* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Arcane Orb's constant pure damage output is devastating to Dragon Knight.
* Dragon Knight's relatively low mana pool leads to heavy damage from Sanity's Eclipse, which also bypasses his armor.

* Slardar can chase Dragon Knight down with Guardian Sprint and stun him with both Slithereen Crush and his passive Bash of the Deep. He can also use Corrosive Haze to whittle Dragon Knight's armor.

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Heroes that lose a great amount of their tankiness and become easier to finish off: Bristleback, Spectre, Phantom Assassin, Enchantress, Dragon Knight.
* Once you have an Aghanim's Scepter, Shadow Demon instantly reaches a new power spike and becomes a counter for a variety of heroes that have strong passives.
* Heroes that lose a great amount of their tankiness and become easier to finish off: Bristleback, Spectre, Phantom Assassin, Enchantress, Dragon Knight.
* Heroes that lose a great amount of damage output and become less threatening: Phantom Assassin, Sven, Slark, Phantom Lancer.
* You can always stack camps and farm the scepter with Shadow Poison.

* Flux will slow and damage Mirana even after she Leaps, since she will likely not be near allies.
* Arc Warden can place Magnetic Field on an ally who has been hit by Sacred Arrow to protect them.
Additional:
* Arc Warden can use his summons to prevent Sacred Arrow from hitting himself or his allies.
* Mirana doesn't build items that give armor often, so she usually can't fight against a late game Arc Warden.

* Gust prevents Mirana from escaping away from Leap and Moonlight Shadow before she builds defensive items.
* On the other hand, Mirana can Leap or close the gap with Moonlight Shadow to disable Drow Ranger's Marksmanship bonus.

* Dragon Knight has no built-in disengage from Frost Arrows, and Marksmanship procs ignore base armor, bypassing Dragon Knight’s durability for the most part, making Drow one of the few heroes that can deal enough sustained damage to solo kill Dragon Knight.
* With Aghanim's Shard, Frost Arrows also apply hypothermia stacks, reducing her target’s regen, which is especially potent against tanks like Dragon Knight. (A similar effect can also be achieved with an Eye of Skadi)

* Fury swipes can tear Dragon knight down as it stacks infinitely.

* Earthbind prevents Mirana from Leaping or going invisible with Moonlight Shadow. She can be easily killed by Poof and Ransack while disabled.
* Landing a Sacred Arrow on Meepo does not render him helpless, as all of the other Meepos can still fight back.

* If Slark sees the Sacred Arrow before it hits him, he can use Dark Pact to remove it a moment later.
* Pounce prevents Mirana from escaping with Leap.
* Slark can survive Mirana's Aghanim's Scepter​ combo with Shadow Dance.

* Lich's constant slows with Frost Blast and Chain Frost will slow Dragon Knight to a crawl, especially in a crowded teamfight.

* Abaddon can remove Sacred Arrow's stun from his teammates with Aphotic Shield, or remove it from himself with Borrowed Time.
* Borrowed Time makes Abaddon almost impossible to burst down with Mirana's Aghanim's Scepter combo.
Additional:
* Sacred Arrow can be instantly dispelled by Aphotic Shield.

* Track detects Mirana and her allies during Moonlight Shadow.

* Windrun quickly dodge Mirana's Sacred Arrow and misses her attacks.
* Shackleshot through tree with Focus Fire via Aghanim's Scepter​ combo can kill Mirana quickly, before using Leap or Moonlight Shadow.

* Puck can initiate on Mirana with Waning Rift to prevent her from going invisible or Leaping.
* A Mirana caught in Dream Coil will stun herself if she tries to Leap away.
* Puck's Burst damage takes advantage of Mirana's below average health.
* Puck can dodge Sacred Arrow and Starstorm with Phase Shift.
Additional:
* Mirana's spells are laid out to assassinate enemies. Puck can easily avoid the slow moving Sacred Arrow, and also can avoid Starstorm with Phase Shift, since the meteors have a delay.
* If Puck casts either Waning Rift or Dream Coil in the area, Mirana cannot Leap away.

