* Kinetic Field prevents Dawnbreaker from escaping with Celestial Hammer.
* Kinetic Field and Static Storm can pin down Dawnbreaker after she jumps in with Solar Guardian.
* Glimpse can force Dawnbreaker out of a fight right after she uses Solar Guardian.

* Disruptor can always Glimpse back Io or his target after he Relocated nearby.
* Even better, thanks to the indicator on the ground, you can even preemptively drop Static Storm and Kinetic Field on the spot they will relocate to.
* Thunder Strike and Glimpse are also good tools to bring back an Io that Tethered away in the fog of war.
Additional:
* Glimpse directly negates Relocate.

* Cold Embrace can render the extra attack speed from Overcharge meaningless.
* Splinter Blast and Winter's Curse are very affective against Io, as it has to stay close to its tethered hero.

* Living Armor can be used to save a hero from a Relocate gank.

* Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.

* Fireblast is a good tool to interrupt Io during its escapes through Tether.
* Ignite can be one of the few spells with enough total damage to out-trade the sustained healing Io provides for its fellow laner.
* However, picking other supports that focus less on the laning phase is generally a better choice against Io.

* Burning Barrage and Searing Arrows allow Clinkz to quickly kill Io due to its low armor.
* Clinkz iz a hero that very often goes for Orchid Malevolence, and its upgrade Bloodthorn. And if Clinkz has it, he will be able to silence Io and prevent him from escaping wit either Tether or Relocate.

* Spiked Carapace can stop Dawnbreaker's Solar Guardian which will eliminate her global presence and limits her movement around the map.

* Ice Blast prevents Io from healing an ally with Tether and prevents healing from Overcharge
* Io is a common Mekansm builder which is useless if he is affected by Ice Blast.
Additional:
* Ice Blast prevents Io from healing the target.

* Lightning Storm will usually hit both Io and his Tethered target since both will be close enough for the lightning to jump. It can then be followed up by Split Earth.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and his Tethered target.
Additional:
* Io is a hero who needs to be close to it's tethered target to make it effective, and that's where Leshrac gets the advantage thanks to many of his area-of-effect abilities.
* Lightning Storm will usually hit both Io and its tethered target since both will be close enough for the lightning to jump.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to both, Io and its tethered target.

* Nethertoxin disables Dawnbreaker's Luminosity|Dawnbreaker. Since she's a melee hero, she needs to close gap to attack and Nethertoxin will be bad for her since she cannot heal.
* Viper Strike and Poison Attack will severely slow her down and combined with Nethertoxin, it will be her death sentence (unless her Celestial Hammer or Solar Guardian are off cooldown). Besides that, chasing her down will be easy due to the slow.

* Lich's Chain Frost forces Io to either give up providing buff to his ally with Tether or suffer devastating damage with his tethered ally.
* Lich can easily use Sinister Gaze to disable Io from getting away with Tether or Relocate.

* Lucent Beam can be used to cancel both, Tether and Relocate.
* Like with Leshrac's Diabolic Edict, Lightning Storm and Pulse Nova abilities. Luna's Moon Glaives and Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with Aghanim's Scepter.

* Phantom Strike allows Phantom Assassin jump directly to Io.
* Coup de Grace can make a short work of Io's low health and armor.

* Grimstroke can catch Io and his ally easily with SoulBind as Io has a tendency to tether himself with an ally frequently.
* Io is highly vulnerable to disables. Hence, Grimstroke's Phantom's Embrace is a great ability to hinder Io's potential.
Additional:
* Soulbind can target both Io and its Tethered ally, allowing Grimstroke and his team to target both with single target spells. Should Io try to Relocate, Phantom's Embrace can stop its channel to prevent escape.

* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.

* Heroes with low armor and little mobility, like Huskar, Io, etc. will also have an unfortunate fate.

* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Fragile heroes: Bounty Hunter has decent nuking capabilities with Shiruken Toss and Jinada thus making fragile heroes easy picks for ganking. Few examples of such heroes are:Crystal Maiden, Pugna, Skywrath Mage, Io, Witch Doctor, etc.

* Squishy heroes (Io, Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper

* Take Aim and Assassinate allow Sniper to reach Io even if it stays in the backline.