* Medusa lacks mobility or escape mechanisms. Earth Spike and Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* In addition to easily breaking her commonly bought Linken's Sphere with its low cooldown, Mana Drain can quickly drain her Mana Shield, making her far less tanky.

* Hex and Earth Spike can hold Clinkz down, giving him no chance to use Black King Bar or Skeleton Walk.
* Finger of Death quickly kills Clinkz due to his low health.

* Smoke Cloud prevents the use of Death Pact, Searing Arrows and Skeleton Walk, so Clinkz can neither defend himself against Riki nor fight back effectively.
* It's hard to gank Riki as you have to find him first.

* He won't be around waiting for Medusa to Stone Gaze and pin him until she bears a true sight.
* With Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can still deal huge amount of damage through Cloak and Dagger via backstabs, drying out Medusa's protection in a whim at random occassions.

* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* His Fiend's Grip will leave Medusa defenseless after he's done, if his teammates can provide cover for him or he initiates at the right time by Spell immunity.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Phantom Lancer with Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding your team in the process.

* Heroes with no AoE abilities will struggle against Phantom Lancer: Clinkz, Phantom Assassin, Broodmother

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Heroes that excel at grouping up with their team very early will be able to take advantage of a Clinkz that tries to pick off heroes that are alone: Brewmaster, Dazzle, Tidehunter.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Heroes with low health and low armor: Clinkz, Crystal Maiden.

* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Additional:
* Level 4 Mana Burn burns 38,5% of Medusa's mana every 4 seconds if Medusa only increases her mana pool with intelligence. Additionally, 60% of the Mana Burn damage gets mitigated by Mana Shield, burning even more mana.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.

* Unlike other illusion heroes, Tempest Double won't be instantly destroyed by Stone Gaze since it is considered a clone and not an illusion.
* He can use either his own or his double's Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + Spark Wraith to slow Medusa's move speed to a crawl.
* Arc Warden has a farming advantage with double Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.

* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, after an Incapacitating Bite she will get her swarmed in no time.
* Medusa usual do not build a BKB to benefit from Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away mana.
Additional:
* Incapacitating Bite will give Medusa a dire time to clear horde of small spiderlings or retaliate Broodmother herself.
* Spin Web will allow broodmother to pick her own fights and sometimes slip away to ambush Medusa.

* Nether Ward will cause an unfriendly area for Medusa, draining her mana.

* The long silence at night prevents Clinkz from escaping with invisibility if Night Stalker can sneak up on him. He also has really low base health, so Night Stalker can usually kill him alone during one cast of Crippling Fear at night.

* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Additional:
* Ursa's status resistance from Enrage will ignore Medusa's gaze.
* Ursa can stack damage with Fury Swipes easily against her Mana Shield in a prolonged team match.

* EMP is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Additional:
* EMP allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Clinkz survivability depends entirely on Skeleton Walk. Corrosive Haze not only makes its invisibility useless, but also makes Clinkz even more vulnerable to physical damage.
Additional:
* Slardar can reveal Clinkz with Corrosive Haze and make him easy to kill, and his Bash of the Deep also hits hard against Clinkz's naturally low health pool.
* Slardar's Guardian Sprint can catch up with Clinkz's Skeleton Walk.
* The stun and slow from Slardar's Slithereen Crush can hold Clinkz in place.

* Cold Embrace can heal herself or an ally, as well as protecting them from Clinkz's physical attacks and wasting his mana if Searing Arrows is on autocast.
* Winter's Curse allows Winter Wyvern to turn Clinkz's high damage (and high attack speed if he used Strafe) against his allies, or take advantage of Clinkz's fragility if he can't use Skeleton Walk.

* Silencer burns easily through her effective hp from Mana Shield, by taking away her int.
* Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. Can force her to use Manta Style before he has cast Global Silence and Medusa usually does not want to build Black King Bar.

* Medusa is a fairly immobile hero that deals damage around her with Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.
Additional:
* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.

