* Black King Bar is useless for Phantom Assassin against Spectre, since all of the Spectre's abilities go through spell immunity,
* Blur cannot evade Desolate because its damage is a separate damage instance and is applied before the attack hits.
* Spectre's high durability provided by Dispersion and damage block items makes her one of the hardest carries to take down.
* Phantom Assassin has no way to stop Spectre from killing her allies.
Additional:
* Dispersion makes it hard for Phantom Assassin to burst down Spectre while also reflecting back Phantom Assassin's high burst damage against herself.
* Desolate ignores the evasion from Blur.
* Black King Bar is useless against Spectre as all of her skills pierce spell immunity.

* Haunt can ruin Enigma's initiation with Blink Dagger, no matter where he is on the map.
* Spectre often buys Radiance, which allows her to deal damage over time to Enigma and put Blink Dagger on cooldown.
* Dispersion reflects the damage of Midnight Pulse and Black Hole inflicted back to Enigma. This can get even worse for Enigma if Spectre buys Blade Mail.
* All of Spectre's abilities ignore spell immunity, which means that even with Black King Bar, Enigma has absolutely little to no chance against Spectre at any stage of the game.

* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.

* Astral Imprisonment can save allies from a Black Hole combo. When upgraded with Aghanim's Scepter and Aghanim's Shard, it becomes exceedingly difficult to land good Black Hole against Outworld Destroyer's team.
* Astral Imprisonment can also cancel Black Hole while Enigma does not have Black King Bar.

* Winter's Curse, when directly targeted on Enigma, goes through Black King Bar, stopping Enigma's Black Hole channeling. It also turns his team against him, potentially killing him.
* Splinter Blast can be targeted on an eidolon, killing off other eidolons and damaging nearby heroes as well.

* Many physical-only single-target heroes like Lifestealer, Sven, Wraith King, Phantom Assassin, Templar Assassin can have their damage mitigated by Cold Embrace.

* Enfeeble greatly reduces Phantom Assassin's burst damage.
* Nightmare and Fiend's Grip can ground Phantom Assassin, who normally blinks around with Phantom Strike, and stop her from outputting damage, even with Black King Bar.
* Phantom Assassin's low health pool early on makes her susceptible to Brain Sap and Fiend's Grip's heavy nuke damage.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes with gap-closing abilities who attempt to use them for escaping Bloodseeker will suffer serious damage from Rupture: Phantom Assassin, Anti-Mage, Faceless Void, Riki, Slark, Spirit Breaker.

* Blood Rite can potentially force him to activate Black King Bar prematurely, before pulling off a Black Hole combo.
* Bloodseeker can find an Enigma out of position and Rupture him, making it difficult to initiate properly in a team fight, as it pierces through Black King Bar

* Doom, Disruptor with Aghanim's Scepter, and hex abilities all prevent item usage, which is a severe problem for Phantom Assassin as it prevents her from using Black King Bar, the one item that helps protect her against the aforementioned dangers. Doom and Shadow Demon with Aghanim's Scepter also disables Phantom Assassin's Evasion and Critical Strike, removing much of her damage and survivabaility.

* Doom pierces spell immunity and can prevent Enigma from casting any spells or using items until the duration of the spell depletes, as well as cancelling a Black Hole. This can however, be blocked by a Linken's Sphere, a common item on Enigma.

* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, Enigma, Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa.

* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult.
* Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from initiating with Black Hole.
Additional:
* Mana Shield makes Medusa harder to kill with Enigma's Black Hole and Pulse combo.
* Medusa's Split Shot can kill Demonic Conversion creeps easier and Mystic Snake bounces off from them.
* Stone Gaze makes it hard for Enigma to approach Medusa for a Black Hole.

* Despite her high mobility, Hex or Earth Spike can lock Phantom Assassin down and make her vulnerable.
* Although she has high evasion through Blur, Phantom Assassin has a rather low health pool, making her weak to Lion's magical burst.

* Lion's disables are also really effective against channeling Heroes, like Enigma or Crystal Maiden.

* Enigma's abilities have a huge mana cost, meaning that Nether Ward will deal a lot of damage to Enigma.
* Pugna can heal allies trapped inside Black Hole thanks to Life Drain.
* Nether Blast can easily kill Eidolons, especially when Enigma is pushing.

* Heroes that can apply early pressure before Phantom Assassin has farm are massive threats: Axe, Viper, Meepo, Pugna, Slark etc.

