* Astral Imprisonment can allow Outworld Destroyer to save himself or allies from Kunkka's full kit.
* Sanity's Eclipse deal a large amount of damage, as Kunkka's mana pool is much smaller than Outworld Destroyer's.
* Arcane Orb deals pure damage, shredding through Kunkka and his team even with Ghostship's buff.

* Rage negates Kunkka's X Marks the Spot.
* As a strength hero with high strength gain and very little armor, as well as low agility gain, Kunkka is vulnerable to Lifestealer's Feast and Open Wounds.

* Arcane Orb's pure damage ignores Mars' Bulwark.
* Astral Imprisonment can be used to stop Mars from being disruptive or save allies from his abilities.
* Sanity's Eclipse deals high damage to Mars, due to his low intelligence.

* Rage, acting as a pseudo-Black King Bar, completely negates Mars' initiation if used in time.
* Feast does damage and heals based on max health, perfect against high-health strength heroes like Mars.
* Infest allows Lifestealer to potentially save allies from Mars' initiation with a quick burst of extra health.

* Outworld Destroyer's pure and magical damage is particularly effective against Axe.
* Astral Imprisonment is an excellent way to defend against an initiating Axe.
* Sanity's Eclipse deals high damage to Axe due to his low mana pool.
Additional:
* Berserker's Call bonus armor doesn't block Arcane Orb's pure damage.
* Astral Imprisonment can be used to prevent an ally or Outworld Destroyer himself from an Axe initiation.
* Axe's low mana means he's susceptible to a powerful Sanity's Eclipse.

* Feast makes it impossible to put Lifestealer's health for a Culling Blade and also deals high damage to Axe due to his naturally high health.
* However, Lifestealer's Rage can be pierced by Berserker's Call, Counter Helix and Culling Blade.

* Sanity's Eclipse deals more damage the less max mana the heroes hit by it have, making Pudge an ideal target.
* Outworld Destroyer can save allies or himself caught by Dismember or Meat Hook with Astral Imprisonment.

* The lifesteal of Feast scales accordingly to the max health of its target, which is effective against Pudge due to his high health and further health granted by stacks of Flesh Heap.
* Lifestealer can activate Rage to be spell immune, making Rot deal no damage.
* Pudge's plentiful health makes him an ideal target for Lifestealer's Aghanim's Shard ability, Open Wounds.

* Rage prevents Earthshaker from damaging and stunning Lifestealer.
* Feast is very effective against Earthshaker, because of him being a strength hero, allowing Lifestealer to heavily harass and kill him.
* Open Wounds prevents Earthshaker from escaping after he initiated.
* Infest gives Lifestealer an easy way to escape should he get caught out by Earthshaker.

* Outworld Destroyer's pure and magical damage is particularly effective against Earthshaker.
* Astral Imprisonment catches Earthshaker while he blinks in, preventing him from executing his combo.
* Earthshaker has mana troubles, and Outworld Destroyer's abilities can press this by stealing intelligence comes from Arcane Orb, therefore depleting his mana pool and mana regeneration.
* Sanity's Eclipse deals high damage to Earthshaker, due to his low intelligence and mana pool.

* Rage renders Lifestealer immune to the damage from Burning Spears.
* Feast makes Lifestealer one of few heroes that can outlast Huskar in a one-on-one fight.

* Heroes with pure damage can kill Huskar when he inevitably gets low on health: Outworld Destroyer, Silencer.

Additional:
* Outworld Destroyer can dodge Life Break with Astral Imprisonment, leaving him unharmed while Huskar loses HP.
* Sanity's Eclipse can deal massive damage to Huskar before he builds up his Berserker's Blood stacks due to Huskar's low mana pool.

* Rage protects Lifestealer nearly from all of Invoker's spells.
Additional:
* Rage grants immunity from Invoker's spells and can dispel most of the disables such as the armor loss from Forge Spirit and the constant stuns of Cold Snap.

