* Arcane Bolt's low cooldown allows him to deal consistent damage to Morphling, and is a viable way to disable Linken's Sphere.
* Ancient Seal prevents Morphling from using any of his skills, giving Skywrath Mage and his team ample time to burst Morphling down.
* Mystic Flare coupled with a stun/root can easily burst Morphling down, especially if he has more stats shifted to Agility.
* Alternatively, Morphling can use Morph to use Skywrath Mage's own silence and nukes against him.

* Skywrath Mage can easily harass Alchemist in the laning phase with multiple Arcane Bolts. Additionally, if Alchemist is in the process of throwing an Unstable Concoction, and has no way to dispel Ancient Seal, the self stun becomes an easy set up for Mystic Flare.
* Caution, however, as a decently farmed Alchemist with {Item ID:Radiance} and {Item ID:Manta Style} can easily send illusions to harass and force Skywrath Mage out.

* Ice Blast stops Attribute Shift (Strength Gain) from recovering adional health, and using it will even bring Morphling closer to the shatter threshold.
* In lane, Ice Vortex slows Morphling's already poor movement speed to a crawl; this, coupled with the amplification of magic damage, can set up an early kill on Morphling if Ancient Apparition has a suitable lane partner.
Additional:
* Ice Blast stops Morphling from gaining additional health with Attribute Shift.
* Using Attribute Shift would even bring Morphling closer to the shatter threshold.
* In the lane, Ice Vortex slows Morphling's already poor movement speed to a crawl; this, coupled with the amplification of magic damage, can set up an early kill on Morphling if Ancient Apparition has a suitable lane partner.

* Ice Blast nullifies the health regeneration granted by Chemical Rage, which Alchemist greatly relies on to stay alive in battle.
* Alchemist tends to build Armlet of Mordiggian which can be deadly during Ice Blast.
Additional:
* Ice Blast cancels out Chemical Rage's rapid health regeneration. It can also take advantage of Alchemist's Armlet of Mordiggian toggling, as it will make HP drain insanely fast, essentially killing the bearer in no time.

* Jumping on Axe with Waveform will make Morphling an easy target for a counter-initiation with Berserker's Call.
* Morphling is often played at low health to maximise the bonuses from Attribute Shift (Agility Gain), and also because his abilities cost health to use. This makes him especially vulnerable to Culling Blade.
* However, Morphling is common Linken's Sphere carrier to block Culling Blade forces Axe to use Battle Hunger to pop the Spell Block first.
* Attribute Shift (Agility Gain) gives Morphlig no protection against the pure damage of Culling Blade. Its attack speed bonus also means that Counter Helix will proc more often.

* Axe can force Alchemist to attack him with Berserker's Call. High attack speed from Chemical Rage will cause Counter Helix to proc multiple times.
* This can get worse if axe has Blade Mail, which then returns all damage to Alchemist himself.
* Axe's abilities can pierce through Black King Bar, which is a common item for Alchemist.
* Berserker's Call grants Axe a huge bonus armor, which greatly counters Alchemist's physical damage for the most part.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* Dark Pact also allows him to just purge off the stun if timed correctly.
* Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.

* Necrophos's Reaper's Scythe can finish off a low-health Morphling.

* Reaper's Scythe can kill Alchemist before Chemical Rage has the time to heal him.
* Ghost Shroud can prevent Alchemist from attacking Necrophos, as well as make him immune to Acid Spray and Unstable Concoction damage.
* Heartstopper Aura will do damage as long as Necrophos is alive based on health percentage, which is a problem for a strength hero such as Alchemist.

* In general, attacks of the melee heroes who are entirely reliant on dealing physical damage and/or have very little to no area-of-effect abilities will make Underlord tickle and will have no effect against him, and will be unable to ambush Underlord and his team if Underlord chooses to use Dark Rift to get to a designated point of the map: Phantom Assassin, Terrorblade, Troll Warlord, Drow Ranger, Phantom Lancer, Chaos Knight, Sven, Wraith King, Bounty Hunter, Alchemist, Templar Assassin, Nyx Assassin, Bane.

* Underlord's Atrophy Aura reduces Morphling's high base damage gained through agility shift.

* Melee heroes that get kited easily have hard times dealing with Puck without any lockdowns, as Puck is one of the most mobile heroes. Heroes like Sven, Lifestealer, Ursa and Alchemist may have problems to get to Puck without proper initiation items. They also lack reliable lockdowns, as their disables are easily avoidable for Puck, or are just a soft disable.