* Enigma lack burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Enigma finishes his initiation: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.

* Heroes with illusions and summons can be hard for Phantom Assassin to deal with, as she lacks any AoE abilities to deal with them without items: Broodmother, Phantom Lancer, Chaos Knight, Naga Siren, Terrorblade.

Additional:
* Phantom Assassin's single target abilities make her very helpless against swarms of Spiderlings without Battle Fury.
* Because Phantom Assassin is always reliant on critical strikes, Broodmother will usually have enough time to use Spin Web to save herself.
* Silken Bola cripples Phantom Assassin greatly due to her being 100% reliant on physical attacks.

* Heroes such as Lone Druid, Tidehunter and Viper can be very problematic for Phantom Assassin because they give her very little time to farm and become scary.

* Most summons and illusions can barely hurt Tidehunter at all, after their attacks get reduced by Anchor Smash and blocked by Kraken Shell: Nature's Prophet, Enigma
* Also Ravage's large area of effect and damage can easily damage all those units at once, or just straight up clear them.

Additional:
* Tidehunter's Anchor Smash will cripple all of Enigma's Eidolons, and at a higher level, Tidehunter will be capable to instantly kill the whole group of them for a boost of gold.
* Kraken Shell negates Eidolons's damage and Enigma's auto attacks, making laning against Tidehunter nearly impossible for Enigma.
* Ravage has an insane radius, and considering that Enigma is prone to waiting around for a Blink Dagger and Black King Bar combo, Ravage's stun may catch Enigma off guard and put Blink Dagger on cooldown, limiting him a crucial teamfight time.

* In general, Brewmaster's Cinder Brew and Thunder Clap makes him good against physical damage carries: Ursa, Clinkz, Faceless Void, Troll Warlord, Templar Assassin, Phantom Assassin.

* Heroes who produce many summons will have a hard time against Storm's Dispel Magic during teamfight: Broodmother, Enigma, Nature's Prophet.

* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Luna, Puck, Slark, Nyx Assassin, etc.

Additional:
* Enigma's uncontrollable damage from Malefice and Midnight Pulse make him easy to stun with Spiked Carapace.
* Black Hole can be easily interrupted by Impale or Spiked Carapace.

* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she gains an item advantage: Lina, Necrophos, Nyx Assassin, Gyrocopter. Should be noted these heroes are usually quite squishy and don't scale well with health. So to some respect, they are on a time crunch.

* Heroes that can apply early pressure before Phantom Assassin has farm are massive threats: Axe, Viper, Meepo, Pugna, Slark etc.

Additional:
* Slark's Pounce allows him to close the gap on Phantom Assassin and prevent her from escaping with Phantom Strike.
* As a hero who typically builds Silver Edge, Slark can use it to disable Phantom Assassin's Blur and Coup de Grace, thus taking down her attack evasion and drastically reducing her damage output.
* Because Phantom Assassin is always reliant on critical strikes, Slark will have plenty of time to escape with Pounce, Shadow Dance and Silver Edge (provided that he purchased it already).
* Essence Shift can be very harmful for Phantom Assassin as losing the agility means that her physical damage will be also reduced, which can also weaken Coup de Grace if Slark manages to steal lots of agility from her.
* Overall, any attempt for Phantom Assassin to take down Slark will hurt her more than Slark.

* Enigma lack burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Enigma finishes his initiation: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.

* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, Enigma, Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa.

* Heroes with strong channeling spells like Crystal Maiden's Freezing Field, Bane's Fiend's Grip, and Enigma's Black Hole can easily be interrupted from a long range by Nether Swap, assuming they don't have a Linken's Sphere.

Additional:
* Vengeful Spirit can interrupt Black Hole's channeling through Black King Bar by using Nether Swap from a safe distance.
* Vengeful Spirit's Level 25 Talent can make her Magic Missile pierce spell immunity, giving her another option to use in conjunction with Nether Swap to cancel Enigma's Black Hole channeling through Black King Bar and Linken's Sphere.

* In early to mid stage, Silence is also a great way to counter escape oriented heroes such as Anti-Mage, Queen of Pain, and Phantom Assassin to prevent them from escaping, provided that they don't have any basic dispels.

* Heroes who can clear the waves of Enigma's Eidolons: Lina, Luna, Dawnbreaker, Jakiro, Shadow Shaman, Death Prophet, Keeper of the Light, Invoker, Keeper of the Light, Puck.

