* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: Lich, Necrophos, Oracle, and Leshrac.

Additional:
* Although he can be effective against Anti-Mage in an aggro offlane, Lich has a hard time nuking down Anti-Mage in the midgame due to his Counterspell.
* All of Lich's abilities are also targeted, which makes it much harder to disable Anti-Mage.
* In the lategame, Anti-Mage can easily pick off Lich with Blink, and the high mana cost of Chain Frost along with Lich's large mana pool makes him vulnerable to Mana Void.
* Blink allows Anti-Mage to escape Chain Frost.

* Dark Seer's strength lies in his high-mana cost skills. So Mana Break can be a great nuisance for him, since it can reduce his mana and prevent him from casting his spells.
* Mana Void can deal a lot of damage if Dark Seer spent a lot of mana on his abilities.

* Weaver doesn't care much about Lich's slows thanks to Shukuchi.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Shukuchi so that it stops bouncing around.
* Unless Lich bursts Weaver immediately, Lich has no hard disables or silences to prevent him from using Time Lapse.

* Dark Seer's only disable is Vacuum. Though he starts off with high armor and health, he'll eventually have a hard time dealing with high mobility heroes such as Weaver or Queen of Pain.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

Additional:
* Rupture can deal a lot of damage to either a surged Dark Seer or his allies and prevent the target from getting into position.

* If Thirst activated, Lich doesn't slow Bloodseeker.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Thirst or forces Bloodseeker to build Blade Mail can cause Lich to accidentally kill himself with Chain Frost.
* Even Lich builds Glimmer Cape or Force Staff are suicidal item against Bloodseeker when he is affected by Rupture.

* Queen of Pain can easily escape Chain Frost thanks to Blink.
* His low survivability makes an easy kill for Shadow Strike, Scream of Pain & Sonic Wave.

* Dark Seer's only disable is Vacuum. Though he starts off with high armor and health, he'll eventually have a hard time dealing with high mobility heroes such as Weaver or Queen of Pain.

* Lycan doesn't care much about Lich's slows thanks to Shapeshift.
* Chain Frost can bounce to the wolves that Lycan summons.
Additional:
* Lich possesses a lot of slows, which Lycan doesn't care about when he Shapeshifts.
* Lich has no in-built escape, which makes him a good target for Lycan.

* Lich is going to have a hard time nuking Huskar because of his high health regeneration from Berserker's Blood.
* Lich is a squishy support without an escape mechanism, making Lich an easy kill thanks to Life Break and Burning Spear.
* Once Huskar has Armlet of Mordiggian, even a maxed out Frost Blast will struggle to finish Huskar off.

* Fortune's End dispels Ion Shell and Surge, making any gank attempt on Dark Seer in the laning phase likely to succeed.
* Fate's Edict prevents all magical damage that comes from Dark Seer's abilities.
* Fortune's End dispels Ion Shell on creeps, which Dark Seer relies on to farm and zone.
Additional:
* Fortune's End can dispel Ion Shell, which cripples Dark Seer economy since it's his most efficient tool for farming.
* Fortune's End can dispel Surge, effectively slowing his movement speed making him vulnerable to ganks or skirmishes.

* Lich does not pose a big threat to Zeus in teamfights, as his spells don't have great cast range and Zeus should be too far back for a Chain Frost to bounce among him and his allies.
* Lich has a low health pool, allowing Zeus to burst him down quickly.

* A Sniper who is somewhat competent at positioning is hardly going to be affected by any of Dark Seer's spells thanks to Take Aim.
* However, an illusion of Sniper made with Wall of Replica is extremely powerful, and hard to deal with.

* Flame Guard makes Dark Seer not deal any damage with his skills to Ember Spirit.

* X Marks the Spot prevents Dark Seer or his allies from escaping with Surge.

* The constant dispel from Demonic Purge will make any attempt to save the victim or himself by Surge become futile. For what it's worth, Demonic Purge will also dispel Ion Shell.

* Phantom Assassin can easily escape Lich's slows with Phantom Strike.
* Phantom Assassin's Coup De Grace can be used to burst down the squishy Lich.

* Chain Frost can bounce to the treants that Nature's Prophet summons.
* Nature's Prophet's Sprout can be used to isolate and burst down the squishy Lich.
Additional:
* His treants can prevent Chain Frost from jumping to Nature's Prophet or his allies.

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Heroes with low health will die easily during Duels, and can be farmed for damage in the early game: Crystal Maiden, Lich, Techies, Rubick

* Heroes with low health: Lich, Crystal Maiden, Lion.

* In general, melee heroes without blink mechanisms or spell immunity will have a hard time positioning against Pit of Malice: Sven, Tiny, Wraith King, Dragon Knight, Meepo, Doom, Bounty Hunter, Dark Seer, Undying, Alchemist, Legion Commander.

* Dark Seer relies on Surge for most of his mobility, so he's not very vulnerable to slows, but much more to root effects and walls or pseudo-walls such as Disruptor's Kinetic Field or Slark's Pounce.

* Abilities that deal low damage with high amounts of instances are irrelevant against Pudge during Flesh Heap's active: Gyrocopter's Rocket Barrage and Dark Seer's Ion Shell are just a couple examples.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes who lack burst damage will have a hard time against Mars: Phantom Lancer, Nature's Prophet, Lich.

* In general, heroes who are melee with no way to fight back can be very easily poked by Monkey King to gain his Jingu Mastery stacks: Dark Seer, Riki, Rubick.