* Queen of Pain usually outlanes Invoker, giving her team a significant early game advantage while Invoker is still farming.
* Blink allows Queen of Pain to escape from Invoker's combo if he doesn't have disables.

* Rage protects Lifestealer nearly from all of Invoker's spells.
Additional:
* Rage grants immunity from Invoker's spells and can dispel most of the disables such as the armor loss from Forge Spirit and the constant stuns of Cold Snap.

* Blink makes it hard for Gyrocopter to pin down Queen of Pain.
* Sonic Wave is very effective at ganking Gyrocopter in the early game.

* Rage ignores all of Gyrocopter's magical attacks.
* Feast helps Lifestealer out-damage Gyrocopter at close range.

* With Feast and Rage, Lifestealer is nearly impossible for Clockwerk to bring down, and is the last hero Clockwerk wants to be trapped with in Power Cogs.

* Blink allows Quen of Pain to easily escape ganking or initiating attempts with Hookshot and Power Cogs.

* He's the kind of hero that likes to remain at low hp, which is perfect for Queen of Pain to burst with Sonic Wave.
* You should be able to blink away after he jumps on you with Life Break.

* Rage renders Lifestealer immune to the damage from Burning Spears.
* Feast makes Lifestealer one of few heroes that can outlast Huskar in a one-on-one fight.

* Rage allows him to dispel Blinding Light from himself.
* Open Wounds allows him to slow and kill Keeper of the Light.

* Heroes with teleports to escape Will-O-Wisp: Phantom Assassin, Puck, Queen of Pain, Storm Spirit

* The lifesteal of Feast scales accordingly to the health of its target, which is effective against Pudge due to his high health and further health granted by stacks of Flesh Heap.
* Lifestealer can activate Rage to completely negate magic damage, therefore rendering the damage of Rot and Dismember null.
* Pudge's plentiful health makes him an ideal target for Open Wounds.

* Heroes with a high degree of mobility and invisibility are hard to catch with Meat Hook: Ember Spirit, Riki, Clinkz, Queen of Pain.

* Lifestealer can close the distance to Sniper by using Infest on a fast or durable creep to tank Sniper's damage.
* Open Wounds will reduce Sniper's mobility heavily, and Rage's attack speed bonus helps in taking down Sniper.

* Heroes with high mobility can approach Sniper: Anti-Mage, Earth Spirit, Io, Nature's Prophet, Pangolier, Puck, Queen of Pain and most notably Riki.

* Queen of Pain can Blink to both escape and initiate onto Void Spirit.
* She is also a very common Orchid Malevolence carrier, which can prevent Void Spirit from contributing much in fights.

* Heroes with burst damage of their own won't be afraid to go toe to toe with Void Spirit, like Ursa, Lifestealer, or Axe.

* Lifestealer excels at killing high health heroes with Feast, and Sven is no exception.
* Rage stops Storm Hammer from hitting Lifestealer.
* Rage and Open Wounds helps Lifestealer survive against Sven's high physical damage.

* Feast deals damage and heals Lifestealer based on the target's maximum HP, which is greatly effective against naturally high HP heroes such as Doom.
* Rage allows Lifestealer to become spell immune to negate the magical damage of Infernal Blade and Scorched Earth.
* Doom has no effective means of escape from Open Wounds. This is particularly devastating in lane, where Doom may have to play a much more passive, conservative play style as a result.

* Feast will deal a large amount of damage to Tiny's large health pool.
* Rage protects Lifestealer from Tiny's magical burst damage.

* Rage protects Lifestealer from all of Lina's abilities (except an upgraded Laguna Blade).
* Open Wounds is great to keep Lina in place because she has no abilities to help her escape.

* Rage is very useful against Zeus, as it negates magic damage and provides spell immunity. In addition, the increased attack speed can tear Zeus apart in combination with Open Wounds.
* Lifestealer can avoid Thundergod's Wrath with Infest.

* Rage ignores all of Viper's magical damage.
* Feast and Open Wounds combine to heal through Viper's physical damage.

* Often you can burst Drow Ranger down before she has a chance to try and Gust you away. Try to have a teammate bait her Gust out before you Blink and get the drop on her.

* Lifestealer's Rage lets him clear Remote Mines and Proximity Mines with proper vision.
Additional:
* Rage protects Lifestealer from all of Techies' magic damage and disables and dispels Stasis Trap's debuff .
* Usually teams will have a hard time pushing high-ground against Techies, but Lifestealer can just pop Rage and walk uphill without fear of Techies.

