Broodmother
[wiki] rating: 1.6 (winrate: 53% pickrate: 2%)Phantom Lancer
[wiki] rating: 1.6 (winrate: 51% pickrate: 10%)Medusa
* Phantom Lancer with 
Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* 
Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding your team in the process.
Oracle
* Heroes who are not easily crippled by Fate's Edict or Fortune's End, such as 
Timbersaw, or those who can dispel them, such as 
Phantom Lancer, can kill Oracle unhindered.
Anti-Mage
[wiki] rating: 1.6 (winrate: 49% pickrate: 13%)Oracle
* Anti-Mage can withstand magical burst damage much better than other carries, making him effective against nukers: 
Lich, 
Necrophos, 
Oracle, and 
Leshrac.
Additional:
* Oracle has minimal damage potential against Anti-Mage due to 
Counterspell, and may even have some ability damage reflected at himself.
* Anti-Mage can easily overwhelm Oracle with 
Mana Break and 
Mana Void.
* 
Blink allows Anti-Mage to easily chase and take advantage of Oracle's low mobility.
Medusa
* Anti-Mage easily destroys 
Mana Shield with Mana Break, especially once he has 
Manta Style.
* Anti-Mage effectively avoids 
Stone Gaze with Blink, and can reinitiate after its duration is over.
Additional:
* Anti-Mage's Mana Break burns Medusa's mana easily, especially when coupled with a Manta Style.
* Can easily initiate on Medusa with Blink, burning her mana or forcing her to use Stone Gaze.
* Mana Void is effective against Medusa's big mana pool and mana usage, presenting a huge hazard to Medusa's allies around her since her Mana Shield still gives her some protection if she has mana.
Bristleback
[wiki] rating: 1.6 (winrate: 46% pickrate: 8%)Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: 
Tidehunter, 
Bristleback, 
Slardar.
Oracle
* Fortune's End cannot dispel 
Warpath stacks on Bristleback or 
Quill Spray stacks on allies.
* 
Bristleback can heavily reduce Oracle's damage output. With it, Oracle may accidentally heal Bristleback with Purifying Flames, especially if Bristleback has bonus magic resistance.
Nyx Assassin
[wiki] rating: 1.0 (winrate: 54% pickrate: 7%)Medusa
* With her passive 
Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from 
Mystic Snake and Split Shot can trigger Spiked Carapace.
* 
Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Additional:
* Level 4 
Mana Burn burns 38,5% of Medusa's mana every 4 seconds if Medusa only increases her mana pool with intelligence. Additionally, 60% of the Mana Burn damage gets mitigated by Mana Shield, burning even more mana.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's 
Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with 
Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.
Arc Warden
[wiki] rating: 1.0 (winrate: 54% pickrate: 4%)Medusa
* Unlike other illusion heroes, 
Tempest Double won't be instantly destroyed by Stone Gaze since it is considered a clone and not an illusion.
* He can use either his own or his double's 
Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + 
Spark Wraith to slow Medusa's move speed to a crawl.
* Arc Warden has a farming advantage with double 
Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.
Ursa
[wiki] rating: 1.0 (winrate: 51% pickrate: 16%)Medusa
* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Additional:
* Ursa's status resistance from 
Enrage will ignore Medusa's gaze.
* Ursa can stack damage with 
Fury Swipes easily against her Mana Shield in a prolonged team match.
Invoker
[wiki] rating: 1.0 (winrate: 50% pickrate: 16%)Medusa
* 
EMP is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* 
Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* 
Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Additional:
* EMP allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.
Lion
[wiki] rating: 1.0 (winrate: 50% pickrate: 17%)Oracle
* Heroes with long disables, like 
Lion, 
Night Stalker, or 
Legion Commander, can prevent Oracle from using spells or items.
Medusa
* Medusa lacks mobility or escape mechanisms. Earth Spike and Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* In addition to easily breaking her commonly bought 
Linken's Sphere with its low cooldown, Mana Drain can quickly drain her Mana Shield, making her far less tanky.
