* Magnus has very mediocre damage against Alchemist, because he can survive the stun duration of Reverse Polarity with Chemical Rage.

* Jakiro's abilities deal damage over time, which can disrupt Magnus's attempts to initiate with Blink Dagger and Reverse Polarity.
* Macropyre not only disables Blink Dagger for a considerable duration, but can also destroy Trees, revealing Magnus's cover and position.

* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.

* Jakiro's damage over time force Chen to use Hand of God prematurely, potentially wasting chance to save his allies during teamfight.
* Macropyre can also disrupt Chen's jungling work.
Additional:
* Liquid Fire and Dual Breath can clear Chen's creeps, and kill his allies before he uses Hand of God.
* Macropyre can quickly clear Chen's creeps and deal intense damage to his allies.

* Greevil's Greed makes Broodmother’s spiderlings far more valuable to Alchemist making it important that he does farm them as opposed to other heroes where the spider's bounties are negligible.
* Acid Spray makes it difficult to attack Alchemist in lane without losing some spiderlings to the damage over time, potentially giving him farm he wouldn't have otherwise.
Additional:
* Alchemist can easily farm Spiderlings with Acid Spray and Greevil's Greed.
* Alchemist's Chemical Rage nullifies Broodmother's Insatiable Hunger

* Broodmother and her Spiderlings need to be very careful during the laning stage against Jakiro, as Jakiro can take down Broodmother's Spiderlings, preventing her from pushing as well as gaining a good amount of gold.

* Jakiro's AoE abilities are great against Phantom Lancer:
* Dual Breath slows down and damages Phantom Lancer and his illusions.
* Liquid Fire will not only deal AoE damage but also lowers Phantom Lancer's attack speed.
* Ice Path and Macropyre combo can easily clear all of Phantom Lancer's illusions.
* Jakiro can predict Doppelganger and Ice Path on top.
Additional:
* Jakiro's spells inflict AoE damage, meaning he can take down Phantom Lancer's illusion army very quickly.

* Heroes that require burst damage to kill will be difficult for Phantom Lancer to take down: Timbersaw, Axe, Bristleback, Alchemist and Underlord

* Jakiro's Macropyre can help him to escape from Sprout and quickly clears Treants.
* Jakiro can disrupt Nature's Prophet's escape attempt with Sprout and Teleportation by using Ice Path.
Additional:
* Jakiro's skill arsenal can ruin Nature's Prophet's gameplay: Dual Breath and Liquid Fire can clear treants from Nature's Call while simultaneously slowing Nature's Prophet, Ice Path can disrupt Nature's Prophet's escaping attempt with Teleportation, and Macropyre can easily clear treants from Nature's Call.

* Alchemist gets a huge amount of additional gold from killing Nature's Prophet's treants thanks to Greevil's Greed

Additional:
* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.

* Chemical Rage out-heals Doom to a large degree throughout all stages of the game. Should Alchemist be chemically enraged before being Doomed, Alchemist can become a difficult target to effectively lockdown and kill, thanks to the health regeneration and movement speed bonuses granted by his ultimate.
* Alchemist is an ineffective target for Doom. Alchemist isn't totally reliant on his skills to be effective during a teamfight, due to the right-click nature of the hero.

* With his AoE damage, Jakiro can easily kill Chaos Knight's Phantasm illusions.
* Chaos Knight usually doesn't buy a Black King Bar, making him vulnerable to an Ice Path into Macropyre combination.

* Jakiro's area of effect abilities can hit Dark Willow even while she is hidden during the Shadow Realm.

* Chemical Rage kills Phoenix very quickly in Supernova.

* Ice Path allows Jakiro to easily cancel Freezing Field.
* Freezing Field makes Crystal Maiden an easy target for all of his abilities without a Black King Bar.
* With the talent for Macropyre dealing Pure Damage and ignoring spell immunity, Black King Bar becomes nearly useless for Crystal Maiden, as its high damage over time and long duration will force Crystal Maiden to forcefully cancel Freezing Field.
Additional:
* Ice Path allows Jakiro to easily cancel Freezing Field.
* Freezing Field makes Crystal Maiden an easy target for all of his abilities without a Black King Bar.
* upgraded Macropyre can deal pure damage-over-time and pierce spell immunity, making Black King Bar nearly useless for Crystal Maiden, as its high damage over time and long duration will force Crystal Maiden to forcefully cancel Freezing Field.

* With Dual Breath, Liquid Fire and Macropyre Jakiro can quickly remove all Living Armor from a target.
* Ice Path allows Jakiro to prevent Treant Protector from using Overgrowth while staying at a safe distance.

* Both Ice Path and Macropyre are the good setup while Earthshaker after blinking in and stay out of Echo Slam initiation radius.
* Liquid Fire damage over time potentially disable Earthshaker's Blink Dagger.

* Chemical Rage negates almost all damage from Burning Spears.
Additional:
* Chemical Rage mitigates damage from Burning Spear.

* All of Jakiro's skills are Area of Effect, which can easily affect all Meepos in a targeted area.

