* Her Spiderlings can harass Luna in lane heavily, as Luna has no AoE abilities to clear Spiderlings.
* Broodmother can knock down towers in the early game quickly, and limit Luna's farming space.

* Chain Frost can bounce to the Spiderlings that Broodmother spawns.

* His highly damaging nuke spells with low cooldowns is not something Luna wants to go against.
* Thundergod's Wrath can be used before a fight to harm Luna before she activates her Black King Bar, reducing her survivability for that fight.

* Lich does not pose a big threat to Zeus in teamfights, as his spells don't have great cast range and Zeus should be too far back for a Chain Frost to bounce among him and his allies.
* Lich has a low health pool, allowing Zeus to burst him down quickly.

* All his abilities is decent in Rubick's kit:
* Frost Blast allows Rubick to harass and constantly slow down enemies.
* Frost Shield increases Rubick's as well as his allies' and tower's survivability to physical attacks.
* A well-timed Chain Frost can be devastating to the enemy team.

* Lucent Beam is a solid magic nuke.
* Eclipse can cause massive damage if cast in the right time.
* Rubick has a good chance to steal Eclipse for Luna has only two cast abilities.
* Aghanim's Scepter greatly increased the effectiveness of the ability, including more damage as well as longer cast range. In addition, it allows him to cast it on another hero so Rubick doesn't have to get close to the enemy team in teamfights.

* Escape-type carries: Slark, Storm Spirit, Weaver.

* Weaver doesn't care much about Lich's slows thanks to Shukuchi.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Shukuchi so that it stops bouncing around.
* Unless Lich bursts Weaver immediately, Lich has no hard disables or silences to prevent him from using Time Lapse.

* Phantom Assassin can easily escape Lich's slows with Phantom Strike.
* Phantom Assassin's Coup De Grace can be used to burst down the squishy Lich.

* All assassin-type carries in a one against one situation: Meepo, Phantom Assassin, Riki, Ursa.

* Heroes who lack burst damage will have a hard time against Mars: Phantom Lancer, Nature's Prophet, Lich.

* Heroes who cannot fight back during Arena of Blood in the early and mid game: Abaddon, Anti-Mage, Broodmother, Drow Ranger, Luna, Sniper, Troll Warlord, Weaver, Clinkz.

* Lycan doesn't care much about Lich's slows thanks to Shapeshift.
* Chain Frost can bounce to the wolves that Lycan summons.
Additional:
* Lich possesses a lot of slows, which Lycan doesn't care about when he Shapeshifts.
* Lich has no in-built escape, which makes him a good target for Lycan.

* Because of her low range, Luna cannot easily destroy Healing Ward.
* Both Blade Fury and Omnislash are direct counters to Eclipse, offering Juggernaut spell immunity.

* If Thirst activated, Lich doesn't slow Bloodseeker.
* If he sees Chain Frost is targeting him, he can easily isolate himself with Thirst or forces Bloodseeker to build Blade Mail can cause Lich to accidentally kill himself with Chain Frost.
* Even Lich builds Glimmer Cape or Force Staff are suicidal item against Bloodseeker when he is affected by Rupture.

* Phantom Lancer creates many illusions to tank Luna's Eclipse.
* Doppelganger can be used to dodge a number of Lucent Beams during Eclipse.
* Phantom Lancer can chase Luna effectively regardless of her high movement speed thanks to Phantom Rush and Spirit Lance.
* Although her Moon Glaives kill his illusions quickly, Luna's low health pool is easily exploited by the sheer damage output from his illusions.

* Luna has low HP, low range and often stalks through jungle. She cannot properly disarm Proximity Mines and could fall victim to their traps.
* Of course, if Luna happens to catch Techies off-guard, they won't be able to survive for long against Eclipse, Lucent Beam, and right-clicks.

* Sniper usually sits at the back and it's hard for Luna to get close to him to attack.
* Due to Sniper's Shrapnel and his long range, Luna has a hard time taking high ground despite her Moon Glaives being fantastic for taking Barracks and buildings.

