* Amazingly, Enchantress has even lower health than Pugna. Though she does pack quite a punch through Impetus, she can't use it if she is under Decrepify.
* Pugna's Magical DPS is way greater than the heal from Nature's Attendants, which will also harm her quite a bit if she's next to Nether Ward.

* Vendetta breaks Untouchable and deals great damage against her.
* Enchantress' lack of mobility makes her a primary target for ganking with Vendetta.
* Spiked Carapace can reflect Impetus and stun Enchantress.
* Mana Burn can deal tremendous damage against her due to being an Intelligence hero.
Additional:
* Vendetta disables Untouchable.
* Spiked Carapace reflects the damage from Impetus.
* Enchantress is a rather squishy hero, making her fall easily to Nyx Assassin's high burst damage.

* Outworld Destroyer's high intelligence gain and fragility makes him an easy target for a massive Mana Burn, as well as killing him outwards with Nyx Assassin's high burst damage.
* Astral Imprisonment can be easily exploited by Nyx Assassin with his abilities. As long as Astral Imprisonment was not cast on Nyx Assassin, it will make an opportunity for an easy stun, either by Spiked Carapace (if Outworld Destroyer hid his allies or your allies) or Impale (if he hid himself). If Astral Imprisonment was cast on Nyx Assassin, using Spiked Carapace while banished will proc the stun after the disable, since Spike Carapace has a 0 second cast time and Astral Imprisonment deals damage right after the disable ends.
* An ill-timed Sanity's Eclipse or well timed Spiked Carapace can deal a lot of damage to Outworld Destroyer and stun him, unless Outworld Destroyer used Black King Bar beforehand.
Additional:
* Outworld Devourer's high mana pool, high intelligence, and low health makes him a prime target for Mana Burn.
* If timed correctly, Spiked Carapace will return the full damage from Sanity's Eclipse back to Outworld Devourer. Even a reflected Arcane Orb can deal significant damage and make him vulnerable to a follow-up from Nyx Assassin.
* Spiked Carapace is also the perfect tool against Astral Imprisonment: if used on Nyx, he can reflect the damage back as he comes out of the prison by casting the ability while imprisoned.

* For the better part of the game, he will take more damage from your ward than he deals to you with Arcane Orb.
* It will take a huge difference in farm or itemization between you for him to deal any damage to you with Sanity's Eclipse, provided he doesn't die first from casting it next to your ward.
* Decrepify allows Pugna to be immune to the attacks from Arcane Orb.

* Nether Ward will cause an unfriendly area for Medusa, draining her mana.

* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Additional:
* Level 4 Mana Burn burns 38,5% of Medusa's mana every 4 seconds if Medusa only increases her mana pool with intelligence. Additionally, 60% of the Mana Burn damage gets mitigated by Mana Shield, burning even more mana.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.

* Nether Ward discourages Tinker from using abilities and items due to its high damage against heavy mana usage.

* His whole skillset acts like a counter to Tinker:
* Impale prevents Tinker from blinding Nyx Assassin or fighting back, while giving Nyx' allies time to catch up to Tinker's position.
* Mana Burn generally deals more damage to intelligence based heroes like Tinker
* Spiked Carapace can stun Tinker at a moment of Nyx Assassin's choosing if March of the Machines has been cast. It is also quite easy to time Spiked Carapace against Heat Seeking Missiles.
* Vendetta allows Nyx to approach Tinker in the trees or wait for him in common hiding spots and deal heavy damage to his low armor.
Additional:
* March of the Machines and Heat-Seeking Missile allow easy Spiked Carapace stuns.
* As a fragile hero that relies on mana and intelligence items, Tinker is vulnerable to Mana Burn.
* Nyx Assassin's stuns can interrupt Rearm and leave Tinker helpless.

* Skywrath Mage's low health makes him rather easy prey for Nyx Assassin and his lack of armor generally means he'll take the full brunt of a Vendetta strike.
* Mana Burn is annoying at all stages of the game as it turns Skywrath Mage's high intelligence growth against him.
* Spiked Carapace gives Nyx some degree of protection against Skywrath's spells.