* Most of the of Jakiro's damage-over-time abilities put Blink Dagger on cooldown, potentially forcing Enigma to prematurely activate Black King Bar.
* Jakiro's Dual Breath, Liquid Fire, Macropyre and Liquid Frost from Aghanim's Shard can take out Enigma's Eidolons, reduce Enigma's attack speed and put Enigma's Blink Dagger on cooldown.
* Jakiro can easily cancel Black Hole with Ice Path as Enigma is a very easy target while channeling it.
* Aghanim's Scepter upgraded Macropyre can deal pure damage-over-time and pierce spell immunity, which can discourage Enigma from initiating with Black Hole.
Additional:
* Most of the of Jakiro's damage-over-time abilities put Enigma's Blink Dagger on cooldown, potentially forcing him to prematurely activate Black King Bar.
* Jakiro's Dual Breath, Liquid Fire, Macropyre and Liquid Frost from Aghanim's Shard can take out Enigma's Eidolons, reduce Enigma's attack speed and put Enigma's Blink Dagger on cooldown.
* Jakiro can easily cancel Black Hole with Ice Path as Enigma is a very easy target while channeling it.
* upgraded Macropyre can deal pure damage-over-time and pierce spell immunity, which can discourage Enigma from initiating with Black Hole.

* Chemical Rage will take down Tombstone in no time.
Additional:
* With Greevil's Greed, Alchemist can farm Tombstone zombies and gain a significant gold advantage.

* Jakiro's damage over time abilities can clear Naga Siren's illusions and can hurt real Naga Siren even for the duration of Song of the Siren.
* Naga Siren is not a hero that likes to go for Black King Bar, and that makes her very vulnerable to Jakiro's damage over time in every phase of the game.
Additional:
* Jakiro's damage over time abilities can clear Naga Siren's illusions and can hurt real Naga Siren even for the duration of Song of the Siren.
* Naga Siren is not a hero that likes to go for Black King Bar, and that makes her very vulnerable to Jakiro's damage over time in every phase of the game.

* Riki can easily be caught in an Ice Path and Macropyre combo as he finishes Tricks of the Trade, Jakiro just has to be careful about Riki's Smoke Screen when dealing with Riki.

* Jakiro's area-of-effect abilities make him strong against heroes who rely on illusions and summons: Terrorblade, Naga Siren Chaos Knight, Phantom Lancer, Broodmother, Nature's Prophet, Lycan, Wraith King.

* Jakiro's area-of-effect abilities make him strong against heroes who rely on illusions and summons: Terrorblade, Naga Siren Chaos Knight, Phantom Lancer, Broodmother, Nature's Prophet, Lycan, Wraith King.

* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: Morphling, Naga Siren, Spectre.

* Heroes that have disposable area-targeted spells can force her to undo her Meld: Leshrac, Puck, Tiny, Jakiro,. An experienced Templar Assassin could try to use Refraction before Meld so she can tank through those damage without getting her Blink disabled.

Additional:
* All of Jakiro's active skills can be targeted on an area, which is effective at forcing Templar Assassin to move should she Meld away.
* Many of Jakiro's spells utilize damage-over-time mechanics, which makes it easy to strip away layers of Refraction.

* Heroes with channeling spells are very easy targets for Jakiro's abilities: Crystal Maiden, Dawnbreaker, Enigma, Pudge, Shadow Fiend, Shadow Shaman, Warlock.

* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: Morphling, Naga Siren, Spectre.

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Heroes with channeling spells are very easy targets for Jakiro's abilities: Crystal Maiden, Dawnbreaker, Enigma, Pudge, Shadow Fiend, Shadow Shaman, Warlock.

* Heroes with channeling spells are very easy targets for Jakiro's abilities: Crystal Maiden, Dawnbreaker, Enigma, Pudge, Shadow Fiend, Shadow Shaman, Warlock.

* Heroes with channeling spells are very easy targets for Jakiro's abilities: Crystal Maiden, Dawnbreaker, Enigma, Pudge, Shadow Fiend, Shadow Shaman, Warlock.

* Heroes with channeling spells are very easy targets for Jakiro's abilities: Crystal Maiden, Dawnbreaker, Enigma, Pudge, Shadow Fiend, Shadow Shaman, Warlock.

* Jakiro's area-of-effect abilities make him strong against heroes who rely on illusions and summons: Terrorblade, Naga Siren Chaos Knight, Phantom Lancer, Broodmother, Nature's Prophet, Lycan, Wraith King.

* Heroes with large magical AoE damage will fare well against Omniknight: Lich, Ancient Apparition, Jakiro, Disruptor

* Jakiro has 3 damage over time spells, 2 of which are from debuffs on Puck (Dual Breath and Liquid Fire) and 1 affecting an entire area (Macropyre), making it easy for him to disable the blink dagger.
* Ice Path is also strong against Puck, as he can cast it towards Puck during Phase Shift, who then gets instantly stunned once Phase Shift ends.
Additional:
* Jakiro has 3 damage over time spells, 2 of which are from debuffs on Puck (Dual Breath and Liquid Fire) and 1 affecting an entire area (Macropyre), making it easy for him to disable the blink dagger.
* Ice Path is also strong against Puck, as he can cast it towards Puck during Phase Shift, who then gets instantly stunned once Phase Shift ends.

* Ice Path is a great stun for Berserker's Call and with a Eul's Scepter of Divinity can really catch Axe off guard.
* Dual Breath and Liquid Fire can be a devistating combination for Axe (especially if he takes Battle Hunger at level 1) before he has any natural regeneration sustain from items.
Additional:
* Ice Path neutralizes initiation attempts with Berserker's Call, and its long area of effect discourages follow-ups from Axe's teammates.
* Ice Path serves as a large obstacle to stop Axe from chasing down fleeing stragglers to kill with Culling Blade.
* Jakiro's many damage-per-second skills prevent Axe from initiating with his Blink Dagger. And since Axe rarely buys Black King Bar, he's vulnerable to Jakiro's abilities and counter-initiaions.

* Heroes with damage over time abilities can quickly eat through Gravekeeper's Cloak charges like Huskar, Jakiro and Queen of Pain.