* Astral Imprisonment allows Outworld Destroyer to save himself or ally from Invoker's combo, or remove Invoker from a fight temporarily.
* Arcane Orb's pure damage will deal a lot of damage against Invoker's mediocre strength gain.
* EMP is useless against Outworld Destroyer by activating Equilibrium.
* However, be aware that Sanity's Eclipse will most likely not deal any damage at all, due to Invoker's high intelligence gain compared to Outworld Destroyer's.

* Primal Beast is mostly played in the offlane role, so picking a carry who can escape from him is essential. Heroes such as Troll Warlord, Lone Druid and Outworld Destroyer, or generally any carry with a stun, slow or ability to fight back will stop him from having the good start he needs.

* Special mention to Lifestealer as he has magic immunity in Rage which protects agaisnt Primal Beast. However, if he doesn't use it the long chain stun potential can be deadly, denying him to use Feast for a lengthy time.

* Lifestealer deserves a special mention because in a fight to the death with equal farm, his lifesteal will do no where near as much sustain as Gods Strength's damage output. However, Rage means he can always disengage at will if he's quick on the trigger. This is one of those matchups that can really go either way.

* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.

* In general, heroes with spell immunity abilities won't be caught inside by Pit of Malice: Juggernaut, Lifestealer.

* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.

Additional:
* Arcane Orb 's pure damage can do great damage to Underlord.
* Sanity's Eclipse can tear down Underlord's health by a large amount, since his mana pool is very low compare to OD's high mana pool.

* Arcane Orb's pure damage ignores Timbersaw's Reactive Armor.
* Astral Imprisonment, if timed correctly, can interrupt Timber Chain, preventing him from escaping.
Additional:
* Arcane Orb deals constant pure damage, which bypasses Timbersaw's Reactive Armor.
* Sanity's Eclipse can hit targets inside Astral Imprisonment, which helps Outworld Destroyer finish off Timbersaw before he escapes with Timber Chain. It can also drain his mana, limiting his ability to escape should he survive.

* Rage provides spell immunity to Lifestealer and thus nullifies all of Lion's abilities.
* Open Wounds allows Lifestealer to easily catch Lion out and prevent him from escaping.

* Sanity's Eclipse does massive damage to Wraith King who naturally has a low mana pool and typically doesn't build items to increase it.
* Wraithfire Blast's slow projectile speed makes it easy to avoid using Astral Imprisonment.

* Feast is good against high health strength heroes such as Alchemist.
* Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.

* Outworld Destroyer is not exceptionally dangerous to Necrohpos because of his Ghost Shroud, but his Astral Imprisonment can save his allies from Necrophos's Reaper's Scythe, though only if he uses it at the right time, If an Outworld Destroyer is nearby, Necrophos should not use Reaper's Scythe unless he has banished himself, or has banished two heroes within 15 seconds

* Rage ignores all of Viper's magical damage, although Viper Strike can pierce spell immunity and slows him down.
* Feast and Open Wounds from Aghanim's Shard can be combined to heal through Viper's physical damage.

* Rage protects Lifestealer from all of Lina's abilities (except an upgraded Laguna Blade).
* Open Wounds is great to keep Lina in place because she has no abilities to help her escape.

* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.

* Feast deals damage and heals Lifestealer based on the target's maximum HP, which is greatly effective against naturally high HP heroes such as Doom.
* Rage allows Lifestealer to become spell immune to negate the magical damage of Infernal Blade and Scorched Earth.
* Doom has no effective means of escape from Open Wounds. This is particularly devastating in lane, where Doom may have to play a much more passive, conservative play style as a result.

* Rage protects Lifestealer from all of Techies' magic damage and disables and dispels Reactive Tazer's debuff .
* Usually teams will have a hard time pushing high-ground against Techies, but Lifestealer can just pop Rage and walk uphill without fear of Techies.
Additional:
* Lifestealer's Rage lets him clear Proximity Mines without taking damage, and allows him to hit heroes whom Techies has used Reactive Tazer on.

* Rage protects Lifestealer from all of Dark Willow's abilities.
Additional:
* Rage protects and dispels all of Dark Willow's abilities.