* With Bloodthorn, Clinkz becomes a strong counter to heroes who rely on evasion and blind such as Windranger, Phantom Assassin, Troll Warlord and Keeper of the Light.

* Despite Clinkz's fragility, his harassment in the early game can be devastating; as he can kite Enigma and his Eidolons and claim their bounty with Burning Barrage and Searing Arrows.
* Clinkz often goes for a disabling item like Orchid Malevolence or Gleipnir, which allows him to cancel Enigma's Black Hole until Enigma gets Black King Bar.
* Even with Black King Bar, Clinkz can still easily kill Enigma as all of his abilities ingore spell immunity, and Enigma is a very easy target for Burning Barrage, which means Clinkz can solo Enigma at any stage of the game unless Clinkz is caught in Black Hole.

* Fissure does a great job at interrupting Black Hole immediately, especially with Blink Dagger and Aether Lens.
* Echo Slam's damage potential increases due to the eidolons created by Demonic Conversion.

* Retaliate makes it very unlikely for Phantom Assassin to win the lane against Warrunner. Double Edge can also be used to wear her down, as she has a much smaller health pool than that of Centaur Warrunner until purchasing a Ring of Health
Additional:
* Retaliate deals damage to Phantom Assassin for every attack and Stifling Dagger thrown at Centaur.
* Blur cannot evade Double Edge.

* Borrowed Time can give Abaddon a second chance after a Black Hole combo.
* Aphotic Shield can be used to save allies or Abaddon himself from Malefice.
* Abaddon can easily heal himself as well as his allies during a team fight, especially with Aghanim's Scepter upgraded Borrowed Time.

* Pit of Malice prevents Phantom Assassin from either escaping or engaging with Phantom Strike.
* Phantom Assassin's damage output is entirely physical, therefore Atrophy Aura Atrophy Aura is very hazardous for her in most of the stages, particularly since it also affects Coup De Grace Coup de Grace, hindering Phantom Assassin's main source of damage.
* Without proper items and any area-of-effect ability/item, Phantom Assassin cannot stop Underlord and his team to escape with Fiend's Gate, nor she can intercept them if Underlord chooses to teleport on any area of the map.

* Zeus can break Blink Dagger with his long range abilities and global range ultimate, Thundergod's Wrath.
* Lightning Bolt has a long range and a mini-stun, providing a way for him to cancel Black Hole from safe distances, assuming Enigma doesn't have his Black King Bar.
* Zeus' Aghanim's Scepter upgraded ability Nimbus has a global range and mini-stun, making it an even more effective way to cancel Black Hole before Enigma initiates with Black King Bar.
* Zeus is typically able to position himself at a safe distance from the fight, making him a difficult target to capture in a Black Hole.

* Without Black King Bar, Luna will be able to cancel Enigma's Black Hole from safe distance with her Lucent Beam or with 0.25s Eclipse Lucent Ministun talent and counter-initiate with Eclipse. This can get even worse for Enigma once Luna gets Aghanim's Scepter and combines it with 0.25s Eclipse Lucent Ministun talent that will allow Luna to use Eclipse from safe distance.
* If Luna chooses to use Eclipse in anticipation right after Enigma jumps in with Blink Dagger, she will be able to kill Enigma before he even gets a chance to use Black Hole.
* Moon Glaives combined with Lunar Blessing can make a short work of Enigma's Eidolons before Luna uses Eclipse.
* Bear in mind, however, that once Enigma gets Black King Bar, Luna will be out of solutions to cancel Black Hole, and going for Abyssal Blade on Luna can be risky due to Abyssal Blade's very short cast range.

* Moon Glaives can ignore certain abilities that either trigger on attack or give evasion under the condition that the heroes who have them are not primary targets. Examples include: Centaur Warrunner, Windranger, Phantom Assassin, Hoodwink etc.

* Heroes who build a Black King Bar (or have any sources of spell immunity) to channel abilities/items can still get interrupted by Dismember: Enigma, Juggernaut, Phantom Assassin, Pugna, Elder Titan.

Additional:
* Even with Black King Bar, Pudge's Meat Hook and Dismember can still disable Engima while he is channeling Black Hole.
* Pudge's Aghanim's Shard upgraded Dismember and Meat Hook are great ways to save allies from Black Hole.
* Enigma is prone to ganks in the jungle or in the off-lane without proper vision. Pudge can take advantage of Enigma's lack of mobility, and gank him often.

