* Gust can hit Dark Willow beyond a defensive Bramble Maze, and before she gets close enough to hit Drow Ranger with Bedlam.
* Drow Ranger's long range allows her to hit Dark Willow's team without venturing into her Bramble Maze.

* Nyx Assassin's high burst damage can be the bane of Dark Willow, as her low health makes it difficult to survive long enough to escape through Shadow Realm.
* Spiked Carapace can be triggered by walking deliberately into Bramble Maze, leaving Dark Willow stunned and defenseless.

* Spiked Carapace allows Nyx to get an easy long-duration stun on Weaver once he uses Shukuchi, and then he can follow up with Impale.
* Vendetta works as a great setup for both Impale and Spiked Carapace and can deal decent damage to Weaver. Additionally he can neutralize The Swarm beetles due to his invisibility duration.

* A well-timed Gust will prevent Weaver from escaping, and a silenced Weaver usually dies very quickly.
* Precision Aura easily removes The Swarm beetles or counteracted by Shadow Blade/Silver Edge.
Additional:
* A well-timed Gust followed by Frost Arrows will prevent Weaver from escaping with Shukuchi. A Weaver silenced for more than 3 seconds usually dies very quickly.
* Due to her high attack speed, Drow Ranger can easily kill The Swarm beetles.

* Spiked Carapace can stop Dawnbreaker's Solar Guardian which will eliminate her global presence and limits her movement around the map.

* Gust can shut down most of Dawnbreaker's abilities, rendering her useless.
* Frost Arrows followed by a high attack speed, makes it hard for Dawnbreaker to escape.

* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Additional:
* Level 4 Mana Burn burns of Medusa's mana every 5 seconds if Medusa only increases her mana pool with intelligence. Additionally, 70% of the Mana Burn damage gets mitigated by Mana Shield, burning even more mana.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Windranger heavily relies on her abilities for any form of tactical advantage and damage. A well timed silence will make her useless: Puck,Silencer, Death Prophet, Skywrath Mage, Drow Ranger, Earth Spirit, Grimstroke.

* Many of Nyx Assassin's abilities are good against Windranger.
* Impale is great for stunning Windranger and allowing additional disables to be landed.
* Mana Burn is useful against Windranger's decent intelligence growth and also burns some mana, preventing her from using more abilities.
* Spiked Carapace is easy to use against Powershot.
* Vendetta allows Nyx Assassin to sneak up on and deal massive damage to Windranger without giving Windranger a chance to use Windrun to evade it.
* Nyx Assassin's item build allows him to easily deal with Windranger.

* Heroes with silence: Death Prophet, Riki, Drow Ranger.

* Nyx Assassin takes advantage of Invoker's massive intelligence gain and mana pool to do tons of damage using Mana Burn, as the spell does more damage based on the target's intelligence.
* Nyx Assassin can simply activate Spiked Carapace while under many Invoker's abilities to stun him.

* Any heroes with silences can negate the majority of Outworld Destroyer's damage output: Death Prophet, Night Stalker, Drow Ranger, Doom .

* Outworld Destroyer's high mana pool, high intelligence, and makes him a prime target for Mana Burn.
* If timed correctly, Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Destroyer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.
Additional:
* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed Sanity's Eclipse or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used Black King Bar beforehand.

* Heroes with low health and armor are especially vulnerable to Marksmanship's high damage output: Clinkz, Crystal Maiden.

* Crystal Maiden has a very bad movement speed, so Impale is easy to land against her. Furthermore, even while trapped by Frostbite, Nyx Assassin can still cast Impale.
* Crystal Maiden has very low armor, so Vendetta is very effective.
* Nyx Assassin has two ways to stop Freezing Field, provided she doesn't get a Black King Bar. He can pop Spiked Carapace and simply walk into the field, or he can use Impale to interrupt the field, since Crystal Maiden has to channel it.
Additional:
* Spike Carapace easily interrupts Freezing Field.
* Frostbite's damage over time sets up an easy Spiked Carapace stun.
* Crystal Maiden is extremely fragile and dies quickly to Nyx Assassin's burst damage.