* Lifestealer's Rage makes him immune to all of Ogre's magical debuffs and also dispels them.
* Ogre's as hero with great durability and high health is great target for Lifestealer in any stage of the game, thanks to Feast.
Additional:
* Ogre Magi has nothing against Rage and his high health pool amplifies Feast.

* Astral Imprisonment protects an ally for much of Rolling Thunder's duration, especially at the lower levels. As Rolling Thunder has a considerable cast animation, an Outworld Destroyer with Blink Dagger can initiate on him and destroy his timing.

* The pure damage provided by Arcane Orb is a great addition for killing Ember Spirit.
* Astral Imprisonment fully negates all magic damage of Flame Guard and Searing Chains and will temporarily save himself from Sleight of Fist's physical damage, and Ember Spirit is not a hero that can counter these skills.

* Rage ignores all of Gyrocopter's magical attacks.
* Feast helps Lifestealer out-damage Gyrocopter at close range.

* Feast will deal a enormous amount of damage because of Tiny's huge health pool.
* Rage protects Lifestealer from Tiny's magical burst damage.

* Astral Imprisonment can be used to protect allies by imprisoning either them or Spirit Breaker.
* Arcane Orb will heavily drain Spirit Breaker's intelligence, rendering him almost useless and unable to cast spells. Spirit Breaker's low intelligence also means Sanity's Eclipse will deal a lot of damage to him.

* Feast deals damage and heals lifestealer based on the target max health. Because Spectre often emphasises on building stat items to increase her HP pool, lifestealer can deal a lot of damage to her and heal himself at the same time.
* Ghoul Frenzy slows target, which is bad for Spectre if she does not have Spectral Dagger ready.
* Spectre cannot response to infest if lifestealer choose to stay inside his high mobility allies to approach the backline. Rage's bonus movement speed and spell immunity make it even more frustrating.

* With Feast and Rage, Lifestealer is nearly impossible for Clockwerk to bring down, and is the last hero Clockwerk wants to be trapped with in Power Cogs.

* Rage grants Lifestealer immunity to all of Jakiro's spells. Note: magic resistance will not dispel the attack speed slow effects from Dual Breath and Liquid Fire.

* Rage is very useful against Zeus, as it negates magic damage and provides spell immunity. In addition, the increased attack speed can tear Zeus apart in combination with Open Wounds.
* Lifestealer can avoid Thundergod's Wrath with Infest.

* Rage can be used to escape from a Glimpse and to move out of Kinetic Field.
* Infest allows Lifestealer to dodge Glimpse.

* Being a strength hero with a high strength gain means Feast can give her a hard time,especially later in the game.
* However,Starbreaker's physical damage can control him in the laning phase.

* Outworld Destroyer can steal more mana with Astral Imprisonment from Skywrath Mage with Shield of the Scion (granted by Aghanim's Shard). Shield of the Scion grants Skywrath Mage bonus intelligence every time he deals magic damage to an enemy hero with his abilities. The higher his intelligence, the larger his mana pool. Since Astral Imprisonment steals based on the target's max mana, Outworld Destroyer can steal much more mana from Skywrath Mage.

* Astral Imprisonment is a versatile nuisance:
* If it is cast on a low-enough-health unit at least 1 second into Shallow Grave's duration, the Shallow Grave will end during the imprisonment, and the target will take lethal damage when released.
* It can be used remove Dazzle from the fight at a time he could have saved someone.
* It lets himself or an ally dodge all of Poison Touch's effects, for long enough to recover their Blink Dagger.

* Outworld Destroyer can save an ally hero caught by Duel with Astral Imprisonment, and he can inflict heavy damage on Legion Commander with Arcane Orb to aid his ally. However, if he gets caught, he is unlikely to survive the duel, due to his lack of durability.
Additional:
* Astral Imprisonment prevents Legion Commander from killing her opponents in Duels.