* If Phantom Assassin jumps on Pudge first with Phantom Strike, she will be a very easy target for Pudge's Meat Hook and Dismember combo.
* Even though it can deal damage based on Pudge's max health, Fan of Knives from Aghanim's Shard cannot disable Pudge's Flesh Heap as Flesh Heap is one of the few passive abilities that cannot be disabled by break.
* Both Meat Hook and Dismember ignore spell immunity which allows Pudge to disable Phantom Assassin even while she has Black King Bar active.
* Pudge occassionally buys armor items like Blade Mail, which in combination with many stacks from Flesh Heap can make Phantom Assassin have little effect against Pudge.

* Chaotic Offering's spell immunity piercing stun can stop Black Hole's channeling. Due to this ability's large area of effect, it can be cast at a safe distance from the Black Hole. It also goes through Black King Bar and Linken's Sphere
* Fatal Bonds can be used to make Enigma's Eidolons easier to kill, potentially feeding the enemy team. Also, it's constant damage will put Blink Dagger on cooldown, potentially forcing Enigma to prematurely activate Black King Bar.
Additional:
* Chaotic Offering pierces spell immunity and is an area of effect ability, therefore it doesn't matter if Enigma buys Black King Bar or Linken's Sphere, Warlock will always be able to cancel the channeling of Black Hole.
* Enemies often get clumped up around Black Hole to hit your allies, giving you a perfect opportunity to cast Fatal Bonds, Chaotic Offering, and Upheaval on multiple enemies.

* Hookshot's stun pierces through spell immunity and Enigma's channeling can be easily cancelled from a safe distance, assuming none of his allies are in the way, and the Black Hole is not centered directly on Enigma.
Additional:
* Black Hole requires channelling, making it easy to be interrupted with Hookshot.
* Enigma lacks mobility without a Blink Dagger and also is squishy, making him fall easily when ganked by Clockwerk.

* Whirling Axes (Melee) makes it hard to land a Coup De Grace.
* Troll Warlord often buys Silver Edge and Monkey King Bar, the items that greatly help against Phantom Assassin's Blur ability.
* Battle Trance completely negates Phantom Assassin's large damage output, preventing Troll Warlord from dying easily. The lifesteal also allows Troll Warlord to restore much of his health.
Additional:
* Troll Warlord can build a Silver Edge or a Monkey King Bar to completely ignore Blur.
* Whirling Axes (Melee) provides a 60% miss chance, making a Coup de Grace critical strike very hard to land.
* Battle Trance negates Coup de Grace, preventing Troll Warlord from dying to her critical hits.

* Fire Spirits applies a severe attack speed slow, severely hindering Phantom Assassin's damage output. While Phantom Strike may be able to slightly remedy the problem, Phoenix's high magical damage output completely ignore Blur's evasion, resulting in severe damage to her low health pool.
Additional:
* While her Phantom Strike does give limited extra attack speed, she cannot use the ability against the Phoenix Sun, and while her Blur may protect her from attacks, Phoenix's strong magical DPS burns away her small health pool quickly, and the attack speed slow makes her unable to fight back (provided she has no source of spell immunity).

* Walrus PUNCH! can interrupt Black Hole and it can pierce spell immunity.
* In pretty much any phase of the game, Tusk's abilities can easily cancel Black Hole and disrupt Enigma's positioning.

* Phantom Assassin relies on her Blur to stay alive, but is very vulnerable to Sand King's heavy magic damage.
* With Burrowstrike, Sand King can often catch Phantom Assassin before she can use her Black King Bar.
* Sand King can dodge Stifling Dagger with Sandstorm.
* Phantom Assassin has a hard time killing Sand King because of his high mobility.

* Phantom Assassin's Blur will be useless if Windranger managed to get Monkey King Bar or Bloodthorn, and other than Stifling Dagger, Phantom Assassin has no abilities that can bypass Windrun.
* Additionally, Phantom Assassin doesn't like building Monkey King Bar because her crits are reliant on attack damage.
* Focus Fire can still deal considerable damage despite Blur's evasion due to the increased attack speed.

* Sharpshooter disables both Blur and Coup De Grace, especially with the level 25 talent.
* Because Phantom Assassin is often reliant on critical strikes, Hoodwink can have enough time to simply move near a tree and escape with Scurry.