* Eul's Scepter of Divinity and Light Strike Array combo will disable Mirana if she tries to Leap away.
* Laguna Blade's magical (pure with Aghanim's Scepter) burst damage takes advantage of Mirana's below average health.
Additional:
* Moonlight Shadow does little good against Dragon Slave and Light Strike Array.
* Lina's damage burst can quickly kill Mirana's teammates before she saves them with Moonlight Shadow.

* Dragon Knight is easily harassed by Poison Attack after the laning stage ends.
* Corrosive Skin protects Viper from Breathe Fire and returns damage.
* Nethertoxin mitigates Dragon Blood, Dragon's Knight main source of armor and health regeneration.
* Between Poison Attack and Viper Strike, Viper can keep Dragon Knight permanently slowed even in Elder Dragon Form.
Additional:
* In the early game, a Dragon Knight without Black King Bar is basically defenseless against Viper.
* Viper can harass Dragon Knight at any time with his Poison Attack.
* Corrosive Skin reduces damage from Dragon Fire and inflicts damage to him.
* Nethertoxin disables Dragon Blood, negating his main survivability.
* Viper Strike and Poison Attack can severely slow him down even with his Elder Dragon Form.

* Timbersaw's pure damage will kill Dragon Knight surprisingly fast, especially if he gets caught in a bad position while laning.

* Viscous Nasal Goo slows down Dragon Knight and lowers armor, locking him down and making him more vulnerable.

* Heroes who rely strongly on melee physical damage will fare badly against Omniknight's Guardian Angel: Phantom Assassin, Juggernaut, Dragon Knight, Lycan, Ursa, Troll Warlord

* Huskar can burn down Dragon Knight's health quickly during the early to mid game, but is not as effective during the late game. However, Life Break remains a constant threat due to the slow and percentage-based damage.

Additional:
* Huskar can negate Dragon Knight's passive with multiple trades of Burning Spear.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Overgrowth has a great duration, which prevents the units caught from attacking, moving and Blinking. Heroes like Storm Spirit, Mirana, Anti-Mage and others won't be able to do much if they're caught.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* In general, heroes with long cooldowns on their abilities or ultimate will struggle against the relentless pressure provided by Dark Rift or Fiend's Gate (Requires Aghanim's Scepter): Terrorblade, Dragon Knight, Omniknight.

* Elder Titan's Natural Order completely nullifies Dragon Knight's high armor.

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.

* Heroes that relies on armor or other type of physical damage negation are easy for Gyrocopter to take down during the early game with his magical damage: Axe, Dragon Knight, Sven.

* Heroes with no mobility will take some good damage from Sand King's spells: Dragon Knight, Jakiro, Pugna, Earthshaker,...

* Durable heroes relied a lot on their main passive effects and items' effects such as Bristleback, Underlord, Spectre and Dragon Knight can be disabled easily with Sharpshooter's break, reducing their potential in teamfights.

* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes who relies on high armor such as Dragon Knight, Tidehunter, and Pudge can be melted by Eye of the Storm.

Additional:
* Static Link saps Dragon Knight of his already low base damage, making him even more useless in a fight if he gets kited.
* Storm Surge makes Razor much faster than Dragon Knight, and hard to catch.
* Eye of the Storm melts Dragon Knight's armor and bypasses Black King Bar, his core item.

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Mirana's Leap is ineffective if Lycan uses Shapeshift. It also allows him to dodge Sacred Arrow.

* The long silence of Crippling Fear at night prevents Mirana from escaping with Moonlight Shadow and Leap. She also has really low base health, so Night Stalker can usually kill her during one cast of Crippling Fear at night.
* With Dark Ascension and Gem of True Sight, Night Stalker can find and kill Mirana, and he is a tanky hero capable of fighting Mirana any stage of the game.

* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.
Additional:
* Rupture can quickly kill Mirana if she tries to Leap away.
* Thirst detects Mirana and her allies during Moonlight Shadow.

* Heartstopper Aura and Reaper's Scythe go right through Dragon Knight's armor.