* Queen of Pain can easily escape Chain Frost thanks to Blink.
* His low survivability makes an easy kill for Shadow Strike, Scream of Pain & Sonic Wave.

* Rage prevents Earthshaker from damaging and stunning Lifestealer.
* Feast is very effective against Earthshaker, because of him being a strength hero, allowing Lifestealer to heavily harass and kill him.
* Open Wounds prevents Earthshaker from escaping after he initiated.
* Infest gives Lifestealer an easy way to escape should he get caught out by Earthshaker.

* Rage grants Lifestealer immunity to all of Jakiro's spells. Note: magic resistance will not dispel the attack speed slow effects from Dual Breath and Liquid Fire.

* Ogre Magi has nothing against Rage and his high health pool amplifies Feast.
Additional:
* Lifestealer's Rage makes him immune to all of Ogre's magical debuffs and also dispels them.
* Ogre's as hero with great durability and high health is great target for Lifestealer in any stage of the game, thanks to Feast.

* Leshrac's high magic damage is ignored by Rage.
* Lifestealer can get in Leshrac's face with Rage and mitigate any other damage taken by Leshrac with Open Wounds.

* Rage protects and dispels all of Dark Willow's abilities.
Additional:
* Rage protects Lifestealer from all of Dark Willow's abilities.

* Feast is good against high health strength heroes such as Alchemist.
* Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.

* Rage will dispel Laser's blind and turns him spell immune for the duration so Tinker cannot damage him.
* Feast will quickly bring down Tinker due to being so fragile.
Additional:
* Lifestealer's Rage makes him immune to all of Tinker's damage and debuffs.
* Lifestealer can infest any mobile hero (teams usually pick one against Tinker), which ensures that Tinker will die if he is caught.

* Heroes with mobility spells (such as Queen of Pain's Blink and Clockwerk with Hookshot) can easily avoid Lil' Shredder and Mortimer Kisses.
* Heroes with high movement speeds like Pugna and Meepo can run around, to, or away from Snapfire during Mortimer Kisses and dodge the projectiles easily due to their slow speed.

* Queen of Pain can be a good hero for dealing with Ember Spirit with Orchid Malevolence, her pure damage nuke in Sonic Wave and a slow in Shadow Strike. However, Queen of Pain can be punished by Ember Spirit, as his Searing Chains prevents her from getting Blink off.

* Heroes with mobility spells can quickly escape from Stroke of Fate or break out of Soulbind: Anti-Mage, Queen of Pain, Morphling, Storm Spirit

* Timbersaw has a difficult time against magical and pure damage: Lina, Leshrac, Enchantress, Queen of Pain

* Heroes with considerable mobility can easily escape from a rolling Pangolier: Anti-Mage, Queen of Pain, Void Spirit, Storm Spirit, Ember Spirit, Earth Spirit, moreover, if a player is familiar with how Rolling Thunder work, they can adjust their movement to avoid it entirely and of course outplay the Pangolier player.

* Blinking heroes like Anti-Mage or Queen of Pain can often chase down an injured Brewmaster after his ultimate expires.

* Heroes with spell immunity-granting spells will render Phoenix useless against them, as Phoenix has almost no spell immunity-piercing ability, other than the stun at the end of Supernova: Lifestealer, Juggernaut.

* In general, heroes with spell immunity abilities won't be caught inside by Pit of Malice: Juggernaut, Lifestealer.

* Heroes with built-in spell immunity can become immune to all of Outworld Devourer's spells: Lifestealer's Rage and Juggernaut's Blade Fury.

* Dark Seer's only disable is Vacuum. Though he starts off with high armor and health, he'll eventually have a hard time dealing with high mobility heroes such as Weaver or Queen of Pain.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* Heroes that can instantly kill creeps greatly reduce the effectiveness of Chen's converted army: Lifestealer, Doom, Mirana, Clinkz.

* Heroes with escaping and disjointing abilities can be good against Juggernaut:Anti-Mage Riki, Queen of Pain, Puck, Storm Spirit, Ember Spirit, Slark etc.

* Special mention goes to Queen of Pain as she could kill herself with Sonic Wave if your Nether Ward is up.