* Telekinesis has a longer range than the AoE of Black Hole for the purposes of cancelling it.
* All of Enigma's spells are useful to Spell Steal.
* Malefice is useful for interrupting channeling spells or long cast animations. Its stun duration is also amplified thanks to Spell Steal's debuff amplification.
* Demonic Conversion can be used to push or counter-push a lane.
* Midnight Pulse is useful to block an area or for team fights.
* Black Hole is very easy to steal, as it is a channeled ability. It's also one of the best ultimate abilities for team fights, and it can easily turn the fight around for the enemy team. It also does more damage and has a larger cast range thanks to Arcane Supremacy. A stolen Black Hole can also cancel Enigma's Black Hole.

* Mass summoning heroes: Broodmother, Nature's Prophet and Enigma all have summons Puck can clear clear with Illusory Orb and Waning Rift instantly, due to their summons having low health.

* Puck relies mainly on magical burst damage, which Phantom Assassin is most vulnerable against.
* Phase Shift and Illusory Orb disjoint Stifling Dagger, also allowing to kite Phantom Assassin.
* Dream Coil will stun Phantom Assassin if she uses Phantom Strike to blink away.

* An isolated Enigma in the early game can be easily killed by Storm Spirit thanks his higher mobility and dueling potential. However, Storm Spirit can be killed when caught by Enigma's full combo, especially if Enigma has Black King Bar.
* Storm can kill all of Enigma's Eidolons relatively quickly without much risk, slowing down Enigma's farming speed, preventing him from split pushing, and giving Storm its considerable bounty, especially if Enigma chooses the Level 25 Talent that gives him more Eidelons.
* Storm can zip through Black Hole stunning Enigma while he's channelling until Enigma buys Black King Bar.

* Morphling's naturally high armor thanks to his high agility makes it hard for Phantom Assassin to take him down with Coup de Grace.
* Phantom Assassin is vulnerable to magical damage, falling easily to Adaptive Strike + Ethereal Blade combo.

* Black Hole is a channeling ability and Earth Spirit has at least two possibilities which can interrupt these kind of spells. Enigma is exposed and cannot move while using Black Hole, thus making it easy for Earth Spirit to stop the feared ability with the huge range of Rolling Boulder and forcing Enigma to quickly rush a Black King Bar to prevent this.
* Enigma is level dependant, squishy and relativly defenseless in the early game and therefore vulnerable to aggressive roam maneuvers in this stage of the game. Earth Spirit excels at ganking, shutting down a jungling or otherwise solo farming Enigma.

* Phantom Assassin does not deal with early aggression very easily (especially when magical damage). A competent Batrider can make life very difficult with Sticky Napalm followed by any other spell.

* Like Abbadon's Borrowed Time, Reincarnation can bring Wraith King back to life, giving him a second chance to counter initiate or escape after a Black Hole combo.

* Static Link can lower the damage output from Coup de Grace procs, hindering Phantom Assassin's main source of damage.
* Eye of the Storm strikes cannot be evaded by Blur.
* Both Static Link and Eye of the Storm pierces spell immunity, as Phantom Assassin is often reliant on Black King Bar.
Additional:
* Static Link greatly lowers the damage output from Coup De Grace, hindering Phantom Assassin's main source of damage.
* Eye of the Storm strikes cannot be evaded by Blur.

* Reactive Armor helps Timbersaw sustain harassment from Stifling Dagger.
* Phantom Assassin has a moderate health pool and usually appears in the front line of battle, making her vulnerable to Timbersaw's magic burst.
* Timbersaw can easily escape from Phantom Assassin thanks to his Timber Chain.
Additional:
* Reactive Armor helps Timbersaw sustain harassment from Stifling Dagger, as well as ganking attempts.
* Phantom Assassin is a hero with moderate HP pool, and usually appears in the front line of battle. Because Blur does nothing against spells, she is vulnerable to Timbersaw's skills.
* Timbersaw can easily escape from Phantom Assassin thanks to his Timber Chain.

* Bristleback's constant harass from Quill Spray will greatly hurt Enigma's laning and kill his Eidolons.

* Stone Form can easily interrupt heroes with long channeling spells, like Crystal Maiden, Bane, Witch Doctor, or Enigma.

* Heroes who rely on basic attacks will suffer from Laser: Phantom Assassin, Wraith King, Huskar.

Additional:
* The blind from Laser can render Phantom Assassin useless if she is not protected by Black King Bar.
* Tinker is a natural Scythe of Vyse carrier and can permanently disable Phantom Assassin, not giving her a chance to activate Black King Bar or any other items if she has them.

