* Rupture can quickly kill Mirana if she tries to Leap away.
* Thirst detects Mirana and her allies during Moonlight Shadow.
Additional:
* Thirst detects Mirana or her ally at low health during Moonlight Shadow.
* Rupture deals high damage when Mirana uses Leap.

* Heroes with fast movement abilities will suffer huge damage when afflicted by Rupture: Spirit Breaker, Earth Spirit, Dark Seer.

* Flux will slow and damage Mirana even after she Leaps, since she will likely not be near allies.
* Arc Warden can place Magnetic Field on an ally who has been hit by Sacred Arrow to protect them.
* As Necronomicon is his core item, Arc Warden can reveal Mirana and her allies hiding in Moonlight Shadow and the Necronomicon Warrior can kill Mirana with Last Will if he is unintentionally killed with Starstorm upgraded by Aghanim's Scepter or Sacred Arrow.
Additional:
* If Arc Warden builds Necronomicon 3 he can reveal Mirana's team while Moonlight Shadow is active.
* A Starstorm upgraded by Aghanim's Scepter can accidentally kill a Necronomicon Warrior, which can lead to her death if she hasn't built a Black King Bar.
* Arc Warden can use his summons to prevent Sacred Arrow from hitting himself or his allies.
* Mirana doesn't build items that give armor often, so she usually can't fight against a late game Arc Warden.

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc Warden

* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.

* The long silence of Crippling Fear at night prevents Mirana from escaping with Moonlight Shadow and Leap. She also has really low base health, so Night Stalker can usually kill her during one cast of Crippling Fear at night.
* With Dark Ascension and Gem of True Sight, Night Stalker can find and kill Mirana, and he is a tanky hero capable of fighting Mirana any stage of the game.

* Overgrowth has a great duration, which it prevents the units caught from attacking, moving and any short of blinking. Heroes like Storm Spirit, Mirana, Anti-Mage and others won't be able to do much if they're caught.

* Spirit Breaker's slow attacks cannot harm a hero shielded by Living Armor.
Additional:
* Living Armor can mitigate a large portion of Spirit Breaker's damage since his attacks are slow.
* Treant Protector can also counter initiate Spirit Breaker with Leech Seed and his bash from Nature's Guise before he manages to escape.

* If Slark sees the Sacred Arrow before it hits him, he can use Dark Pact to remove it a moment later.
* Pounce prevents Mirana from escaping with Leap.
* Slark can survive Mirana's Aghanim's Scepter​ combo with Shadow Dance.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Astral Imprisonment can be used to protect allies by imprisoning either them or Spirit Breaker.
* Arcane Orb will heavily drain Spirit Breaker's intelligence, rendering him almost useless and unable to cast spells. Spirit Breaker's low intelligence also means Sanity's Eclipse will deal a lot of damage to him.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Devourer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Earthbind's root prevents/interrupts Charge of Darkness.
* As a single target focused hero without much damage output, Spirit Breaker is ineffective in general against Meepo. Consider upgrading Nether Strike with Aghanim's Scepter to spam AoE stuns against Meepo clones.
Additional:
* Spirit Breaker heavily relies on disabling one enemy at a time therefore rendering him useless against five Meepos at once.

* Earthbind prevents Mirana from Leaping or going invisible with Moonlight Shadow. She can be easily killed by Poof and Ransack while disabled.
* Landing a Sacred Arrow on Meepo does not render him helpless, as all of the other Meepos can still fight back.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes that usually builds Linken's Sphere as a core item: Weaver, Medusa, Morphling, Queen of Pain, Storm Spirit

* Heroes with ways to protect themselves or allies from Spirit Breaker's initiation: Shadow Demon

* Heroes with summons or illusions makes Sacred Arrow harder to land: Shadow Demon, Phantom Lancer, Nature's Prophet.

* Pit of Malice can be cast in the path of Spirit Breaker's Charge of Darkness to cancel it.
* Dark Rift provides a way to escape from a gank for Underlord and his teammates.

* Clockwerk can use Power Cogs to repel Spirit Breaker when he charges in with Charge of Darkness.
* Spirit Breaker's slow 0.6 second attack animation attacks do little damage against Clockwerk. It can also constantly be interrupted by Battery Assault.
* Nether Strike's 1.2 second charge time gives Clockwerk plenty of time to activate Blade Mail and for Battery Assault to cancel it.
Additional:
* Battery Assault will continuously prevent Spirit Breaker from using Nether Strike, Charge of Darkness and even right clicking because of his long attack animation.
* Charge of Darkness can be cancelled by a correctly timed Hookshot.
* Should Clockwerk or his allies be targeted by Charge of Darkness, he can stop it by casting Power Cogs in Spirit Breaker's path or around the target.

* Bramble Maze stops Charge of Darkness in its tracks. Its very long duration means it can be used as an obstacle to block off an incoming Spirit Break during teamfights.
* Shadow Realm and Bedlam can be activated when Dark Willow sees Charge of Darkness coming, preventing Spirit Breaker from using Nether Strike after the initial stun.

* Mirana's Leap is ineffective if Lycan uses Shapeshift. It also allows him to dodge Sacred Arrow.
* As a natural Necronomicon carrier, he can reveal Mirana and her allies hiding in Moonlight Shadow and the Necronomicon Warrior can kill Mirana from an unintentional Sacred Arrow or Starstorm upgraded with Aghanim's Scepter.