Oracle
* Lion is extremely dependent on his abilities. Silences like 
Silencer's 
Last Word, magic resistance like Oracle's 
Fate's Edict, and dispels like Legion Commander's 
Press the Attack all make his abilities less effective.
Silencer
[wiki] rating: 1.0 (winrate: 49% pickrate: 5%)Oracle
* Oracle's reliance on spamming his spells can be easily hindered by Silencer's Arcane Curse.
* Last Word and Global Silence negates Oracle's attempt to save his allies with his spells.
* Fate's Edict is useless against Glaives of Wisdom's pure damage.
Medusa
* Silencer burns easily through her effective hp from Mana Shield, by taking away her int.
* 
Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. Can force her to use Manta Style before he has cast 
Global Silence and Medusa usually does not want to build 
Black King Bar.
Oracle
* Fortune's End can nullify Arcane Curse, Last Word, and Global Silence, if cast at the right time with the right targets.
* Fate's Edict can prevent Silencer from attacking, which he relies on with 
Glaives of Wisdom, for a lot of his damage.
Slark
[wiki] rating: 1.0 (winrate: 48% pickrate: 13%)Medusa
* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift removes 1 of every attribute, lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.
Additional:
* Medusa is especially vulnerable to 
Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* 
Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.
Riki
[wiki] rating: 1.0 (winrate: 48% pickrate: 5%)Medusa
* He won't be around waiting for Medusa to Stone Gaze and pin him until she bears a true sight.
* With 
Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can still deal huge amount of damage through 
Cloak and Dagger via backstabs, drying out Medusa's protection in a whim at random occassions.
Naga Siren
[wiki] rating: 0.6 (winrate: 54% pickrate: 2%)Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: 
Riki, 
Naga Siren, 
Terrorblade, 
Juggernaut, 
Spectre, 
Slark,
Drow Ranger.
Clinkz
[wiki] rating: 0.6 (winrate: 53% pickrate: 4%)Oracle
* Heroes who can take advantage of Oracle's low mobility or catch him out of position, such as 
Clinkz and 
Anti-Mage, can easily pick him off.
Night Stalker
[wiki] rating: 0.6 (winrate: 52% pickrate: 5%)Oracle
* Heroes with long disables, like Lion, Night Stalker, or Legion Commander, can prevent Oracle from using spells or items.
Weaver
[wiki] rating: 0.6 (winrate: 51% pickrate: 13%)Medusa
* Other heroes with mana burning or manipulating abilities will make Medusa much less tanky: Lion, 
Mirana, 
Weaver.
Templar Assassin
[wiki] rating: 0.6 (winrate: 51% pickrate: 5%)Oracle
* Because Oracle uses few, powerful instances of damage to kill enemies, 
Templar Assassin's 
Refraction and 
Visage's 
Gravekeeper's Cloak can absorb his burst damage.
Tidehunter
[wiki] rating: 0.6 (winrate: 50% pickrate: 10%)Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Elder Titan
[wiki] rating: 0.6 (winrate: 49% pickrate: 1%)Oracle
* 
Elder Titan's 
Echo Stomp can turn into a 5 second stun on an ally under the effect of False Promise, as it delays all damage and makes it impossible to break the damage threshold of Echo Stomp.
Timbersaw
[wiki] rating: 0.6 (winrate: 48% pickrate: 8%)Oracle
* Heroes who are not easily crippled by Fate's Edict or Fortune's End, such as Timbersaw, or those who can dispel them, such as Phantom Lancer, can kill Oracle unhindered.
Drow Ranger
[wiki] rating: 0.6 (winrate: 47% pickrate: 4%)Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.
Spectre
[wiki] rating: 0.6 (winrate: 47% pickrate: 3%)Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.
Oracle
* Oracle's burst damage is ineffective against 
Dispersion.