* Lifestealer's Rage renders him immune to all of Marci's disables and magic damage for a good duration.
* His passive Feast deals bonus damage based on the enemy's max health and heals for the same amount. As a tanky Strength hero, Marci's own strength will be her undoing as well.

* Astral Imprisonment wastes Borrowed Time's duration.
* Outworld Destroyer's Sanity's Eclipse can kill Abaddon before Borrowed Time triggers due to the lack of intelligence for Abaddon.

* Feast is an effective tool against Centaur Warrunner, who generally has high health and low armor, and compensates the reflected damage of Retaliate.
* If activated, Rage can protect Lifestealer from Hoof Stomp, Double Edge, and Stampede.

* Leshrac's high magic damage is ignored by Rage.
* Lifestealer can get in Leshrac's face with Rage and mitigate any other damage taken by Leshrac with Open Wounds.

* Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* Sanity's Eclipse deals heavy damage to Lone Druid.

* Outworld Destroyer's pure damage will mop up Primal Split's units very quickly.

* Arcane Orb's pure damage penetrates Guardian Angel's defense.
* Astral Imprisonment's mana steal is devastating to Omniknight's already low mana pool.

* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.

* With Aghanim's Scepter upgraded Infest, Lifestealer can use it on enemy heroes to attack them and disarm them from inside, even if they are spell immune, which can give him the edge over the heroes he's weak against like Ursa, Phantom Assassin, Terrorblade or Troll Warlord.

* Heroes who have most or all their abilities (damage or disable) unable to pierce spell immunity: Keeper of the Light, Lina, Lion, Zeus.

Additional:
* Rage allows him to be immune to all of Ezalor's abilities. Also, the increased movement speed combined with the slow from Ghoul Frenzy and the squishy nature of Ezalor allows Lifestealer to take him down very quickly.

* Shadow Demon, Outworld Destroyer and Tusk can all save a Lasso'd teammate with their defensive spells.

* Heroes with spell immunity-granting spells will render Phoenix useless against them, as Phoenix has almost no spell immunity-piercing ability, other than the stun at the end of Supernova: Lifestealer, Juggernaut.

* Lifestealer with Rage and Infest
* Heroes that can remove the Track debuff with their skills:
* Abaddon with Aphotic Shield and Borrowed Time
* Huskar with Life Break
* Juggernaut with Blade Fury
* Legion Commander with Press the Attack
* Lifestealer with Rage and Infest
* Naga Siren with Mirror Image
* Omniknight with Heavenly Grace
* Oracle with Fortune's End and False Promise
* Phantom Lancer with Doppelganger
* Slark with Dark Pact
* Ursa with Enrage
* Weaver with Time Lapse
* Tidehunter with Kraken Shell when damage received reaches the threshold.

* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: Lifestealer, Doom, Mirana, Clinkz.

* Juggernaut and Lifestealer have abilities (Blade Fury and Rage respectively) that prevent Crystal Maiden from using her spells on them in the early game, before Black King Bar and other magical reduction is even an issue.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Enigma lack burst damage, and that makes him vulnerable to heroes who can recover themselves and turn the fight around to their advantage after Enigma finishes his initiation: Faceless Void, Terrorblade, Ursa, Weaver, Broodmother, Slark, Abaddon, Wraith King, Lifestealer.

* Astral Imprisonment can save allies from a Black Hole combo. When upgraded with Aghanim's Scepter and Aghanim's Shard, it becomes exceedingly difficult to land good Black Hole against Outworld Destroyer's team.
* Astral Imprisonment can also cancel Black Hole while Enigma does not have Black King Bar.

* Slark, Lifestealer, Morphling and other heroes with good escape mechanisms are a nuisance to deal with in the early phase of the game.

* Arcane Orb's constant pure damage output is devastating to Dragon Knight.
* Dragon Knight's relatively low mana pool leads to heavy damage from Sanity's Eclipse, which also bypasses his armor.