* Heroes who build mana boosting items but have low mana regeneration are especially vulnerable against Mana Break and Mana Void: Timbersaw, Slark, Shadow Fiend, Clinkz, Bristleback Nyx Assassin, Magnus

* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has Manta Style.
* Anti-Mage effectively avoids Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* Anti-Mage's Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with Blink, burning her mana or forcing her to use Stone Gaze.
* Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.

* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift removes 1 of every attribute, lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.
Additional:
* Medusa is especially vulnerable to Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.

* The extra damage from Searing Arrows is largely blocked by Dragon Knight's armor.

* Zeus can reveal Clinkz with Lightning Bolt.
* He is vulnerable to Zeus's magical nukes, due to his low health pool.

* By using Morph, Morphling can use Death Pact and Searing Arrows to counter Clinkz himself.
* Waveform can allow Morphling to easily chase down Clinkz.
* Clinkz's low health pool also makes him vulnerable to Morphling's magical nukes, especially his Ethereal Blade and Adaptive Strike combo.

* Lina's damage burst can quickly kill Clinkz before he saves them with Skeleton Walk.
* Fiery Soul attack speed bonus removes Burning Army easily in all stages of the game.

* Invisibility reliant heroes: Heroes with invisibility abilities or those that have invested into invisibility items are hindered by Bounty Hunter's Track. Few examples of such heroes are:Clinkz, Riki, Treant Protector, etc.

Additional:
* Track reveals Clinkz if he tries to escape with Skeleton Walk, allowing Bounty Hunter to gain lots of gold if he kills Clinkz.
* Jinada with physical damage items can quickly kill Clinkz due to his low health.

* Heroes with high armor like Dragon Knight, or with abilities to cause attacks to miss like Phantom Assassin, Riki and Tinker will be hard to deal with, as Clinkz relies almost entirely on physical attacks.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Other heroes with mana burning or manipulating abilities will make Medusa much less tanky: Lion, Mirana, Weaver.

* Sand King is a strong ganker, allowing him to shut down squishy heroes in the early game: Phantom Assassin, Clinkz, Sniper, Enchantress,...

* Other heroes with mana burning or manipulating abilities will make Medusa much less tanky: Lion, Mirana, Weaver.

* Fragile carries with no reliable escaping mechanism can be bursted down in no time: Sniper, Drow Ranger, Clinkz

* Even though Linken's Sphere will block your silence, you can cast Arcane Bolt to break it or wait until someone on your team breaks it. In addition, Linken's Sphere builders are usually squishy targets vulnerable to silences: Weaver, Queen of Pain, Morphling, Clinkz, etc. Don't forget that Ancient Seal also increases the magical damage these enemies take, along with silencing them.

* Heroes who take a long time to become strong are in for a rough mid game, such as Outworld Destroyer, Magnus, Medusa, and Anti-Mage.

* In general, Brewmaster's Cinder Brew and Thunder Clap makes him good against physical damage carries: Ursa, Clinkz, Faceless Void, Troll Warlord, Templar Assassin, Phantom Assassin.

* Clinkz, Sniper, Lone Druid, Troll Warlord, Legion Commander and Wraith King are some of the Heroes that base themselves on attacks with little or no spell power, so they suffer in the grassy hands of Overgrowth.

Additional:
* Clinkz will often roam the map alone, and Treant Protector's Nature's Guise allows him to set up kills with his allies on Clinkz from invisibility.
* Treant Protector's very high damage allowing him to trade hits or contest last hits with Clinkz, while Living Armor can be used to sustain the harass.
* Living Armor protects any of Treant's allies ganked by Clinkz.
* In teamfights, Treant Protector's Overgrowth can disarm Clinkz, preventing him from turning invisible and holding him in place even if he has a Black King Bar.
* Leech Seed slows Clinkz, preventing him from repositioning or fleeing away from danger.

* Heroes that excel at grouping up with their team very early will be able to take advantage of a Clinkz that tries to pick off heroes that are alone: Brewmaster, Dazzle, Tidehunter.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.

* Chakra Magic can drain her current mana, draining away her effective health in a sneaky way.
* Will-O-Wisp will keep Medusa busy after she got hit by Blinding Light.