown, so damage over time spells can be hazardous for Chen, forcing him to use it prematurely: Jakiro, Venomancer, Viper, Dazzle, Phoenix.

* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: Lifestealer, Doom, Mirana, Clinkz.

* Heroes with cleave abilities and area of effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Squishy heroes without good escape mechanism: Crystal Maiden, Chen.

* Invisibility heroes can sneak past Chen's creeps and pick him off: Nyx Assassin, Weaver, Bounty Hunter Riki.

* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper

* Heroes with damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Heroes that can summon units will have their summons destroyed very quickly if badly micro-managed, like Chen, Lycan, and Phantom Lancer.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. However, Chen can convert enemy summons with Holy Persuasion, as long as they don't bunch up.

* Hand of God has a long cooldown, so damage over time spells can be hazardous for Chen, forcing him to use it prematurely: Jakiro, Venomancer, Viper, Dazzle, Phoenix.

* Squishy heroes (Io, Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.

* Heroes with cleave abilities and area of effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Heroes with cleave abilities and area of effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. However, Chen can convert enemy summons with Holy Persuasion, as long as they don't bunch up.

* Heroes with summons/illusions/neutral creep armies: Beastmaster, Chen, Naga Siren

* Heroes with damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Heroes with cleave abilities and area of effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Venomancer's damage over time can force Chen to use Hand of God prematurely, potentially wasting a chance to save his allies during a teamfight.

* Take Aim and Assassinate allow Sniper to reach Io even if it stays in the backline.