* Silencer is rather squishy and has poor mobility without items, making him an easy target for Nyx.
* Silencer's intelligence steal ability is a complete disadvantage against Nyx Assassin as Mana Burn will deal increasing damage for each point of intelligence Silencer has stolen, turning Silencer's intelligence steal against him.

* Heroes who rely on passive abilities and attacks, such as Drow Ranger, Wraith King, and Lone Druid, can render Silencer useless. But remember that a smart Silencer will most likely buy Silver Edge to counter this if he is played as carry.

* Nyx Assassin deals large amounts of pure damage with Vendetta and magical damage with Impale and Mana Burn, allowing him to ignore Terrorblade's armor and burst his low health pool down before he can use Sunder.
* Nyx Assassin commonly buys Urn of Shadows, Dagon and Meteor Hammer which deal magic damage that ignore Terrorblade's armor.
* Mana Burn might drain too much mana for Terrorblade to be able to use Sunder if he isn't careful in the early to mid game.

* Marksmanship allows Drow Ranger to pierce Terrorblade's high natural base armor and when upgraded with Aghanim's Scepter, it will allow her to clear Terrorblade's illusions.
* Gust can prevent Terrorblade from from using Sunder.
* Since Terrorblade doesn't like to buy armor items like Assault Cuirass, he will be very vulnerable to Drow Ranger's high physical burst damage.

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes that outrange Plague Ward after obtaining talents that increase attack range.

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill you, Nyx being particularly deadly. Watch Slark carefully, as he can break either (but not both unless you are making a mistake) of your disables, with Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn you from prey to predator.

* With 4 active abilities, Shadow Shaman is weak against silencing foes such as silencer, Drow Ranger and Death Prophet.

* Due to Pugna's incredible intelligence growth and terrible strength growth, Nyx should always be able to take you out with his combo, with or without an added Dagon. Mana Burn will deal a large amount of damage in particular, especially in the late game.
* Spiked Carapace is also a great tool versus Pugna. A good player will wait for you in Vendetta until you farm a creep wave with Nether Blast and reflect it back at you as their initiation and setup for Impale.
Additional:
* Nether Blast's animation makes it easy to time Spiked Carapace for a stun.
* Pugna has the largest intelligence gain in the game, making him a prime target for Mana Burn.
* Pugna needs to channel Life Drain, making him easy to hit with Impale.

* Nyx can walk into Firefly with Spiked Carapace and stun Batrider if he has no Spell Immunity, even if Batrider is focusing on other enemy hero.

* The huge physical damage taken from Vendetta will force Necrophos to use Ghost Shroud, which is good for a followup with Dagon and Ethereal Blade, both of which are common items on Nyx Assassin.
* Using Ghost Shroud also sets Necrophos up for a Mana Burn or Impale.

* Spiked Carapace stops Snapfire's Mortimer Kisses.

* Mana Burn is capable of removing most of Storm Spirit's large mana pool, along with dealing heavy damage and quickly depleting his chances of escaping a gank or fight.
Additional:
* Mana Burn removes much-needed mana for Ball Lightning.
* Spiked Carapace triggers on Static Remnant for an easy stun.

* Mana Burn does tons of damage against Lina because of her high intelligence. The mana burn also prevents Lina from casting her full combo.
* Spiked Carapace can easily be used to counter Lina's abilities because of their long cast animation, and could probably kill Lina outright if Laguna Blade is reflected.

* Nyx Assassin can take advantage of every one of Puck's weaknesses. His entire skill set is very effective in countering Puck.
* Because Illusory Orb is such a slow moving projectile, Nyx Assassin can simply walk into the orb and activate Spiked Carapace, stunning Puck and setting up an easy Impale. This can be circumvented by using Phase Shift while the orb is traveling, however, that means that Puck cannot use Phase Shift to dodge any other skill nor use it to safely blink away from a fight.
* Puck is an intelligence hero that likes to build intelligence items such as Eul's Scepter of Divinity, Scythe of Vyse, and Dagon. This makes Mana Burn that much more deadly against Puck.
* An ill-timed Phase Shift can turn into an easy setup for Impale.
Additional:
* Illusory Orb is easy to reflect with Spiked Carapace, either stunning Puck and setting up an easy Impale or forcing a premature Phase Shift.
* Puck is an intelligence hero that tends to build intelligence items, making it vulnerable to Mana Burn.
* An ill-timed Phase Shift can easily set Puck up to be stunned by Impale.
* Puck's low base armor and below average agility gain mean it is always susceptible to Vendetta.