* Disarm provided by Fate's Edict is not as significant debilitation for Spectre as it might be for other carries since She can do damage even without landing attacks.
Medusa
* Stone Gaze negates Dispersion's damage reduction and allows Medusa to kite Spectre.
* Spectre's small mana pool is depleted quickly by Mystic Snake.
* Split Shot can clear Haunt illusions quickly.
Terrorblade
[wiki] rating: 0.6 (winrate: 46% pickrate: 4%)Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.
Bane
[wiki] rating: 0.4 (winrate: 54% pickrate: 3%)Medusa
* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* His 
Fiend's Grip will leave Medusa defenseless after he's done, if his teammates can provide cover for him or he initiates at the right time by Spell immunity.
Oracle
* Heroes with dispels can dispel Bane's disables from their allies: Oracle, Legion Commander, 
Omniknight
Sniper
[wiki] rating: 0.4 (winrate: 49% pickrate: 6%)Medusa
* Medusa is a fairly immobile hero that deals damage around her with Split Shot. Sniper should outrange her and should stay out of harm's way from Split Shot.
* More importantly, Sniper should have enough attack range to fire at Medusa during her Stone Gaze without turning to stone, so the ultimate is mostly wasted against him.
Additional:
* Sniper can outrange both Medusa's arrows and Stone Gaze, allowing him to focus her down during a teamfight.
Oracle
* Fortune's End can catch out or impair position-based heroes with low mobility, such as 
Sniper or 
Razor.
Shadow Demon
[wiki] rating: 0.4 (winrate: 47% pickrate: 2%)Oracle
* 
Disruption can protect Shadow Demon's allies from Fortune's End, preserving healing or buffs. It can also catch Oracle's allies, allowing 
Shadow Poison and 
Soul Catcher to be used without being dispelled.
* 
Demonic Purge prevents over-time healing during False Promise, such as Purifying Flames and 
Urn of Shadows. If he has Aghanim's Scepter, this issue can persist for longer or on multiple allies.
* It will not, however, prevent healing from instant abilities, items, or auras, making 
Mekansm a good choice against him.
Oracle
* Heroes who can dispel will be able to remove Shadow Poison before Shadow Demon can build up a big stack, or remove Soul Catcher's debuff to instantly bring the health of affected heroes back to a considerable amount: 
Abaddon, Slark, Legion Commander, Oracle.
Keeper of the Light
[wiki] rating: 0.4 (winrate: 45% pickrate: 4%)Medusa
* 
Chakra Magic can drain her current mana, draining away her effective health in a sneaky way.
* 
Will-O-Wisp will keep Medusa busy after she got hit by 
Blinding Light.
Oracle
* Heroes with dispels: Legion Commander, Oracle, Slark
Faceless Void
[wiki] rating: 0.4 (winrate: 41% pickrate: 3%)Oracle
* 
Time Walk and 
Backtrack allow Faceless Void to easily negate Oracle's burst damage.
* 
Time Dilation is effective against Oracle's low-cooldown spells. Although dispellable with Fortune's End, it can still catch Oracle off guard if Fortune's End is on cooldown.
Oracle
* Any hero that can nullify effects of Chronosphere: (Omniknight, 
Keeper of the Light with Aghanim's Scepter during daytime, 
Winter Wyvern), banishing him or Faceless Void (
Outworld Destroyer, 
Shadow Demon, 
Earth Spirit with Aghanim's Scepter) or protecting him in other ways (
Dazzle, Oracle, Abaddon) can greatly limit Chronosphere's potential.
Necrophos
[wiki] rating: -2.0 (winrate: 50% pickrate: 3%)Oracle
* Fortune's End can dispel 
Ghost Shroud, rending Necrophos vulnerable to physical damage. Also it's worth noting that Necrophos takes additional magic damage when in Ethereal state, which makes Purifying Flames a powerful nuke against him.
