* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult.
* Mystic Snake can be potentially detrimental to Enigma's initiation. Getting hit by the latter high-damage bounces (from standing behind his Eidolons or his teammates) can hinder his mana pool, preventing him from executing a strong initiation.
Additional:
* Mana Shield makes Medusa harder to kill with Enigma's Black Hole and Pulse combo.
* Medusa's Split Shot can kill Demonic Conversion creeps easier and Mystic Snake bounces off from them.
* Stone Gaze makes it hard for Enigma to approach Medusa for a Black Hole.

* Walrus PUNCH! can interrupt Black Hole and it can pierce spell immunity.
* In pretty much any phase of the game, Tusk's abilities can easily cancel Black Hole and disrupt Enigma's positioning.

* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.

* Ice Shards can easily interfere with Rolling Thunder, making him stuck inside the arc and wasting his ultimate. Do not panic and use Shield Crash to get out of that position.
* Snowball helps Tusk and his allies follow a fleeing Pangolier, keep in mind that the Pangolier can always counter-initiate with his Rolling Thunder.
* Walrus PUNCH! deals heavy damage even during his Rolling Thunder.

* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.

* Snowball negates Rupture and protects Tusk allies when Ruptured.

* Walrus PUNCH! makes Legion Commander lose Duel easily, especially when she doesn't have Blade Mail. Tusk can also snowball dueled allies, preventing them from taking damage for a large portion of the duel's duration.

* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.

* Snowball can be used to save allies or himself during Venomous Gale and Poison Nova.
* Venomancer lacks mobility and has low base health, so he can be killed by Walrus PUNCH!

* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
* Mana Shield reduces the impact of Decay and Flesh Golem's Plague Aura.

* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.

* Poof won't damage Medusa and she can Gaze an entire flock of Meepos.
* Mystic Snake will easily become the bane of Meepo early game.

* Mana Shield tanks most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops to 15%/17%/19% health (before reductions).
* Heartstopper Aura does not chip away at Medusa's mana, this makes it not a threat as it deals damage based on current health.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.

* Shadow Fiend's lack of mobility and low base health make him an easy target for early ganks.

* Snowball allows Tusk to easily cancel Freezing Field from a safe distance without putting himself in any danger.
* Walrus PUNCH! is most certainly a high enough damage nuke to easily kill off Crystal Maiden.
* Ice Shards can prevent the already immobile Crystal Maiden from escaping, making her an easy kill for either Tusk or a teammate.
Additional:
* Crystal Maiden's low health and armor make her an easy target for Walrus PUNCH!
* Tusk's Snowball can protect allies and cancel Freezing Field.
* Snowball and Walrus PUNCH! can interrupt Freezing Field.

* Tusk can Walrus Kick Monkey King from Wukong's Command, making his ultimate useless.

* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces Rage, wasting its cooldown and making Lifestealer unable to fight.

* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
* Untouchable is ignored by secondary attacks from Split Shot.

* Her Mana Shield is too tough for Lycan to break.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake

* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mana Shield negates much of Sven's burst damage.

* If Medusa activates Stone Gaze, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.

* Heroes with cleave or multi-target attacks can quickly take on Familiars and reduce Visage's firepower like Gyrocopter, Kunkka, Magnus and Medusa.

Additional:
* Summoned gargoyles will give Medusa free target practice.
* Mana Shield will resist Soul Assumption instances without effort.

* Heroes who do not have nor rely on passive abilities make Nethertoxin much less effective: Clinkz, Pugna, Nature's Prophet, Dark Seer, Lycan, Tusk

Additional:
* Viper Strike can be countered through Snowball, wasting Viper's mana through his ultimate.

* Heroes that are able to slow Tiny's attack speed, like Tusk and Phoenix, will greatly limit his Physical damage output.

* Because Templar Assassin does not have escape potential in lane, any support hero with roaming potential and a Dust of Appearance can be great at shutting her down early game: Earth Spirit, Spirit Breaker, Tusk, Bounty Hunter, Riki, Warlock.

* Heroes with spell immunity or pseudo-blinks which provide invulnerability: Lifestealer, Juggernaut, Omniknight, Huskar , and Tusk have spells which allow them to easily escape Dream Coil.

* Heroes who can anticipate, intercept and counter attack against Phantom Assassin once she jumps on them with Phantom Strike provided that they are able to do so in time: Axe, Luna, Troll Warlord, Viper, Tinker, Lina, Shadow Demon, Pugna, Doom, Medusa, Terrorblade etc.

* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper

* Heroes with cleave abilities and area of effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.

* Shadow Demon, Outworld Destroyer and Tusk can all save a Lasso'd teammate with their defensive spells.

* Heroes with long range abilities are also able to touch Zeus, such as Clockwerk, Kunkka, Puck, Skywrath Mage, Spirit Breaker, Tusk and others.

* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.

* Snowball can protect Tusk and his teammates from a Spear of Mars stun after an Arena of Blood, and with proper targeting, even bring them out of the Arena. This is especially noticeable in the earlier stages of the game before allies buy Black King Bar and rely on this less. Even during the late-game, Tusk can purchase a Blink Dagger to save allies that are caught before Black King Bars can be used by Blinking in and Snowballing out.
* Tag Team is a constant threat to Mars in-lane, as even with early Bulwark points it deal so much damage and slow that Mars is forced to back off from the lane and play defensively every time the spell is used.
* Worth noting is that Ice Shards can be detrimental to Tusk's own team by creating terrain that Spear of Mars can latch on, though using it conservatively is a good enough solution in most cases.

* Mystic Snake can harass Axe in lane and drain his small mana pool.
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to pursue.

* Snowball and Ice Shards keep Drow Ranger down and preventing her from running away.
* Snowball also lets Tusk get to Drow Ranger and stop her Marksmanship bonus. It can also be to save allies affected by Gust.
* Tag Team allows Tusk to slow her down and land a killing blow on her.
* Walrus PUNCH! slows Drow Ranger and deals a huge amount of damage to her.

* Stone Gaze negates Dispersion's damage reduction and allows Medusa to kite Spectre.
* Split Shot can clear Haunt illusions quickly.

* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.

* Heroes with abilities that can save teammates are also effective such as Shadow Demon, Dazzle, Oracle, Bane, Pugna, Tusk, Winter Wyvern, Io, Underlord, Treant Protector and Keeper of the Light.

* Pugna's low health and reliance on channeled abilities make him very vulnerable to Tusk, although Pugna can win in a straight up 1v1 later in the game.

* Snowball allows Tusk to move himself and allies towards Sniper whilst invulnerable and hidden.
* His Ice Shards may also block pathing for Sniper as he has no means of moving through obstacles. In addition, Tag Team can hinder Sniper's escape.
Additional:
* Tusk alone or with his teammates can close Sniper's long range easily with Snowball, even wasting Shrapnel, ending with a very vulnerable Sniper.
* Walrus PUNCH! damage can easily kill Sniper instantly due to his low health.