* Jakiro's Macropyre can help him to escape from Sprout and can disrupt Nature's Prophet's jungling.
* Jakiro can disrupt Nature's Prophet's escape attempt with Teleportation with Ice Path.
Additional:
* Jakiro's skill arsenal can ruin Nature's Prophet's gameplay: Dual Breath and Liquid Fire can clear treants from Nature's Call while simultaneously slowing Nature's Prophet, Ice Path can disrupt Nature's Prophet's escaping attempt with Teleportation and Macropyre can not only clear treants from Nature's Call, but also can free Jakiro from Sprout.

* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin

Additional:
* Nature's Prophet is often by himself. Clinkz can use invisibility to hunt him down and kill him, although a Quelling Blade may be needed to cut through his Sprout. Orchid Malevolence may also be needed if 3-4 seconds are not enough time to kill him, as he can teleport away.
* Clinkz can match Nature's Prophet's ability to split push.

* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: Lifestealer, Doom, Mirana, Clinkz.

* Jakiro's damage over time force Chen to use Hand of God prematurely, potentially wasting chance to save his allies during teamfight.
* Macropyre can also disrupt Chen's jungling work.
Additional:
* Liquid Fire and Dual Breath can clear Chen's creeps, and kill his allies before he uses Hand of God.
* Macropyre can quickly clear Chen's creeps and deal intense damage to his allies.

* Heroes with invisibility and high mobility can jump on and focus down Earthshaker before he has a chance to initiate: Clinkz, Slark, Storm Spirit

* Both Ice Path and Macropyre are the good setup while Earthshaker after blinking in and stay out of Echo Slam initiation radius.
* Liquid Fire damage over time potentially disable Earthshaker's Blink Dagger.

* Heroes with large magical AoE damage will fare well against Omniknight: Lich, Ancient Apparition, Jakiro, Disruptor

* Heroes who can harass Omniknight out of lane will keep him weak in the mid game: Viper, Venomancer, Clinkz

* Strafe and Searing Arrows allow Clinkz to quickly kill Io due to its low armor.

* Clinkz's high damage output and insane attack speed late-game can take Kunkka out of the fight before it begins.
* Strafe and Searing Arrows together can kill allies easily even under Ghostship's buff.
* Skeleton Walk can allow Clinkz to make a quick escape after Kunkka's combo, or even avoid it all together.

* Jakiro has 3 damage over time spells, 2 of which are from debuffs on Puck (Dual Breath and Liquid Fire) and 1 affecting an entire area (Macropyre), making it easy for him to disable the blink dagger.
* Ice Path is also strong against Puck, as he can cast it towards Puck during Phase Shift, who then gets instantly stunned once Phase Shift ends.

* All of Jakiro's skills are Area of Effect, which can easily affect all Meepos in a targeted area.

* Jakiro's abilities deal damage over time, which can disrupt Magnus's attempts to initiate with Blink Dagger and Reverse Polarity.
* Macropyre not only disables Blink Dagger for a considerable duration, but can also destroy Trees, revealing Magnus's cover and position.

* Axe is a hero that is very vulnerable against magical nuke damage and disables, Jakiro is perfect against him with all of his spells.
Additional:
* Ice Path neutralizes initiation attempts with Berserker's Call, and its long area of effect discourages follow-up from Axe's teammates.
* Ice Path serves as a large obstacle to stop Axe from chasing down fleeing stragglers to kill with Culling Blade.
* Jakiro's many damage-per-second skills prevent Axe from initiating with his Blink Dagger.

* Clinkz does not have any passive abilities at all, making Nethertoxin nearly useless.
* Viper's Corrosive Skin cannot protect him from Clinkz's combined attack from Strafe, Searing Arrows, Burning Army and Orchid Malevolence.
Additional:
* Clinkz does not have any passive abilities at all, making Nethertoxin nearly useless.
* Viper's Corrosive Skin provides no protection against Clinkz's physical damage output.

* With his AoE damage, Jakiro can easily kill Chaos Knight's Phantasm illusions.
* Chaos Knight usually doesn't buy a Black King Bar, making him vulnerable to an Ice Path into Macropyre combination.
Additional:
* Ice Path and Macropyre punish Reality Rift with a long stun and heavy damage across all illusions.

* Huskar's Berserker's Blood provides no protection against Clinkz's physical damage output.
* Huskar has no way to disrupt Clinkz's attacks and no way to kill Clinkz alone, as Clinkz can easily go invisible, teleport away, or even fight back.
* Clinkz will often build the items that counter Huskar and the items he usually builds. These include Black King Bar or Monkey King Bar for Heaven's Halberd, or a disable item like Scythe of Vyse or Bloodthorn to prevent him from using Inner Fire to disarm.

* Heroes who can easily harass Crystal Maiden out of lane in the early game (Clinkz, Viper) can prevent Crystal Maiden from being able to level effectively, and can ultimately slow down her level 6, 12, and 18 to a point where enemy carries already have items to address her ultimate.

