* Reality Rift lets Chaos Knight bypass the Spirit Bear and jump onto Lone Druid.
* The Spirit Bear's lack of scaling means it dies quickly to Chaos Knight during the late-game.

* Chaos Knight's Level 20 Talent: Reality Rift Pierces Spell Immunity allows for quick bursting down of Lifestealer during his Rage.
* Phantasm dispels Open Wounds.
* Lifestealer has no way of dealing with Chaos Knight's illusions.

* Lone Druid and his Spirit Bear lack mobility, and are easy overwhelmed after being slowed by Diffusal Blade.
* Savage Roar is useless since Phantom Lancer can return to fight him again with his Phantom Rush.

* Aside from his ultimate, Lifestealer has no AoE abilities to deal with Phantom Lancer's illusions, nor does he have the mobility to escape Phantom Rush.
* Doppelganger dispels Open Wounds.
* Phantom Lancer usually builds Diffusal Blade, which a problem for a low already mana hero like Lifestealer.
Additional:
* Doppelganger dispels Open Wounds.
* Lifestealer has no way of dealing with Phantom Lancer's illusions.
* Phantom Lancer also commonly builds Diffusal Blade, which poses a large problem to Lifestealer and his low mana pool.

* Lifestealer is a great target for Morphling to use Morph, as he can use Rage to gain spell immunity and a movement speed boost.
* Morphling's high armor also makes Lifestealer's attacks do less damage.

* Morphling can ignore Spirit Bear and shorten the distance to Lone Druid with Waveform.
* Morphling can use his nukes to burst Lone Druid down, provided he is not rooted/disabled by Spirit Bear beforehand.

* Heroes with illusions: Chaos Knight, Naga Siren, Phantom Lancer

* Unless Lone Druid purchases a Black King Bar for his Spirit Bear, Ensnare will easily kite the Bear.
* Song of the Siren allows Naga Siren and her team to completely bypass the Spirit Bear and hunt for the Druid himself when starting a fight.
* Lone Druid's lack of innate AoE capabilities mean that Naga Siren's illusions have no problem against him.

* Many physical-only single-target heroes like Lifestealer, Sven, Wraith King, Phantom Assassin etc.

* Cold Embrace can protect allies from Lone Druid and the Spirit bear, who mainly deal physical damage
* Winter's Curse can turn Lone Druid and the Spirit Bear against his teammates.

* Lifestealer cannot use Rage, Infest or Open Wounds when affected by Smoke Cloud's silence, and Feast cannot heal him effectively because of the blind, leaving him very weak both offensively and defensively.
* Infest ganks are harder when the enemy team has a Riki, as there are often only four heroes on the map that you can initiate on.

* Riki: Smoke Screen can prevent Lone Druid from using True Form and Savage Roar, additionally it cause the spirit bear to miss on attacks which reduce the chances of getting rooted from it, with diffusal Blade, he can keep Lone Druid or the Spirit Bear inside the Smoke.

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar

* Lone Druid and The Spirit Bear cannot burst down Bristleback due to Bristleback
* Bristleback can easily run to Lone Druid without any hesitation, with Viscous Nasal Goo to reduce armor and slow the Spirit Bear or Lone Druid and Quill Spray can deal damage to both Lone Druid and the Spirit Bear at the same time

* Lacking any stun and being heavily dependent on his physical attacks and spell immunity, Lifestealer has no way to stop Black Hole, assuming he does not initiate Enigma first with Abyssal Blade.
* Enigma's abilities, with exception of Malefice, can pierce spell immunity and deal pure damage (and percentage-based damage in Midnight Pulse's case), putting Lifestealer in potentially adverse situations.

* Static Link cannot be dispelled by Rage or Infest, so Razor will be able to track Lifestealer down during an attempted escape.
* Storm Surge makes it hard for Lifestealer to catch Razor.
* Static Link can stop Open Wounds from getting any additional lifesteal, but keep in mind Lifestealer can still utilize Feast.
* Eye of the Storm penetrates the spell immunity of Rage.

* Clinkz relies heavily on the physical damage provided by Searing Arrows, which completely overrides the capabilities of Rage.
* Open Wounds is near worthless against Clinkz as he can instantly run away with Skeleton Walk before returning later on.
* Clinkz, by nature will often build items that Lifestealer hates dealing with such as physical damage items like Desolator or Daedalus and instant silences or hexes from Bloodthorn and Scythe of Vyse.

* Primal Roar pierces Rage and can disable Lifestealer in fights.

* The passive armor provided by Berserker's Rage makes Troll Warlord resilient to Feast in early game.
* The 60% miss chance given by Whirling Axes (Melee) is useful when Rage is not active.
* Battle Trance can purge Open Wounds, negating a large amount of Lifestealer's sustain in fights.

* Lifestealer's Feast will most likely not out-heal the damage from Fury Swipes and Overpower in the early to mid game.
Additional:
* Lifestealer can't fight Ursa in any stage of the game because of his high physical damage with Fury Swipes and Overpower.

* Lone Druid during True Form and the Spirit bear has high HP, meaning Spirit Siphon can be very effective against them since they deal percentage damage

* Lifestealer relies on Open Wounds to slow enemies to burst them, but Windranger can use Windrun to escape through Open Wounds duration.
* Windrun and Focus Fire can easily allow Windranger to kite Lifestealer and do good amounts of damage in the process.