* Outworld Destroyer's pure damage from Arcane Orb can go through Cold Embrace.
* Outworld Destroyer can negate the healing from Cold Embrace using Astral Imprisonment, and steal mana while doing so.
* Outworld Destroyer's damage during Winter's Curse is reduced due to Arcane Orb being unable to target allies.
Additional:
* Winter Wyvern must never put her allies in Cold Embrace against Outworld Destroyer as Arcane Orb will continue to deal damage to the defenseless hero.
* Arcane Orb does not hit his allies when he is taunted by Winter's Curse, making it weak against allies, but strong versus enemies.
* Astral Imprisonment can protect a target inflicted with Winter's Curse.

* Arcane Orb's pure damage, making Counterspell ineffective.
* Sanity's Eclipse will hit Anti-Mage while he is disabled from Astral Imprisonment, and forces him to take heavy damage due to his low intelligence.
* Essence Flux keeps Outworld Destroyer at high mana, thus greatly reducing the damage from Mana Void.
Additional:
* Counterspell doesn't work versus Arcane Orb because it does pure damage.
* Anti-Mage cannot burn all of Outworld Destroyer's mana without disables due to Essence Flux.
* Anti-Mage's Manta Style illusions are quickly destroyed by Arcane Orb.
* However, if the enemy has multiple means of removing mana, Mana Void becomes a threat to Outworld Destroyer, Anti-Mage has better mobility than Outworld Destroyer with Blink, and Counterspell blocks a large portion of the damage from Sanity's Eclipse.

* Sanity's Eclipse will likely instantly kill all illusions.

* Rage will dispel Laser's blind and turns him spell immune for the duration so Tinker cannot damage him.
* Feast will quickly bring down Tinker due to being so fragile.
Additional:
* Lifestealer's Rage makes him immune to all of Tinker's damage and debuffs.
* Lifestealer can infest any mobile hero (teams usually pick one against Tinker), which ensures that Tinker will die if he is caught.

* With Aghanim's Scepter upgraded Infest, Lifestealer can use it on enemy heroes to attack them and disarm them from inside, even if they are spell immune, which can give him the edge over the heroes he's weak against like Ursa, Phantom Assassin, Terrorblade or Troll Warlord.

* Most Illusion based heroes (like Chaos Knight and Terrorblade) can't use their illusion beneficially against Sanity's Eclipse's high AoE burst damage.

Additional:
* Arcane Orb deals pure damage against the real Terrorblade, bypassing his high base armor.
* Arcane Orb and Sanity's Eclipse will make very short work of Terrorblade and his illusions.

* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.

Additional:
* Outworld Destroyer's pure damage from Arcane Orb is very effective at killing Troll Warlord quickly.
* Astral Imprisonment removes Troll Warlord from a fight for four seconds, minimizing his contribution to a teamfight, and potentially wasting over half of Battle Trance's duration.
* Troll Warlord gains a measly 1 intelligence point per level, meaning Sanity's Eclipse is especially effective, often instantly killing him.

* With Aghanim's Scepter upgraded Infest, Lifestealer can use it on enemy heroes to attack them and disarm them from inside, even if they are spell immune, which can give him the edge over the heroes he's weak against like Ursa, Phantom Assassin, Terrorblade or Troll Warlord.

* With Aghanim's Scepter upgraded Infest, Lifestealer can use it on enemy heroes to attack them and disarm them from inside, even if they are spell immune, which can give him the edge over the heroes he's weak against like Ursa, Phantom Assassin, Terrorblade or Troll Warlord.

* Ursa struggles against heroes with strong (and especially undispellable) disables (Disruptor, Puck, Shadow Demon, Outworld Destroyer and etc).

* Tanky melee heroes that can easily be kited, which allows Outworld Destroyer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.