* Nether Ward will make Skywrath Mage next to useless in fights, as his low hp pool will not allow him to sustain through the damage of the ward should he choose to cast spells. Be wary though that Skywrath's huge burst will make very quick work of Pugna's low hp should the ward be destroyed, and Decrepify won't help you at all.
Additional:
* Due to the high mana cost of his spells and the low cool down of them, Nether Ward can seriously damage Skywrath Mage if he isn't careful.
* Skywrath Mage's fragility makes him very susceptible to Pugna's high burst damage.

* Leshrac needs to be close to target in order to do damage, Pugna can outrun Leshrac with ease due to his superior movement speed.
* Split Earth can also be hard to land on Pugna for the same reason.
* Leshrac uses huge amounts of mana to do damage, Nether Ward forces him to either not contribute in a fight or kill himself in the process.
Additional:
* Nether Ward punishes Leshrac's constant mana usage from spamming spells.
* Leshrac needs to be in the thick of the fight to deal damage, and so cannot escape from Nether Blast nor Life Drain easily.

* Nyx Assassin's Spiked Carapace will stun Leshrac when hit by any of his AOE abilities.
* Mana Burn deals high damage due to Leshrac's high intelligence gain and burns a large amount of Leshrac's essential mana pool.

* Spiked Carapace stops Snapfire's Mortimer Kisses.
* Snapfire's low armor and agility gain means that Vendetta will deal a decent amount of damage.

* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.
* Heroes with mobility spells (such as Queen of Pain's Blink and Clockwerk with Hookshot) can easily avoid Lil' Shredder and Mortimer Kisses.
* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.

* Mana Burn does tons of damage against Lina because of her high intelligence. The mana burn also prevents Lina from casting her full combo.
* Spiked Carapace can easily be used to counter Lina's abilities because of their long cast animation, and could probably kill Lina outright if Laguna Blade is reflected.

* Nether Ward will be problematic for heavy nukers and spammers like Skywrath Mage, Lina, Lion and Invoker, but don't use Decrepify defensively against them as you'll be helping them out more than anything.

* Heroes with high burst damage: Lina, Lion, Luna, Nyx Assassin, Queen of Pain.

* Decrepify prevents Shadow Fiend from attacking for its duration, potentially preventing him from getting a kill.
* Nether Ward can do heavy damage to Shadow Fiend if he tries to cast his Requiem of Souls and spamming Shadowraze.
Additional:
* Decrepify prevents Shadow Fiend from attacking for its duration, potentially preventing him from getting a kill.
* Nether Ward can do heavy damage to Shadow Fiend if he tries to cast his Requiem of Souls and his Shadowraze.

* Heroes with break abilities: Nyx Assassin, Shadow Demon (with Aghanim's Scepter), Viper.

* Nether Blast, Decrepify and Life Drain deal high magical damage and bypasses Bulwark.
* Nether Ward reduces the amount of abilities Mars can use during fights and forces Mars to be careful about the heavy mana cost of Arena Of Blood.
* Pugna is one of few heroes that can contest Mars' ability to push and defend towers early on.

* Nether Ward can do a ton of damage to Disruptor because of his high mana costs.
* Life Drain can be used to heal an ally trapped by Static Storm-Kinetic Field combo (if Pugna is not a target).

* Heroes that can pick you off: Clinkz, Nyx Assassin, Puck, Riki.

* Ethereal state disarms the target and makes them more vulnerable to magic damage, both of which Phantom Assassin despises. Especially Pugna and any hero that is wielding Ethereal Blade, such as Mirana, Nyx Assassin or Morphling.

* Ethereal state disarms the target and makes them more vulnerable to magic damage, both of which Phantom Assassin despises. Especially Pugna and any hero that is wielding Ethereal Blade, such as Mirana, Nyx Assassin or Morphling.

* Heroes with damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Heroes with damage burst can often kill Chen or his allies before he can use Hand of God: Lina, Techies, Shadow Fiend, Pugna, Nyx Assassin.

