* Shadow Dance allows Slark to attack Lifestealer for its duration without any way for Lifestealer to fight back.
* Slark commonly buys a Silver Edge, which can break Lifestealer's Feast, severely diminishing his damage output and lifesteal.

* Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* Dark Pact also allows him to just purge off the stun if timed correctly.
* Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.

* Ice Blast prevents Lifestealer from lifestealing and healing with Infest in fights.

* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.
Additional:
* Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.

* Alchemist's reliance on fast attack speed to do single-target damage makes him vulnerable to Static Link. It also goes through Black King Bar, which is a standard item on Alchemist.
* Eye of the Storm is great against high health strength heroes as it reduces their survivability to physical damage.
* Razor has early lane push to counter Acid Spray.

* Static Link cannot be dispelled by Rage or Infest, so Razor will be able to track Lifestealer down during an attempted escape.
* Storm Surge makes it hard for Lifestealer to catch Razor.
* Static Link can stop Open Wounds from getting any additional lifesteal, but keep in mind Lifestealer can still utilize Feast.
* Eye of the Storm penetrates the spell immunity of Rage.

* Untouchable greatly reduces Chemical Rage's attack speed advantage.

* Since Untouchable pierces Spell Immunity, Lifestealer cannot burst her down even with Rage; meaning she can heal herself back to full HP.

* Clinkz can use Burning Army in teamfights which will cause a problem for Alchemist.

* Clinkz relies heavily on the physical damage provided by Searing Arrows, which completely overrides the capabilities of Rage.
* Clinkz, by nature will often build items that Lifestealer hates dealing with such as physical damage items like Desolator or Daedalus and instant silences or hexes from Bloodthorn and Scythe of Vyse.

* Corrosive Haze followed by Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* Bash of the Deep will deal lots of damage during the laning phase.

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar {Hero ID:Terrorblade}

* Alchemist is a well-known Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate Unstable Concoction.

* Melee carries such as Sven, Ursa or Lifestealer can be slowed and easily kited with Demonic Purge.

* Lifestealer cannot use Rage, Infest or Open Wounds when affected by Smoke Cloud's silence, and Feast cannot heal him effectively because of the blind, leaving him very weak both offensively and defensively.
* Infest ganks are harder when the enemy team has a Riki, as there are often only four heroes on the map that you can initiate on.

* Lifestealer can't fight Ursa in any stage of the game because of his high physical damage with Fury Swipes and Overpower.
Additional:
* Lifestealer's Feast will most likely not out-heal the damage from Fury Swipes and Overpower in the early to mid game.

* Heroes without an escape mechanism: Shadow Fiend, Alchemist

Additional:
* Chemical Rage will rarely save Alchemist against Ursa's Fury Swipes.
* Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.

* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.

* Although Lifestealer can avoid Eclipse with Rage and Infest, Luna's physical damage can be enough to deal with him.
* Manta Style is a common pick on Luna, which can help her dispel slows from Ghoul Frenzy and Open Wounds. In addition, Lifestealer is not good against illusions created by Manta Style.
Additional:
* Although Lifestealer can avoid Eclipse with Rage and Infest, Luna's physical damage from Moon Glaives and Lunar Blessing can be enough to deal with him.
* Manta Style is a common pick on Luna, which can help her dispel slows from Ghoul Frenzy and Open Wounds. In addition, Lifestealer is not good against illusions created by Manta Style.

* Though The Swarm can be blocked by Rage, it can be used to lower Lifestealer's already low armor, making him even more vulnerable to physical damage while the Rage is on cooldown.
* Lifestealer has no strong disables on his own and thus he cannot catch up with nor escape from Weaver when he uses Shukuchi.
* Weaver is a hero who relies mainly on direct attacks in order to deal damage, which means Lifestealer's Rage will have little effect against him.
Additional:
* Open Wounds's slow is ignored by Shukuchi.
* Lifestealer has no other lockdown and relies on being on top of enemies; Weaver can kite him with ease.

* Primal Roar pierces Rage and can disable Lifestealer in fights.

* Chronosphere provides excellent lockdown against Rage.
* Faceless Void's Time Lock stops Lifestealer from getting health regeneration from auto-attacks

* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.

* Windrun and Focus Fire can easily allow Windranger to kite Lifestealer and do good amounts of damage in the process.

* Chaos Knight's Level 20 Talent: Reality Rift Pierces Spell Immunity allows for quick bursting down of Lifestealer during his Rage.
* Lifestealer has no way of dealing with Chaos Knight's illusions.
Additional:
* Level 20 talent allows Reality Rift to bypass spell immunity provided by Rage, thus negating the advantage Lifestealer has in his kit.
* The fact that Lifestealer lacks wave clearing and reliable lockdown makes it difficult to fight Chaos Knight's illusions.
* Feast is largely negated by Chaos Knight's high burst damage from Chaos Strike.

* Lifestealer is a great target for Morphling to use Morph, as he can use Rage to gain spell immunity and a movement speed boost.
* Morphling's high armor also makes Lifestealer's attacks do less damage.

* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces Rage, wasting its cooldown and making Lifestealer unable to fight.

* Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.

* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* Desolator, Sange and Yasha or Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.

* Heroes that lack burst damage will have a difficult time taking down Monkey King, and fare badly against Jingu Mastery: Legion Commander, Lifestealer, Weaver, Wraith King

* Heroes with summons: Lycan, Broodmother, Visage.

* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include Alchemist, Crystal Maiden and Zeus.

* Heroes with summons: Lycan, Broodmother, Visage.

* Heroes with illusions: Chaos Knight, Naga Siren, Phantom Lancer

* Heroes with escape abilities : Anti-Mage Dark Seer Slark Storm Spirit Windranger Weaver can kite Lifestealer due to him having no lockdown

* With the exception of Magic Missile (unless the player takes the Level 25 Talent "Magic Missile Pierces Spell Immunity"), all of Vengeful Spirit's spells ignore Spell Immunity. This also makes her good against heroes with built-in Spell Immunity like Lifestealer or Juggernaut or heroes that tend to pick up Black King Bar, like Sven.

* If there is nothing to Infest to Juggernaut's {AD:Omnislash|Juggernaut} will Demolish him

* Chaotic Offering can stop heroes who like to use spell immunity and teleport scrolls to safely farm during the early to mid game, since it stuns and also goes through spell immunity. Notable examples: Juggernaut, Lifestealer.

* Heroes with escape abilities : Anti-Mage Dark Seer Slark Storm Spirit Windranger Weaver can kite Lifestealer due to him having no lockdown

* Many physical-only single-target heroes like Lifestealer, Sven, Wraith King, Phantom Assassin, Templar Assassin can have their damage mitigated by Cold Embrace.

* Heroes with spell immunity can still be disabled by Fiend's Grip: Juggernaut, Lifestealer, Pangolier.

Additional:
* Fiend's Grip can disable Lifestealer through Rage.

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar {Hero ID:Terrorblade}

* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Heroes who can delivers a big chunk of damage in few hits will find themselves struggle against Templar Assassin's Refraction: Sven, Phantom Assassin, Ursa, Wraith King, Lifestealer

* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like Sven, Lifestealer, Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.

* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like Sven, Lifestealer, Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.

* Heroes with escape abilities : Anti-Mage Dark Seer Slark Storm Spirit Windranger Weaver can kite Lifestealer due to him having no lockdown

* Pugna's Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.

* Heroes that rely on physical damage are ineffective against Dragon Knight due to his high armor: Phantom Assassin,Bloodseeker, Lifestealer, Troll Warlord, Sven

* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, Lifestealer etc.

* Sprout is good for trapping melee carries with no escape abilities: Sven, Alchemist, Lifestealer etc.

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar {Hero ID:Terrorblade}

* Lacking any stun and being heavily dependent on his physical attacks and spell immunity, Lifestealer has no way to stop Black Hole , assuming he does not initiate Enigma first with Abyssal Blade.
* Enigma's Black Hole and Midnight Pulse damage can pierce through Lifestealer's Rage.
* However, if Lifestealer manages to get Aghanim's Scepter and combines it with Abyssal Blade, he will be able to disable Enigma's Black Hole inside him with Infest and he will be able to help his allies recover themselves from Enigma's initiation with Open Wounds if Lifestealer gets Aghanim's Shard.

* Aside from his ultimate, Lifestealer has no AoE abilities to deal with Phantom Lancer's illusions, nor does he have the mobility to escape Phantom Rush.
* Doppelganger dispels Open Wounds.
* Phantom Lancer usually builds Diffusal Blade, which a problem for a low already mana hero like Lifestealer.
Additional:
* Lifestealer has no way of dealing with Phantom Lancer's illusions.
* Phantom Lancer also commonly builds Diffusal Blade, which poses a large problem to Lifestealer and his low mana pool.

* Troll Warlord can manfight lifestealer at any stage of the game thanks to his high attack speed and miss chance from Whirling Axes (Melee).
* Whirling Axes (Melee) has lower cool down, Troll can liberally apply it on Lifestealer, even if the later try to dispel it with Rage.
* Berserker's Rage pierces through spell immunity, allows troll to hold lifestealer in place for extended period.
* Feast deals minimal damage to Troll Warlord, since Troll will build mostly for damage and survivability rather than tankiness in general.
Additional:
* The passive armor provided by Berserker's Rage makes Troll Warlord resilient to Feast in early game.
* The 60% miss chance given by Whirling Axes (Melee) is useful when Rage is not active.
* Battle Trance can purge Open Wounds, negating a large amount of Lifestealer's sustain in fights.

* Terrorblade's illusions and ranged attacks in Metamorphosis can burst down Lifestealer very quickly.
* Terrorblade has low health due to his low strength gain, which reduces Feast's lifesteal and damage.
* Terrorblade's high armor makes Lifestealer's Desolator useless.
* Because Lifestealer usually walks around with high HP in fights due to his lifesteal (and sometimes Armlet of Mordiggian), he is a great target for Terrorblade's Sunder.
Additional:
* Reflection's illusion carries Feast as well, making it useful to use against him.
* Feast cannot compensate for Terrorblade's incoming high damage, due to his low Strength gain.
* Open Wounds (requires Aghanim's Shard) is a lot harder to land on the real Terrorblade if he has illusions around him. But remember that Terrorblade's illusions from Conjure Image have different colors than other illusions which can be seen even by enemy team, and that can make it easy for Lifestealer to detect real Terrorblade unless Terrorblade buys Manta Style.
* Lifestealer relies on right-clicks to deal damage, and Terrorblade's high armor can reduce his damage significantly.