* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.

* Silence will prevent Chen from activating Hand of God.
* Crypt Swarm and Exorcism can clear Chen's creeps and heavily damage Chen.
* Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.

* Chemical Rage kills Phoenix very quickly in Supernova.

* Silence (and mana burns) will be a persistent problem for Phoenix, as it is heavily reliant on its abilities whether defensively or offensively, so heroes like Death Prophet, Skywrath Mage, and even Nyx Assassin must be closely observed to prevent being shut down by these heroes.
* Hexes are a greater threat to Phoenix as they also disable items, preventing Phoenix from dispelling the debuff on its own.

* High health heroes like Pudge and Undying gain strength by using abilities. Focusing them with Spirit Siphon can let you heal more health and deal more damage to them.

* Chemical Rage will take down Tombstone in no time.
Additional:
* With Greevil's Greed, Alchemist can farm Tombstone zombies and gain a significant gold advantage.

* Alchemist gets a huge amount of additional gold from killing Nature's Prophet's treants thanks to Greevil's Greed

Additional:
* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.

* Exorcism can quickly kill any Treants or Necronomicon units. Silence also prevents him from using Teleportation to escape or Sprout to lock you down.
Additional:
* Crypt Swarm helps clear treant pushes.
* Silence prevents Nature's Prophet from using Sprout or Teleportation.
* Exorcism kills all treants.

* Because Timbersaw relies heavily on his spells to deal damage, Silence can easily disable him in a team fight.
* Exorcism's spirits do not count as regular attacks, and will not add stacks of Reactive Armor.

* Kraken Shell neither dispels nor provides damage reduction against Spirit Siphon. This ability also drains health based on percentage damage, making Tidehunter's large healthpool a very appealing target. Furthermore, the health gained from the Siphon is independent from the amount of damage dealt, so Death Prophet will always heal a large amount of from Tidehunter's pool even if Tidehunter has magic reduction items or abilities on him, which makes her an untargetable enemy for you as this easily outweights any damage output you can provide.
* Exorcism is yet another ability from which Kraken Shell provides no useful protection, as the spirits completely ignore the damage block and are unaffected by the dispel. This ability also creates an unfriendly area where your blink will be constantly cancelled, reducing your ability to land a good Ravage.
* Ravage does not stop neither Spirit Siphon nor Exorcism, making the ability mostly ineffective against her. Additionally, Death Prophet usually builds Eul's Scepter of Divinity, which can be used to dodge the stun entirely.

* Exorcism's ghosts will automatically clear all Proximity Mines revealed when Death Prophet walks near them, provided that the ghosts do not have a specific target at that time.

* Magnus has very mediocre damage against Alchemist, because he can survive the stun duration of Reverse Polarity with Chemical Rage.

* Spirit Siphon and Exorcism can damage through his Resonant Pulse shields.
* Silence can prevent Void Spirit escape or contributing much in fights.

* Silence will prevent Queen of Pain from using Blink to escape or chase.
* If Queen of Pain uses Blink to close the gap to Death Prophet, Death Prophet will be in range for Spirit Siphon and typically gain an advantage over Queen of Pain.

* Death Prophet abilities disables Earthshaker's Blink Dagger.
* Silence can be used to silence Earthshaker after he blinks in, preventing him from executing his combo.

* Death Prophet's Silence allows her to prevent Bounty Hunter from escaping with Shadow Walk.
* If Bounty Hunter cannot escape with Shadow Walk while affected by Silence, she will be able to burst him down with Crypt Swarm and Spirit Siphon.

* Lone Druid during True Form and the Spirit bear has high HP, meaning Spirit Siphon can be very effective against them since they deal percentage damage

* Exorcism kills Primal Split's units very quickly.

* Spirit Siphon exploits her naturally high HP to deal a good amount of DPS. She may break the link with Rebound, but Silence covers that problem.
* Marci's poor armor makes her vulnerable to Exorcism.

* Chemical Rage negates almost all damage from Burning Spears.
Additional:
* Chemical Rage mitigates damage from Burning Spear.

