* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.

* Damage reduction from Atrophy Aura prevents Bloodseeker from killing targets and gaining his Thirst bonuses.
* Pit of Malice's area of effect catches Bloodseeker easily, negating his speed bonus during teamfights.
* Dark Rift allows Underlord to transport Ruptured allies to the fountain, rendering it useless.

* Pit of Malice can be cast in the path of Spirit Breaker's Charge of Darkness to cancel it.
* Dark Rift provides a way to escape from a gank for Underlord and his teammates.

* If Medusa activates Stone Gaze, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.

* Atrophy Aura's percentage-based damage reduction greatly diminishes Legion Commander's overall damage output, even if she has won many Duels
* Legion Commander cannot get out the way of Firestorm because she is stationary.
Additional:
* Atrophy Aura makes it hard for Legion Commander to win Duels.
* Fiend's Gate can be used to save Underlord and his allies from a Duel or to intercept Legion Commander, because outside from Overwhelming Odds, Legion Commander has no other area-of-effect abilities.

* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.

* Heroes with disables that ignore spell immunity will render Phantom Assassin quite useless in teamfights throughout the game: Axe, Enigma, Vengeful Spirit, Doom, Bane, Beastmaster, Pudge, Medusa.

* Pit of Malice prevents Phantom Assassin from either escaping or engaging with Phantom Strike.
* Phantom Assassin's damage output is entirely physical, therefore Atrophy Aura Atrophy Aura is very hazardous for her in most of the stages, particularly since it also affects Coup De Grace Coup de Grace, hindering Phantom Assassin's main source of damage.
* Without proper items and any area-of-effect ability/item, Phantom Assassin cannot stop Underlord and his team to escape with Fiend's Gate, nor she can intercept them if Underlord chooses to teleport on any area of the map.

* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.

* Heroes with powerful rooting abilities will disable most of Pangolier's skills, a bonus point if it pierces spell immunity since it will also be able to stop Pangolier during his Rolling Thunder: Treant Protector, Meepo, Crystal Maiden, Dark Willow, Underlord, Naga Siren

* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mana Shield negates much of Sven's burst damage.

* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use Dark Rift to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* Firestorm will easily clear Chen's creeps.
* Pit of Malice will trap Chen and render him helpless.
* Atrophy Aura gives bonus damage to Underlord for each killed creep and weakens Chen's damage.
* Dark Rift can counter Chen's pushing attempts, and he has nothing to intercept it.

* Heroes with cleave abilities and area of effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* In general, melee heroes without blink mechanisms or spell immunity will have a hard time positioning against Pit of Malice: Sven, Tiny, Wraith King, Dragon Knight, Meepo, Doom, Bounty Hunter, Dark Seer, Undying, Alchemist, Legion Commander.

* Poof won't damage Medusa and she can Gaze an entire flock of Meepos.
* Mystic Snake will easily become the bane of Meepo early game.

* In general, melee heroes without blink mechanisms or spell immunity will have a hard time positioning against Pit of Malice: Sven, Tiny, Wraith King, Dragon Knight, Meepo, Doom, Bounty Hunter, Dark Seer, Undying, Alchemist, Legion Commander.

* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.

* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.

* Firestorm makes quick work of Treants and Atrophy Aura gives him temporary damage for every Treant killed.
* Pit of Malice can stop Teleportation channeling.
* Atrophy Aura greatly reduces Nature's Prophet's damage and he has no other good way to deal damage.
* Fiend's Gate can counter split-pushing, which is something that Nature's Prophet relies on a lot.

* In general, melee heroes without blink mechanisms or spell immunity will have a hard time positioning against Pit of Malice: Sven, Tiny, Wraith King, Dragon Knight, Meepo, Doom, Bounty Hunter, Dark Seer, Undying, Alchemist, Legion Commander.

* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.

* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to pursue.

* Atrophy Aura decreases Troll Warlord's damage.
* Pit of Malice helps lock down Troll Warlord.
* Battle Trance disallows Troll from running out of both Firestorm and Pit of Malice.

* Dark Rift allows Underlord to transport allies from poison damage-over-time to the fountain.
* Underlord usually buys Pipe of Insight that gives a magic resistance to allies, inhibiting the damage from Venomancer abilities.

* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult.
* Stone Gaze can cancel Enigma's Black Hole even through spell immunity, which can discourage Enigma from initiating with Black Hole.
Additional:
* Mana Shield makes Medusa harder to kill with Enigma's Black Hole and Pulse combo.
* Medusa's Split Shot can kill Demonic Conversion creeps easier and Mystic Snake bounces off from them.
* Stone Gaze makes it hard for Enigma to approach Medusa for a Black Hole.

