* Heroes with summons: Lycan, Broodmother, Visage.

* Although he can avoid Eclipse with Rage and Infest, Luna's physical damage can be enough to deal with him.
* Manta Style is a common pick on Luna, which can help her dispel Open Wounds. In addition, Lifestealer is not good against illusions created by Manta Style.

* Lucent Beam can cancel Tether and Relocate.
* Moon Glaives and Eclipse make short work of Io and its tethered ally.

* Heroes with low armor and little mobility, like Huskar, Io, etc. will also have an unfortunate fate.

* Magnetic Field is useless against melee heroes, so Lycan can attack Arc Warden without missing.
* Flux doesn't affect Lycan that much, because Shapeshift grants immunity to slows and because he is never alone.
* If their Tempest Double has been called, Lycan can still kill Arc Warden before the double expires.

* Luna's Moon Glaives allow her to clear Arc Warden's Tempest Double.
* Luna's short range and fast movement speed allow her to fight Arc Warden inside his Magnetic Field.

* Aggressively blinking is not going to end well against Luna, because Queen of Pain will be an easy target for Lucent Beam & Eclipse.
* Queen of Pain's HP is abysmal, so Luna can quickly kill Queen of Pain as soon as she initiates with Blink.

* Shapeshift is useful for killing or escaping Silencer.
* Summon Wolves, and later Necronomicon units, can be used to hunt a badly wounded Silencer down - even when Lycan himself can't fight.

* Shapeshift allows Lycan to chase down Earth Spirit.

* Lycan doesn't care much about Lich's slows thanks to Shapeshift.
* Chain Frost can bounce to the wolves that Lycan summons.
Additional:
* Lich possesses a lot of slows, which Lycan doesn't care about when he Shapeshifts.
* Lich has no in-built escape, which makes him a good target for Lycan.

* Even though Luna is the kind of hero that Bounty Hunter can handle due to Shadow Walk rendering him safe from Eclipse, smart Luna will always buy Dust of Appearance, allowing her to provide vision on him to her team, and possibly, kill Bounty Hunter with Eclipse.
Additional:
* Even though Luna is the kind of hero that Bounty Hunter can handle due to Shadow Walk rendering him safe from Eclipse, smart Luna will always buy Dust of Appearance, allowing her to provide vision on him to her team, and possibly, kill Bounty Hunter with Eclipse.

* If Luna can use Eclipse in anticipation, Magnus will be killed before he can even manages to cast Reverse Polarity.
* Aghanim's Scepter upgraded Eclipse is a very good counter-initiation tool against Magnus when he casts Reverse Polarity, granted as long as Luna can cast it from safe distance.

* Moon Glaives can easily clear Chen's creeps while Eclipse can kill Chen's allies before he can react.
Additional:
* Luna's Moon Glaives and Lunar Blessing can easily kill Chen's creeps.

* Illusion and heroes with summons are difficult to kill with Chen's single-target offensive spells: Terrorblade, Phantom Lancer, Chaos Knight, Broodmother, Naga Siren, Lycan, Visage. However, Chen can convert enemy summons with Holy Persuasion, as long as they don't bunch up.

* Lycan is a common Necronomicon 3 carrier, hindering his attempt of initiate or escape using Vendetta.
* And the Last Will can be killed quickly with Nyx Assassin's high burst damage, although he can at least partially counter it with a well-timed Spiked Carapace.
* Lycan's high HP easily shrug off Nyx Assassin's burst damage and fend him off.

* Shapeshift allows Lycan to escape from Upheaval with 650 movement speed.
* Warlock doesn't have a lot of AoE abilities to deal with Lycan's wolves from Summon Wolves.

* It is almost impossible for Bane to use Fiend's Grip properly against Luna's allies due to the huge cast range of the Lucent Beam.
Additional:
* Luna's Lucent Beam can be used to disable Bane while he is channeling Fiend's Grip.
* Luna's Eclipse will often be able to kill Bane before he can even act.

* Heroes with single-target abilities will be overwhelmed by Lycan and his summons: Wraith King, Bane, Phantom Assassin.