* The Swarm is not blocked by Rage and can be used to lower Lifestealer's already low armor, making him even more vulnerable to physical damage.
* Shukuchi renders the Open Wounds slow pretty useless, as it gives Weaver maximum movement speed, allowing him to escape or kite around Lifestealer.
* However, Weaver is a common Linken's Sphere carrier to block and Time Lapse to dispel Open Wounds.
Additional:
* Open Wounds's slow is ignored by Shukuchi.
* Lifestealer has no other lockdown and relies on being on top of enemies; Weaver can kite him with ease.

* Ghost Shroud can be use both offensively to slow Lone Druid or Defensively to prevent Lone Druid and The Spirit Bear from attacking him.
* Heartstopper aura burns the Spirit bear High HP over time. Additionally, it can deal decent damage to Lone Druid during his True Form.

* Brewmaster can make the Spirit Bear a much smaller threat with Cinder Brew.
* Cyclone removes the bear from a fight so that his team can easily focus on the hero.
* While most heroes would be worn down by a Spirit Bear Radiance in the time it takes to kill Lone Druid, Brewmaster is protected in Primal Split.

* Chain Frost will bounce between Lone Druid and his bear, forcing them to separate or suffer high amounts of damage.
Additional:
* Chain Frost can deliver high amounts of damage to Lone itself and his bear if they do not separate fast from each other.

* Dark Pact can be used to remove Open Wounds.
* Shadow Dance allows Slark to attack Lifestealer for its duration without any way for Lifestealer to fight back.
* Slark commonly buys a Silver Edge, which can break Lifestealer's Feast, severely diminishing his damage output and lifesteal.

* Grimstroke's Soulbind will always reliably connect onto both of them if they are close together.

* Paralyzing Cask is likely to bounce between him and his bear every single time.
* Lone Druid's lack of mobility makes him vulnerable to Death Ward and Maledict.

* Terrorblade's illusions and ranged attacks in Metamorphosis can burst down Lifestealer very quickly.
* Terrorblade has low health due to his low strength gain, which reduces Feast's lifesteal and damage.
* Terrorblade's high armor makes Lifestealer's Desolator useless.
* Because Lifestealer usually walks around with high HP in fights due to his lifesteal (and sometimes Armlet of Mordiggian), he is a great target for Terrorblade's Sunder.
Additional:
* Reflection's illusion carries Feast as well, making it useful in fights.
* Feast cannot compensate for Terrorblade's incoming high damage, due to his low Strength gain.
* Open Wounds is a lot harder to land on the real Terrorblade if he has illusions around him.
* Lifestealer relies on right-clicks to deal damage, and Terrorblade's high armor can reduce his damage by quite a bit.

* Since Untouchable pierce Spell immunity, Lifestealer cannot burst her down even with Rage ; meaning she can heal herself back to full HP.

* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces Rage, wasting its cooldown and making Lifestealer unable to fight.

* Blur allows Phantom Assassin to escape from Lone Druid and the spirit bear. Additionally, it provides evasion which effectively reduce the damage output from the Spirit Bear and reduce the chances to root her, forcing him to invest in Monkey King Bar
* At late game, Phantom Assassin will out carry Lone Druid.

* Reverse Polarity pierces through Rage, wasting part of it's duration.
* Magnus is tanky and mobile hero and hard for Lifestealer to focus and kill in all stages of a game.

* Chronosphere provides excellent lockdown against Rage.
* Faceless Void's Time Lock stops Lifestealer from getting health regeneration from auto-attacks

* Heroes with summons: Lycan, Broodmother, Visage.

* Heroes with spell immunity can still be disabled by Fiend's Grip: Juggernaut, Lifestealer, Pangolier.

Additional:
* Fiend's Grip can disable Lifestealer through Rage.

* Heroes with summons: Lycan, Broodmother, Visage.

* Pugna: Decrepify prevent the Spirit bear from attacking or protect allies from it.

* Heroes who can delivers a big chunk of damage in few hits will find themselves struggle against Templar Assassin's Refraction: Sven, Phantom Assassin, Ursa, Wraith King, Lifestealer

* Heroes that lack burst damage will have a difficult time taking down Monkey King, and fare badly against Jingu Mastery: Legion Commander, Lifestealer, Weaver, Wraith King

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar

* Clinkz, Sniper, Lone Druid, Troll Warlord, Legion Commander and Wraith King are some of the Heroes that base themselves on attacks with little or no spell power, so they suffer in the grassy hands of Overgrowth.

* Timbersaw: Lone Druid will have a hard time dealing with Timbersaw due to his tankiness and high Armor from Reactive Armor

* Heroes that rely on physical damage are ineffective against Dragon Knight due to his high armor: Phantom Assassin,Bloodseeker, Lifestealer, Troll Warlord

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar

* With the exception of Magic Missile (unless the player takes the Level 25 Talent "Magic Missile Pierces Spell Immunity"), all of Vengeful Spirit's spells ignore Spell Immunity. This also makes her good against heroes with built-in Spell Immunity like Lifestealer or Juggernaut or heroes that tend to pick up Black King Bar, like Sven.

* Ice Blast prevents Lifestealer from lifestealing and healing with Infest in fights.

* Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* Sanity's Eclipse deals heavy damage to Lone Druid.

* Firestorm's percentage damage can quickly demolish the Spirit Bear's high HP
* Pit of Malice will allow allies to easily kite Lone Druid due to his low mobility

* Although he can avoid Eclipse with Rage and Infest, Luna's physical damage can be enough to deal with him.
* Manta Style is a common pick on Luna, which can help her dispel Open Wounds. In addition, Lifestealer is not good against illusions created by Manta Style.

* Lone druid's bear attacks on Phoenix's Supernova Egg don't increase the hit count. Given that Lone Druid's main hero often doesn't have much farm, the Supernova Egg is less likely to get killed.