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes has attack range talent can also outrange Plague Ward.

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Pugna can save allies with both healing or by making them ethereal.

* Mana Burn is strong against Keeper of the Light due to his high mana pool.
* Spiked Carapace can be used to reflect Illuminate damage and stun Keeper of the Light.
* Vendetta allows Nyx Assassin to follow Keeper of the Light around if he tries to split-push.

* Nether Blast is one of the best tower pushing abilities in the game, with a low cooldown. A competent Pugna will (at the very least) destroy tier 2 towers and make space for his team before Spectre can finally come online.
* Spectre's spells, while not spammable, have a fairly high mana cost, so Nether Ward can be fairly damaging to Spectre early game. The mana degen will also dampen Spectre's early game power significantly.
* Once Pugna gets Aghanim's Scepter, he can spam Life Drain on any illusion Spectre summons, whether it'd be from Haunt, Manta Style, or some other means.
* In addition, Pugna can disable Spectre's Desolate ability (although its damage is pure, it requires physical attacks) with his Decrepify ability, leaving Spectre only with Spectral Dagger.

* All of Pugna's abilities are active, making Demonic Purge break from Aghanim's Scepter useless.
* Nether Ward punishes Shadow Demon's constant mana usage from spamming spells, especially Shadow Poison.
* An attempt to save an ally using Disruption can easily become a perfect setup for a Nether Blast for the enemy.
* Life Drain can be used to heal Pugna or an ally against Shadow Demon's abilites.
* However, it can be cancelled by Disruption until Pugna buys defensive items.

* With Vendetta, Nyx Assassin can move closely to Ember Spirit when he's farming with his Flame Guard and use Spiked Carapace with Impale to provide a reliable and long disable.
* Mana Burn is also good, as Ember Spirit relies on his limited mana pool for the early to midgame.
Additional:
* Spiked Carapace can be easily triggered by Flame Guard or Battle Fury, setting up a deadly Impale.

* Nyx can walk into Firefly with Spiked Carapace and stun Batrider if he has no Spell Immunity.

* Vendetta disables Vengeance Aura and allows him to attack Vengeful Spirit with Impale and Mana Burn.
* Spiked Carapace is easy to use against a Wave of Terror or Magic Missile.

* Nether Ward will be problematic for heavy nukers and spammers like Skywrath Mage, Lina, Lion and Invoker, but don't use Decrepify defensively against them as you'll be helping them out more than anything.

* Vendetta allows Nyx to sneak up on Lion and deal massive damage to him, especially when followed up with an Impale, Mana Burn, or even Dagon.
* Spiked Carapace has the potential to not only nullify Lion's damage, but also cripple and potentially deal massive damage to Lion, especially if he reflects Finger of Death.

* Even though Pugna's low HP means that he can be quickly burst down, his Nether Ward heavily punishes casters whose spells cost a lot of mana, like Zeus. Casting 4 of his active spells, including Nimbus, close to an enhanced level 4 Nether Ward, can make the ward deal up to 1750 magical damage.
* Decrepify can further increase the damage dealt by Nether Ward upon Zeus. However, if used on Pugna himself or on one of his allies, it will amplify the damage done by Zeus' abilities.

* Many of Nyx Assassin's abilities are good against Windranger.
* Impale is great for stunning Windranger and allowing additional disables to be landed.
* Mana Burn is useful against Windranger's decent intelligence growth and also burns some mana, preventing her from using more abilities.
* Spiked Carapace is easy to use against Powershot.
* Vendetta allows Nyx Assassin to sneak up on and deal massive damage to Windranger without giving Windranger a chance to use Windrun to evade it.
* Nyx Assassin's item build allows him to easily deal with Windranger.

* Decrepify can be used on allies to prevent them from attacking Axe and triggering Counter Helix during Berserker's Call. He can also cast it on Axe to prevent anyone from attacking him.
* Life Drain can be used to heal himself or allies caught in Berserker's Call, preventing them from dropping low enough for Axe to kill them with Culling Blade.

