* Jakiro's Macropyre can help him to escape from Sprout and can disrupt Nature's Prophet's jungling.
* Jakiro can disrupt Nature's Prophet's escape attempt with Teleportation with Ice Path.
Additional:
* Jakiro's skill arsenal can ruin Nature's Prophet's gameplay: Dual Breath and Liquid Fire can clear treants from Nature's Call while simultaneously slowing Nature's Prophet, Ice Path can disrupt Nature's Prophet's escaping attempt with Teleportation and Macropyre can not only clear treants from Nature's Call, but also can free Jakiro from Sprout.

* Heroes that have AoE damage: Lina, Keeper of the Light, Timbersaw, Leshrac, Bristleback, Axe

* Jakiro's abilities deal damage over time, which can disrupt Magnus's attempts to initiate with Blink Dagger and Reverse Polarity.
* Macropyre not only disables Blink Dagger for a considerable duration, but can also destroy Trees, revealing Magnus's cover and position.

* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, Elder Titan, Faceless Void, Rubick, Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, Phoenix, Razor, Huskar, Batrider, Kunkka, Tidehunter, Wraith King, Sand King.

* Keeper of the Light can stall pushes with {Ability ID:Illuminate|Keeper of the Light} this makes him strong against pushing heroes: Terrorblade Naga siren Nature's Prophet and Anti-Mage

* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: Morphling, Naga Siren, Spectre.

* Chakra Magic can drain her current mana, draining away her effective health in a sneaky way.
* Will-O-Wisp will keep Medusa busy after she got hit by Blinding Light.

* Axe is a hero that is very vulnerable against magical nuke damage and disables, Jakiro is perfect against him with all of his spells.
Additional:
* Ice Path neutralizes initiation attempts with Berserker's Call, and its long area of effect discourages follow-ups from Axe's teammates.
* Ice Path serves as a large obstacle to stop Axe from chasing down fleeing stragglers to kill with Culling Blade.
* Jakiro's many damage-per-second skills prevent Axe from initiating with his Blink Dagger.

* Riki can easily be caught in an Ice Path and Macropyre combo as he finishes Tricks of the Trade.

* Both Ice Path and Macropyre are the good setup while Earthshaker after blinking in and stay out of Echo Slam initiation radius.
* Liquid Fire damage over time potentially disable Earthshaker's Blink Dagger.

* With Dual Breath, Liquid Fire and Macropyre Jakiro can quickly remove all Living Armor from a target.
* Ice Path allows Jakiro to prevent Treant Protector from using Overgrowth while staying at a safe distance.
* Macropyre destroy trees, which where Treant protector might be hiding

* Ice Path allows Jakiro to easily cancel Freezing Field.
* Freezing Field makes Crystal Maiden an easy target for all of his abilities without a Black King Bar.
* With the talent for Macropyre dealing Pure Damage and ignoring spell immunity, Black King Bar becomes nearly useless for Crystal Maiden, as its high damage over time and long duration will force Crystal Maiden to forcefully cancel Freezing Field.

* Blinding Light can easily push Monkey King out of Wukong's Command, as well as blinding him.
* Will-O-Wisp destroys trees in a massive area, damaging Monkey King's mobility
* However, Keeper of the Light can be easily ganked by Monkey King during early-mid game stage.
Additional:
* Blinding Light can knock Monkey King outside of his ultimate, Wukong's Command or can generally blind him effectively.
* Will-O-Wisp stun Monkey King from Tree Dance by destroying his tree.

* Wraith King's poor mobility makes him vulnerable to Illuminate.
* Blinding Light can reduce his damage output as well as his already abysmal mobility.
* Chakra Magic drains Wraith King's much-needed mana resulting in him not being able to reincarnate

* Dual Breath slows down Phantom Lancer and his illusions.
* Liquid Fire will not only deal AoE damage but also lowers Phantom Lancer's attack speed.
* An Ice Path and Macropyre combo can easily clear all of Phantom Lancer's illusions.
Additional:
* Jakiro's spells inflict AoE damage, meaning he can take down Phantom Lancer's illusion army very quickly.

