* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Lone Druid and his Spirit Bear lack mobility, and are easy overwhelmed after being slowed by Diffusal Blade.

* Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* Sanity's Eclipse deals heavy damage to Lone Druid.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Devourer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Riki: Smoke Screen can prevent Lone Druid from using True Form and Savage Roar, additionally it cause the spirit bear to miss on attacks which reduce the chances of getting rooted from it, with diffusal Blade, he can keep Lone Druid or the Spirit Bear inside the Smoke.

* Overgrowth has a great duration, which it prevents the units caught from attacking, moving and any short of blinking. Heroes like Storm Spirit, Mirana, Anti-Mage and others won't be able to do much if they're caught.

* Clinkz, Sniper, Lone Druid, Troll Warlord, Legion Commander, Wraith King and others are some of the Heroes that bases themselves on attacks with little or no spell power, suffering in the grassy hands of Overgrowth.

* Rupture can quickly kill Mirana if she tries to Leap away.
* Thirst detects Mirana and her allies during Moonlight Shadow.
Additional:
* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.

* Ghost Shroud can be use both offensively to slow Lone Druid or Defensively to prevent Lone Druid and The Spirit Bear from attacking him.
* Heartstopper aura burns the Spirit bear High HP over time. Additionally, it can deal decent damage to Lone Druid during his True Form.

* Flux will slow and damage Mirana even after she Leaps, since she will likely not be near allies.
* Arc Warden can place Magnetic Field on an ally who has been hit by Sacred Arrow to protect them.
* As Necronomicon is his core item, Arc Warden can reveal Mirana and her allies hiding in Moonlight Shadow and the Necronomicon Warrior can kill Mirana with Last Will if he is unintentionally killed with Starstorm upgraded by Aghanim's Scepter or Sacred Arrow.
Additional:
* If Arc Warden builds Necronomicon 3 he can reveal Mirana's team while Moonlight Shadow is active.
* A Starstorm upgraded by Aghanim's Scepter can accidentally kill a Necronomicon Warrior, which can lead to her death if she hasn't built a Black King Bar.
* Arc Warden can use his summons to prevent Sacred Arrow from hitting himself or his allies.
* Mirana doesn't build items that give armor often, so she usually can't fight against a late game Arc Warden.

* The long silence of Crippling Fear at night prevents Mirana from escaping with Moonlight Shadow and Leap. She also has really low base health, so Night Stalker can usually kill her during one cast of Crippling Fear at night.
* With Dark Ascension and Gem of True Sight, Night Stalker can find and kill Mirana, and he is a tanky hero capable of fighting Mirana any stage of the game.

* Mirana's Leap is ineffective if Lycan uses Shapeshift. It also allows him to dodge Sacred Arrow.
* As a natural Necronomicon carrier, he can reveal Mirana and her allies hiding in Moonlight Shadow and the Necronomicon Warrior can kill Mirana from an unintentional Sacred Arrow or Starstorm upgraded with Aghanim's Scepter.

* Windrun quickly dodge Mirana's Sacred Arrow and misses her attacks.
* Shackleshot through tree with Focus Fire via Aghanim's Scepter​ combo can kill Mirana quickly, before using Leap or Moonlight Shadow.

* Chain Frost will bounce between Lone Druid and his bear, forcing them to separate or suffer high amounts of damage.
Additional:
* Chain Frost can deliver high amounts of damage to Lone itself and his bear if they do not separate fast from each other.

* Reality Rift lets Chaos Knight bypass the Spirit Bear and jump onto Lone Druid.
* The Spirit Bear's lack of scaling means it dies quickly to Chaos Knight during the late-game.

* Lone druid's bear attacks on Phoenix's Supernova Egg don't increase the hit count. Given that Lone Druid's main hero often doesn't have much farm, the Supernova Egg is less likely to get killed.

* Lone Druid during True Form and the Spirit bear has high HP, meaning Spirit Siphon can be very effective against them since they deal percentage damage

* Cold Embrace can protect allies from Lone Druid and the Spirit bear, who mainly deal physical damage
* Winter's Curse can turn Lone Druid and the Spirit Bear against his teammates.