* Lucent Beam allows Luna to easily cancel Freezing Field.
* Without Black King Bar protection, Lucent Beam and Eclipse can make a short work out of Crystal Maiden's abysmal health.
* Skilled Luna will always buy Dust of Appearance, allowing her team to have a vision on Crystal Maiden while invisible and during channeling Freezing Field.

* Moon Glaives is effective at destroying Familiars and will remove one instance of Gravekeeper's Cloak upon each hit to Visage, leaving him susceptible to damage.

* Void's slow is useless against Lycan by activating Shapeshift.
* Night Stalker's single target abilities (with the exception of Void upgraded by Aghanim's Scepter) is not very effective against Lycan's Summon Wolves and Necronomicon minions during the early and mid game.

* Luna has Moon Glaives and Lunar Blessing to help her destroy Tombstone, and this becomes more effective if Luna is equipped with Manta Style.
* Defending with Zombies from Tombstone against Luna is not a good idea because Eclipse will strike only Undying.

* Lunar Blessing gives allies bonus damage and armor required to endure against Atrophy Aura early on.
* Eclipse can be devastating for Underlord's team when they're grouped up for Dark Rift, it can also be used to intercept arrivals with Dark Rift. And Pit of Malice does not prevent Luna to use it.
* To make things even better, Aghanim's Scepter upgraded Eclipse can finish off Underlord or any of his teammates escape attempts with Dark Rift if timed correctly.
Additional:
* Lunar Blessing gives allies bonus damage required to endure against Atrophy Aura early on.
* Eclipse can be devastating for Underlord's team when they're grouped up for Dark Rift, it can also be used to intercept arrivals with Dark Rift. And Pit of Malice does not prevent Luna from using it.
* To make things even worse, Aghanim's Scepter upgraded Eclipse can finish off Underlord or any of his teammates escape attempts with Dark Rift if timed correctly.

* Heroes with single-target abilities will be overwhelmed by Lycan and his summons: Wraith King, Bane, Phantom Assassin.

* Heroes with high burst damage: Lina, Lion, Luna, Nyx Assassin, Queen of Pain.

* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Pugna

* Skywrath mage also has a terrible time fighting against anything that isn't a hero. As Mystic Flare only affects heroes, his skills are mostly target-based and he has terrible strength and agility, he can easily be kited or harassed by illusion-based heroes like Chaos Knight and Phantom Lancer, or by Heroes that summon other units like Lone Druid, Lycan and Beastmaster.

* Heroes with low armor and little mobility, like Huskar, Io, etc. will also have an unfortunate fate.

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: Clinkz, Pugna, Nature's Prophet, Dark Seer, Lycan, Tusk

* Illusion heroes like the aforementioned Phantom Lancer or Naga Siren, or heroes that tend to buy Manta Style, like Luna or Juggernaut, will give Slardar a hard time, as his damage is single-targeted.

* Moon Glaives and Lunar Blessing help Luna to tear off Nature's Prophet's treants.
* Luna can easily cancel Teleportation with her Lucent Beam.

* Lycan's ultimate makes him immune to slows from Ursa's Earthshock as well as allowing him to outmaneuver Ursa during Enrage. Lycan can also easily chase down Ursa while shapeshifted, should Ursa try to flee.

* A Lycan with Shapeshift can always run down Puck and kill him very quickly due to his low armor. It is important to abuse as many cliffs and trees as possible to escape from a Lycan.

* Provided Luna is able to cast it in time, Eclipse can help win a Duel from Legion Commander.
* If Luna isn't the target, she can easily use Lucent Beam and Eclipse to win the fight for the ally.
Additional:
* A well-timed Eclipse before a Duel usually prevents Legion Commander from winning Duels, if Luna is the target.
* Meanwhile, when Luna is not a target, Eclipse and Lucent Beam can also help an ally win a Duel against Legion Commander.
* However, skilled Legion Commander players will always have a Black King Bar or Aghanim's Scepter handy since both abilities do not pierce through spell immunity.

* Luna can push very fast with Moon Glaives, which is something Riki cannot deal with well.
* Luna is naturally very fast, making it hard for Riki to trap her in Smoke Cloud.
* Even though Riki can evade Eclipse with his invisibility, smart Luna will always buy Dust of Appearance, providing vision on Riki to her allies and herself.

