* Magnus has very mediocre damage against Alchemist, because he can survive the stun duration of Reverse Polarity with Chemical Rage.

* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, Elder Titan, Faceless Void, Rubick, Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, Phoenix, Razor, Huskar, Batrider, Kunkka, Tidehunter, Wraith King, Sand King.

* Chemical Rage kills Phoenix very quickly in Supernova.

* Any hero with high attack speed will be a threat to Phoenix when it initiates, as they can easily tear down a Supernova, perhaps even while debuffed by Fire Spirits: Juggernaut, Clinkz, Troll Warlord, Beastmaster, Lina.

* Heroes with summons can find their summons eliminated easily by Lina, like Broodmother, Nature's Prophet, and Chen.

Additional:
* Light Strike Array in combination with Dragon Slave can easily clear Broodmother's spiders.
* Laguna Blade offers extensive damage that can kill Broodmother early on or before she is able to use Insatiable Hunger in attempts to salvage a fight.

* Greevil's Greed makes Broodmother’s spiderlings far more valuable to Alchemist making it important that he does farm them as opposed to other heroes where the spider's bounties are negligible.
* Acid Spray makes it difficult to attack Alchemist in lane without losing some spiderlings to the damage over time, potentially giving him farm he wouldn't have otherwise.
Additional:
* Alchemist can easily farm Spiderlings with Acid Spray and Greevil's Greed.
* Alchemist's Chemical Rage nullifies Broodmother's Insatiable Hunger

* Heroes with high magical burst can easily kill Huskar when he is at low health: Lion, Lina, Skywrath Mage

* Chemical Rage negates almost all damage from Burning Spears.
Additional:
* Chemical Rage mitigates damage from Burning Spear.

* Alchemist's Acid Spray can heavily damage Chen's creeps and disrupt his jungling.
* Alchemist builds items like Radiance and Battle Fury, allowing him to quickly clear Chen's creeps.
* Alchemist's Greevil's Greed will grant him more bonus gold as he kills Chen's creeps.

* Heroes with summons can find their summons eliminated easily by Lina, like Broodmother, Nature's Prophet, and Chen.

Additional:
* Lina's high damage burst from Dragon Slave, Light Strike Array and Laguna Blade can easily kill Chen's allies or Chen himself before he can use Hand of God.

* Chemical Rage out-heals Doom to a large degree throughout all stages of the game. Should Alchemist be chemically enraged before being Doomed, Alchemist can become a difficult target to effectively lockdown and kill, thanks to the health regeneration and movement speed bonuses granted by his ultimate.
* Alchemist is an ineffective target for Doom. Alchemist isn't totally reliant on his skills to be effective during a teamfight, due to the right-click nature of the hero.

* Lina has very high magic burst damage to use against the low-health-pool Luna. Laguna Blade can also be upgraded with Aghanim's Scepter to bypass Luna's Black King Bar, making Lina even more of a threat.

* Dragon Slave deals reliable magic damage during the laning phase against Mars.
* Lina's Eul's Scepter of Divinity and Light Strike Array combo can interrupt Mars from being disruptive for a decent amount of time and leave him vulnerable for follow up stuns.
* Laguna Blade deals massive magical damage, and pure damage with Aghanim's Scepter.

* Laguna Blade ends Gyrocopter very quickly in the early to mid game.

* Being a hero with low health and abysmal mobility, Lina can nuke her down easily.
* Since Crystal Maiden's Freezing Field is a channeled ability, Lina can use her Light Strike Array to cancel it easily.

* Light Strike Array and Dragon Slave allows Lina to destroy trees, countering Nature's Guise and Eyes in the Forest.
* Lina has many tools to remove Living Armor's protection.

* Eul's Scepter of Divinity and Light Strike Array combo will disable Mirana if she tries to Leap away.
* Laguna Blade's magical (pure with Aghanim's Scepter) burst damage takes advantage of Mirana's below average health.
Additional:
* Moonlight Shadow does little good against Dragon Slave and Light Strike Array.
* Lina's damage burst can quickly kill Mirana's teammates before she saves them with Moonlight Shadow.

* Laguna Blade can kill Dazzle quickly before he casts Shallow Grave.

* Chemical Rage will take down Tombstone in no time.
Additional:
* With Greevil's Greed, Alchemist can farm Tombstone zombies and gain a significant gold advantage.

* Venomancer has low health, which makes him vulnerable to Lina's heavy magic damage.
* Fiery Soul attack speed bonus removes Plague Wards easily in all stages of the game.

* Light Strike Array catches Meepo and his clones if he tried to gank Lina with Earthbind & Poof.
* Laguna Blade can quickly kill Meepo and his clones before they escape with Poof.

* Guardian Angel is generally useless against Lina as she primarily relies on magical damage. Lina can also dispel it with Eul's Scepter of Divinity as she is a hero who often goes for it.
* Laguna Blade can often finish off Omniknight's allies before he can save them with Purification and Heavenly Grace. This can become even worse once Lina buys Aghanim's Scepter, that will change Laguna Blade's damage type from magical to pure and allow it to ignore both, any form of spell immunity and Guardian Angel.

* Alchemist gets a huge amount of additional gold from killing Nature's Prophet's treants thanks to Greevil's Greed

Additional:
* Acid Spray and Greevil's Greed will quickly destroy pushes with treants.

* Heroes with summons can find their summons eliminated easily by Lina, like Broodmother, Nature's Prophet, and Chen.

Additional:
* Lina can easily prevent Nature's Prophet's Teleportation escape attempts with Light Strike Array, and can clear Sprout's trees instantly.
* Lina's Dragon Slave and Light Strike Array can kill Nature's Prophet's Treants.

* Heroes with low health or rely on evasion can easily be bursted down, like Phantom Assassin or Terrorblade.

Additional:
* Laguna Blade is one of the best tools to kill Terrorblade before he can use Sunder due to its high magical (pure with Aghanim's Scepter) burst damage.
* Dragon Slave and Light Strike Array allows Lina to clear Terrorblade's illusions from both, Conjure Image and Manta Style.

* Heroes who have channeled abilities can be stunned by Light Strike Array, like Witch Doctor with Death Ward and Bane's Fiend's Grip.

Additional:
* Light Strike Array cancels out Death Ward from a long distance.

* Heroes who deal single instance burst damage will only proc Bristleback once: Lina, Lion.

* Heroes with powerful spammable abilities will prove problematic for Grimstroke as Ink Swell does not protect him from them: Zeus, Skywrath Mage, Tinker, Lina

* Heroes with high damage output who can burst down Morphling before he has time to use Attribute Shift (Strength Gain), like Lina and Lion.

Additional:
* Light Strike Array catches Morphling while he jumps in from Waveform and also prevents Morphling from using his abilities.
* Laguna Blade can kill Morphling quickly before he shifts into Attribute Shift (Strength Gain).

* Heroes with high burst damage: Lina, Lion, Luna, Nyx Assassin, Queen of Pain.

* Abilities that can destroy trees can give Hoodwink a disadvantage: Timbersaw, Windranger, Lina.

* Since Windranger is bad against magical damage, heroes with continuous magical damage or magical nukes can blast her: Zeus, Tinker, Leshrac, Viper, Skywrath Mage, Lion, Lina, Venomancer.

* Heroes that can kill Death Prophet with nukes can prevent her from using Exorcism to its full duration or using it at all: Lina, Lion, Puck, Morphling.

* Heroes whose abilities can affect multiple enemies at once: Lina, Luna, Jakiro, Leshrac, Invoker, Lina

* Heroes who have channeled abilities can be stunned by Light Strike Array, like Witch Doctor with Death Ward and Bane's Fiend's Grip.

* Heavy nukers will do well against Cold Embrace (Lina, Zeus etc).

* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Puck, Slark, Nyx Assassin, etc.

* Pudge has low armor and mobility, making him suspectible to her physical attacks (if Lina is the carry).
* Because Dismember is a channeled ability, it can be canceled through Light Strike Array within a distance.

* Lina's damage burst can quickly kill Clinkz before he saves them with Skeleton Walk.
* Fiery Soul attack speed bonus removes Burning Army easily in all stages of the game.

* Lina is a common Eul's Scepter of Divinity carrier which can waste some duration of Borrowed Time and following up with Laguna Blade if timed correctly.

* Lina can burst Vengeful Spirit down, provided she can land Light Strike Array before Vengeful Spirit lands her Magic Missile.
* Laguna Blade deals massive damage, often being enough to kill a squishy Vengeful Spirit.

* Timbersaw has a difficult time against magical and pure damage: Lina, Leshrac, Enchantress, Queen of Pain

* Enchantress has pitiful health, and cannot tank Lina's heavy magic damage.
* Untouchable is decently countered by Fiery Soul, exposing Enchantress' weakness to physical damage due to her low armor.
* Lina is decent at clearing creeps and can kill Enchantress' creeps quickly.
Additional:
* Enchantress has a very small health pool and cannot tank Lina's heavy magic burst.
* Untouchable is decently countered by Fiery Soul, exposing Enchantress' weakness to physical damage due to her low armor.
* Lina is decent at clearing creeps and can kill Enchantress' creeps quickly.

* Heroes with low health or rely on evasion can easily be bursted down, like Phantom Assassin or Terrorblade.

Additional:
* Light Strike Array catches Phantom Assassin when she jumps in.
* Laguna Blade kills Phantom Assassin's abysmal health before she can do anything in early to mid game and also pierces her spell immunity when upgraded with Aghanim's Scepter.

* Dragon Slave will make quick work of the spawned illusions from Disruption.
* An attempt to save an ally using Disruption can easily become a perfect setup for a Light Strike Array for the enemy.
* Lina usually builds Eul's Scepter of Divinity to dispel Soul Catcher and Linken's Sphere to block Disruption and Demonic Purge.
* Shadow Demon doesn't have the burst damage to take Lina out of the fight quickly, although Demonic Purge can help his allies kill a squishy Lina.

* Lina builds Shadow Blade (and upgrades it into a Silver Edge), which makes it hard for Ancient Apparition to land his abilities.
* Laguna Blade can kill Ancient Apparition easily due to his low health pool and lack of mobility.

* Laguna Blade deals amplified magical damage (pure from Aghanim's Scepter) to Necrophos when he is under the effects of Ghost Shroud.
Additional:
* Laguna Blade's damage will be greatly amplified during Ghost Shroud.