* Black Hole is a channeling ability and Earth Spirit has at least two possibilities which can interrupt these kind of spells. Enigma is exposed and cannot move while using Black Hole, thus making it easy for Earth Spirit to stop the feared ability with the huge range of Rolling Boulder and forcing Enigma to quickly rush a Black King Bar to prevent this.
* Enigma is level dependant, squishy and relativly defenseless in the early game and therefore vulnerable to aggressive roam maneuvers in this stage of the game. Earth Spirit excels at ganking, shutting down a jungling or otherwise solo farming Enigma.

* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult.
* Mystic Snake can be potentially detrimental to Enigma's initiation. Getting hit by the latter high-damage bounces (from standing behind his Eidolons or his teammates) can hinder his mana pool, preventing him from executing a strong initiation.
Additional:
* Mana Shield makes Medusa harder to kill with Enigma's Black Hole and Pulse combo.
* Medusa's Split Shot can kill Demonic Conversion creeps easier and Mystic Snake bounces off from them.
* Stone Gaze makes it hard for Enigma to approach Medusa for a Black Hole.

* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.

* Heroes with considerable mobility can easily escape from a rolling Pangolier: Anti-Mage, Queen of Pain, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, moreover, if a player is familiar with how Rolling Thunder work, they can adjust their movement to avoid it entirely and of course outplay the Pangolier player.

* Rolling Boulder and Geomagnetic Grip disable Faceless Void so he cannot escape with Time Walk.
* Rolling Boulder will allow Earth Spirit to get on top of Faceless Void at all stages of the game.

* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mystic Snake eats away at Sven's small mana pool.
* Mana Shield negates much of Sven's burst damage.

* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.

* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
* Untouchable is ignored by secondary attacks from Split Shot.

* Geomagnetic Grip is not blocked by Linken's Sphere and can silence Morphling, preventing Morphling from using Waveform or Attribute Shift to escape from ganks.
* In addition, Boulder Smash and Rolling Boulder provide a solid lockdown if used together.

* Earth Spirit can easily disrupt Dismember because he can disable from a long distance with a Stone Remnant and Rolling Boulder. With talent he can even pull his teammates out of Dismember and also silence Pudge with Geomagnetic Grip.

* Mystic Snake can harass Axe in lane and drain his small mana pool.
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to pursue.

* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces Rage, wasting its cooldown and making Lifestealer unable to fight.

* Geomagnetic Grip can be used to silence Earthshaker after he blinks in, preventing him from executing his combo.
* Magnetize does damage over time and thus disables Earthshaker's Blink Dagger for a long time.

* Boulder Smash and Geomagnetic Grip allow Earth Spirit to easily disrupt Freezing Field, regardless of where Crystal Maiden is due to their incredible range. Earth Spirit is quite possibly the best hero for stopping long channeling abilities, and Crystal Maiden is vulnerable to him without a Black King Bar.
* All of Earth Spirit's spells allow him to easily close in on Crystal Maiden and kill her. Since she is a low health support, she generally stays behind in teamfights, but Earth Spirit can easily close the distance.
* Crystal Maiden has low movement speed and no other escape mechanism, rendering her extremely vulnerable to Earth Spirit's arsenal of long-range, damaging spells.

* Mana Shield tanks most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops to 15%/17%/19% health (before reductions).
* Heartstopper Aura does not chip away at Medusa's mana, this makes it not a threat as it deals damage based on current health.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.

* Boulder Smash can return Tusk after his initiation.
* Geomagnetic Grip prevents Tusk from using Snowball to escape.

* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
* Mana Shield reduces the impact of Decay and Flesh Golem's Plague Aura.

* Boulder Smash can smash Monkey King out of the Wukong's Command radius.
* Rolling Boulder destroys trees and helps Earth Spirit close the gap between him and Monkey King.

* If Medusa activates Stone Gaze, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.

* Boulder Smash will push Sand King out of Sand Storm to reveal his position or an activated Epicenter off of Earth Spirit's allies, potentially wasting his combo
* Rolling Boulder and Geomagnetic Grip allow Earth Spirit to easily stun and silence Sand King and interrupt the channeling of Epicenter, completely ruining his initiation.

* Tinker is an easy target for Earth Spirit to initiate on. He likes to split push lanes once he acquires Boots of Travel and Earth Spirit can jump him with his Rolling Boulder and disable him to buy enough time for his teammates to come and assist Earth Spirit.
* The huge range of Stone Remnant and Rolling Boulder enables Earth Spirit to stop Tinker from teleporting to his fountain since Tinker tends to buy Blink Dagger most of the time to escape.

* Summoned gargoyles will give Medusa free target practice.
* Mana Shield will resist Soul Assumption instances without effort.

* Boulder Smash's and Geomagnetic Grip's (upgraded with Aghanim's Scepter) repositioning and disables make it very difficult for Razor to keep enemies within range of Static Link and Eye of the Storm.

* Squishy heroes (Io, Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.

* Heroes that can gank Shadow Fiend in the early game: Earth Spirit, Nyx Assassin, Riki, Spirit Breaker.

* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.

* Because Templar Assassin does not have escape potential in lane, any support hero with roaming potential and a Dust of Appearance can be great at shutting her down early game: Earth Spirit, Spirit Breaker, Tusk, Bounty Hunter, Riki, Warlock.

Additional:
* Templar Assassin is dependant on Refraction in teamfights. Because Magnetize deals damage per second and Earth Spirit is even able to refresh the duration of his ultimate he is suitable for wasting Refraction and allowing his team to take her down.

* Earth Spirit's useful kit of Slows, Stuns, and Silences can set up kills on Ogre Magi and the silence can stop him from using his abilities.

* Squishy heroes (Io, Crystal Maiden, Lina...), as Earth Spirit can deal tons of damage with Magnetize.

* Windranger heavily relies on her abilities for any form of tactical advantage and damage. A well timed silence will make her useless: Puck,Silencer, Death Prophet, Skywrath Mage, Drow Ranger, Earth Spirit, Grimstroke.

* Heroes with cleave abilities and area of effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.

* Poof won't damage Medusa and he can Gaze an entire flock of Meepos.
* Mystic Snake will easily become the bane of Meepo early game.

* Rolling Boulder and Geomagnetic Grip prevent Terrorblade from using Sunder.

* Stone Gaze negates Dispersion's damage reduction and allows Medusa to kite Spectre.
* Spectre's small mana pool is depleted quickly by Mystic Snake.
* Split Shot can clear Haunt illusions quickly.

* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.

* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.

* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.

* Earth Spirit is a dangerous foe to encounter for Invoker in the early stages of the game. Since Invoker needs to gain levels as fast as possible and is not very strong in the early game, Earth Spirit can use his incredible early game power to gank Invoker and ruin his game plan.
* Earth Spirit combines stuns and silences with his spells and can apply them from a great distance. This is bad for Invoker as he is dependent on a smart usage of his spells with Invoke and Earth Spirit can disrupt his combos easily.

* Positioning-reliant heroes (Windranger, Tidehunter, Ursa...), since Earth Spirit can disrupt positioning with his Boulder Smash.

* Her Mana Shield is too tough for Lycan to break in.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake