* Mana Burn does tons of damage against Lina because of her high intelligence. The mana burn also prevents Lina from casting her full combo.
* Spiked Carapace can easily be used to counter Lina's abilities because of their long cast animation, and could probably kill Lina outright if Laguna Blade is reflected.

* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Additional:
* Level 4 Mana Burn burns 38,5% of Medusa's mana every 4 seconds if Medusa only increases her mana pool with intelligence. Additionally, 60% of the Mana Burn damage gets mitigated by Mana Shield, burning even more mana.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.

* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Additional:
* Ursa's status resistance from Enrage will ignore Medusa's gaze.
* Ursa can stack damage with Fury Swipes easily against her Mana Shield in a prolonged team match.

* Light Strike Array has a long delay, making her vulnerable for Ursa's burst.
* Enrage can protect Ursa against Lina's high magical burst.

* Phantom Lancer with Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding your team in the process.

* Doppelganger can be used to easily dodge Light Strike Array if timed correctly.
* Phantom Lancer can quickly deplete Lina's mana pool with his illusions and deal massive damage from it simultaneously since Phantom Lancer is a natural Diffusal Blade carrier.

* Silencer burns easily through her effective hp from Mana Shield, by taking away her int.
* Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. Can force her to use Manta Style before he has cast Global Silence and Medusa usually does not want to build Black King Bar.

* Arcane Curse discourages Lina from using her abilities, preventing her from building up Fiery Soul stacks.
* Last Word and Global Silence are great against Lina for the same reason, as well as interrupting her combos and preventing her from casting spells.

* Blink allows Anti-Mage to get on top of Lina and deal damage with his Mana Break.
* Counterspell makes Anti-Mage tanky against Lina's heavy magic damage.
* A well-timed Counterspell can block and reflect Laguna Blade.
* Mana Void is very strong against Lina, who has a high mana pool and quickly depletes it during fights.

* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has Manta Style.
* Anti-Mage effectively avoids Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* Anti-Mage's Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with Blink, burning her mana or forcing her to use Stone Gaze.
* Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.

* Rubick will find all Lina's abilities useful:
* Dragon Slave provides a good way to clear creep waves and allows Rubick to deal tons of magical damage in teamfights.
* Light Strike Array gives Rubick a solid area stun, which is easy to set up right after Telekinesis.
* Laguna Blade gives Rubick a massive damage boost and great solo kill potential.

* Because of her need to get status items early to tank it up, Rubick can greatly reduce her damage early with Fade Bolt
* Her stationary nature and the slow cast time of her spells makes it easier for Rubick to steal Stone Gaze or Mystic Snake
* Aghanim's Scepter's Mystic Snake is often better used by Rubick than by Medusa

* Nether Ward will be problematic for heavy nukers and spammers like Skywrath Mage, Lina, Lion and Invoker, but don't use Decrepify defensively against them as you'll be helping them out more than anything.

* Nether Ward will cause an unfriendly area for Medusa, draining her mana.

* Heroes with long animations can be frequently interrupted with Cold Snap: Earthshaker, Monkey King, Shadow Fiend Lina

* EMP is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Additional:
* EMP allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.

* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift removes 1 of every attribute, lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.
Additional:
* Medusa is especially vulnerable to Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.

* Dark Pact can be cast during the cast animation of Light Strike Array and dispel its stun.
* Pounce allows Slark to close the gap to Lina.
* Shadow Dance prevents Lina from killing Slark with her Laguna Blade when his HP gets low.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Heroes with spell immunity until Lina buys Aghanim's Scepter, like Lifestealer with Rage and Juggernaut with Blade Fury.

* Razor naturally builds tank items which allow him to survive Lina's burst better than other heroes.
* Static Link makes Lina's high attack speed do very little damage.

* Unlike other illusion heroes, Tempest Double won't be instantly destroyed by Stone Gaze since it is considered a clone and not an illusion.
* He can use either his own or his double's Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + Spark Wraith to slow Medusa's move speed to a crawl.
* Arc Warden has a farming advantage with double Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.

* Medusa lacks mobility or escape mechanisms. Earth Spike and Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* In addition to easily breaking her commonly bought Linken's Sphere with its low cooldown, Mana Drain can quickly drain her Mana Shield, making her far less tanky.

* Medusa is a fairly immobile hero that deals damage around her with Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.
Additional:
* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.

* He won't be around waiting for Medusa to Stone Gaze and pin him until she bears a true sight.
* With Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can still deal huge amount of damage through Cloak and Dagger via backstabs, drying out Medusa's protection in a whim at random occassions.

* Nethertoxin prevents buildup of Fiery Soul stacks.
* Corrosive Skin provides magic resistance against Lina's spells.
* Poison Attack and Viper Strike can burn away Lina's small health pool.

* Chakra Magic can drain her current mana, draining away her effective health in a sneaky way.
* Will-O-Wisp will keep Medusa busy after she got hit by Blinding Light.

* Time Walk will easily backtrack Lina's burst damage (especially Laguna Blade) if not timed correctly.
* During Chronosphere, squishy heroes like Lina will be main target of Faceless Void in his ultimate.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Heroes with low mobility that rely on spells: Zeus, Lina, Crystal Maiden.

* Low health spellcasters: Lina, Witch Doctor, Tinker, Keeper of the Light, all rely heavily on their spells and are fragile heroes. They all also have avoidable spells, allowing Puck to get to them and quickly burst them down.

* Other heroes with mana burning or manipulating abilities will make Medusa much less tanky: Lion, Mirana, Weaver.

* Heroes with powerful nuke can waste their precious abilites on her Refraction during a ganking attempt or chaos combat: Lich, Lina, Sniper, Outworld Destroyer Zeus

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Heroes who take a long time to become strong are in for a rough mid game, such as Outworld Destroyer, Magnus, Medusa, and Anti-Mage.

* Squishy heroes (Io, Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Heroes with abilities that can pull Lina out of position can easily bring her to their team mates, like Batrider with Flaming Lasso and Pudge with his Meat Hook.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Spectral Dagger and Haunt allow Spectre to get close to Lina.
* Desolate is very strong against Lina, who's usually a bit isolated in fights because of her high attack and cast range.
* Dispersion can mitigate a good portion of Lina's burst damage, allowing Spectre to turn on her afterwards.
Additional:
* Spectre can very easily close the distance on Lina with Haunt and Spectral Dagger, and due to Lina's abysmal mobility without a Blink Dagger and terrible health pool and armor, Lina easily gets slaughtered due Desolate.
* Dispersion can mitigate a good portion of Lina's burst damage, allowing Spectre to turn against her afterwards.

* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* His Fiend's Grip will leave Medusa defenseless after he's done, if his teammates can provide cover for him or he initiates at the right time by Spell immunity.

* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, after an Incapacitating Bite she will get her swarmed in no time.
* Medusa usual do not build a BKB to benefit from Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away mana.
Additional:
* Incapacitating Bite will give Medusa a dire time to clear horde of small spiderlings or retaliate Broodmother herself.
* Spin Web will allow broodmother to pick her own fights and sometimes slip away to ambush Medusa.