* Nether Blast, Decrepify and Life Drain deal high magical damage and bypasses Bulwark.
* Nether Ward reduces the amount of abilities Mars can use during fights and forces Mars to be careful about the heavy mana cost of Arena Of Blood.
* Pugna is one of few heroes that can contest Mars' ability to push and defend towers early on.

* Nether Ward will cause an unfriendly area for Medusa, draining her mana.

* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* His Fiend's Grip will leave Medusa defenseless after he's done, if his teammates can provide cover for him or he initiates at the right time by Spell immunity.

* Heroes that wish to disrupt fights with spell combos or big ultimates are vulnerable to the long stun of Fiend's Grip: Disruptor, Death Prophet, Enigma, Faceless Void, Invoker, Lich, Magnus, Mars, Medusa, Outworld Destroyer, Phoenix, Puck, Queen of Pain, Shadow Fiend, Treant Protector, Underlord, Winter Wyvern, Witch Doctor, Zeus.

* Heroes with break abilities: Nyx Assassin, Shadow Demon (with Aghanim's Scepter), Viper.

* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Additional:
* Level 4 Mana Burn burns 38,5% of Medusa's mana every 4 seconds if Medusa only increases her mana pool with intelligence. Additionally, 60% of the Mana Burn damage gets mitigated by Mana Shield, burning even more mana.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.

* Ursa is a special mention because despite his high physical damage attacking from the front won't achieve much against Mars but isn't a great target for Mars either since Ursa is very resistant to damage with Enrage so there isn't much that can be done to stop Ursa from going on your team.

* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Additional:
* Ursa's status resistance from Enrage will ignore Medusa's gaze.
* Ursa can stack damage with Fury Swipes easily against her Mana Shield in a prolonged team match.

* EMP is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Additional:
* EMP allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.

* Heroes with high magical or pure damage will bypass Bulwark: Timbersaw, Dark Willow, Enigma, Invoker, Pugna, Skywrath Mage, Tinker, Zeus, Oracle.

* Bulwark is generally irrelevant against Riki as he primarily deals bonus damage from behind.
Additional:
* Blink Strike gives bonus backstab damage. Along with Tricks of the Trade it completely bypasses Bulwark.

* He won't be around waiting for Medusa to Stone Gaze and pin him until she bears a true sight.
* With Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can still deal huge amount of damage through Cloak and Dagger via backstabs, drying out Medusa's protection in a whim at random occassions.

* Unlike other illusion heroes, Tempest Double won't be instantly destroyed by Stone Gaze since it is considered a clone and not an illusion.
* He can use either his own or his double's Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + Spark Wraith to slow Medusa's move speed to a crawl.
* Arc Warden has a farming advantage with double Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.

* Burning Spear's magical damage is very troublesome for Mars in the laning stage.
* Life Break's percentage-based magical damage bypasses Bulwark, and can also be used to jump in or out of Arena Of Blood.

* Arcane Orb's pure damage ignores Mars' Bulwark.
* Astral Imprisonment can be used to stop Mars from being disruptive or save allies from his abilities.
* Sanity's Eclipse deals high damage to Mars, due to his low intelligence.

* Firestorm and Pit of Malice are very disruptive in team fights, completely matching Mars especially since it can all be cast inside Arena Of Blood and also does percentage-based magical damage, negating Bulwark.
* Dark Rift can save any allies of Underlord trapped in Arena Of Blood.
* Atrophy Aura allows Underlord to lane against Mars quite well since he does not have the best base damage during the early game.
* Underlord is a common carrier of both Pipe of Insight and Mekansm/Guardian Greaves, allowing his team to combat Mars in the mid to late game.

* Mars has no way to trade with Ogre Magi in the early game thanks to his high base health, resistance and Ignite.
* Once Ogre Magi gets level 2 he may also have Bloodlust, which makes him even harder to deal with in lane.
* Fireblast can be ridiculously strong later on in the game for controlling Mars.
* Spear of Mars, which is Mars' main source of damage in the early game, cannot guarantee kills early on Ogre Magi.

* Medusa lacks mobility or escape mechanisms. Earth Spike and Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* In addition to easily breaking her commonly bought Linken's Sphere with its low cooldown, Mana Drain can quickly drain her Mana Shield, making her far less tanky.

* Venomancer's spells all deal magical damage, ignoring Bulwark.
* Venomancer's multiple slows are especially effective at kiting Mars.
* Plague Wards can attack through Arena Of Blood.
Additional:
* Venomancer's poison attacks are all magical damage, ignoring Bulwark.
* Venomancer's multiple slows are especially effective against Mars' low mobility.
* Plague Wards can attack through Arena of Blood.

* Silencer burns easily through her effective hp from Mana Shield, by taking away her int.
* Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. Can force her to use Manta Style before he has cast Global Silence and Medusa usually does not want to build Black King Bar.

* Storm Spirit's abilities all do magical damage, which can bypass Bulwark.
* Ball Lightning can escape through Arena of Blood and it is easy to dodge Spear of Mars.
Additional:
* Ball Lightning makes it almost impossible to catch Storm Spirit without someone else initiating for you.
* Overload is not reduced by Bulwark and the magical damage spam can wear down Mars quickly.

