* All of Lion's abilities are active making Demonic Purge break from Aghanim's Scepter useless.
* Hex and Mana Drain can make quick work of whatever illusions you're creating, especially when he acquires his Talents as level 20 and 25.
* An attempt to save an ally using Disruption can easily become a perfect setup for a Earth Spike or Finger of Death with Aghanim's Scepter for the enemy.

* All of Queen of Pain's abilities are active making Demonic Purge break from Aghanim's Scepter useless.
* Although, Demonic Purge can help his allies kill a squishy Queen of Pain.
* Blink allows Queen of Pain to escape from Shadow Demon's abitlity if he doesn't have disables.
* An attempt to save an ally using Disruption can easily become a perfect setup for a Sonic Wave for the enemy.
* Queen of Pain usually builds Eul's Scepter of Divinity to dispel Shadow Poison and Soul Catcher and Linken's Sphere or Spell Block talent to block Disruption and Demonic Purge.

* Drow has a very low health pool, allowing Lion to burst her down.
* Drow has no innate escape mechanism, making her an easy target for Lion's disables.
* Lion should be wary of Drow's Gust however, as he has no natural means to deal with it.

* Often you can burst Drow Ranger down before she has a chance to try and Gust you away. Try to have a teammate bait her Gust out before you Blink and get the drop on her.

* Heroes with high magical burst damage will kill Gyrocopter before he gets to do much: Lina, Lion, Zeus

* Blink makes it hard for Gyrocopter to pin down Queen of Pain.
* Sonic Wave is very effective at ganking Gyrocopter in the early game.

* Blinking heroes like Anti-Mage or Queen of Pain can often chase down an injured Brewmaster after his ultimate expires.

* Hex's instant cast time will force Brewmaster into the awkward situation of needing some form of spell immunity or block to prevent being immediately hex upon blinking in, or wait until Lion has used all his crowd control before entering a fight. His direct magic burst also makes Brewmaster's Drunken Brawler worthless versus Lion.

* Lion possesses two strong disables in Earth Spike and Hex and heavy magic burst with Finger of Death which help lock him down and prevent him from escaping with Activate Fire Remnant. When getting his Blink Dagger Lion can punish Ember Spirit's overextension immediately, or initiate a fight on him with disables.
Additional:
* Ember lacks any protection against Lion's disables early in the game and often does not acquire any later, allowing Lion to Hex or Earth Spike him before he escapes through his Fire Remnant.
* Although Flame Guard can prevent magic damage, it does not stop Lion's disables, and Lion can usually break through it with Finger of Death.

* Queen of Pain can be a good hero for dealing with Ember Spirit with Orchid Malevolence, her pure damage nuke in Sonic Wave and a slow in Shadow Strike. However, Queen of Pain can be punished by Ember Spirit, as his Searing Chains prevents her from getting Blink off.

* Timbersaw has a difficult time against magical and pure damage: Lina, Leshrac, Enchantress, Queen of Pain

* Hex greatly reduces Timbersaw's mobility.
* In addition, Lion can follow up with his Earth Spike and Mana Drain combo, preventing Timbersaw to escape with Timber Chain. And he can finish Timbersaw off with Finger of Death if the latter's HP is low enough.

* He's the kind of hero that likes to remain at low hp, which is perfect for Queen of Pain to burst with Sonic Wave.
* You should be able to blink away after he jumps on you with Life Break.

* Heroes with high magical burst can easily kill Huskar when he is at low health: Lion, Lina, Skywrath Mage

* Mana Drain is very effective against heroes that have mana burn abilities such as Anti-Mage, Nyx Assassin and Keeper of the Light.

* Heroes with teleports to escape Will-O-Wisp: Phantom Assassin, Puck, Queen of Pain, Storm Spirit

* Heroes that can jump on her: Slark, Queen of Pain, Anti-Mage

Additional:
* Untouchable won't mitigate magic damage, and a squishy Enchantress is very vulnerable to Queen of Pain's magic burst.

* Heroes with nukes: Bane, Lich, Lion, Skywrath Mage

Additional:
* Enchantress is very fragile without any form of magic resistance, allowing Lion to easily burst her down.
* Nature's Attendants is a slow heal, making it ineffective against Lion's burst.
* Enchantress lacks any escape mechanism apart from her raw movement speed, allowing Lion to disable her.
* Since Lion's damage comes mostly from his skills, Untouchable does nothing to mitigate it.

* Heroes with high burst damage: Lina, Lion, Luna, Nyx Assassin, Queen of Pain.

* Heroes with high burst damage: Lina, Lion, Luna, Nyx Assassin, Queen of Pain.

* Finger of Death can instantly shred many targets especially fragile Heroes like Keeper of the Light, Ancient Apparition, or Bounty Hunter.

* Heroes with mobility/escape mechanisms to dodge Ancient Apparition abilites, or to easily jump on him: Riki, Queen of Pain, Phantom Assassin, Windranger, Bounty Hunter, Spirit Breaker, Night Stalker, Storm Spirit, Juggernaut, etc.

