* Jakiro's Macropyre can help him to escape from Sprout and can disrupt Nature's Prophet's jungling.
* Jakiro can disrupt Nature's Prophet's escape attempt with Teleportation with Ice Path.
Additional:
* Jakiro's skill arsenal can ruin Nature's Prophet's gameplay: Dual Breath and Liquid Fire can clear treants from Nature's Call while simultaneously slowing Nature's Prophet, Ice Path can disrupt Nature's Prophet's escaping attempt with Teleportation and Macropyre can not only clear treants from Nature's Call, but also can free Jakiro from Sprout.

* Spirit Breaker can chase Nature's Prophet from anywhere on the map with Charge of Darkness, making it hard for Nature's Prophet to split-push.
* Charge of Darkness and Nether Strike gives vision of Nature's Prophet when he tries to Sprout himself and teleport away.
Additional:
* Charge of Darkness allows Spirit Breaker to catch Nature's Prophet out when he tries to split push.
* Nature's Prophet can't hide in his Sprout against Spirit Breaker, as his Charge of Darkness provides vision on its target.
* Spirit Breaker can easily cancel Nature's Prophet's Teleportation.

* Charge of Darkness provides shared vision over its target, keeping track of heroes who rely on invisibility, mobility, or illusions: Riki, Broodmother, Phantom Lancer

* Riki can easily be caught in an Ice Path and Macropyre combo as he finishes Tricks of the Trade.

* All of Jakiro's active skills can be targeted on an area, which is effective at forcing Templar Assassin to move should she Meld away.
* Many of Jakiro's spells utilize damage-over-time mechanics, which makes it easy to strip away layers of Refraction.

* Because Templar Assassin does not have escape potential in lane, any support hero with roaming potential and a Dust of Appearance can be great at shutting her down early game: Earth Spirit, Spirit Breaker, Tusk, Bounty Hunter, Riki, Warlock.

* Dual Breath slows down Phantom Lancer and his illusions.
* Liquid Fire will not only deal AoE damage but also lowers Phantom Lancer's attack speed.
* An Ice Path and Macropyre combo can easily clear all of Phantom Lancer's illusions.
Additional:
* Jakiro's spells inflict AoE damage, meaning he can take down Phantom Lancer's illusion army very quickly.

* Charge of Darkness provides shared vision over its target, keeping track of heroes who rely on invisibility, mobility, or illusions: Riki, Broodmother, Phantom Lancer

* Jakiro has 3 damage over time spells, 2 of which are from debuffs on Puck (Dual Breath and Liquid Fire) and 1 affecting an entire area (Macropyre), making it easy for him to disable the blink dagger.
* Ice Path is also strong against Puck, as he can cast it towards Puck during Phase Shift, who then gets instantly stunned once Phase Shift ends.

* Bristleback, Centaur Warrunner, Spirit Breaker, Pudge, Huskar: These heroes are too tanky for Puck to burst down. Also, all of them have spells which can deal with and shut Puck down reliably.

* Broodmother and her Spiderlings need to be very careful during the laning stage against Jakiro, as Jakiro can take down Broodmother's Spiderlings, preventing her from pushing.

* Charge of Darkness provides shared vision over its target, keeping track of heroes who rely on invisibility, mobility, or illusions: Riki, Broodmother, Phantom Lancer

* Heroes with long-lasting, undispellable debuffs will pinpoint the true Naga Siren: Spirit Breaker, Bloodseeker.

* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: Morphling, Naga Siren, Spectre.

* Jakiro's abilities deal damage over time, which can disrupt Magnus's attempts to initiate with Blink Dagger and Reverse Polarity.
* Macropyre not only disables Blink Dagger for a considerable duration, but can also destroy Trees, revealing Magnus's cover and position.

* Magic Missile has a considerably long cast time, making it difficult to stop Charge of Darkness with it.
* Other than Magic Missile, Vengeful Spirit has no way of canceling Nether Strike.

* Charge of Darkness allows Spirit Breaker to gank Shadow Fiend in the early game, preventing him from getting Necromastery stacks.
* Nether Strike and Charge of Darkness can be used to prevent Shadow Fiend from casting Requiem of Souls.

* Charge of Darkness can be used to chase down Pangolier if he escapes with Swashbuckle or Rolling Thunder.
* Nether Strike ignores Rolling Thunder's spell immunity, and will still hit Pangolier if he rolls or dashes away.

* Charge of Darkness keeps vision of Monkey King, even when he is in the trees.
* Nether Strike locks onto Monkey King and focuses damage on him during Wukong's Command.

* Charge of Darkness can be used to escape or counter-initiate against a Relocate gank.
* Greater Bash and Nether Strike is devastating due to Io's low armor, and can even knock it away from tethered target.

* With his AoE damage, Jakiro can easily kill Chaos Knight's Phantasm illusions.
* Chaos Knight usually doesn't buy a Black King Bar, making him vulnerable to an Ice Path into Macropyre combination.
Additional:
* Ice Path and Macropyre punish Reality Rift with a long stun and heavy damage across all illusions.

* Jakiro's damage over time force Chen to use Hand of God prematurely, potentially wasting chance to save his allies during teamfight.
* Macropyre can also disrupt Chen's jungling work.
Additional:
* Liquid Fire and Dual Breath can clear Chen's creeps, and kill his allies before he uses Hand of God.
* Macropyre can quickly clear Chen's creeps and deal intense damage to his allies.