* Heroes that cannot move in fights such as a Dueling Legion Commander or anyone channeling a spell like Bane, Pudge, or Enigma are easy Sacred Arrow targets.

* Heroes with no AoE abilities will struggle against Phantom Lancer: Phantom Assassin, Broodmother

* Fate's Edict cripples many heroes who rely on attacks, such as Phantom Assassin, Sven, or Enchantress, without a dispel or a Black King Bar.

* Heroes who can clear the waves of Enigma's Eidolons: Lina, Luna, Dawnbreaker, Jakiro, Shadow Shaman, Death Prophet, Keeper of the Light, Invoker, Keeper of the Light, Puck.

* Heroes who can clear the waves of Enigma's Eidolons: Lina, Luna, Dawnbreaker, Jakiro, Shadow Shaman, Death Prophet, Keeper of the Light, Invoker, Keeper of the Light, Puck.

* Doom, Disruptor with Aghanim's Scepter, and hex abilities all prevent item usage, which is a severe problem for Phantom Assassin as it prevents her from using Black King Bar, the one item that helps protect her against the aforementioned dangers. Doom and Shadow Demon with Aghanim's Scepter also disables Phantom Assassin's Evasion and Critical Strike, removing much of her damage and survivabaility.

* Enigma lack burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Enigma finishes his initiation: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.

* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, Enigma, Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa.

* Enigma lack burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Enigma finishes his initiation: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.

* Heroes with heavy early and mid-game magical damage are also problematic for Phantom Assassin due to being able to easily kill her before she gains an item advantage: Lina, Necrophos, Nyx Assassin, Gyrocopter. Should be noted these heroes are usually quite squishy and don't scale well with health. So to some respect, they are on a time crunch.

* Heroes who can clear the waves of Enigma's Eidolons: Lina, Luna, Dawnbreaker, Jakiro, Shadow Shaman, Death Prophet, Keeper of the Light, Invoker, Keeper of the Light, Puck.

* Heroes who can clear the waves of Enigma's Eidolons: Lina, Luna, Dawnbreaker, Jakiro, Shadow Shaman, Death Prophet, Keeper of the Light, Invoker, Keeper of the Light, Puck.

* Heroes with low health or rely on evasion can easily be bursted down, like Phantom Assassin or Terrorblade.

* Heroes who rely on physical damage are easily negated by Ghost Shroud: Phantom Assassin, Wraith King, Juggernaut.

* Heroes with illusions and summons can be hard for Phantom Assassin to deal with, as she lacks any AoE abilities to deal with them without items: Broodmother, Phantom Lancer, Chaos Knight, Naga Siren, Terrorblade.

* Enigma lack burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Enigma finishes his initiation: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.

* Doom, Disruptor with Aghanim's Scepter, and hex abilities all prevent item usage, which is a severe problem for Phantom Assassin as it prevents her from using Black King Bar, the one item that helps protect her against the aforementioned dangers. Doom and Shadow Demon with Aghanim's Scepter also disables Phantom Assassin's Evasion and Critical Strike, removing much of her damage and survivabaility.

* Heroes that rely on physical damage are ineffective against Dragon Knight due to his high armor: Phantom Assassin,Bloodseeker, Lifestealer, Troll Warlord, Sven

* Heroes with powerful channeling abilities are easily interrupted by Phantom's Embrace: Bane, Pudge, Witch Doctor, Crystal Maiden, Enigma.

* Overgrowth prevents Phantom Assassin from using Blink Strike even through her spell immunity.
* Living Armor reduces Phantom Assassin's physical damage whenever she attempts to gank an allied hero.

* While Phantom Assassin can kill Skywrath Mage in a few strikes, Skywrath Mage can also do the same to her if she is not careful.
* Arcane Bolt's long range and low cooldowns allows Skywrath Mage to severely harass Phantom Assassin in lane.
* Ancient Seal prevents Phantom Assassin from escaping or engaging with Phantom Strike.
* Mystic Flare's heavy magical damage nukes Phantom Assassin down quickly during the early to mid game.

