* Ranged heroes that can easily harass Axe: Drow Ranger, Sniper, Lion.

* Hand of God and Divine Favor make it hard for Axe to finish off allies with Culling Blade.

* If Meepo ganks Lion with Poof and Earthbind, he will be an easy target for Earth Spike & AoE Hex from his level 25 talent.

* Chen can use Holy Persuasion on creeps controlled by Enchant.
* Ironically, Enchantress can Enchant Chen's creeps.

* Enchantress is very fragile without any form of magic resistance, allowing Lion to easily burst her down.
* Nature's Attendants is a slow heal, making it ineffective against Lion's burst.
* Enchantress lacks any escape mechanism apart from her raw movement speed, allowing Lion to disable her.
* Since Lion's damage comes mostly from his skills, Untouchable does nothing to mitigate it.

* His creeps can trigger Proximity Mines and Stasis Trap, wasting them.
Additional:
* Holy Persuasion creeps can be used to clear mines.
* If Chen has an Aghanim's Scepter he can send his Ancient creeps to defuse visible Remote Mines with little risk of giving up their bounties because their magic resistance is extremely high.

* Heroes with forced movement spells or non-interrupting forced movement, such as Lion, Drow Ranger, Magnus, Mars, as they can cancel blast-off mid air in lane, removing his ability to deny himself and output damage.

* Mana Drain is a headache for Bristleback to deal with during the laning stage, as it denies him the ability to get last hits with Quill Spray.
* Finger of Death deals high damage to Bristleback, and only triggers his passive once.

* Due to Clockwerk's slow damage output, Chen can often save a trapped enemy with Hand of God.
* Penitence's damage amplification may allow Chen and his allies to kill Clockwerk quickly after his initiation.
* Chen's creeps can be used to block Hookshot initiation from all sides, as well as distribute Battery Assault's damage.
Additional:
* Due to Clockwerk's slow damage output, Chen can often save a trapped ally with Hand of God.
* Clockwerk does not have any source of damage to deal with Chen Creeps.
* Chen can use his creeps to block Clockwerk's attempts to use Hookshot.

* Mana Drain rapidly saps Morphling's already low mana pool, making him unable to use Waveform or Adaptive Strike. Additionally, Hex prevents these abilities as well.
* An Earth Spike and Finger of Death combo can burst an unwary Morphling down if he has his strength fully shifted to agility.

* All of Lion's abilities are active making Demonic Purge break from Aghanim's Scepter useless.
* Hex and Mana Drain can make quick work of whatever illusions you're creating, especially when he acquires his Talents at level 20 and 25.
* An attempt to save an ally using Disruption can easily become a perfect setup for a Earth Spike or Finger of Death with Aghanim's Scepter for the enemy.

* Ember lacks any protection against Lion's disables early in the game and often does not acquire any later, allowing Lion to Hex or Earth Spike him before he escapes through his Fire Remnant.
* Although Flame Guard can prevent magic damage, it does not stop Lion's disables, and Lion can usually break through it with Finger of Death.
Additional:
* Lion possesses two strong disables in Earth Spike and Hex and heavy magic burst with Finger of Death which help lock him down and prevent him from escaping with Activate Fire Remnant. When getting his Blink Dagger Lion can punish Ember Spirit's overextension immediately, or initiate a fight on him with disables.

* Lion will continuously Mana Drain Tiny, depleting his small mana pool for his abilities.
* Hex will keep Tiny from using his high damage spells and attack damage.

* Shadow Shaman has no effective burst damage, thus Chen has a lot of time to save an ally with his creeps or Hand of God from a gank.
* Chen can use {U:Centaur Conqueror} or {U:Mud Golem} to interrupt Shadow shaman's Shackles channeling
* Mass Serpent Ward can be easily teared down by Chen's creep army

* Despite her high mobility, Hex or Earth Spike can lock Phantom Assassin down and make her vulnerable.
* Although she has high evasion through Blur, Phantom Assassin has a rather low health pool, making her weak to Lion's magical burst.
Additional:
* Hex and Earth Spike's fast cast animations easily catches Phantom Assassin when she jumps in to attack.
* Finger of Death often ends Phantom Assassin before she can do anything in the early to mid game.

* Drow has a very low health pool, allowing Lion to burst her down.
* Drow has no innate escape mechanism, making her an easy target for Lion's disables.
* Lion should be wary of Drow's Gust however, as he has no natural means to deal with it.

* Chen in the early game is a faster pusher than Arc Warden until Arc Warden buys Maelstrom.

* Bane has zero Spells to deal with multiple Chen's Creeps.
* Fiend's Grip can be easily interrupted by {U:Centaur Conqueror} and {U:Mud Golem} abilities.

* Hex's instant cast time will force Brewmaster into the awkward situation of needing some form of spell immunity or block to prevent being immediately hex upon blinking in, or wait until Lion has used all his crowd control before entering a fight. His direct magic burst also makes Brewmaster's Drunken Brawler worthless versus Lion.

* Lion has two low cast point disables (Hex and Earth Spike) to control Ursa before he buys a Black King Bar.
* Hex is one of the few abilities that cannot be dispelled even with an Aghanim's Scepter upgraded Enrage.
* Lion can control Ursa's low mana pool via Mana Drain.

* Wraith King has a very low mana pool and depends on it to cast Reincarnation. Mana Drain will render him useless.
* Wraith King has very low mobility, making it easy for Lion to disable and harass him.
Additional:
* While not being able to confront Wraith King by himself, Lion's Mana Drain helps in draining Wraith King's mana, preventing him from reincarnating unless he has his Aghanim's Shard.
* Lion's Earth Spike and Hex provide decent lockdown against Wraith King as well, preventing the latter from benefiting from Vampiric Spirit bonuses.