* Mana Drain is a headache for Bristleback to deal with during the laning stage, as it denies him the ability to get last hits with Quill Spray.
* Finger of Death deals high damage to Bristleback, and only triggers his passive once.

* Medusa lacks mobility or escape mechanisms. Earth Spike and Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* In addition to easily breaking her commonly bought Linken's Sphere with its low cooldown, Mana Drain can quickly drain her Mana Shield, making her far less tanky.

* Mana Drain rapidly saps Morphling's already low mana pool, making him unable to use Waveform or Adaptive Strike. Additionally, Hex prevents these abilities as well.
* An Earth Spike and Finger of Death combo can burst an unwary Morphling down if he has his strength fully shifted to agility.

* Lion has two low cast point disables (Hex and Earth Spike) to control Ursa before he buys a Black King Bar.
* Hex is one of the few abilities that cannot be dispelled even with an Aghanim's Scepter upgraded Enrage.
* Lion can control Ursa's low mana pool via Mana Drain.

* Wraith King has a very low mana pool and depends on it to cast Reincarnation. Mana Drain will render him useless.
* Wraith King has very low mobility, making it easy for Lion to disable and harass him.
Additional:
* While not being able to confront Wraith King by himself, Lion's Mana Drain helps in draining Wraith King's mana, preventing him from reincarnating.
* Lion's Earth Spike and Hex provide decent lockdown against Wraith King as well, preventing the latter from benefiting from Vampiric Aura bonuses.

* Lion will continuously Mana Drain Tiny, depleting his small mana pool for his abilities.
* Hex will keep Tiny from using his high damage spells and attack damage.

* Blink allows Queen of Pain to avoid ganks and keep her distance, preventing Monkey King from building up Jingu Mastery.
* Scream of Pain and Sonic Wave will hit Monkey King when he is disguised, or on a tree.
* The large AoE and low cooldown also helps Queen of Pain hit the real Monkey King inside of Wukong's Command.

* Despite her high mobility, Hex or Earth Spike can lock Phantom Assassin down and make her vulnerable.
* Although she has high evasion through Blur, Phantom Assassin has a rather low health pool, making her weak to Lion's magical burst.
Additional:
* Hex and Earth Spike's fast cast animations easily catches Phantom Assassin when she jumps in to attack.
* Finger of Death often ends Phantom Assassin before she can do anything in the early to mid game.

* Both Hex and Mana Drain destroys Naga Siren's illusions in an instant, making it hard to teamfight or push against a team with Lion. If Lion chooses the AoE effect talent for Hex or the multi-target Mana Drain, it can negate her pushing potential entirely.
* Earth Spike is an AoE disable with good damage. If used well, it can help distinguish the true Naga Siren by the damage they take (illusions take more damage).

* Queen of Pain usually outlanes Invoker, giving her team a significant early game advantage while Invoker is still farming.
* Blink allows Queen of Pain to escape from Invoker's combo if he doesn't have disables.

* Queen of Pain can easily escape Chain Frost thanks to Blink.
* His low survivability makes an easy kill for Shadow Strike, Scream of Pain & Sonic Wave.

* Although Weaver can potentially Time Lapse out of any burst, Weaver has a fragile health pool, and Lion's disables can kill him before.
* Weaver is very mana dependent and has a rather small mana pool in the beginning of the game. Mana Drain can deplete him of mana and lessen his early game presence.
* Earth Spike can be point targeted and hits through Shukuchi to make him vulnerable.
* Linken's Sphere is easily broken by targeted spells with low cooldown.

* With a lot of disables with good range, he might cancel your Echo Stomp.
* Mana Drain can be used to drain Elder Titan's already low mana pool.

* Queen of Pain can Blink to both escape and initiate onto Void Spirit.
* She is also a very common Orchid Malevolence carrier, which can prevent Void Spirit from contributing much in fights.

* Blink can instantly break Static Link, making it useless against her.
* Queen of Pain doesn't fully rely on her physical attack damage, so she can still fight after being hit with Static Link.

* Blink allows Quen of Pain to easily escape ganking or initiating attempts with Hookshot and Power Cogs.

* Hex and Mana Drain can be used to immediately destroy Spectre's illusion when she Haunts. A fast fingered Lion can protect himself and a teammate.
* Hex and Earth Spike are good lockdown spells to control and kill Spectre, especially if she doesn't buy defensive items like Linken's Sphere and Black King Bar.
* Finger of Death can be used to burst down Spectre when she is low on life as she has very poor magic resistance.

* Hex and Earth Spike can hold Clinkz down, giving him no chance to use Black King Bar or Skeleton Walk.
* Finger of Death quickly kills Clinkz, due to his low health.

* Heroes with high mobility can approach Sniper: Anti-Mage, Earth Spirit, Io, Nature's Prophet, Pangolier, Puck, Queen of Pain and most notably Riki.

* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.
* Mana Drain and Hex instantly kill any illusions. Finger of Death upgraded with Aghanim's Scepter also shreds most illusions.
* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.

* Heroes with mobility spells can quickly escape from Stroke of Fate or break out of Soulbind: Anti-Mage, Queen of Pain, Morphling, Storm Spirit

* In general, heroes such as Lion, Silencer, Skywrath Mage, Sven, Ogre Magi and others with reliable disables are crucial to killing Techies before they can suicide.

* Heroes with a high degree of mobility and invisibility are hard to catch with Meat Hook: Ember Spirit, Riki, Clinkz, Queen of Pain.

* Heroes with mobility spells (such as Queen of Pain's Blink and Clockwerk with Hookshot) can easily avoid Lil' Shredder and Mortimer Kisses.
* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.

* Heroes with considerable mobility can easily escape from a rolling Pangolier: Anti-Mage, Queen of Pain, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, moreover, if a player is familiar with how Rolling Thunder work, they can adjust their movement to avoid it entirely and of course outplay the Pangolier player.

* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.
* Mana Drain and Hex instantly kill any illusions. Finger of Death upgraded with Aghanim's Scepter also shreds most illusions.
* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.

* Heroes with high burst damage through their physical attacks or spells can kill Dazzle or his allies before he has a chance to use Shallow Grave. (Lina, Lion, etc.)

* Dark Seer's only disable is Vacuum. Though he starts off with high armor and health, he'll eventually have a hard time dealing with high mobility heroes such as Weaver or Queen of Pain.

* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Pugna
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Pugna

* Any heroes with stuns or silences: Death Prophet, Lion, Shadow Shaman, Skywrath Mage

* Once you farm up an Orchid Malevolence or a Scythe of Vyse, you're suddenly a lot more fearsome to elusive heroes like Storm Spirit or even that pesky Puck.

* Since Windranger is bad against magical damage, heroes with continuous magical damage or magical nukes can blast her: Zeus, Tinker, Leshrac, Viper, Skywrath Mage, Lion, Lina, Venomancer.

* Heroes that can drain mana negatively affect Viper's ability to use Poison Attack, Nethertoxin and Viper Strike: Lion, Anti-Mage

* Finger of Death can instantly shred many targets especially fragile Heroes like Keeper of the Light, Ancient Apparition, or Bounty Hunter.

* Heroes with escaping and disjointing abilities can be good against Juggernaut: Riki, Queen of Pain, Puck, Storm Spirit, Ember Spirit, Slark etc.

* Heroes that usually builds Linken's Sphere as a core item: Weaver, Medusa, Morphling, Queen of Pain, Storm Spirit

* Mana Drain has an extremely long range and low cooldown. It can easily deplete most heroes of their entire mana pools, especially those with smaller mana pools such as Tiny or Spirit Breaker.

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin

* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.
* Mana Drain and Hex instantly kill any illusions. Finger of Death upgraded with Aghanim's Scepter also shreds most illusions.
* One of Lion's level 20 talents lets Mana Drain affect 2 secondary targets. This can make things difficult for heroes like Phantom Lancer, Chaos Knight, and Terrorblade who rely on illusion armies.

Additional:
* Mana Drain is a real problem to Chaos Knight early game, considering his already low mana pool.
* Aghanim's Scepter upgraded Finger of Death is an AoE ability, which can deal a tremendous amount of damage to his illusions.
* Hex with a level 25 talent instantly disposes Chaos Knight's illusions.

* Lion's disables are also really effective against channeling Heroes, like Enigma or Crystal Maiden.

* Heroes who have a high mobility (Queen of Pain, Storm Spirit, Slark, etc.).

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Mana Drain depletes Nercophos' mana pool, preventing him from using his abilities.
* Finger of Death deals high magical damage, which becomes amplified by Ghost Shroud.

* Heroes with heavy magical nukes will take advantage of Slarks poor HP or force him to use Shadow Dance early: Lina, Lion, Zeus

* Both Scream of Pain and Sonic Wave should hit him during his Shadow Dance.

* Finger of Death's burst damage can kill him due to his low health pool, and Ethereal Blade only makes it worse. If Lion purchased an Aghanim's Scepter, the situation only grows worse.
* If Meepo ganks Lion with Poof and Earthbind, he will be an easy target for Earth Spike & AoE Hex from his level 25 talent.

* Ranged heroes that can easily harass Axe: Drow Ranger, Sniper, Lion.

* Special mention goes to Queen of Pain as she could kill herself with Sonic Wave if your Nether Ward is up.

* Lion's disables are also really effective against channeling Heroes, like Enigma or Crystal Maiden.

* Heroes with long disables, like Lion, Night Stalker, or Legion Commander, can prevent Oracle from using spells or items.

* Heroes with damage over time abilities can quickly eat through Gravekeeper's Cloak charges like Huskar, Jakiro and Queen of Pain.