* Fate's Edict fully negates the damage from 
Reaper's Scythe, which its own delayed animation makes it relatively easy to predict and nullify.
Additional:
* During the laning stage, Oracle's 
Purifying Flames nullifies any damage that Heartstopper Aura might inflict.
* Fate's Edict and 
False Promise can protect an ally from Reaper's Scythe.
* Oracle can dispel Ghost Shroud with 
Fortune's End.
Medusa
* Mana Shield tanks most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops to 15%/17%/19% health (before reductions).
* Heartstopper Aura does not chip away at Medusa's mana, this makes it not a threat as it deals damage based on current health.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.
Sven
[wiki] rating: -1.6 (winrate: 43% pickrate: 1%)Oracle
* Fate's Edict cripples many heroes who rely on attacks, such as 
Phantom Assassin, 
Sven, or 
Enchantress, without a dispel or a Black King Bar.
Medusa
* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mystic Snake eats away at Sven's small mana pool.
* Mana Shield negates much of Sven's burst damage.
Enchantress
[wiki] rating: -1.6 (winrate: 46% pickrate: 1%)Medusa
* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
* Untouchable is ignored by secondary attacks from Split Shot.
Oracle
* Heroes with little health or magic resistance are easily picked off with Oracle's magic burst, such as 
Skywrath Mage, 
Crystal Maiden, or Enchantress.
Beastmaster
[wiki] rating: -1.6 (winrate: 53% pickrate: 6%)Oracle
* False Promise effectively nullifies Primal Roar's single-target initiation on allies.
* Purifying Flames kills Beastmaster's Hawk instantly and Boar with two casts.
Medusa
* Heroes with Linken's Sphere as core item: Weaver, 
Morphling, Medusa.
Legion Commander
[wiki] rating: -1.4 (winrate: 47% pickrate: 11%)Oracle
* Heroes with long disables, like Lion, Night Stalker, or Legion Commander, can prevent Oracle from using spells or items.
Oracle
* Fate's Edict prevents Legion Commander from attacking for a few seconds, potentially saving Oracle's ally.
* Fortune's End dispels Press the Attack's healing and attack speed buff, as well as the movement speed bonus from Overwhelming Odds.
* False Promise protects allies and prevents Legion Commander from winning Duels and gaining bonus damage.
Additional:
* Provided that the enemy team does not have an 
Axe, Oracle can guarantee that his ally survives for the duration of the Duel with False Promise and has decent nuke potential to help ally to win a Duel. He can also disarm Legion Commander with Fate's Edict.
* Oracle can dispel enemy buffs like 
Overwhelming Odds and Press the Attack with Fortune's End.
Medusa
* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.
Mars
[wiki] rating: -1.2 (winrate: 48% pickrate: 16%)Medusa
* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.
Oracle
* Heroes with high magical or pure damage will bypass Bulwark: Timbersaw, 
Dark Willow, 
Enigma, 
Invoker, 
Pugna, Skywrath Mage, 
Tinker, 
Zeus, Oracle.
Doom
[wiki] rating: -1.0 (winrate: 44% pickrate: 2%)Oracle
* Supports with useful teamfight or contribution spells will be helpless against Doom: Dazzle, Oracle, 
Warlock.
Oracle
* Heroes with the ability to heal allies, or those with good defensive abilities: 
Chen, Dazzle, 
Io, Oracle, Omniknight, 
Witch Doctor, Winter Wyvern, Abaddon, etc.
Medusa
* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.
Meepo
[wiki] rating: -1.0 (winrate: 45% pickrate: 1%)Medusa
* Poof won't damage Medusa and he can Gaze an entire flock of Meepos.
* Mystic Snake will easily become the bane of Meepo early game.
Ember Spirit
[wiki] rating: -1.0 (winrate: 47% pickrate: 9%)Oracle
* Oracle can shut down both of Ember's early game abilities. Fortune's End can dispel 
Flame Guard on Ember Spirit and 
Searing Chains on allies.
