* Acorn Shot combined with attack modifiers such as Maelstrom or Daedalus makes a quick work of Phantom Lancer's illusions.
* Bushwhack will stun Phantom Lancer and his illusions if they're near a tree.
Additional:
* Bushwhack will stun and make a quick work of Phantom Lancer and his illusion when he's near a tree.
* Sharpshooter breaks Juxtapose and deals hefty damage.
* Sharpshooter ignores Illusions and will only damage and breaks the real phantom lancer, when used right, this will allow you to reveal the real phantom lancer amongst his Illusions

* Heroes that rely on illusions will suffer against Ion Shell, which kills them very quickly: Phantom Lancer, Chaos Knight, Naga Siren, Meepo.
* Heroes that rely on illusions typically spawn very strong illusions inside your Wall of Replica that you should use against them or their team.

* Durable heroes relied a lot on their main passive effects and items' effects such as Bristleback, Underlord, Spectre and Dragon Knight can be disabled easily with Sharpshooter's break, reducing their potential in teamfights.

* Dark Seer can pull together Spectre's illusions with Vacuum, and Wall of Replica creates an illusion of Spectre that deals massive damage.

* Hex and Earth Spike do not cancel Sharpshooter, making those two abilities ineffective against her.
* Although Hoodwink should be wary of his Finger of death, as it can possibly kill her.

* Dark Seer's Vacuum and Ion Shell allows him to clear the wave of Terrorblade's illusions.
* Wall of Replica can create stronger illusions of Terrorblade.
* If Dark Seer can use Vacuum to help teammates land their AoE skills, Terrorblade will be quickly killed before he even gets a chance to use Sunder.
Additional:
* Dark Seer's Vacuum and Ion Shell allows him to clear a wave of Terrorblade's illusions.
* Because Terrorblade builds stat items like Eye of Skadi, Dark Seer can create a very strong illusion of Terrorblade with Wall of Replica.
* If Dark Seer can use Vacuum to help teammates land their AoE abilities, Terrorblade will be quickly killed before he even gets a chance to use Sunder.

* Sharpshooter deals massive damage to Bristleback and applies a high duration disable on his passive.
* Bushwhack and Scurry can be used to easily kite Bristleback.
Additional:
* Bristleback and Warpath can be disabled by Hoodwink's Sharpshooter ability for a long period of time, reducing his both offense and defense.
* Scurry and Bushwhack can be used to kite bristleback.

* Hoodwink can easily Scurry away from a Phantom Strike, make her difficult to be chased through trees, as well as provide passive evasion, effectively stalling Phantom Assassin from a quick kill.
* Landing a Sharpshooter arrow applies Break and a burst of magic damage, disabling Phantom Assassin's crucial passive skills and dealing huge damage to her.
Additional:
* Sharpshooter disables both Blur and Coup De Grace, especially with the level 25 talent.
* Because Phantom Assassin is often reliant on critical strikes, Hoodwink can have enough time to simply move near a tree and escape with Scurry.

* Sharpshooter can kill easy when Morphling is going on full agility strategy (Only in early and mid game).
* Scurry can help to catch up Morphling when using Waveform or for escape.

* Ion Shell destroys Refraction's protection stacks in short time.
* Surge ignores the massive slow from Psionic Trap.

* Abaddon can be killed without triggering his ultimate Borrowed Time due to the break applied by Sharpshooter.

* Venomancer is a low health hero and low range hero who is easy to harass with Ion Shell on a creep in the early game .
* Venomancer depends entirely on all his slows to keep distance or chase, but Surge ignores slows, so is nearly impossible to hunt or run away from Dark Seer or his surged teammates.

* Dark Seer can take great advantage of Divided We Stand by putting an Ion Shell on a clone in order to harass them effectively.
* Vacuum can take a single Meepo and disable them for him and his teammates to take out.

* Ion Shell is a very powerful weapon against Broodmother's Spiderlings and makes her laning much harder.
Additional:
* Ion Shell zones out Broodmother in the laning phase, and can kill her spiderlings if used on one Spiderling in a group.
* Vacuum can pull Broodmother out of the treeline.

* Huskar’s low health play style put him at extreme risk to Sharpshooter's extreme damage. In addition, it breaks Berserker's Blood, nullifying Huskar's power source.

* Dark Seer's Vacuum and Ion Shell can clear a wave of Chen's Creeps effectively.

* Heroes with haste can negate Enchant's slow: Weaver, Dark Seer, Lycan, Centaur Warrunner.

* Certain heroes can mess up with Pangolier's positioning and timing (especially if he intends to use Rolling Thunder during combat): Vengeful Spirit, Keeper of the Light, Huskar, Dark Seer

* The haste provided by Dark Seer's Surge or a {Rune:Haste} renders your slows ineffective.

* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: Clinkz, Pugna, Nature's Prophet, Dark Seer, Lycan, Tusk

* Durable heroes relied a lot on their main passive effects and items' effects such as Bristleback, Underlord, Spectre and Dragon Knight can be disabled easily with Sharpshooter's break, reducing their potential in teamfights.

* Dark Seer can increase the movement speed of allies with Surge, breaking Static Link.

* Heroes that rely on illusions will suffer against Ion Shell, which kills them very quickly: Phantom Lancer, Chaos Knight, Naga Siren, Meepo.
* Heroes that rely on illusions typically spawn very strong illusions inside your Wall of Replica that you should use against them or their team.

* Heroes with evasions: Phantom Assassin, Brewmaster, Hoodwink, Windranger.

* Heroes with hastes: Dark Seer, Lycan

* Heroes that rely on illusions will suffer against Ion Shell, which kills them very quickly: Phantom Lancer, Chaos Knight, Naga Siren, Meepo.
* Heroes that rely on illusions typically spawn very strong illusions inside your Wall of Replica that you should use against them or their team.

* Monkey King often hides in trees, where he can be easily caught with Bushwhack.
* Acorn Shot can target enemies in the fog, including Monkey King when he is on a tree.
* Sharpshooter provides flying vision along the cast indicator while charging, which can be used to scout the trees for Monkey King.

* Durable heroes relied a lot on their main passive effects and items' effects such as Bristleback, Underlord, Spectre and Dragon Knight can be disabled easily with Sharpshooter's break, reducing their potential in teamfights.

* Living Armor can be destroyed quickly with Ion Shell.

* Surge allows for Dark Seer and his allies to escape from Upheaval due to it ignoring any slow.