* Greevil's Greed makes Broodmother’s spiderlings far more valuable to Alchemist making it important that he does farm them as opposed to other heroes where the spider's bounties are negligible.
* Acid Spray makes it difficult to attack Alchemist in lane without losing some spiderlings to the damage over time, potentially giving him farm he wouldn't have otherwise.
Additional:
* Alchemist can easily farm Spiderlings with Acid Spray and Greevil's Greed.
* Alchemist's Chemical Rage nullifies Broodmother's Insatiable Hunger

* In the same vein, heroes with silences — especially with the AoE ones like Death Prophet's Silence — can also prevent Crystal Maiden from being able to impact a fight.

* Any heroes with stuns or silences: Death Prophet, Lion, Shadow Shaman, Skywrath Mage

* Windranger heavily relies on her abilities for any form of tactical advantage and damage. A well timed silence will make her useless: Puck,Silencer, Death Prophet, Skywrath Mage, Drow Ranger, Earth Spirit, Grimstroke.

* High health heroes like Pudge and Undying gain strength by using abilities. Focusing them with Spirit Siphon can let you heal more health and deal more damage to them.

* In early to mid stage, Silence is also a great way to counter escape oriented heroes such as Anti-Mage, Queen of Pain, and Phantom Assassin to prevent them from escaping, provided that they don't have any basic dispels.

* A couple of long-range heroes with excellent laning like Mirana, Lina, Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.

* With 4 active abilities, Shadow Shaman is weak against silencing foes such as silencer, Drow Ranger and Death Prophet.

* Heroes who can silence will shut down Dark Willow entirely: Death Prophet, Silencer, Drow Ranger

* Death Prophet is a terrible Flaming Lasso target if Exorcism has already been used, since it can still damage Batrider and his teammates, but if Batrider manages to Lasso her before that, it can lead to Death Prophet being quickly burst down.

* Because all of Warlock's abilities are active abilities, silences can make his impact in fights minimal. Be cautious of heroes that carry silences like Death Prophet, Puck, and the aforementioned Silencer.

* Heroes that can punish aggressive heroes, such as: Leshrac, Shadow Demon, Pugna, Death Prophet.

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Heroes that require burst damage to kill will be difficult for Phantom Lancer to take down: Timbersaw, Axe, Bristleback, Alchemist and Underlord

* As a spellcaster, silences will nullify him entirely. Some notable examples are Death Prophet, Drow Ranger, Bloodseeker, Disruptor and many others.
* Doom, as usual, fits this description nicely.

Additional:
* His low mobility tends to make him an easy target for Spirit Siphon and the ghosts from Exorcism.
* His magical nukes can also be healed with Spirit Siphon.
* Silence is great against any spellcaster, and Zeus is no exception to this.

* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .

* Heroes with good counter-push abilities to clear creep waves can hinder Jakiro's early pushing ability: Death Prophet, Sniper, Tinker, Windranger.

* Chemical Rage out-heals Doom to a large degree throughout all stages of the game. Should Alchemist be chemically enraged before being Doomed, Alchemist can become a difficult target to effectively lockdown and kill, thanks to the health regeneration and movement speed bonuses granted by his ultimate.
* Alchemist is an ineffective target for Doom. Alchemist isn't totally reliant on his skills to be effective during a teamfight, due to the right-click nature of the hero.

* Heroes with silencing abilities that are not blocked by Linken's Sphere, like Puck's Waning Rift, Death Prophet's Silence or Silencer's Global Silence.

Additional:
* While Morphling can burst her down with Adaptive Strike (Agility), Death Prophet does have tools to disrupt him. A Morphling affected by Silence makes it unable to use Attribute Shift (Strength Gain) to increase its health pool or use Waveform to escape.

* Quas-Exort Invoker is also a good matchup due to the fact he has no Wex to run faster due to the movement impairment on his stealth. The Forge Spirit and Cold Snap combo doesn't harm her as well since you can drain Invoker's HP with Spirit Siphon which forces him to retreat.
* Silence also prevents Invoker from using Invoke or casting his main spells temporarily. There is no way Invoker can block it unless he has Eul's Scepter of Divinity to cyclone himself or has help from allies.