* When Ember Spirit is affected by Fortune's End, his 
Fire Remnants move at 0 movement speed.
* Disarming him with Fate's Edict does affect Ember's 
Sleight of Fist ability, possibly making him useless for a few seconds in the late game without a dispel or spell immunity. This is especially good if he has a rapier or two. However, positioning for this is difficult when Ember plays far back.
Witch Doctor
[wiki] rating: -1.0 (winrate: 47% pickrate: 13%)Oracle
* It is especially easy for Oracle to negate the damage from Maledict, and even heal through it with Fate's Edict and Purifying Flames.
* If by some miracle an enemy is still about to die because of Maledict, he can still save him with False Promise.
Batrider
[wiki] rating: -1.0 (winrate: 47% pickrate: 1%)Oracle
* False Promise dispels Flaming Lasso.
* Fortune's End can root Batrider after he uses Flaming Lasso. It can also dispel Sticky Napalm and Flamebreak.
* Fate's Edict when used on a Lasso'd target will leave them immune to magical damage, making it difficult to burst them quickly before the Lasso ends.
Omniknight
[wiki] rating: -1.0 (winrate: 47% pickrate: 1%)Oracle
* Fortune's End's AoE dispel will remove Guardian Angel.
Additional:
* With Fortune's End, Oracle can dispel 
Guardian Angel in an area of effect.
Techies
[wiki] rating: -1.0 (winrate: 48% pickrate: 8%)Oracle
* Since Techies' skills are all magical damage, casting Fate's Edict immediately upon hearing the warning sound from 
Proximity Mines and 
Blast Off! can render Oracle or an ally immune to the burst damage from these skills.
* If timed correctly, 
Remote Mines can also be countered using the same technique.
Additional:
* Fate's Edict gives 100% magic resistance, which prevents most of Techies' damage and his Fortune's End dispels Stasis Trap root.
Lifestealer
[wiki] rating: -1.0 (winrate: 48% pickrate: 5%)Medusa
* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces 
Rage, wasting its cooldown and making Lifestealer unable to fight.
Pangolier
[wiki] rating: -1.0 (winrate: 49% pickrate: 12%)Medusa
* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.
Phoenix
[wiki] rating: -1.0 (winrate: 50% pickrate: 9%)Oracle
* Phoenix does significant magic damage over time which can either be dispelled or negated by Fate's Edict.
* Since Phoenix sacrifices some of his health to cast abilities it makes him very vulnerable to Oracle's burst potential
Slardar
[wiki] rating: -1.0 (winrate: 50% pickrate: 5%)Medusa
* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.
Medusa
* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.
Oracle
* Fortune's End applies a basic dispel which can be used to dispel Corrosive Haze, or even Slardar's own Guardian Sprint.
* False Promise is able to dispel Corrosive Haze and Slithereen Crush stun/slow from any allies Oracle chooses to cast it on.
* Fate's Edict can also be cast on Slardar to prevent him from proccing his Bash of the Deep.
Undying
[wiki] rating: -1.0 (winrate: 50% pickrate: 4%)Medusa
* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
* Mana Shield reduces the impact of Decay and Flesh Golem's Plague Aura.
Jakiro
[wiki] rating: -1.0 (winrate: 50% pickrate: 9%)Oracle
* Fate's Edict allowed Oracle to make allies spell immune, allowing him to save allies from Jakiro's spells.
* Fate's Edict can be cast onto Jakiro to disarm him and prevent him from pushing with his Liquid Fire.
* False Promise allows Oracle to free allies from Jakiro's Ice Path.
Spirit Breaker
[wiki] rating: -1.0 (winrate: 51% pickrate: 8%)Medusa
* If Medusa activates Stone Gaze, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.