* Ice Path allows Jakiro to easily cancel Freezing Field.
* Freezing Field makes Crystal Maiden an easy target for all of his abilities without a Black King Bar.
* With the talent for Macropyre dealing Pure Damage and ignoring spell immunity, Black King Bar becomes nearly useless for Crystal Maiden, as its high damage over time and long duration will force Crystal Maiden to forcefully cancel Freezing Field.

* Despite Clinkz's fragility, his harassment in the early game can be devastating; as he can kite Enigma and his Eidolons and claim their bounty.

* Broodmother and her Spiderlings need to be very careful during the laning stage against Jakiro, as Jakiro can take down Broodmother's Spiderlings, preventing her from pushing.

* Heroes that can jump and kill him: Meepo, Clinkz, Templar Assassin

* Heroes with AoE abilities will hit Slark in Shadow Dance: Lina, Jakiro, Underlord, Leshrac, Dark Seer, Earthshaker, Timbersaw, Crystal Maiden

* Due to Tiny's non-existent agility gain, high physical damage heroes are more effective against him (Clinkz, Phantom Assassin, Templar Assassin, Ursa, Wraith King etc).

* Heroes with a high degree of mobility and invisibility are hard to catch with Meat Hook: Ember Spirit, Riki, Clinkz, Queen of Pain.

* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: Morphling, Naga Siren, Spectre.

* Heroes that can pick you off: Clinkz, Nyx Assassin, Puck, Riki.

* With Bloodthorn, Clinkz becomes a strong counter to heroes who rely on evasion and blind such as Windranger, Phantom Assassin, Troll Warlord and Keeper of the Light.

* Ancient Apparition has no escape or reliable control and is very fragile, which makes him an easy target for anyone who can get on top of him, like Phantom Assassin or Clinkz.

* Any hero with high attack speed will be a threat to Phoenix when it initiates, as they can easily tear down a Supernova, perhaps even while debuffed by Fire Spirits: Juggernaut, Clinkz, Troll Warlord, Beastmaster, Lina.

* Clinkz can use Burning Army in teamfights which will cause a problem for Alchemist.

* Heroes with damage over time abilities can quickly eat through Gravekeeper's Cloak charges like Huskar, Jakiro and Queen of Pain.

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes has attack range talent can also outrange Plague Ward.

* Ember Spirit's Flame Guard provides no protection against Clinkz's physical damage output.
* Ember Spirit's low armor and health make him easy to kill quickly if a teammate can hold him down.
* If Clinkz has farmed an item that can disable, he can sneak up to and hunt down Ember Spirit while he farms or split pushes alone.

* Dual Breath slows down Phantom Lancer and his illusions.
* Liquid Fire will not only deal AoE damage but also lowers Phantom Lancer's attack speed.
* An Ice Path and Macropyre combo can easily clear all of Phantom Lancer's illusions.
Additional:
* Jakiro's spells inflict AoE damage, meaning he can take down Phantom Lancer's illusion army very quickly.

* All of Jakiro's active skills can be targeted on an area, which is effective at forcing Templar Assassin to move should she Meld away.
* Many of Jakiro's spells utilize damage-over-time mechanics, which makes it easy to strip away layers of Refraction.

* With Dual Breath, Liquid Fire and Macropyre Jakiro can quickly remove all Living Armor from a target.
* Ice Path allows Jakiro to prevent Treant Protector from using Overgrowth while staying at a safe distance.

* Searing Arrows makes Clinkz one of the hardest heroes for Clockwerk to lane against.

* Heroes with good escapes can usually outmaneuver and escape from Spectre: Slark, Clinkz, Weaver

* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: Morphling, Naga Siren, Spectre.

* Clinkz relies heavily on the physical damage provided by Searing Arrows, which completely overrides the capabilities of Rage.
* Open Wounds is near worthless against Clinkz as he can instantly run away with Skeleton Walk before returning later on.
* Clinkz, by nature will often build items that Lifestealer hates dealing with such as physical damage items like Desolator or Daedalus and instant silences or hexes from Bloodthorn and Scythe of Vyse.

* Considering Rubick's abysmal armor, Rubick is a squishy target for Clinkz to gank. None of his spells are useful except for Skeleton Walk.
* Clinkz usually builds Orchid Malevolence, which disables Rubick's ability to retaliate.
* Vast numbers of Sentry Wards are needed to deal with Clinkz because of Skeleton Walk, making it harder for Rubick to buy more expensive and more useful support items like Glimmer Cape or Mekansm.

* With Bloodthorn, Clinkz becomes a strong counter to heroes who rely on evasion and blind such as Windranger, Phantom Assassin, Troll Warlord and Keeper of the Light.

* Riki can easily be caught in an Ice Path and Macropyre combo as he finishes Tricks of the Trade.