* Abaddon can remove Sacred Arrow's stun from his teammates with Aphotic Shield, or remove it from himself with Borrowed Time.
* Borrowed Time makes Abaddon almost impossible to burst down with Mirana's Aghanim's Scepter combo.
Additional:
* Sacred Arrow can be instantly dispelled by Aphotic Shield.

* Ensnare is good vs bear.
* In teamfights, song of the siren may be used to properly set up and coordinate an attack on Lone Druid in the backline, bursting him down, allowing to completely ignore the bear.
* Druid lack innate AoE capabilities giving him no good way of dealing with illusions.

* Brewmaster can make the Spirit Bear a much smaller threat with Cinder Brew.
* Cyclone removes the bear from a fight so that his team can easily focus on the hero.
* While most heroes would be worn down by a Spirit Bear Radiance in the time it takes to kill Lone Druid, Brewmaster is protected in Primal Split.

* Eul's Scepter of Divinity and Light Strike Array combo will disable Mirana if she tries to Leap away.
* Laguna Blade's magical (pure with Aghanim's Scepter) burst damage takes advantage of Mirana's below average health.
Additional:
* Moonlight Shadow does little good against Dragon Slave and Light Strike Array.
* Lina's damage burst can quickly kill Mirana's teammates before she saves them with Moonlight Shadow.

* Earthbind prevents Mirana from Leaping or going invisible with Moonlight Shadow. She can be easily killed by Poof and Ransack while disabled.
* Landing a Sacred Arrow on Meepo does not render him helpless, as all of the other Meepos can still fight back.

* If Slark sees the Sacred Arrow before it hits him, he can use Dark Pact to remove it a moment later.
* Pounce prevents Mirana from escaping with Leap.
* Slark can survive Mirana's Aghanim's Scepter​ combo with Shadow Dance.

* Laser blinds Lone Druid, making his attacks miss. Furthermore, a Tinker with Aghanim's Scepter is sure to blind both Lone Druid and his bear, negating his ability to root or deal physical damage.

* Puck can initiate on Mirana with Waning Rift to prevent her from going invisible or Leaping.
* A Mirana caught in Dream Coil will stun herself if she tries to Leap away.
* Puck's Burst damage takes advantage of Mirana's below average health.
* Puck can dodge Sacred Arrow and Starstorm with Phase Shift.
Additional:
* Mirana's spells are laid out to assassinate enemies. Puck can easily avoid the slow moving Sacred Arrow, and also can avoid Starstorm with Phase Shift, since the meteors have a delay.
* If Puck casts either Waning Rift or Dream Coil in the area, Mirana cannot Leap away.

* Grimstroke's Soulbind will always reliably connect onto both of them if they are close together.

* Lone Druid and The Spirit Bear cannot burst down Bristleback due to Bristleback
* Bristleback can easily run to Lone Druid without any hesitation, with Viscous Nasal Goo to reduce armor and slow the Spirit Bear or Lone Druid and Quill Spray can deal damage to both Lone Druid and the Spirit Bear at the same time

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Devourer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.

* Pugna: Decrepify prevent the Spirit bear from attacking or protect allies from it.

* Heroes that rely on invisibility can be tracked with Charge of Darkness opening them to team attacks: Bounty Hunter, Mirana, Riki

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Timbersaw: Lone Druid will have a hard time dealing with Timbersaw due to his tankiness and high Armor from Reactive Armor

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Blur allows Phantom Assassin to escape from Lone Druid and the spirit bear. Additionally, it provides evasion which effectively reduce the damage output from the Spirit Bear and reduce the chances to root her, forcing him to invest in Monkey King Bar
* At late game, Phantom Assassin out carry Lone Druid.

* Besides Lone Druid and Meepo, Doom is potentially good versus every hero since Doom will render any hero helpless for a prolonged 15 seconds. This is particularly true for fragile heroes that heavily rely on mobility to stay alive.

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.