* The huge physical damage taken from Vendetta will force Necrophos to use Ghost Shroud, which is good for a followup with Dagon and Ethereal Blade, both of which are common items on Nyx Assassin.
* Using Ghost Shroud also sets Necrophos up for a Mana Burn or Impale.

* Pugna's Decrepify can render Templar Assassin's physical attacks useless.
* Pugna can also cast Life Drain on Templar Assassin, burning her Refraction instances.
* On the other hand, Pugna generally has low health and armor. Use this to your advantage.

* Nyx Assassin has a lot of burst damage from his Impale, Mana Burn, Dagon, and the bonus damage from Vendetta. All of this damage is enough to kill Drow Ranger.
* Nyx Assassin is usually invisible most of the time thanks to his ability Vendetta, which allows him to gank Drow Ranger easily.

* Spiked Carapace allows Nyx to get an easy long-duration stun on Weaver once he uses Shukuchi, and then he can follow up with Impale.
* Vendetta works as a great setup for both Impale and Spiked Carapace and can deal decent damage to Weaver. Additionally he can neutralize The Swarm beetles due to his invisibility duration.

* Troll Warlord can't switch targets at will, in order to build Fervor stacks, which makes it easy to use Decrepify in order to save allies
* During Battle Trance, Pugna can easily use Nether Blast, Decrepify and Life Drain on him

* Nether Ward can punish Timbersaw, as Timbersaw is a spell-caster with low cooldowns. Furthermore, Timbersaw usually appears in the midst of battle, placing himself in range of Nether Ward's Mana Flares.
* Timbersaw has no stuns or silences to stop Life Drain. Since all of Pugna's Spells are magical, the damage can be devastating to Timbersaw, especially when combined with Decrepify
Additional:
* Nether Ward can punish Timbersaw, as Timbersaw is a spell-caster with low cooldowns. Furthermore, Timbersaw usually appears in the midst of battle, placing himself in range of Nether Ward's Mana Flares.
* Timbersaw has no stuns or silences to stop Life Drain. Since all of Pugna's Spells are magical, the damage can be devastating to Timbersaw.
* Decrepify can further increase all the magical damage done to Timbersaw, bypassing the enhanced physical resistance he can get from Reactive Armor.

* Crystal Maiden has a very bad movement speed, so Impale is easy to land against her. Furthermore, even while trapped by Frostbite, Nyx Assassin can still cast Impale.
* Crystal Maiden has very low armor, so Vendetta is very effective.
* Nyx Assassin has two ways to stop Freezing Field, provided she doesn't get a Black King Bar. He can pop Spiked Carapace and simply walk into the field, or he can use Impale to interrupt the field, since Crystal Maiden has to channel it.
Additional:
* Spike Carapace easily interrupts Freezing Field.
* Frostbite's damage over time sets up an easy Spiked Carapace stun.
* Crystal Maiden is extremely fragile and dies quickly to Nyx Assassin's burst damage.

* Decrepify turns the target ethereal, protecting them from Chaos Knight's and his illusions' attacks.
* Life Drain instantly destroys illusions. It can effectively negate Phantasm when upgraded with Aghanim's Scepter.
* Nether Blast quickly clears out illusions and can harass Chaos Knight in lane.

* Impale interrupts Upheaval.
* Nyx Assassin Vendetta allows him to escape from Warlock's Upheaval with maximum move speed.
* Warlock's low health pool and mobility can easily take down by Nyx Assassin's burst damage.

* Cold Embrace is a death sentence against Pugna, since its the perfect setup for all his abilities, especially Life Drain.
* Decrepify can be cast to save the ally under Winter's Curse effect, wasting most of its duration.
* Winter Wyvern's abilities require a lot of mana, allowing Nether Ward to deal lots of damage.

* Nyx Assassin's high burst damage can be the bane of Dark Willow, as her low health makes it difficult to survive long enough to escape through Shadow Realm.
* Spiked Carapace can be triggered by walking deliberately into Bramble Maze, leaving Dark Willow stunned and defenseless.