* Lifestealer with Rage and Infest
* Heroes that can remove the Track debuff with their skills:
* Abaddon with Aphotic Shield and Borrowed Time
* Huskar with Life Break
* Juggernaut with Blade Fury
* Legion Commander with Press the Attack
* Lifestealer with Rage and Infest
* Naga Siren with Mirror Image
* Omniknight with Heavenly Grace
* Oracle with Fortune's End and False Promise
* Phantom Lancer with Doppelganger
* Slark with Dark Pact
* Ursa with Enrage
* Weaver with Time Lapse
* Tidehunter with Kraken Shell when damage received reaches the threshold.

* Heroes with damage over time abilities can quickly eat through Gravekeeper's Cloak charges like Huskar, Jakiro and Queen of Pain.

* Heroes with magic immune abilities can negate most of Visage's attacks like Pangolier and Lifestealer.

* Feast's lifesteal makes it nearly impossible for Axe to initiate and bring Lifestealer's health low enough for Culling Blade, even with many procs of Counter Helix.
* Feast's healing is calculated as a percentage of a target's max health, turning Axe's high health against him. This allows Lifestealer to trade against Axe much better than most other heroes.
Additional:
* Feast makes it impossible to put Lifestealer's health for a Culling Blade and also deals high damage to Axe due to his naturally high health.
* However, Lifestealer's Rage can be pierced by Berserker's Call.

* All of Queen of Pain's abilities are active, making Demonic Purge break from Aghanim's Scepter useless.
* However, Demonic Purge can help his allies kill a squishy Queen of Pain.
* Blink allows Queen of Pain to escape from Shadow Demon's abilities if he doesn't have disables.
* An attempt to save an ally using Disruption can easily become a perfect setup for a Sonic Wave for the enemy.
* Queen of Pain usually builds Eul's Scepter of Divinity to dispel Shadow Poison and Soul Catcher and Linken's Sphere or Spell Block talent to block Disruption and Demonic Purge.

* Rage provides spell immunity to Lifestealer and thus nullifies all of Lion's abilities.
* Open Wounds allows Lifestealer to easily catch Lion out and prevent him from escaping.

* Blink allows Queen of Pain to avoid ganks and keep her distance, preventing Monkey King from building up Jingu Mastery.
* Scream of Pain and Sonic Wave will hit Monkey King when he is disguised, or on a tree.
* The large AoE and low cooldown also helps Queen of Pain hit the real Monkey King inside of Wukong's Command.

* Rage negates Kunkka's X Marks the Spot.
* As a strength hero with high strength gain and very little armor, as well as low agility gain, Kunkka is vulnerable to Lifestealer's Feast and Open Wounds.

* Heroes who have a high mobility (Queen of Pain, Storm Spirit, Slark, etc.).

* Heroes with high burst damage: Lina, Lion, Luna, Nyx Assassin, Queen of Pain.

* Feast is an effective tool against Centaur Warrunner, who generally has high health and low armor, and compensates the reflected damage of Retaliate.
* If activated, Rage protects Lifestealer from Hoof Stomp, Double Edge, and Stampede.

* Once you farm up an Orchid Malevolence or a Scythe of Vyse, you're suddenly a lot more fearsome to elusive heroes like Storm Spirit or even that pesky Puck.

* Rage can be used to escape from a Glimpse and to move out of Kinetic Field.
* Infest allows Lifestealer to dodge Glimpse.

* Juggernaut and Lifestealer have abilities (Blade Fury and Rage respectively) that prevent Crystal Maiden from using her spells on them in the early game, before Black King Bar and other magical reduction is even an issue.

* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Pugna
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Pugna

* Heroes that usually builds Linken's Sphere as a core item: Weaver, Medusa, Morphling, Queen of Pain, Storm Spirit

* Lifestealer's Rage negates Sand King's spells which do magical damage.

* Once you farm up an Orchid Malevolence or a Scythe of Vyse, you're suddenly a lot more fearsome to elusive heroes like Storm Spirit or even that pesky Puck.

* Heroes with spell immunity or pseudo-blinks which provide invulnerability: Lifestealer, Juggernaut, Omniknight, Huskar , and Tusk have spells which allow them to easily escape Dream Coil.

* Rage completely negates all of Nyx Assassin's abilities except Vendetta, while Open Wounds allow him to quickly close the gap.
* Infest combined with an ancient creep makes Nyx Assassin an easy target with Dust of Appearance or a Gem of True Sight.

* Blink can instantly break Static Link, making it useless against her.
* Queen of Pain doesn't fully rely on her physical attack damage, so she can still fight after being hit with Static Link.