* With his AoE damage, Jakiro can easily kill Chaos Knight's Phantasm illusions.
* Chaos Knight usually doesn't buy a Black King Bar, making him vulnerable to an Ice Path into Macropyre combination.
Additional:
* Ice Path and Macropyre punish Reality Rift with a long stun and heavy damage across all illusions.

* Jakiro's damage over time force Chen to use Hand of God prematurely, potentially wasting chance to save his allies during teamfight.
* Macropyre can also disrupt Chen's jungling work.
Additional:
* Liquid Fire and Dual Breath can clear Chen's creeps, and kill his allies before he uses Hand of God.
* Macropyre can quickly clear Chen's creeps and deal intense damage to his allies.

* Illuminate clears Beastmaster's summons and is effective against his push.

* Broodmother and her Spiderlings need to be very careful during the laning stage against Jakiro, as Jakiro can take down Broodmother's Spiderlings, preventing her from pushing.

* Ezalor's Chakra Magic will drain Enigma's mana pool rather quickly and won't let him chase or initiate with Black Hole properly.
* Will-O-Wisp will disable any close caster like Enigma, forcing him have to keep his Eidolons at maximum count and keep a safe distance.
* Illuminate can wipe the pushing Eidolons in a lane with ease, diminishing Enigma's laning presence by a lot.

* Any hero that can nullify effects of Chronosphere: (Omniknight, Keeper of the Light with Aghanim's Scepter during daytime, Winter Wyvern), banishing him or Faceless Void (Outworld Destroyer, Shadow Demon, Earth Spirit with Aghanim's Scepter) or protecting him in other ways (Dazzle, Oracle, Abaddon) can greatly limit Chronosphere's potential.

* Keeper of the Light's AoE blind can keep Sven from landing hits.

* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: Morphling, Naga Siren, Spectre.

* Keeper of the Light can stall pushes with {Ability ID:Illuminate|Keeper of the Light} this makes him strong against pushing heroes: Terrorblade Naga siren Nature's Prophet and Anti-Mage

* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: Morphling, Naga Siren, Spectre.

* Heroes with large magical AoE damage will fare well against Omniknight: Lich, Ancient Apparition, Jakiro, Disruptor

* Melee carries during the laning phase: Sven, Slark

* Heroes with AoE abilities will hit Slark in Shadow Dance: Lina, Jakiro, Underlord, Leshrac, Dark Seer, Earthshaker, Timbersaw, Crystal Maiden

* Heroes with flying vision such as Visage, Beastmaster, Keeper of the Light, or Night Stalker can scout your mines from outside their trigger radius.

* Certain heroes can mess up with Pangolier's positioning and timing (especially if he intends to use Rolling Thunder during combat): Vengeful Spirit, Keeper of the Light, Huskar, Dark Seer

* Heroes that punish mobile heroes: Bloodseeker, Keeper of the Light

* Heroes with damage over time abilities can quickly eat through Gravekeeper's Cloak charges like Huskar, Jakiro and Queen of Pain.

* Keeper of the Light has a blind, which causes Lycan to miss his attacks.

* All of Jakiro's skills are Area of Effect, which can easily affect all Meepos in a targeted area.

* All of Jakiro's active skills can be targeted on an area, which is effective at forcing Templar Assassin to move should she Meld away.
* Many of Jakiro's spells utilize damage-over-time mechanics, which makes it easy to strip away layers of Refraction.

* Jakiro has 3 damage over time spells, 2 of which are from debuffs on Puck (Dual Breath and Liquid Fire) and 1 affecting an entire area (Macropyre), making it easy for him to disable the blink dagger.
* Ice Path is also strong against Puck, as he can cast it towards Puck during Phase Shift, who then gets instantly stunned once Phase Shift ends.