* Mana Burn can instantly deplete Tidehunter's low mana pool, especially in the early game, potentially preventing Tidehunter from casting Ravage.
* Ravage's travel time allows Nyx Assassin to easily stun Tidehunter with Spiked Carapace.
* Vendetta offers a very rare break effect, which fully disables Kraken Shell and makes Tidehunter susceptible to follow-up disables.

* Nyx Assassin can take advantage of every one of Puck's weaknesses. His entire skill set is very effective in countering Puck.
* Because Illusory Orb is such a slow moving projectile, Nyx Assassin can simply walk into the orb and activate Spiked Carapace, stunning Puck and setting up an easy Impale. This can be circumvented by using Phase Shift while the orb is traveling, however, that means that Puck cannot use Phase Shift to dodge any other skill nor use it to safely blink away from a fight.
* Puck is an intelligence hero that likes to build intelligence items such as Eul's Scepter of Divinity, Scythe of Vyse, and Dagon. This makes Mana Burn that much more deadly against Puck.
* An ill-timed Phase Shift can easily set himself up to be stunned by Impale.
Additional:
* Illusory Orb is easy to reflect with Spiked Carapace, either stunning Puck and setting up an easy Impale or forcing a premature Phase Shift.
* Puck is an intelligence hero that tends to build intelligence items, making it vulnerable to Mana Burn.
* An ill-timed Phase Shift can easily set Puck up to be stunned by Impale.
* Puck's low base armor and below average agility gain mean it is always susceptible to Vendetta.

* Any hero who can counter-initiate in anticipation without getting caught in Reverse Polarity: Sven, Omniknight, Enigma, Luna, Naga Siren, Mars, Jakiro, Venomancer, Elder Titan, Faceless Void, Rubick, Keeper of the Light, Pugna, Invoker, Spectre, Alchemist, Treant Protector, Lina, Oracle, Zeus, Shadow Shaman, Phoenix, Razor, Huskar, Batrider, Kunkka, Tidehunter, Wraith King, Sand King.

* Since Life drain takes out illusions instantly, Pugna with a scepter is decent versus plenty of illusion heroes, most notably Naga Siren and Terrorblade and the aforementioned Chaos Knight. Phantom Lancer is an exception.

* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin

* Nyx Assassin can reflect Life Break with Spiked Carapace.

* Heroes with mana burn: Nyx Assassin, Invoker, Outworld Destroyer, Pugna

* Mana Burn is capable of removing most of Storm Spirit's large mana pool, along with dealing heavy damage and quickly depleting his chances of escaping a gank or fight.
Additional:
* Mana Burn removes much-needed mana for Ball Lightning.
* Spiked Carapace triggers on Static Remnant for an easy stun.

* Heroes who can drain mana can make Omniknight useless after he uses one or two abilities: Lion, Anti-Mage, Nyx Assassin

* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

Additional:
* Nyx Assassin takes advantage of Invoker's massive intelligence gain and mana pool to do tons of damage using Mana Burn, as the spell does more damage based on the target's intelligence.
* Nyx Assassin can simply activate Spiked Carapace while under many Invoker's abilities to stun him.

* Because Invoker relies on casting a large amount of spells to contribute to fights, Nether Ward can force him to not cast anything at all or take a large amount of damage to cast spells.

* Silence (and mana burns) will be a persistent problem for Phoenix, as it is heavily reliant on its abilities whether defensively or offensively, so heroes like Death Prophet, Skywrath Mage, and even Nyx Assassin must be closely observed to prevent being shut down by these heroes.
* Hexes are a greater threat to Phoenix as they also disable items, preventing Phoenix from dispelling the debuff on its own.

Additional:
* Spiked Carapace reacts on any of the damage over time from Phoenix's abilities and can interrupt Sun Ray and Icarus Dive.

* Since Life drain takes out illusions instantly, Pugna with a scepter is decent versus plenty of illusion heroes, most notably Naga Siren and Terrorblade and the aforementioned Chaos Knight. Phantom Lancer is an exception.