* Chen can take control of the Boar from Call of the wild Boar at any time.

* Mana Drain is very effective against heroes that have mana burn abilities such as Anti-Mage, Nyx Assassin and Keeper of the Light.

* Since Windranger is bad against magical damage, heroes with continuous magical damage or magical nukes can blast her: Zeus, Tinker, Leshrac, Viper, Skywrath Mage, Lion, Lina, Venomancer.

* High priority targets like Queen of Pain, Drow Ranger and even Anti-Mage can't get caught out from Lion's long range disables.

* Heroes with high magical burst damage will kill Gyrocopter before he gets to do much: Lina, Lion, Zeus

* Any heroes with stuns or silences: Death Prophet, Lion, Shadow Shaman, Skywrath Mage

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin

* Heroes with many summons or illusions are much harder to catch with Meat Hook: Nature's Prophet, Phantom Lancer, Chen.

Additional:
* Rot is not very effective against Chen's creeps.
* Chen can use his creeps to cover him or his allies from any attempts of Meat Hook.
* {U:Centaur Conqueror} or {U:Mud Golem} under Chen's control can interrupt Dismember.

* Mana Drain is very effective against heroes that have mana burn abilities such as Anti-Mage, Nyx Assassin and Keeper of the Light.

* Heroes that can keep Marci for a long time in one place so she can't pursue her targets, like Bane, Lion, Shadow Shaman, Invoker, Disruptor and Kunkka.

* Mana Drain has an extremely long range and low cooldown. It can easily deplete most heroes of their entire mana pools, especially those with smaller mana pools such as Tiny or Spirit Breaker.

* Lion's disables are also really effective against channeling Heroes, like Enigma or Crystal Maiden.

* Heroes with high magical burst can easily kill Huskar when he is at low health: Lion, Lina, Skywrath Mage

* Hex and Mana Drain can be used to immediately destroy Spectre's illusion when she Haunts. A fast fingered Lion can protect himself and a teammate.
* Hex and Earth Spike are good lockdown spells to control and kill Spectre, especially if she doesn't buy defensive items like Linken's Sphere and Black King Bar.
* Finger of Death can be used to burst down Spectre when she is low on life as she has very poor magic resistance.

* Hex and Earth Spike can hold Clinkz down, giving him no chance to use Black King Bar or Skeleton Walk.
* Finger of Death quickly kills Clinkz due to his low health.

* Medusa lacks mobility or escape mechanisms. Earth Spike and Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* In addition to easily breaking her commonly bought Linken's Sphere with its low cooldown, Mana Drain can quickly drain her Mana Shield, making her far less tanky.

* Although Weaver can potentially Time Lapse out of any burst, Weaver has a fragile health pool, and Lion's disables can kill him before.
* Weaver is very mana dependent and has a rather small mana pool in the beginning of the game. Mana Drain can deplete him of mana and lessen his early game presence.
* Earth Spike can be point targeted and hits through Shukuchi to make him vulnerable.
* Linken's Sphere is easily broken by targeted spells with low cooldown.

* Both Hex and Mana Drain destroy Naga Siren's illusions in an instant, making it hard to teamfight or push against a team with Lion. If Lion chooses the AoE effect talent for Hex or the shard for multi-target Mana Drain, it can negate her pushing potential entirely.
* Earth Spike is an AoE disable with good damage. If used well, it can help distinguish the true Naga Siren by the damage they take (illusions take more damage).

* Heroes with the ability to heal allies, or those with good defensive abilities: Chen, Dazzle, Io, Oracle, Omniknight, Witch Doctor, Winter Wyvern, Abaddon, etc.

* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.
* Mana Drain and Hex instantly kill any illusions. Finger of Death upgraded with Aghanim's Scepter also shreds most illusions.
* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.

* Hex greatly reduces Timbersaw's mobility.
* In addition, Lion can follow up with his Earth Spike and Mana Drain combo, preventing Timbersaw to escape with Timber Chain. And he can finish Timbersaw off with Finger of Death if the latter's HP is low enough.

* Lion's disables are also really effective against channeling Heroes, like Enigma or Crystal Maiden.

* With a lot of disables with good range, he might cancel your Echo Stomp.
* Mana Drain can be used to drain Elder Titan's already low mana pool.

* Heroes with long disables, like Lion, Night Stalker, or Legion Commander, can prevent Oracle from using spells or items.

* Heroes that can drain mana negatively affect Viper's ability to use Poison Attack, Nethertoxin and Viper Strike: Lion, Anti-Mage

* Heroes with high burst damage: Lina, Lion, Luna, Nyx Assassin, Queen of Pain.

* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.
* Mana Drain and Hex instantly kill any illusions. Finger of Death upgraded with Aghanim's Scepter also shreds most illusions.
* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.

* Heroes with high burst damage through their physical attacks or spells can kill Dazzle or his allies before he has a chance to use Shallow Grave. (Lina, Lion, etc.)

* Finger of Death can instantly shred many targets especially fragile Heroes like Keeper of the Light, Ancient Apparition, or Bounty Hunter.

* Mana Drain depletes Nercophos' mana pool, preventing him from using his abilities.
* Finger of Death deals high magical damage, which becomes amplified by Ghost Shroud.

* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.
* Mana Drain and Hex instantly kill any illusions. Finger of Death upgraded with Aghanim's Scepter also shreds most illusions.
* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.