* Possibly Clinkz's worst enemy. He has many tools to utterly destroy Clinkz.
* Charge of Darkness can be used on Clinkz if Spirit Breaker's team spots him anywhere. This charge will track his location through Skeleton Walk's invisibility and movement speed bonuses.
* When Spirit Breaker charges onto Clinkz, he can easily use Dust of Appearance to guarantee a reveal on him while stunned.
* All three of Spirit Breaker's spells help him and his team quickly close the gap to Clinkz even at the edge of his attack range or when running away with Skeleton Walk.
* Spirit Breaker's high strength and above average armor makes him able to endure Clinkz's onslaught, meanwhile Clinkz will be heavily threatened if Spirit Breaker procs a Greater Bash.
Additional:
* Once caught with dust, Clinkz could be locked down for a long time by Spirit Breaker and has nowhere to escape.
* Charge of Darkness provides shared vision over its target, showing Clinkz even when he is in Skeleton Walk.

* Spirit Breaker's Charge of Darkness semi-reveals Bounty Hunter, taking away his element of surprise for the duration of the charge. Also, as Charge of Darkness shows Bounty Hunter's position, Spirit Breaker's allies can proceed to gank Bounty Hunter while he is roaming alone.

* All of Jakiro's skills are Area of Effect, which can easily affect all Meepos in a targeted area.

* Heroes who can stun multiple units at once: Dark Willow, Spirit Breaker, Slardar, Invoker, and Tidehunter.

* Heroes with long range abilities are also able to touch Zeus, such as Clockwerk, Kunkka, Puck, Skywrath Mage, Spirit Breaker, Tusk and others.

* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: Morphling, Naga Siren, Spectre.

* Generally, heroes that can close the gap on Drow Ranger to cancel her Marksmanship such as Phantom Assassin, Spirit Breaker, and Tusk are effective at limiting her power and bursting her down.

* Warlock is a very strong hero when positioned correctly, and his long cast range helps him with this. However, some Heroes might disrupt or sneakily pass through your allies and deal with you, preventing you from doing your job. Such heroes include Chaos Knight, Spirit Breaker, Riki, and some others.

* Heroes that rely on invisibility can be tracked with Charge of Darkness opening them to team attacks: Bounty Hunter, Mirana, Riki

* Heroes with mobility/escape mechanisms to dodge Ancient Apparition abilites, or to easily jump on him: Riki, Queen of Pain, Phantom Assassin, Windranger, Bounty Hunter, Spirit Breaker, Night Stalker, Storm Spirit, Juggernaut, etc.

* Spirit Breaker's stuns pierce spell immunity, making him a good choice against heroes that heavily rely on Black King Bar; Huskar

* Heroes with damage over time abilities can quickly eat through Gravekeeper's Cloak charges like Huskar, Jakiro and Queen of Pain.

* Axe is a hero that is very vulnerable against magical nuke damage and disables, Jakiro is perfect against him with all of his spells.
Additional:
* Ice Path neutralizes initiation attempts with Berserker's Call, and its long area of effect discourages follow-ups from Axe's teammates.
* Ice Path serves as a large obstacle to stop Axe from chasing down fleeing stragglers to kill with Culling Blade.
* Jakiro's many damage-per-second skills prevent Axe from initiating with his Blink Dagger.

* Spirit Breaker can charge towards Sniper from anywhere on the map with Charge of Darkness.
* Greater Bash deals magical damage, which can prove dangerous to Sniper and his low health.
* Both previous abilities combined with Nether Strike ensures that Spirit Breaker can easily solo kill Sniper.

* Ice Path allows Jakiro to easily cancel Freezing Field.
* Freezing Field makes Crystal Maiden an easy target for all of his abilities without a Black King Bar.
* With the talent for Macropyre dealing Pure Damage and ignoring spell immunity, Black King Bar becomes nearly useless for Crystal Maiden, as its high damage over time and long duration will force Crystal Maiden to forcefully cancel Freezing Field.

* Tinker relies on his high mobility from Boots of Travel and Blink Dagger to survive. Those items don't help him if Spirit Breaker manages to cast Charge of Darkness on him.
* Spirit Breaker can easily cancel Rearm and Boots of Travel.

* Heroes that rely on escapes to stay alive can be caught and locked down for a long time: Queen of Pain, Phantom Assassin

* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: Morphling, Naga Siren, Spectre.

* Heroes that rely on escapes to stay alive can be caught and locked down for a long time: Queen of Pain, Phantom Assassin

* Heroes with AoE abilities will hit Slark in Shadow Dance: Lina, Jakiro, Underlord, Leshrac, Dark Seer, Earthshaker, Timbersaw, Crystal Maiden

* Both Ice Path and Macropyre are the good setup while Earthshaker after blinking in and stay out of Echo Slam initiation radius.
* Liquid Fire damage over time potentially disable Earthshaker's Blink Dagger.

* Anti-Mage usually relies on Blink to escape, but with vision from Charge of Darkness it is easier to catch him.
* Spirit Breaker could single-handedly lock Anti-Mage down for 4 seconds (or even more with lucky bashes), allowing his teammates to follow up.
* As Anti-Mage is an elusive hero who likes to farm alone, Spirit Breaker could choose to charge whenever Anti-Mage is in sight.

* With Dual Breath, Liquid Fire and Macropyre Jakiro can quickly remove all Living Armor from a target.
* Ice Path allows Jakiro to prevent Treant Protector from using Overgrowth while staying at a safe distance.
* Macropyre destroy trees, which where Treant protector might be hiding