* Nethertoxin breaks the damage block from Bulwark.
* Poison Attack and Viper Strike's slows make it difficult for Mars to contribute to fights due to his low mobility.
Additional:
* Nethertoxin breaks Bulwark entirely, making Mars far less tanky. Using Nethertoxin inside Arena of Blood may discourage enemies from following up with Mars' initiation.
* Rod of Atos is currently common on Viper and keeps Mars in position long enough to be killed.
* Viper is not very tanky earlier in the game, so positioning against Mars is important since a well-timed Spear of Mars can be the end of Viper.

* Sticky Napalm slows turn rate, making it difficult for Mars to control the direction he is facing to activate Bulwark.
* Flaming Lasso disables Mars while enemies re-position themselves behind Mars to avoid Bulwark.

* Mars' own father is a formidable foe because Zeus deals mostly magical damage. The high damage, low cooldown nukes of Arc Lightning and Lightning Bolt combined with the percent health magic damage of Static Field will shred Mars' health because it bypasses Bulwark completely.

* If Mars lanes middle, Shadow Fiend can keep the lane pushed against him.
* Shadow Fiend can go an entirely magical based build, which is very effective against Mars.

* Because of her need to get status items early to tank it up, Rubick can greatly reduce her damage early with Fade Bolt
* Her stationary nature and the slow cast time of her spells makes it easier for Rubick to steal Stone Gaze or Mystic Snake
* Aghanim's Scepter's Mystic Snake is often better used by Rubick than by Medusa

* Dragon Slave deals reliable magic damage during the laning phase against Mars.
* Lina's Eul's Scepter of Divinity and Light Strike Array combo can interrupt Mars from being disruptive for a decent amount of time and leave him vulnerable for follow up stuns.
* Laguna Blade deals massive magical damage, and pure damage with Aghanim's Scepter.

* Chakra Magic can drain her current mana, draining away her effective health in a sneaky way.
* Will-O-Wisp will keep Medusa busy after she got hit by Blinding Light.

* Time Walk allows Faceless Void to escape or enter Arena Of Blood, and helps him recover from Mars' burst damage.
* Time Lock's magical damage ignores Bulwark.
* Chronosphere allows Faceless Void to reposition behind Mars, ignoring his Bulwark while he is helplessly frozen in time.
Additional:
* Time Dilation while Spear of Mars and God's Rebuke are on cooldown will make these abilities unusable for a long time, rendering Mars nearly useless.
* Mars cannot turn inside the Chronosphere, which makes it easy to attack him from the back, bypassing Bulwark completely.

* Heroes with high magical or pure damage will bypass Bulwark: Timbersaw, Dark Willow, Enigma, Invoker, Pugna, Skywrath Mage, Tinker, Zeus, Oracle.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Heroes with high magical or pure damage will bypass Bulwark: Timbersaw, Dark Willow, Enigma, Invoker, Pugna, Skywrath Mage, Tinker, Zeus, Oracle.

* Other heroes with mana burning or manipulating abilities will make Medusa much less tanky: Lion, Mirana, Weaver.

* Heroes with high magical or pure damage will bypass Bulwark: Timbersaw, Dark Willow, Enigma, Invoker, Pugna, Skywrath Mage, Tinker, Zeus, Oracle.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Heroes with high magical or pure damage will bypass Bulwark: Timbersaw, Dark Willow, Enigma, Invoker, Pugna, Skywrath Mage, Tinker, Zeus, Oracle.

* Heroes who take a long time to become strong are in for a rough mid game, such as Outworld Destroyer, Magnus, Medusa, and Anti-Mage.

* Heroes with high health especially Strength heroes will take more damage on Sun Ray: Axe, Pudge, Bristleback, Mars.

* Heroes with high magical or pure damage will bypass Bulwark: Timbersaw, Dark Willow, Enigma, Invoker, Pugna, Skywrath Mage, Tinker, Zeus, Oracle.

* Heroes that can save their allies can be a big problem for Mars: Dazzle, Omniknight.

* Heroes with break abilities: Nyx Assassin, Shadow Demon (with Aghanim's Scepter), Viper.

* Heroes that can save their allies can be a big problem for Mars: Dazzle, Omniknight.

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Kunkka's Ghostship and Torrent disrupt fights in Arena Of Blood.

* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, after an Incapacitating Bite she will get her swarmed in no time.
* Medusa usual do not build a BKB to benefit from Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away mana.
Additional:
* Incapacitating Bite will give Medusa a dire time to clear horde of small spiderlings or retaliate Broodmother herself.
* Spin Web will allow broodmother to pick her own fights and sometimes slip away to ambush Medusa.

* Phantom Lancer with Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding your team in the process.

* Medusa is a fairly immobile hero that deals damage around her with Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.
Additional:
* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.

* Anti-Mage easily destroys Mana Shield with Mana Break, especially once he has Manta Style.
* Anti-Mage effectively avoids Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* Anti-Mage's Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with Blink, burning her mana or forcing her to use Stone Gaze.
* Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.