* Firestorm's percentage damage can quickly demolish the Spirit Bear's high HP
* Pit of Malice will allow allies to easily kite Lone Druid due to his low mobility

* Her Mana Shield is too tough for Lycan to break.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake

* In general, heroes with long cooldowns on their abilities or ultimate will struggle against the relentless pressure provided by Dark Rift or Fiend's Gate (Requires Aghanim's Scepter): Terrorblade, Dragon Knight, Omniknight.

* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use Dark Rift to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use Dark Rift to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* Underlord's Atrophy Aura reduces Morphling's high base damage gained through agility shift.

* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.

* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use Dark Rift to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* Firestorm and Pit of Malice are very disruptive in team fights, completely matching Mars especially since it can all be cast inside Arena Of Blood and also does percentage-based magical damage, negating Bulwark.
* Dark Rift can save any allies of Underlord trapped in Arena Of Blood.
* Atrophy Aura allows Underlord to lane against Mars quite well since he does not have the best base damage during the early game.
* Underlord is a common carrier of both Pipe of Insight and Mekansm/Guardian Greaves, allowing his team to combat Mars in the mid to late game.

* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.

* In general, melee heroes without blink mechanisms or spell immunity will have a hard time positioning against Pit of Malice: Sven, Tiny, Wraith King, Dragon Knight, Meepo, Doom, Bounty Hunter, Dark Seer, Undying, Alchemist, Legion Commander.

* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.

* In general, melee heroes without blink mechanisms or spell immunity will have a hard time positioning against Pit of Malice: Sven, Tiny, Wraith King, Dragon Knight, Meepo, Doom, Bounty Hunter, Dark Seer, Undying, Alchemist, Legion Commander.

* Heroes with a lot of burst damage, especially those who rely on casting spells: Lina, Zeus.

* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use Dark Rift to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* Heroes that reduce the damage that Marci can deal during her ultimate, like Razor, Rubick, Bane, Dragon Knight and Underlord.

* In general, heroes with long cooldowns on their abilities or ultimate will struggle against the relentless pressure provided by Dark Rift or Fiend's Gate (Requires Aghanim's Scepter): Terrorblade, Dragon Knight, Omniknight.

* Heroes with cleave or multi-target attacks can quickly take on Familiars and reduce Visage's firepower like Gyrocopter, Kunkka, Magnus and Medusa.

Additional:
* Summoned gargoyles are easy targets to Split Shot.
* Mana Shield will resist Soul Assumption instances without effort.

* Atrophy Aura reduces Terrorblade's damage significantly, even during Metamorphosis.
* Firestorm deals significant damage to Terrorblade and his illusions from a safe distance.
* Pit of Malice can keep Terrorblade and his illusions under control.
* Fiend's Gate can either bail out Underlord's team away from a bad engagement against a Terrorblade under Metamorphosis or caught Terrorblade off guard if he is not careful, and besides Reflection, Terrorblade has no other abilities to intercept Underlord nor his team when they use it to start a teamfight.
* Likewise, Fiend's Gate can be used to quickly move Underlord's team to the frontlines, to strike Terrorblade and his allies during Metamorphosis's 150 seconds of cooldown.
Additional:
* Atrophy Aura reduces Terrorblade's damage significantly, even during Metamorphosis.
* Firestorm deals significant damage to Terrorblade and his illusions from a safe distance.
* Pit of Malice can keep Terrorblade and his illusions under control.
* Fiend's Gate can either bail out Underlord's team away from a bad engagement against a Terrorblade under Metamorphosis or caught Terrorblade off guard if he is not careful, and besides Reflection, Terrorblade has no other abilities to intercept Underlord nor his team when they use it to start a teamfight.
* Likewise, Fiend's Gate can be used to quickly move Underlord's team to the frontlines, to strike Terrorblade and his allies during Metamorphosis's 150 seconds of cooldown.

* Firestorm will destroy Refraction charges very quickly.
* Firestorm will hit Templar Assassin while under the effects of Meld Meld.
* Templar Assassin has a hard time maneuvering around Pit of Malice.

* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces Rage, wasting its cooldown and making Lifestealer unable to fight.

* Atrophy Aura reduces Drow Ranger's damage significantly, as she relies on agility to be effective.

* Medusa's Split Shot will whittle down all of Naga Siren's illusions, including Naga Siren herself.

* Mana Shield tanks most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops significantly.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.

* Medusa cares less than other heroes about armor reduction, since Mana Shield blocks 70% of all damage without taking armor/magic resistance into consideration. This makes 60% of your Corrosive Haze ineffective until Medusa's mana is drained.

* Pit of Malice prevents Riki from casting Blink Strike. or Tricks of the Trade.
* Atrophy Aura reduces Riki's damage.
* Firestorm can be used to harrass Riki in lane.