* High health heroes like Pudge and Undying gain strength by using abilities. Focusing them with Spirit Siphon can let you heal more health and deal more damage to them.

* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
* Mana Shield reduces the impact of Decay and Flesh Golem's Plague Aura.

* Heroes with cleave abilities and area of effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Silence will prevent Chen from activating Hand of God.
* Crypt Swarm and Exorcism can clear Chen's creeps and heavily damage Chen.
* Spirit Siphon heavily damages Chen and slows him, while healing Death Prophet.

* Crypt Swarm helps clear treant pushes.
* Silence prevents Nature's Prophet from using Sprout or Teleportation.
* Exorcism kills all treants.
Additional:
* Exorcism can quickly kill any Treants or Necronomicon units. Silence also prevents him from using Teleportation to escape or Sprout to lock you down.

* Poof won't damage Medusa and he can Gaze an entire flock of Meepos.
* Mystic Snake will easily become the bane of Meepo early game.

* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
* Untouchable is ignored by secondary attacks from Split Shot.

* Lone Druid during True Form and the Spirit bear has high HP, meaning Spirit Siphon can be very effective against them since they deal percentage damage

* Silence will prevent Queen of Pain from using Blink to escape or chase.
* If Queen of Pain uses Blink to close the gap to Death Prophet, Death Prophet will be in range for Spirit Siphon and typically gain an advantage over Queen of Pain.

* Mystic Snake can harass Axe in lane and drain his small mana pool.
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to pursue.

* Because Timbersaw relies heavily on his spells to deal damage, Silence can easily disable him in a team fight.
* Exorcism's spirits do not count as regular attacks, and will not add stacks of Reactive Armor.

* Exorcism's ghosts will automatically clear all Proximity Mines revealed when Death Prophet walks near them, provided that the ghosts do not have a specific target at that time.

* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces Rage, wasting its cooldown and making Lifestealer unable to fight.

* Death Prophet abilities disables Earthshaker's Blink Dagger.
* Silence can be used to silence Earthshaker after he blinks in, preventing him from executing his combo.

* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.

* Exorcism kills Primal Split's units very quickly.

* Mana Shield tanks most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops to 15%/17%/19% health (before reductions).
* Heartstopper Aura does not chip away at Medusa's mana, this makes it not a threat as it deals damage based on current health.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.

* If Medusa activates Stone Gaze, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.

* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.

* Death Prophet's Silence allows her to prevent Bounty Hunter from escaping with Shadow Walk.
* If Bounty Hunter cannot escape with Shadow Walk while affected by Silence, she will be able to burst him down with Crypt Swarm and Spirit Siphon.

* Summoned gargoyles will give Medusa free target practice.
* Mana Shield will resist Soul Assumption instances without effort.

* Her Mana Shield is too tough for Lycan to break in.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake

* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult.
* Mystic Snake can be potentially detrimental to Enigma's initiation. Getting hit by the latter high-damage bounces (from standing behind his Eidolons or his teammates) can hinder his mana pool, preventing him from executing a strong initiation.
Additional:
* Mana Shield makes Medusa harder to kill with Enigma's Black Hole and Pulse combo.
* Medusa's Split Shot can kill Demonic Conversion creeps easier and Mystic Snake bounces off from them.
* Stone Gaze makes it hard for Enigma to approach Medusa for a Black Hole.

* In early to mid stage, Silence is also a great way to counter escape oriented heroes such as Anti-Mage, Queen of Pain, and Phantom Assassin to prevent them from escaping, provided that they don't have any basic dispels.

* High health heroes like Pudge and Undying gain strength by using abilities. Focusing them with Spirit Siphon can let you heal more health and deal more damage to them.

* As a spellcaster, silences will nullify him entirely. Some notable examples are Death Prophet, Drow Ranger, Bloodseeker, Disruptor and many others.
* Doom, as usual, fits this description nicely.

Additional:
* His low mobility tends to make him an easy target for Spirit Siphon and the ghosts from Exorcism.
* His magical nukes can also be healed with Spirit Siphon.
* Silence is great against any spellcaster, and Zeus is no exception to this.

* Death Prophet is a terrible Flaming Lasso target if Exorcism has already been used, since it can still damage Batrider and his teammates, but if Batrider manages to Lasso her before that, it can lead to Death Prophet being quickly burst down.

* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.

* Any heroes with stuns or silences: Death Prophet, Lion, Shadow Shaman, Skywrath Mage

* In the same vein, heroes with silences — especially with the AoE ones like Death Prophet's Silence — can also prevent Crystal Maiden from being able to impact a fight.

* Silence (and mana burns) will be a persistent problem for Phoenix, as it is heavily reliant on its abilities whether defensively or offensively, so heroes like Death Prophet, Skywrath Mage, and even Nyx Assassin must be closely observed to prevent being shut down by these heroes.
* Hexes are a greater threat to Phoenix as they also disable items, preventing Phoenix from dispelling the debuff on its own.

* Because all of Warlock's abilities are active abilities, silences can make his impact in fights minimal. Be cautious of heroes that carry silences like Death Prophet, Puck, and the aforementioned Silencer.

* Heroes with good counter-push abilities to clear creep waves can hinder Jakiro's early pushing ability: Death Prophet, Sniper, Tinker, Windranger.

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* A couple of long-range heroes with excellent laning like Mirana, Lina, Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.

* Windranger heavily relies on her abilities for any form of tactical advantage and damage. A well timed silence will make her useless: Puck,Silencer, Death Prophet, Skywrath Mage, Drow Ranger, Earth Spirit, Grimstroke.

* Any heroes with silences can negate the majority of Outworld Devourer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .

* With 4 active abilities, Shadow Shaman is weak against silencing foes such as silencer, Drow Ranger and Death Prophet.

* Heroes who can silence will shut down Dark Willow entirely: Death Prophet, Silencer, Drow Ranger

* Heroes that can punish aggressive heroes, such as: Leshrac, Shadow Demon, Pugna, Death Prophet.

* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.

* Stone Gaze negates Dispersion's damage reduction and allows Medusa to kite Spectre.
* Spectre's small mana pool is depleted quickly by Mystic Snake.
* Split Shot can clear Haunt illusions quickly.

* Spirit Siphon and Exorcism can damage through his Resonant Pulse shields.
* Silence can prevent Void Spirit escape or contributing much in fights.

* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mystic Snake eats away at Sven's small mana pool.
* Mana Shield negates much of Sven's burst damage.

* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.

* Heroes with silencing abilities that are not blocked by Linken's Sphere, like Puck's Waning Rift, Death Prophet's Silence or Silencer's Global Silence.

Additional:
* While Morphling can burst her down with Adaptive Strike (Agility), Death Prophet does have tools to disrupt him. A Morphling affected by Silence makes it unable to use Attribute Shift (Strength Gain) to increase its health pool or use Waveform to escape.

* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.

* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.

* Quas-Exort Invoker is also a good matchup due to the fact he has no Wex to run faster due to the movement impairment on his stealth. The Forge Spirit and Cold Snap combo doesn't harm her as well since you can drain Invoker's HP with Spirit Siphon which forces him to retreat.
* Silence also prevents Invoker from using Invoke or casting his main spells temporarily. There is no way Invoker can block it unless he has Eul's Scepter of Divinity to cyclone himself or has help from allies.