* Thirst allows Bloodseeker to see where Io relocated to, should either Io or the tethered hero have low health.
* Rupture forces Io to stay in place, preventing it from using the Tether bonus movement speed to escape.

* If Thirst activated, Lich doesn't slow Bloodseeker.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Thirst or forces Bloodseeker to build Blade Mail can cause Lich to accidentally kill himself with Chain Frost.
* Even Lich builds Glimmer Cape or Force Staff are suicidal item against Bloodseeker when he is affected by Rupture.

* Phantom Assassin can easily escape Lich's slows with Phantom Strike.
* Phantom Assassin's Coup De Grace can be used to burst down the squishy Lich.

* Phantom Strike allows Phantom Assassin jump directly to Io.
* Coup de Grace can make a short work of Io's low health and armor.

* Lycan doesn't care much about Lich's slows thanks to Shapeshift.
* Chain Frost can bounce to the wolves that Lycan summons.
Additional:
* Lich possesses a lot of slows, which Lycan doesn't care about when he Shapeshifts.
* Lich has no in-built escape, which makes him a good target for Lycan.

* Heroes with low armor and little mobility, like Huskar, Io, etc. will also have an unfortunate fate.

* Chain Frost can bounce to the Spiderlings that Broodmother spawns.

* Lightning Storm will usually hit both Io and his Tethered target since both will be close enough for the lightning to jump. It can then be followed up by Split Earth.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to Io and his Tethered target.
Additional:
* Io is a hero who needs to be close to it's tethered target to make it effective, and that's where Leshrac gets the advantage thanks to many of his area-of-effect abilities.
* Lightning Storm will usually hit both Io and its tethered target since both will be close enough for the lightning to jump.
* Diabolic Edict and Pulse Nova hit all units near Leshrac, meaning he can do colossal damage to both, Io and its tethered target.

* Burning Barrage and Searing Arrows allow Clinkz to quickly kill Io due to its low armor.
* Clinkz iz a hero that very often goes for Orchid Malevolence, and its upgrade Bloodthorn. And if Clinkz has it, he will be able to silence Io and prevent him from escaping wit either Tether or Relocate.

* Lich is going to have a hard time nuking Huskar because of his high health regeneration from Berserker's Blood.
* Lich is a squishy support without an escape mechanism, making Lich an easy kill thanks to Life Break and Burning Spear.
* Once Huskar has Armlet of Mordiggian, even a maxed out Frost Blast will struggle to finish Huskar off.

* Living Armor can be used to save a hero from a Relocate gank.

* Disruptor can always Glimpse back Io or his target after he Relocated nearby.
* Even better, thanks to the indicator on the ground, you can even preemptively drop Static Storm and Kinetic Field on the spot they will relocate to.
* Thunder Strike and Glimpse are also good tools to bring back an Io that Tethered away in the fog of war.
Additional:
* Glimpse directly negates Relocate.

* Lich does not pose a big threat to Zeus in teamfights, as his spells don't have great cast range and Zeus should be too far back for a Chain Frost to bounce among him and his allies.
* Lich has a low health pool, allowing Zeus to burst him down quickly.

* Lucent Beam can be used to cancel both, Tether and Relocate.
* Like with Leshrac's Diabolic Edict, Lightning Storm and Pulse Nova abilities. Luna's Moon Glaives and Eclipse abilities can make short work of Io and its tethered ally, particularly when upgraded with Aghanim's Scepter.

* Ice Blast prevents Io from healing an ally with Tether and prevents healing from Overcharge
* Io is a common Mekansm builder which is useless if he is affected by Ice Blast.
Additional:
* Ice Blast prevents Io from healing the target.

* Weaver doesn't care much about Lich's slows thanks to Shukuchi.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Shukuchi so that it stops bouncing around.
* Unless Lich bursts Weaver immediately, Lich has no hard disables or silences to prevent him from using Time Lapse.

* Cold Embrace can render the extra attack speed from Overcharge meaningless.
* Splinter Blast and Winter's Curse are very affective against Io, as it has to stay close to its tethered hero.

* Charge of Darkness can be used to escape or counter-initiate against a Relocate gank.
* Greater Bash and Nether Strike is devastating due to Io's low armor, and can even knock it away from tethered target.

* Fireblast is a good tool to interrupt Io during its escapes through Tether.
* Ignite can be one of the few spells with enough total damage to out-trade the sustained healing Io provides for its fellow laner.
* However, picking other supports that focus less on the laning phase is generally a better choice against Io.

* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.
Additional:
* Batrider's Flaming Lasso can be used to cancel Io's attempts to escape with Relocate and drag him away from his Tethered target. And since Io doesn't like buying Linken's Sphere, he will be always vulnerable to Batrider's initiations.
* Io's tendency to stick close to it's Tethered target can make Io and it's target vulnerable to Batrider's harrasing.
* Aghanim's Scepter upgraded Flaming Lasso allows Batrider to catch and drag two heroes at once, not just one. Which can potentially turn Io's Tether against him.

* Queen of Pain can easily escape Chain Frost thanks to Blink.
* His low survivability makes an easy kill for Shadow Strike, Scream of Pain & Sonic Wave.

* Grimstroke can catch Io and his ally easily with SoulBind as Io has a tendency to tether himself with an ally frequently.
* Io is highly vulnerable to disables. Hence, Grimstroke's Phantom's Embrace is a great ability to hinder Io's potential.
Additional:
* Soulbind can target both Io and its Tethered ally, allowing Grimstroke and his team to target both with single target spells. Should Io try to Relocate, Phantom's Embrace can stop its channel to prevent escape.

* Quill Spray is very effective against Io, as it has very low armor and has to stay close to the fight to not break its Tether.

* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper

* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: Lich, Necrophos, Oracle, and Leshrac.

Additional:
* Although he can be effective against Anti-Mage in an aggro offlane, Lich has a hard time nuking down Anti-Mage in the midgame due to his Counterspell.
* All of Lich's abilities are also targeted, which makes it much harder to disable Anti-Mage.
* In the lategame, Anti-Mage can easily pick off Lich with Blink, and the high mana cost of Chain Frost along with Lich's large mana pool makes him vulnerable to Mana Void.
* Blink allows Anti-Mage to escape Chain Frost.

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Heroes with low health will die easily during Duels, and can be farmed for damage in the early game: Crystal Maiden, Lich, Techies, Rubick

* Duel is very effective against Io due to its low health and armor.

* Heroes with low health: Lich, Crystal Maiden, Lion.

* Fragile heroes: Bounty Hunter has decent nuking capabilities with Shiruken Toss and Jinada thus making fragile heroes easy picks for ganking. Few examples of such heroes are:Crystal Maiden, Pugna, Skywrath Mage, Io, Witch Doctor, etc.

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* The haste provided by Dark Seer's Surge or a {Rune:Haste} renders your slows ineffective.

* Heroes that depend on disrupting fights with ability combos or big ultimate abilities are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Heroes that are hard to gank: Axe, Death Prophet, Phantom Lancer

* Heroes with powerful nuke can waste their precious abilites on her Refraction during a ganking attempt or chaos combat: Lich, Lina, Sniper, Outworld Destroyer Zeus

* Heroes who lack burst damage will have a hard time against Mars: Phantom Lancer, Nature's Prophet, Lich.

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Squishy heroes (Io, Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.

* Take Aim and Assassinate allow Sniper to reach Io even if it stays in the backline.

* Chain Frost can bounce to the treants that Nature's Prophet summons.
* Nature's Prophet's Sprout can be used to isolate and burst down the squishy Lich.
Additional:
* His treants can prevent Chain Frost from jumping to Nature's Prophet or his allies.