* Heroes with silencing abilities that are not blocked by Linken's Sphere, like Puck's Waning Rift, Death Prophet's Silence or Silencer's Global Silence.

* Sacred Arrow's long stun duration can prevent Morphling from casting his Waveform or Morph Replicate, making him unable to escape and easier to gank.
* Moonlight Shadow also allows Mirana's team to surprise Morphling while he tries to push towers.
* Mirana usually buys Linken's Sphere to protect herself from single-target abilities, making Morphling's Adaptive Strike and Ethereal Blade harder to use on her.
* However, Mirana also provides a chance to become a good Morph target, allowing Morph to use Leap to run away, if necessary.

* Earthbind disables Waveform, effectively keeping Morphling in place for an extended period of time, allowing Meepo to deal considerable damage with Poof.

* Counterspell's bonus magic resistance causes the Waveform and Adaptive Strike combo to deal significantly less damage.
* Counterspell's active component can reflect the Adaptive Strike back into Morphling, dealing significant damage or even killing him.
* Mana Break combined with Manta Style can quickly burn away Morphling's mana, leaving him unable to use his spells. Black King Bar can no longer be reliably used against Anti mage due to its 50 mana cost.

* Corrosive Haze followed by Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* Bash of the Deep will deal lots of damage during the laning phase.

* Most of Morphling's armor comes from his high agility and it is reduced by Natural Order.
* However, the aura has only 350 range and Elder Titan can be bursted down by Morphling's nuke combo if he isn't careful.
Additional:
* Morphling's high armor is primarily from morphing agility, which is reduced by Natural Order therefore making the hero very vulnerable when it has morphed a lot into agility.
* Morphling usually will Morph into high agility and low strength. This can be taken advantage of with a good stun or silence or by bursting him down before he has the time to Morph back to strength.
* Morphling is very vulnerable to Blade Mail under Natural Order and can easily burst himself down with his own auto-attacks or his magical damage combo.

* Arcane Orb deals pure damage, effectively bypassing Morphling's high armor from Attribute Shift (Agility Gain).
* Sanity's Eclipse is more effective against a low health and mana pool Morphling, enabling Outworld Destroyer to burst Morphling down before he can shift to Strength.
Additional:
* Arcane Orb deals high damage regardless of Morphling's high armor from Attribute Shift (Agility Gain).
* Because of Morphling's very low intelligence gain and base intelligence, Sanity's Eclipse will almost always be effective against Morphling.

* Time Dilation effects Morphling's low cooldown spells, making them unusable for a long time, rendering Morphling nearly useless.
* Morphling cannot use Attribute Shift while he is inside Chronosphere which makes it easy to kill him.

* Morphling relies on Attribute Shift (Agility Gain) to the last hit, Primal Beast can not only match this damage but also threaten Morphling if he sits on low health.
* Morph is not very useful if played as a carry, since Primal Beast rarely right-clicks later on.

* Ember's magic damage build is able to burst down Alchemist due to his low strength gain and Alchemist's normal item pick up.

* Quas-Exort Invoker can win the mid lane easily against Alchemist because Quas regeneration will nullify Acid Spray's damage over time and Exort damage bonus will allow Invoker to out last hit Alchemist.

* Sharpshooter can kill easy when Morphling is going on full agility strategy (Only in early and mid game).
* Scurry can help to catch up Morphling when using Waveform or for escape.

* Rubick's ability to steal Attribute Shift (Strength Gain) makes him extremely annoying to deal with because Rubick's shifted attributes will remain even if he steals a new spell.
* If Rubick moves enough points to strength and then steals Adaptive Strike, he will have a powerful 3-second ranged stun in his arsenal as well.
* Waveform provides a reliable nuke/escape to Rubick.
* Rubick can steal most abilities Morphling uses while Morphed, allowing Rubick to steal his own allies' abilities if the Morphling is not careful.

* Void Spirit can greatly pressure Morphling's farm, which is very bad for a hero who needs a large amount of space.
* Waveform does not provide better mobility than Astral Step.
* If Morphling shifted all of his strength to agility, he can be bursted down by Void Spirit before he can react.
* Doing an Ethereal Blade combo on Void Spirit is incredibly difficult, as Dissimilate and Astral Step can allow him to escape or dodge the projectile.

* Morphling usually has low max health due to shifting strength into agility, which combined with Blast Off's silence will prevent him from using Waveform and Adaptive Strike (Strength), leaving him defenseless and making him an easy target to burst down.