* A well-timed Gust will prevent Rubick from casting abilities from Spell Steal, and his lack of capabilities and low health pool usually dies very quickly.
* Drow Ranger can dispel Fade Bolt's reduction debuff with Manta Style.

* Nyx's Spiked Carapace can reflect the damage of Sharpshooter, instantly killing hoodwink. Nyx can also use Vendetta to position himself in such a way to screen allies from Sharpshooter and catch Hoodwink by surprise.

* Spiked Carapace can be easily triggered by Flame Guard or Battle Fury, setting up a deadly Impale.
Additional:
* With Vendetta, Nyx Assassin can move closely to Ember Spirit when he's farming with his Flame Guard and use Spiked Carapace with Impale to provide a reliable and long disable.
* Mana Burn is also good, as Ember Spirit relies on his limited mana pool for the early to midgame.

* Vendetta disables Vengeance Aura and allows him to attack Vengeful Spirit with Impale and Mana Burn.
* Spiked Carapace is easy to use against a Wave of Terror or Magic Missile.

* Nyx Assassin's Spiked Carapace will stun Leshrac when hit by any of his AOE abilities.
* Mana Burn deals high damage due to Leshrac's high intelligence gain and burns a large amount of Leshrac's essential mana pool.

* Mana Burn can instantly deplete Tidehunter's low mana pool, especially in the early game, potentially preventing Tidehunter from casting Ravage.
* Ravage's travel time allows Nyx Assassin to easily stun Tidehunter with Spiked Carapace.

* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin

* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

Additional:
* Spiked Carapace can be used to reflect Illuminate damage and stun Keeper of the Light.
* Vendetta allows Nyx Assassin to follow Keeper of the Light around if he tries to split-push.
* Keeper of the Light is very squishy and will very quickly die to Vendetta and it's followup abilities.
* However, Mana Burn's Mana Burn can be more or less mitigated with Chakra Magic.

* Heroes reliant on abilities to output damage or escape can be shut down by Gust: Queen of Pain.

* A good Nyx can reflect Queen of Pain's Sonic Wave with his Spiked Carapace, or even initiate a gank on her in Vendetta while she farms a creep wave with Scream of Pain.
* Her strength to intelligence ratio is bad enough that he should be able to kill her without even requiring a Dagon, provided he can get his full combo off.

* Drow Ranger can be difficult to get on top of, thanks to her Frost Arrows and Gust. With these two abilities, Drow Ranger is able to effectively 'kite' Doom and minimize his impact during team fights and laning stage.
* Much of Drow Ranger's effectiveness comes from her passive, which is not disabled by Doom.

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Powerful physical hitters that can destroy Pangolier during his rolling from afar: Drow Ranger, Sniper, Templar Assassin, Arc Warden

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Heroes with high burst damage: Lina, Lion, Luna, Nyx Assassin, Queen of Pain.

* Long ranged heroes like Sniper or Drow Ranger can kite Tiny effectively if he doesn't get the jump on them first.

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: Invoker, Silencer, Nyx Assassin, Skywrath Mage, Shadow Shaman, Lion and etc.

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.

* As a spellcaster, silences will nullify him entirely. Some notable examples are Death Prophet, Drow Ranger, Bloodseeker, Disruptor and many others.
* Doom, as usual, fits this description nicely.

* Heroes that can pick you off: Clinkz, Nyx Assassin, Puck, Riki.

* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

Additional:
* Skywrath Mage's low health makes him rather easy prey for Nyx Assassin and his lack of armor generally means he'll take the full brunt of a Vendetta strike.
* Mana Burn is annoying at all stages of the game as it turns Skywrath Mage's high intelligence growth against him.
* Spiked Carapace gives Nyx some degree of protection against Skywrath's spells.