* Most of the of Jakiro's damage-over-time abilities put Blink Dagger on cooldown, potentially forcing Enigma to prematurely activate Black King Bar.
* Jakiro's Dual Breath, Liquid Fire, Macropyre and Liquid Frost from Aghanim's Shard can take out Enigma's Eidolons, reduce Enigma's attack speed and put Enigma's Blink Dagger on cooldown.
* Jakiro can easily cancel Black Hole with Ice Path as Enigma is a very easy target while channeling it.
* Aghanim's Scepter upgraded Macropyre can deal pure damage-over-time and pierce spell immunity, which can discourage Enigma from initiating with Black Hole.
Additional:
* Most of the of Jakiro's damage-over-time abilities put Enigma's Blink Dagger on cooldown, potentially forcing him to prematurely activate Black King Bar.
* Jakiro's Dual Breath, Liquid Fire, Macropyre and Liquid Frost from Aghanim's Shard can take out Enigma's Eidolons, reduce Enigma's attack speed and put Enigma's Blink Dagger on cooldown.
* Jakiro can easily cancel Black Hole with Ice Path as Enigma is a very easy target while channeling it.
* upgraded Macropyre can deal pure damage-over-time and pierce spell immunity, which can discourage Enigma from initiating with Black Hole.

* Phantom Strike's extra attack speed will cause Phantom Assassin to trigger Counter Helix more often, which can be fatal for Phantom Assassin. Jumping on Axe with Phantom Strike is not a good idea for Phantom Assassin at all as it makes her a seriously easy target for a counter-initiation with Berserker's Call and Blade Mail.
* Most of Axe's abilities pierce Black King Bar, allowing him to lock down Phantom Assassin at any time.
* Berserker's Call greatly reduces Phantom Assassin's ability to crit hard against Axe, and may cause her to kill herself when used with Blade Mail. Berserker's Call can also affect Phantom Assassin even if she has Black King Bar active as Berserker's Call can fully pierce spell immunity, making Berserker's Call one of the best abilities in the game against heroes like Phantom Assassin who wants to kill opponents quickly without being interrupted.
* Culling Blade can often kill Phantom Assassin before she can do anything due to her low health and strength gain. And every time Culling Blade successfully kills Phantom Assassin or any of her teammates, Axe gains permanent armor from it, which in combination with armor items that Axe often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Axe.
* Aghanim's Shard upgraded Counter Helix can weaken Phantom Assassin's damage output, and if her attack damage is weak, Coup De Grace will also suffer from attack damage reduction as well.
Additional:
* Phantom Strike's extra attack speed will cause Phantom Assassin to trigger Counter Helix more often, which can be fatal for Phantom Assassin in the early game. Jumping on Axe with Phantom Strike is not a good idea for Phantom Assassin at all as it makes her a seriously easy target for a counter-initiation with Berserker's Call and Blade Mail.
* Most of Axe's abilities pierce Black King Bar, allowing him to lock down Phantom Assassin at any time.
* Berserker's Call greatly reduces Phantom Assassin's ability to crit hard against Axe, and may cause her to kill herself when used with Blade Mail. Berserker's Call can also affect Phantom Assassin even if she has Black King Bar active as Berserker's Call can fully pierce spell immunity, making Berserker's Call one of the best abilities in the game against heroes like Phantom Assassin who wants to kill opponents quickly without being interrupted.
* Culling Blade can often kill Phantom Assassin before she can do anything due to her low health and strength gain. And every time Culling Blade successfully kills Phantom Assassin or any of her teammates, Axe gains permanent armor from it, which in combination with armour items that Axe often purchases like Blade Mail, Crimson Guard, Assault Cuirass and Shiva's Guard can make Phantom Assassin's attacks only tickle Axe.
* Blade Mail is an item that Axe purchases every game, and which can be used to turn Phantom Assassin's critical strikes from Coup De Grace against herself. This can become even worse if she's affected by Berserker's Call, as she has no way to stop attacking.
* Aghanim's Shard upgraded Counter Helix can weaken Phantom Assassin's damage output, and if her attack damage is weak, Coup De Grace will also suffer from attack damage reduction as well.

* Phantom Assassin's high physical damage is greatly reduced by Bulwark.
* God's Rebuke has true strike, ignoring the evasion from Blur.

* Heroes which rely exclusively on right clicks will struggle somewhat against Blinding Light: Phantom Assassin, Wraith King, Medusa

* Illuminate can wipe the pushing Eidolons in a lane with ease, diminishing Enigma's laning presence by a lot.
* However, Keeper of the Light does not have any way to cancel Black Hole outside from Will-O-Wisp from Aghanim's Scepter.