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Pugna's Nether Ward damages Sand King when he channels Epicenter, preventing him from using Blink Dagger afterward.

* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill you, Nyx being particularly deadly. Watch Slark carefully, as he can break either (but not both unless you are making a mistake) of your disables, with Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn you from prey to predator.

* Pugna: Decrepify prevent the Spirit bear from attacking or protect allies from it.

* Heroes with silence and mana drain abilites, as Ancient Apparition relies entirely on his abilities: Invoker, Silencer, Nyx Assassin, Skywrath Mage, Shadow Shaman, Lion and etc.

* Pugna's Decrepify makes sure that either Alchemist is unable to hit anyone while also being slowed and susceptible to magical damage, or can protect an ally from physical attacks. Besides, Pugna can push early on, when Alchemist is not strong enough to repel it, so by the time Alchemist comes online, he might be forced to sit in base.

* Heroes who are reliant on physical damage will be nullified by Decrepify: Riki, Wraith King, Juggernaut.

* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Puck, Slark, Nyx Assassin, etc.

Additional:
* Enigma's uncontrollable damage from Malefice and Midnight Pulse make him easy to stun with Spiked Carapace.
* Black Hole can be easily interrupted by Impale or Spiked Carapace.

* Heroes who are reliant on physical damage will be nullified by Decrepify: Riki, Wraith King, Juggernaut.

* Decrepify prevents Faceless Void from attacking trapped allies inside Chronosphere, wasting a large portion of its duration if Faceless Void can't dispel it.

* Mana Burn completely drains Pudge's little mana which may render Meat Hook & Dismember unusable.
* Impale and Spiked Carapace used to cancel Dismember if timed perfectly.
* Vendetta grants Nyx Assassin invisibility and a high degree of mobility for a long time, which can make Nyx a difficult target to hook. In addition, it also scouts out Pudge's location and surprising him with his attack, Impale and Mana Burn.

* Assassinate is easy to reflect with Spiked Carapace for massive damage.
* Shrapnel's area damage can set up an easy stun with Spiked Carapace, especially when combined with Vendetta.
* In the early game, Sniper's low health pool and high intelligence makes him easy prey for Nyx Assassin.

* A good Nyx can reflect Queen of Pain's Sonic Wave with his Spiked Carapace, or even initiate a gank on her in Vendetta while she farms a creep wave with Scream of Pain.
* Her strength to intelligence ratio is bad enough that he should be able to kill her without even requiring a Dagon, provided he can get his full combo off.

* Pugna's Decrepify allows him to save allies from being ganked by Viper, since Viper mostly relies on direct attacks in order to deal damage.
* Nether Ward can discourage Viper from spamming his abilities.
* Viper's damage over time is not enough to kill Pugna as he will have more than enough time to save himself (or his allies) with Life Drain and Viper has no solutions to cancel it.
* Pugna has no passive abilities, which renders Nethertoxin nearly useless.

* Once you've taken a point in Retaliate, Nyx can easily initiate on you: he can use Spiked Carapace and hit you with Vendetta. The damage from Retaliate will be reflected back to you, stunning you with no chance to react after he's revealed himself, and should guarantee a successful Impale.

* Decrepify on either hero stops Legion Commander from completing a Duel, and dissuades her from initiating Duels on ethereal allies.
* Life Drain can help Pugna's teammates win a fight, either by killing Legion Commander or replenishing her target's health.
Additional:
* Decrepify prevents Legion Commander from attacking allies during Duel, regardless if it's used on her or on the ally .
* Pugna can easily cast Decrepify, Nether Blast and Life Drain on Legion during the 4/4.75/5.5/8 seconds of duel

* Silencer is rather squishy and has poor mobility without items, making him an easy target for Nyx.
* Mana Burn will deal increasing damage for each 2 points of intelligence Silencer has stolen, turning Silencer's intelligence steal against him.

* Heroes that can punish aggressive heroes, such as: Leshrac, Shadow Demon, Pugna, Death Prophet.