* Heroes with damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Heroes with low health and armor are especially vulnerable to Marksmanship's high damage output: Clinkz, Crystal Maiden.

* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Luna, Puck, Slark, Nyx Assassin, etc.

Additional:
* Enigma's uncontrollable damage from Malefice and Midnight Pulse make him easy to stun with Spiked Carapace.
* Black Hole can be easily interrupted by Impale or Spiked Carapace.

* Vendetta breaks Untouchable and deals great damage against her.
* Enchantress' lack of mobility makes her a primary target for ganking with Vendetta.
* Spiked Carapace can reflect Impetus and stun Enchantress.
* Mana Burn can deal tremendous damage against her due to being an Intelligence hero.
Additional:
* Spiked Carapace reflects the damage from Impetus.
* Enchantress is a rather squishy hero, making her fall easily to Nyx Assassin's high burst damage.

* Spiked Carapace reacts on any of the damage over time from Phoenix's abilities and can interrupt Sun Ray and Icarus Dive.

* Impale and Spiked Carapace interrupts Upheaval with ease.
* Warlock's low health pool, mobility, and high intelligence gain makes him a prime target for Nyx Assassin's burst damage.

* Assassinate is easy to reflect with Spiked Carapace for massive damage.
* Shrapnel's area damage can set up an easy stun with Spiked Carapace, especially when combined with Vendetta.
* In the early game, Sniper's low health pool and high intelligence makes him easy prey for Nyx Assassin.

* None of Anti-Mage's skills are that effective against Drow Ranger. Gust prevents him from Blinking in or out, Counterspell is totally useless against Drow's physical damage, and as she usually doesn't have a high mana pool, Mana Break and Mana Void don't do much either.
* Be careful however that Anti-Mage may eventually farm enough to Blink on top of you and kill you straight away, considering you have no natural tools to escape from him.

* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she gains an item advantage: Lina, Necrophos, Nyx Assassin, Gyrocopter. Should be noted these heroes are usually quite squishy and don't scale well with health. So to some respect, they are on a time crunch.

* Dragon Knight has no built-in disengage from Frost Arrows, and Marksmanship procs ignore base armor, bypassing Dragon Knight’s durability for the most part, making Drow one of the few heroes that can deal enough sustained damage to solo kill Dragon Knight.
* With Aghanim's Shard, Frost Arrows also apply hypothermia stacks, reducing her target’s regen, which is especially potent against tanks like Dragon Knight. (A similar effect can also be achieved with an Eye of Skadi)

* Heroes with forced movement abilities or non-interrupting forced movement, such as Lion, Drow Ranger, Magnus, Mars, as they can cancel blast-off mid air, removing his ability to initiate or escape.

* Mana Burn drains Pudge's little mana which may render Meat Hook and Dismember unusable.
* Impale and Spiked Carapace can be used to cancel Dismember easily, and can even do so when Pudge uses it on Nyx Assassin, if timed correctly.

* Drow Ranger can use Gust to push back Juggernaut before he can get in range to use Omnislash or Blade Fury.

* Gust prevents Mirana from escaping away from Leap and Moonlight Shadow before she builds defensive items.
* On the other hand, Mirana can Leap or close the gap with Moonlight Shadow to disable Drow Ranger's Marksmanship bonus.

* His whole skillset acts like a counter to Tinker:
* Impale prevents Tinker from blinding Nyx Assassin or fighting back, while giving Nyx' allies time to catch up to Tinker's position.
* Mana Burn generally deals more damage to intelligence based heroes like Tinker
* Spiked Carapace can stun Tinker at a moment of Nyx Assassin's choosing if March of the Machines has been cast. It is also quite easy to time Spiked Carapace against Heat Seeking Missiles.
* Vendetta allows Nyx to approach Tinker in the trees or wait for him in common hiding spots and deal heavy damage to his low armor.
Additional:
* March of the Machines and Heat-Seeking Missile allow easy Spiked Carapace stuns.
* As a fragile hero that relies on mana and intelligence items, Tinker is vulnerable to Mana Burn.
* Nyx Assassin's stuns can interrupt Rearm and leave Tinker helpless.