* Life Drain will be always canceled by Lucent Beam if Pugna does not have Black King Bar.
* Decrepify can be suicide against Luna due to Lucent Beam and Eclipse.
* Nether Ward is rather weak against Luna since she does not have abilities that cost a lot of mana.
Additional:
* Luna can shrug off most damage taken from Nether Ward as she only has two castable skills with average mana cost.
* Luna can deal constant damage to Pugna through the low-cooldown Lucent Beam and her right clicks.
* Lucent Beam's considerable range can reliably cancel Pugna's Life Drain.
* Luna is a common Black King Bar carrier, which totally nullifies Pugna's damage output.
* If Pugna uses Decrepify on himself to avoid Luna's right click, she can burst him down with Lucent Beam and Eclipse.

* Though Luna has a hard time laning against Necrophos, his Ghost Shroud won’t protect him in teamfights because it will increase the damage from Lucent Beam and Eclipse.

* Mirana's Leap is ineffective if Lycan uses Shapeshift. It also allows him to dodge Sacred Arrow.
* As a natural Necronomicon carrier, he can reveal Mirana and her allies hiding in Moonlight Shadow and the Necronomicon Warrior can kill Mirana from an unintentional Sacred Arrow or Starstorm upgraded with Aghanim's Scepter.

* Shapeshift allows Lycan to get close and disable Marksmanship.
* Shapeshift also makes him immune to slows like Drow Ranger's Frost Arrows.
Additional:
* The Wolves' speed causes the knockback from Gust to be ineffective.
* She lacks escapes and loses her Marksmanship when someone is near her. Lycan takes advantage of these weaknesses.

* Guardian Angel does not offer protection from Eclipse, though it will negate damage from Moon Glaives.

* The movement speed granted from Shapeshift means that Spectre has no way to punish Lycan if he wants to splitpush or pick off supports. Furthermore, he will kite Haunt and cannot be slowed by Spectral Dagger.
* As Lycan typically has Summon Wolves out and builds Necronomicon, very rarely will he be damaged by Desolate if he does manage to get into a fight against her.
* Lycan is often part of an early game push strategy which is often the best counter to Spectre because she needs a lot of time and space to come online as a late game carry.

* Heroes with haste can negate Enchant's slow: Weaver, Dark Seer, Lycan, Centaur Warrunner.

* Enchantress has pitiful HP so Lucent Beam and Eclipse can kill her very quickly.
* Moon Glaives allows Luna to clear Enchantress' creeps very efficiently.
Additional:
* Enchantress has pitiful HP, even more pitiful than Luna, so Lucent Beam and Eclipse will often harass and/or kill her through her Untouchable.
* With Moon Glaives, Luna can clear Enchantress's creep wave efficiently.

* Lycan and Weaver has abilities that allow them to move at maximum movement speed, and those abilities can't be dispelled, potentially wasting the slow from Demonic Purge.
* You can potentially kill a fragile Weaver by using disruption DURING Shukuchi with a well-placed Sentry Ward, wasting the Shukuchi. But odds are he'll wait to get low health, Time Lapse the damage away and Shukuchi away once more.

* Lucent Beam interrupts Death Ward from a decent range.
* Eclipse kills Witch Doctor during Death Ward, even through Glimmer Cape.

* Cold Embrace is no salvation against Lucent Beam and Eclipse.
* Moon Glaives will not hit a hero affected by Winter's Curse, making it weak against allies, but strong versus enemies.
* Luna has better night vision provided by Lunar Blessing than Winter Wyvern when affected by Arctic Burn.
Additional:
* Cold Embrace is no salvation against Lucent Beam and Eclipse.
* Moon Glaives will not hit a hero affected by Winter's Curse, making it weak against allies, but strong versus enemies.
* Luna has better night vision provided by Lunar Blessing than Winter Wyvern when affected by Arctic Burn.

* Heroes that can stall pushes: Invoker, Keeper of the Light, Lina, Luna.

* Luna can easily prevent Tinker from escaping with Boots of Travel or Rearm with Lucent Beam.
* Luna can also quickly tear Tinker to shreds with Eclipse as soon as he jumps in with Blink Dagger.