* Windrun quickly dodge Mirana's Sacred Arrow and misses her attacks.
* Shackleshot through tree with Focus Fire via Aghanim's Scepter​ combo can kill Mirana quickly, before using Leap or Moonlight Shadow.

* In the early game, Omniknight can look like an easy target for Spirit Breaker, but with Purification and Degen Aura, what could be an opportunity could quickly turn into disaster.
* Heavenly Grace can be used to counter Charge of Darkness by minimizing the damage and lowering the stun duration with status resistance.
* Spirit Breaker's Greater Bash from all sources (Charge of Darkness or normal attacks) deals lesser damage if he is within the radius of Degen Aura.
* Due to this, Spirit Breaker's damage will always be lower when targeting Omniknight.

* Nether Strike can't remove Static Link and reduces Spirit Breaker's physical damage output.
* Eye of the Storm melts Spirit Breaker's armor, and makes him much less tanky.
Additional:
* Static Link drains damage bonus from Greater Bash, it cannot be removed by Nether Strike.
* Eye of the Storm melts Spirit Breaker's armor, and makes him much less tanky.

* Due to Spirit Breaker's low attack speed, Supernova is problematic for Spirit Breaker to take down, and even more so with Fire Spirits debuff applied.
* Icarus Dive grants Phoenix capability to quickly escape to safety.

* Cold Snap allows Invoker to interrupt Charge of Darkness and Nether Strike.
* Tornado's long range can be used to cancel Charge of Darkness.
* Deafening Blast prevents Spirit Breaker from right clicking and thus proccing his Greater Bash.

* Fissure interrupts Spirit Breaker during Charge of Darkness.

* Abaddon can remove Sacred Arrow's stun from his teammates with Aphotic Shield, or remove it from himself with Borrowed Time.
* Borrowed Time makes Abaddon almost impossible to burst down with Mirana's Aghanim's Scepter combo.
Additional:
* Sacred Arrow can be instantly dispelled by Aphotic Shield.

* Eul's Scepter of Divinity and Light Strike Array combo will disable Mirana if she tries to Leap away.
* Laguna Blade's magical (pure with Aghanim's Scepter) burst damage takes advantage of Mirana's below average health.
Additional:
* Moonlight Shadow does little good against Dragon Slave and Light Strike Array.
* Lina's damage burst can quickly kill Mirana's teammates before she saves them with Moonlight Shadow.

* Spirit Breaker's slow attack speed and moderate damage do very little to harm Dragon Knight, even if ganked with Charge of Darkness.

* Searing Chains can stop Charge of Darkness if timed correctly.
* Activate Fire Remnant can be used to escape an approaching Spirit Breaker, or lead Spirit Breaker into a bad situation.
* Activate Fire Remnant and Sleight of Fist allows Ember Spirit to dodge Charge of Darkness if timed correctly.

* Durable heroes: Axe, Bristleback, Tidehunter, Wraith King

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Heroes that can cancel Charge of Darkness: Ogre Magi, Earthshaker.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Devourer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Heroes who rely on invisibility, such as Bounty Hunter, Clinkz, Mirana, Nyx Assassin and Riki, as they will be revealed if caught by Chronosphere.

* Durable heroes: Axe, Bristleback, Tidehunter, Wraith King

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc Warden

* Heroes that usually builds Linken's Sphere as a core item: Weaver, Medusa, Morphling, Queen of Pain, Storm Spirit

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Heroes that usually builds Linken's Sphere as a core item: Weaver, Medusa, Morphling, Queen of Pain, Storm Spirit

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Mana Drain has an extremely long range and low cooldown. It can easily deplete most heroes of their entire mana pools, especially those with smaller mana pools such as Tiny or Spirit Breaker.

* Heroes with silences and hard stuns such as Doom, Silencer, and Lion can keep Mirana from Leaping away.

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc Warden

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Heroes that punish mobile heroes: Bloodseeker, Keeper of the Light

* Malefice prevents Spirit Breaker from using his spells for the duration.
* Demonic Conversion's eidolons have high magic resistance, receiving little damage from Charge of Darkness.

* Due to Spirit Breaker's low attack speed, Tombstone is problematic for Spirit Breaker.
* The zombies summoned from Tombstone apply a stacking movement speed slow, which can significantly reduce Greater Bash's damage.
* Soul Rip and Decay allows Undying and his allies to survive from incoming ganks of Spirit Breaker.

* If Medusa activates Stone Gaze, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.

* Puck can initiate on Mirana with Waning Rift to prevent her from going invisible or Leaping.
* A Mirana caught in Dream Coil will stun herself if she tries to Leap away.
* Puck's Burst damage takes advantage of Mirana's below average health.
* Puck can dodge Sacred Arrow and Starstorm with Phase Shift.
Additional:
* Mirana's spells are laid out to assassinate enemies. Puck can easily avoid the slow moving Sacred Arrow, and also can avoid Starstorm with Phase Shift, since the meteors have a delay.
* If Puck casts either Waning Rift or Dream Coil in the area, Mirana cannot Leap away.

* Heroes that have an escape that doesn't disjoint projectiles: Mirana, Faceless Void, Magnus

* Spirit Breaker won’t do much harm because of Untouchable and Nature's Attendants. Unless Enchantress is low on HP, Spirit Breaker won’t catch her with mere spells.