Ogre Magi
[wiki] rating: -1.0 (winrate: 51% pickrate: 14%)Oracle
* Fate's Edict gives full immunity from Ogre Magi's mostly magical damage.
* Fortune's End can dispel Ignite (when used on allies) and Bloodlust (when used on enemies).
* False Promise can dispel Ignite and Fireblast.
Leshrac
[wiki] rating: -1.0 (winrate: 51% pickrate: 3%)Oracle
* Oracle's Fate's Edict will protect an ally from Leshrac's nuking damage.
* Oracle's False Promise can dispel Leshrac's stun and slow from his abilities, allowing an ally to escape.
* Fortune's End can stop Leshrac from chasing opponents or running away.
Bloodseeker
[wiki] rating: -1.0 (winrate: 51% pickrate: 4%)Medusa
* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.
Dark Seer
[wiki] rating: -1.0 (winrate: 51% pickrate: 3%)Oracle
* Fortune's End can dispel 
Ion Shell, which cripples Dark Seer economy since it's his most efficient tool for farming.
* Fortune's End can dispel 
Surge, effectively slowing his movement speed making him vulnerable to ganks or skirmishes.
Additional:
* Fortune's End dispels Ion Shell and Surge, making any gank attempt on Dark Seer in the laning phase likely to succeed.
* Fate's Edict prevents all magical damage that comes from Dark Seer's abilities.
* Fortune's End dispels Ion Shell on creeps, which Dark Seer relies on to farm and zone.
Troll Warlord
[wiki] rating: -1.0 (winrate: 52% pickrate: 12%)Oracle
* Fate's Edict can disarm Troll, rendering him useless in a teamfight, especially if he has already used Battle Trance.
* Fortune's End and Purifying Flames can provide ample magic damage to help burst down Troll Warlord quickly in the early to mid game.
* False Promise can save an ally from Troll Warlord's initiation, forcing him to switch targets and lose his Fervor stacks, or waste time during Battle Trance.
Ancient Apparition
[wiki] rating: -1.0 (winrate: 52% pickrate: 10%)Oracle
* False Promise can prevent the shatter from 
Ice Blast and Fate's Edict can protect an ally from the magical damage over time for a while.
* Oracle can deny allies who are frostbitten. If he uses Purifying Flames to reach the shatter threshold, it will count as a deny.
* Fortune's End can dispel 
Cold Feet on affected allies, preventing them from getting frozen.
Additional:
* False Promise can dispel the stun from Cold Feet and can save an ally that's about to shatter from Ice Blast, even allowing healing with Purifying Flames by delaying it until after the debuff expires.
* Purifying Flames allows Oracle to deny his allies if they're affected by Ice Blast. If he brings his allies' health to or below the shatter threshold, it will count as him denying the ally. However, this does not work on Oracle himself.
* Fate's Edict provides 100% magic resistance, making it good against all of Ancient Apparition's abilities at all stages of the game.
* Fortune's End can dispel Cold Feet from allies.
Dark Willow
[wiki] rating: -1.0 (winrate: 52% pickrate: 7%)Oracle
* Fortune's End can easily dispel 
Cursed Crown before it times out and stuns. He can also save a stunned ally with False Promise.
* Fate's Edict can easily negate 
Bedlam's over-time damage, since the spell provides no form of control. Similarly, he can also negate the magic burst from 
Shadow Realm.
* Fortune's End can dispel the fear effect from 
Terrorize, and it can remove the root from 
Bramble Maze if you're quick enough. Be mindful that Fortune's End only dispels your allies' debuffs on the primary target.
Additional:
* Fortune's End not being disjointable is almost an ensured disable if Dark Willow tries to escape with Shadow Realm. Dispels Cursed Crown and Terrorize.
* Fate's Edict negates all her magic damage in case she catches a single hero.
* False Promise's strong dispel removes Dark Willow's disables.