Additional:
* Sanity's Eclipse only triggers Bristleback's passive once, and deals high damage against Bristleback's low intelligence.
* Outworld Destroyer's high burst damage is not negated by Bristleback's passive, So even if Bristleback turns his back on Outworld, Outworld Destroyer can decimate Bristleback quickly,
* If Bristleback attempts to flee, or tries to close the gap, Outworld can banish him with Astral Imprisonment, both reducing Bristlebacks much needed mana, and allowing Outworld to move in front of him, forcing him to take the full damage from his spells, This will also allow Outworld to land a devasting Sanity's Eclipse, without it being reduced by Bristleback's passive,

* Outworld Destroyer doesn't care if Razor steals his damage because he does most of his damage through Arcane Orb.
* Astral Imprisonment can prevent Razor from using the stolen damage from Static Link or chasing with Eye of the Storm.
* Sanity's Eclipse will do a ton of damage to Razor due to his low mana pool.

* Arcane Orb deals pure damage, effectively bypassing Morphling's high armor from Attribute Shift (Agility Gain).
* Sanity's Eclipse is more effective against a low health and mana pool Morphling, enabling Outworld Destroyer to burst Morphling down before he can shift to Strength.
Additional:
* Arcane Orb deals high damage regardless of Morphling's high armor from Attribute Shift (Agility Gain).
* Because of Morphling's very low intelligence gain and base intelligence, Sanity's Eclipse will almost always be effective against Morphling.

* Heroes with mana burn: Nyx Assassin, Invoker, Outworld Destroyer, Pugna

* Heroes with spell immunity or pseudo-blinks which provide invulnerability: Lifestealer, Juggernaut, Omniknight, Huskar , and Tusk have spells which allow them to easily escape Dream Coil.

* Heroes with burst damage of their own won't be afraid to go toe to toe with Void Spirit, like Ursa, Lifestealer, or Axe.

* Lifestealer's Rage negates Sand King's spells which do magical damage.

* Lifestealer can close the distance to Sniper by using Infest on a fast or durable creep to tank Sniper's damage.
* Open Wounds and Ghoul Frenzy will reduce Sniper's mobility heavily, and Rage's movement speed bonus helps in closing the gap to Sniper. It also protects him from Assassinate and Shrapnel.
* Infest can dodge an incoming Assassinate.

* Outworld Destroyer can disrupt Slark's attacks with Astral Imprisonment either by banishing Slark or his target.
* Slark's low heathpool means he will die quickly to Arcane Orb if he is directly attacked by Outworld Destroyer
* Slark has low intelligence gain, making him easy to finish with Sanity's Eclipse if he tries to run with Shadow Dance
Additional:
* Arcane Orb deals pure damage, which ignores the armor granted from permanent agility stacks.
* Astral Imprisonment can disrupt any Pounce attempt by banishing the leashed ally.
* Slark's low mana pool makes him more susceptible to Sanity's Eclipse.

* Rage completely negates all of Nyx Assassin's abilities except Vendetta, while Open Wounds allow him to quickly close the gap.
* Infest combined with an ancient creep makes Nyx Assassin an easy target with Dust of Appearance or a Gem of True Sight.

* Lifestealer is not affected by Earthbind or Poof during Rage, making him a difficult target to work around.

* Rage can protect Lifestealer from most of the Silencer's abilities with the exception of Global Silence.
* If Lifestealer can Infest himself on any unit, he can literally avoid being affected by Global Silence.
* Against a carry Silencer, Aghanim's Scepter upgraded Infest can disarm him and allow Lifestealer to attack Silencer from within, even if Silencer is spell immune.
* Open Wounds from Aghanim's Shard can severely slow down Silencer, and allow Lifestealer and his team to heal themselves by attacking Silencer.
Additional:
* Rage can protect Lifestealer from most of the Silencer's abilities with the exception of Global Silence.
* If Lifestealer can Infest himself on any unit, he can literally avoid being affected by Global Silence.
* Against a carry Silencer, Aghanim's Scepter upgraded Infest can disarm him and allow Lifestealer to attack Silencer from within, even if Silencer is spell immune.
* Open Wounds from Aghanim's Shard can severely slow down Silencer, and allow Lifestealer and his team to heal themselves by attacking Silencer.

* Heroes with magic immune abilities can negate most of Visage's attacks like Pangolier and Lifestealer.