* Geomagnetic Grip is not blocked by Linken's Sphere and can silence Morphling, preventing Morphling from using Waveform or Attribute Shift to escape from ganks.
* In addition, Boulder Smash and Rolling Boulder provide a solid lockdown if used together.

* Tidebringer will deal lots of damage to Alchemist before he builds physical survivability items.
* Torrent and X Marks the Spot can control Alchemist at all stages of the game before he has Black King Bar.
* Ghostship's rum buff will greatly reduce the Alchemist's damage output in teamfights including his Radiance.

* Mana Drain rapidly saps Morphling's already low mana pool, making him unable to use Waveform or Adaptive Strike. Additionally, Hex prevents these abilities as well.
* An Earth Spike and Finger of Death combo can burst an unwary Morphling down if he has his strength fully shifted to agility.

* Alchemist is a well-known Radiance carrier among other auras your illusions will benefit from. They also get the extra move speed and reduced base attack time from his Chemical Rage, and it's even better if you can catch him as his own rage is about to expire.
* Disruption will buy enough time for all allies to retreat when Alchemist starts to activate Unstable Concoction.

* Untouchable greatly reduces Chemical Rage's attack speed advantage.

* Visage can quickly kill heroes with low to medium base armor and no innate escape mechanism. Examples include Alchemist, Crystal Maiden and Zeus.

* Heroes with silencing abilities that are not blocked by Linken's Sphere, like Puck's Waning Rift, Death Prophet's Silence or Silencer's Global Silence.

* Heroes without an escape mechanism: Shadow Fiend, Alchemist

Additional:
* Chemical Rage will rarely save Alchemist against Ursa's Fury Swipes.
* Enrage allows Ursa to both be a threat to Alchemist and avoid his over time damage.

* Jakiro's early pushing ability from Liquid Fire makes Jakiro very strong against heroes, that take a long time to get online: Morphling, Naga Siren, Spectre.

* Winter Wyvern's Winter's Curse turns Morphling's high attack damage and attack speed against his targeted teammate.

* Heroes that rely on right-clicks will find that their attacks will miss a lot, due to Whirling Axes (Melee)'s miss chance. Such heroes include Phantom Assassin, Terrorblade, and Morphling.

* Low-health, normally mobile carries with a lot of damage are vulnerable to Bane's nukes and disables: Anti-Mage, Clinkz, Drow Ranger, Faceless Void, Gyrocopter, Juggernaut, Luna, Meepo, Mirana, Monkey King, Morphling, Phantom Assassin, Phantom Lancer, Riki, Shadow Fiend, Slark, Sniper, Terrorblade, Troll Warlord, Weaver.

* Heroes who rely on skills to become a heavy hitter in a certain amount of time can waste their timing because of a lucky Lucky Shot's disarm: Terrorblade, Sven, Clinkz, Windranger, Alchemist, Dragon Knight, Legion Commander

* Heroes with high damage output who can burst down Morphling before he has time to use Attribute Shift (Strength Gain), like Lina and Lion.

Additional:
* Light Strike Array catches Morphling while he jumps in from Waveform and also prevents Morphling from using his abilities.
* Laguna Blade can kill Morphling quickly before he shifts into Attribute Shift (Strength Gain).

* Pugna's Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.

* Arc Warden can counter Morphling's strong pushing capabilities by using Magnetic Field to protect buildings.
* Arc Warden also often builds an Orchid Malevolence or Bloodthorn, which can prove dangerous for Morphling.
* Arc Warden can easily break Linken's Sphere with Flux and then slow him with Spark Wraith, making Arc Warden's Tempest Double a legitimate threat as well.

* Phantom Lancer can effortlessly overwhelm Morphling with a large number of illusions. It becomes even more effective with {Item ID:Diffusal Blade}, which takes away his mana in the process.
* Doppelganger can be used to dodge Adaptive Strike combo and create confusion with two additional illusions.
* Eye of Skadi can be bought to slow and negate the health regeneration from Attribute Shift, and a common item for Phantom Lancer.

* Alchemist has very bad armor and does not build armor items for the large majority of his build, so Jingu Mastery and Wukong's Command can be very deadly.
* Desolator, Sange and Yasha or Diffusal Blade can all be purchased to increase your damage against Alchemist or just to keep your movement speed high enough to match him while Chemical Rage is active.
* Monkey King is an agility hero and scales with armor, so Acid Spray loses it's effectiveness later in the game.