Lycan
[wiki] rating: -1.0 (winrate: 54% pickrate: 3%)Medusa
* Her Mana Shield is too tough for Lycan to break in.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake
Enigma
[wiki] rating: -1.0 (winrate: 55% pickrate: 8%)Medusa
* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult.
* Mystic Snake can be potentially detrimental to Enigma's initiation. Getting hit by the latter high-damage bounces (from standing behind his Eidolons or his teammates) can hinder his mana pool, preventing him from executing a strong initiation.
Additional:
* Mana Shield makes Medusa harder to kill with Enigma's Black Hole and Pulse combo.
* Medusa's Split Shot can kill Demonic Conversion creeps easier and Mystic Snake bounces off from them.
* Stone Gaze makes it hard for Enigma to approach Medusa for a Black Hole.
Magnus
[wiki] rating: -0.6 (winrate: 44% pickrate: 4%)Oracle
* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, 
Luna, Naga Siren, 
Mars, 
Jakiro, 
Venomancer, Elder Titan, 
Faceless Void, 
Rubick, Keeper of the Light, Pugna, Invoker, Spectre, 
Alchemist, 
Treant Protector, 
Lina, Oracle, Zeus, 
Shadow Shaman, 
Phoenix, Razor, 
Huskar, 
Batrider, 
Kunkka, Tidehunter, 
Wraith King, 
Sand King.
Phantom Assassin
[wiki] rating: -0.6 (winrate: 45% pickrate: 16%)Oracle
* Fate's Edict cripples many heroes who rely on attacks, such as Phantom Assassin, Sven, or Enchantress, without a dispel or a Black King Bar.
Crystal Maiden
[wiki] rating: -0.6 (winrate: 49% pickrate: 14%)Oracle
* Heroes with little health or magic resistance are easily picked off with Oracle's magic burst, such as Skywrath Mage, Crystal Maiden, or Enchantress.
Venomancer
[wiki] rating: -0.6 (winrate: 50% pickrate: 5%)Oracle
* Fortune's End and False Promise easily dispel many crippling debuffs, such as Venomancer's 
Venomous Gale, or Skywrath Mage's 
Ancient Seal.
Additional:
* Fortune's End can dispel Venomous Gale and Poison Sting from allies.
* Fate's Edict grants 100% magic resistance to target, inhibiting the damage from Venomancer abilities.
Skywrath Mage
[wiki] rating: -0.6 (winrate: 50% pickrate: 6%)Oracle
* Heroes with little health or magic resistance are easily picked off with Oracle's magic burst, such as Skywrath Mage, Crystal Maiden, or Enchantress.
Wraith King
[wiki] rating: -0.6 (winrate: 51% pickrate: 17%)Oracle
* Heroes with area dispel can kill multiple skeletons at once: 
Brewmaster, Oracle.
Chen
[wiki] rating: -0.6 (winrate: 52% pickrate: 0%)Medusa
* Heroes with cleave abilities and area of effect damage can make quick work of Chen's converted creeps and at same time gain farm: 
Magnus, Jakiro, 
Shadow Fiend, Kunkka, Luna, 
Dragon Knight, Medusa, Alchemist.
Bounty Hunter
[wiki] rating: -0.6 (winrate: 54% pickrate: 10%)Oracle
* Oracle with Fortune's End and False Promise
* Heroes that can remove the Track debuff with their skills:
* Abaddon with 
Aphotic Shield and 
Borrowed Time
* Huskar with 
Life Break
* Juggernaut with 
Blade Fury
* Legion Commander with Press the Attack
* 
Lifestealer with Rage and 
Infest
* Naga Siren with 
Mirror Image
* Omniknight with 
Heavenly Grace
* Oracle with Fortune's End and False Promise
* Phantom Lancer with Doppelganger
* Slark with Dark Pact
* 
Ursa with Enrage
* Weaver with 
Time Lapse
* Tidehunter with 
Kraken Shell when damage received reaches the threshold.