* Flesh Heap's magic resistance allows him to survive Eclipse, and Meat Hook and Dismember can disable Luna through her Black King Bar.
* However, Lucent Beam can still cancel Dismember from a safe distance, even if its damage is going to be reduced.
Additional:
* Pudge can easily survive Luna's Lucent Beam and Eclipse, and his Meat Hook and Dismember can pierce Black King Bar, making Luna one of the perfect victims for ganking.
* However, Lucent Beam can cancel Dismember, as Pudge often doesn't build Black King Bar, and if she is farmed enough, Luna might be able to fight back against Pudge.

* Lina has very high magic burst damage to use against the low-health-pool Luna. Laguna Blade can also be upgraded with Aghanim's Scepter to bypass Luna's Black King Bar, making Lina even more of a threat.

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.

* Heroes with low health: Lich, Crystal Maiden, Lion.

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.

* A couple of nukers and disablers on the same lane can finish a squishy Luna efficiently despite a teammate's assistance: Sven + Shadow Shaman.

* A couple of long-range heroes with excellent laning like Mirana, Lina, Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

* Vulnerable spellcasters with no escape mechanisms are easy targets for Huskar: Lich, Crystal Maiden, Silencer, Keeper of the Light, Venomancer, etc.

Additional:
* Lich is going to have a hard time nuking Huskar because of his high health regeneration from Berserker's Blood.
* Lich is a squishy support without an escape mechanism, making Lich an easy kill thanks to Life Break and Burning Spear.
* Once Huskar has Armlet of Mordiggian, even a maxed out Frost Blast will struggle to finish Huskar off.

* All assassin-type carries in a one against one situation: Meepo, Phantom Assassin, Riki, Ursa.

* The haste provided by Dark Seer's Surge or a {Rune:Haste} renders your slows ineffective.

* A couple of long-range heroes with excellent laning like Mirana, Lina, Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.

* Heroes with powerful nuke can waste their precious abilites on her Refraction during a ganking attempt or chaos combat: Lich, Lina, Sniper, Outworld Destroyer Zeus

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.

* Escape-type carries: Slark, Storm Spirit, Weaver.

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

Additional:
* Demonic Purge takes off Luna's superior mobility, removing the need for chasing her and allowing your team to reposition in team fights or escape when at low HP. If Shadow Demon has Aghanim's Sceptre it will also take away glaive bounces and extra damage from Luna's passive.
* Luna's illusions created by Disruption are very valuable with their Moon Glaives. These will effectively counter her pushing attempts and are painfully effective in team fights.
* Disruption can be used to save an ally from Eclipse.

* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: Lich, Necrophos, Oracle, and Leshrac.

Additional:
* Although he can be effective against Anti-Mage in an aggro offlane, Lich has a hard time nuking down Anti-Mage in the midgame due to his Counterspell.
* All of Lich's abilities are also targeted, which makes it much harder to disable Anti-Mage.
* In the lategame, Anti-Mage can easily pick off Lich with Blink, and the high mana cost of Chain Frost along with Lich's large mana pool makes him vulnerable to Mana Void.
* Blink allows Anti-Mage to escape Chain Frost.

* Hard-hitters who relies mostly on raw stats or good passive and therefore make a perfect target for Dark Portrait: Naga Siren, Faceless Void, Terrorblade, Luna, Anti-Mage

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

* His treants can prevent Chain Frost from jumping to Nature's Prophet or his allies.
Additional:
* Chain Frost can bounce to the treants that Nature's Prophet summons.
* Nature's Prophet's Sprout can be used to isolate and burst down the squishy Lich.

* A couple of nukers and disablers on the same lane can finish a squishy Luna efficiently despite a teammate's assistance: Sven + Shadow Shaman.

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.

* Shadow Dance prevents Luna from damaging Slark, and together with Shadow Blade he can kite her or escape.
* Luna has no way to escape from Pounce's leash.
Additional:
* Luna's lack of mobility and escape abilities makes her easily gankable by Slark.
* Shadow Dance will avoid all the damage from Eclipse.
* For the same reasons, Slark is a good ally for Luna when they are in the same team.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Heroes that wish to disrupt fights with spell combos or big ultimates are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.