Razor
[wiki] rating: -0.6 (winrate: 54% pickrate: 6%)Oracle
* Fortune's End can catch out or impair position-based heroes with low mobility, such as Sniper or Razor.
Visage
[wiki] rating: -0.4 (winrate: 54% pickrate: 1%)Oracle
* Because Oracle uses few, powerful instances of damage to kill enemies, Templar Assassin's Refraction and Visage's Gravekeeper's Cloak can absorb his burst damage.
Medusa
* Summoned gargoyles will give Medusa free target practice.
* Mana Shield will resist Soul Assumption instances without effort.
Rubick
[wiki] rating: 0.0 (winrate: 46% pickrate: 16%)Medusa
* Because of her need to get status items early to tank it up, Rubick can greatly reduce her damage early with Fade Bolt
* Her stationary nature and the slow cast time of her spells makes it easier for Rubick to steal Stone Gaze or Mystic Snake
* Aghanim's Scepter's Mystic Snake is often better used by Rubick than by Medusa
Oracle
* Oracle's high magic damage output can easily take down Rubick's low health pool.
* Because Oracle likes to combine his spells together, the only good 
Spell Steal target he gives is False Promise. This scenario can be avoided by shift queueing Fortune's End and casting it immediately, as it has no cast point, or by staying in the back line of fights if out of mana.
* As a position based hero, Rubick will have a very hard time against Fortune's End due to its absurd range and very long root duration.
Axe
[wiki] rating: 0.0 (winrate: 47% pickrate: 8%)Oracle
* False Promise will not save an ally from 
Culling Blade if their health is low enough.
* Fate's Edict, offensively or defensively, does little to protect Oracle's allies from the majority of Axe's damage.
Medusa
* Mystic Snake can harass Axe in lane and drain his small mana pool.
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to pursue.
Void Spirit
[wiki] rating: 0.0 (winrate: 50% pickrate: 13%)Medusa
* Heroes who take a long time to become strong are in for a rough mid game, such as Outworld Destroyer, Magnus, Medusa, and Anti-Mage.
Oracle
* Heroes that can purge his slow and disables are very difficult to go on and their team: Abaddon, Oracle.
Mirana
[wiki] rating: 0.0 (winrate: 51% pickrate: 16%)Medusa
* Other heroes with mana burning or manipulating abilities will make Medusa much less tanky: Lion, Mirana, Weaver.
Oracle
* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.
Juggernaut
[wiki] rating: 0.0 (winrate: 52% pickrate: 19%)Medusa
* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.
Oracle
* Heroes with abilities that can save teammates are also effective such as Shadow Demon, Dazzle, Oracle, 
Bane, Pugna, 
Tusk, Winter Wyvern, Io, 
Underlord, Treant Protector and Keeper of the Light.
Pugna
[wiki] rating: 0.0 (winrate: 53% pickrate: 4%)Medusa
* 
Nether Ward will cause an unfriendly area for Medusa, draining her mana.
Oracle
* Most of Pugna's damage is magical, which can get blocked by Fate's Edict's 100% magic resistance.
* Oracle has two abilities that apply a dispel, which can easily remove Decrepify on his ally or Oracle.
* Oracle has a very long Attack Range and a very low Base Attack Time, which enables him to take down Nether Ward swiftly from long distance.
Medusa
* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away mana.
Incapacitating Bite will give Medusa a dire time to clear horde of small spiderlings or retaliate Broodmother herself.
Spin Web will allow broodmother to pick her own fights and sometimes slip away to ambush Medusa.
* Even though Medusa can hunt down Spiderlings easily when given enough range, after an Incapacitating Bite she will get her swarmed in no time.
* Medusa usual do not build a BKB to benefit from
Additional:
*
*
Oracle
* Oracle cannot easily deal with swarms of units, making him weak against heroes like
Phantom Lancer or 
Broodmother.