* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift removes 1 of every attribute, lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.
Additional:
* Medusa is especially vulnerable to Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.

* He won't be around waiting for Medusa to Stone Gaze and pin him until she bears a true sight.
* With Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can still deal huge amount of damage through Cloak and Dagger via backstabs, drying out Medusa's protection in a whim at random occassions.

* Pounce and Dark Pact together with some attacks can gank Rubick down quickly. Rubick can seldom retaliate because of the strong dispel of Dark Pact. What is more, Rubick is the type of squishy support that Slark exactly wants to gank.
* Though Shadow Dance is a great spell to steal, Slark's untargetable nature and his low cooldown spells prevents Rubick from stealing it.
* Slark usually builds Diffusal Blade which can prevent Rubick to cast his abilities from Spell Steal.

* Riki has high damage and invisibility, meaning he can easily gank Rubick and kill him before Rubick has the chance to react.
* Almost all of Riki's spells are useless to Rubick.
* Smoke Screen is the only of Riki's spells that can be of some use to Rubick.
* Similar to Clinkz, Rubick has to buy a large amount of Sentry Wards to keep track of Riki due to Cloak and Dagger, preventing Rubick from getting better items.
* Riki is a common Diffusal Blade carrier leaving Rubick no mana to spam abilities from Spell Steal.

* Blink Strike gets Riki close to Drow Ranger and disable Marksmanship.
* Smoke Screen makes Drow Ranger miss her attacks.
* Cloak and Dagger lets Riki stay close to Drow Ranger without her noticing, disabling Marksmanship.
Additional:
* With Blink Strike, Riki can get close to Drow Ranger and disable her Marksmanship, and Smoke Screen will prevent her from using Gust.

* A well-timed Dark Pact can dispel Frost Arrows and Gust, letting Slark engage and escape freely.
* Shadow Dance lets Slark quickly close the gap and deal heavy damage without giving Drow Ranger a chance to retaliate.
* Pounce counteracts Frost Arrows' slow, letting Slark easily pin Drow Ranger down or flee.
Additional:
* Pounce and items like Shadow Blade makes it very difficult for Drow Ranger to keep her distance from Slark, thereby losing her Marksmanship bonus.
* Gust is rarely enough to keep Slark at bay, as Drow Ranger has no movement abilities and will simply be chased down afterwards.
* Drow Ranger's heavy dependence on agility also makes her significantly weaker after being drained by Essence Shift.

* Dark Pact can be used to remove Open Wounds.
* Shadow Dance allows Slark to attack Lifestealer for its duration without any way for Lifestealer to fight back.
* Slark commonly buys a Silver Edge, which can break Lifestealer's Feast, severely diminishing his damage output and lifesteal.

* Lifestealer cannot use Rage, Infest or Open Wounds when affected by Smoke Cloud's silence, and Feast cannot heal him effectively because of the blind, leaving him very weak both offensively and defensively.
* Infest ganks are harder when the enemy team has a Riki, as there are often only four heroes on the map that you can initiate on.

* Sniper has no natural escape and relies on his range and slows to keep himself safe, which you can bypass with Blink Strike and quickly deplete his miniature HP pool.

* Slark is a natural Shadow Blade carrier, and with Pounce Sniper has no opportunity to escape or react.
* With Essence Shift and Shadow Dance, Slark will easily win a fight against Sniper.
Additional:
* Sniper is one of the most gankable heroes in the game, and has no defenses when Pounced on by Slark.

* Riki is a natural Diffusal Blade carrier, and it doesn't help that he's easily capable of sneaking up on you due to Cloak and Dagger.
* Riki can use Smoke Screen on top of you as you're reincarnating, making you a sitting duck for your second life. In addition, the blind prevents Wraith King from landing critical hits from Mortal Strike.
* Wraithfire Blast is quite predictable, and players with good reflexes will disjoint it with Tricks of the Trade.
* There is also a chance he will become invisible again as the projectile travels, disjointing it.

* Dark Pact, if timed correctly, can dispel Wraithfire Blast's stun and slow.
* Since Wraith King has a lot of health and multiple lives, Slark can keep gaining Essence Shift stacks, increasing armor, damage, and attack speed and can beat down Wraith King twice.
* Slark sometimes carries Diffusal Blade to burn mana as an attempt to shut down Reincarnation.
* Because Wraith King has no AoE abilities, Shadow Dance is particularly useful against Wraith King.

* Riki can detect early Roshan attempts because of Cloak and Dagger if he frequently checks the Pit.
* Ursa cannot Enrage when in Smoke Screen (Black King Bar will help though).
* Even if Ursa gets vision over him, Riki can Blink Strike away or use Tricks of the Trade after Ursa's initiation to avoid all Fury Swipes damage until Earthshock's slow is gone.
Additional:
* Riki can detect early Roshan attempts because of Cloak and Dagger if he frequently checks the Pit.
* Ursa cannot Enrage when caught in Smoke Screen and will miss his attacks (although Black King Bar will help with this issue).
* Even if Ursa gets vision over him and initiates with Earthshock, Riki can Blink Strike away or use Tricks of the Trade after Ursa's initiation to avoid Fury Swipes' damage until Earthshock's slow is gone.

* Slark can detect early Roshan attempts due to Shadow Dance if he frequently checks the Pit.
* Enrage cannot restore attributes stolen by Essence Shift and will reduce his physical damage output.
* Even if Ursa initiates with Earthshock, Slark can Pounce away or use Dark Pact after Ursa's initiation to avoid Fury Swipes' damage until Earthshock's slow is gone.

* Flux is dispelled by Dark Pact.
* Pounce allows Slark to avoid Spark Wraiths.
* Tempest Double allows Slark to build up Essence Shift stacks, especially when it is being used for split pushing.

* Smoke Screen prevents Arc Warden from initiating or helping his team, as he struggles to escape the silence with low mobility.
* With Arc Warden's low mobility, Tricks of the Trade is wide enough to deal decent damage to him.

* Riki usually buys Diffusal Blade to initiate, which renders Enchantress' movement speed useless, and is usually followed with Smoke Screen.
* Riki can effectively hit Enchantress by Tricks of the Trade alongside with Diffusal Blade and Smoke Screen's initiation. For a hero like Enchantress, 3 to 4 hits from Riki is a big deal, unless Enchantress built Force Staff earlier.

* Heroes that can jump on her: Slark, Queen of Pain, Anti-Mage

* Heroes with a high degree of mobility and invisibility are hard to catch with Meat Hook: Ember Spirit, Riki, Clinkz, Queen of Pain.

* Dark Pact dispels Dismember if timed perfectly.
* Pudge's low attack speed and poor agility can be lowered even further by Essence Shift.
* Shadow Dance grants Slark invisibility and a high degree of mobility, which can make Slark a difficult target to hook and also protects him from Pudge's Dismember (including allies with an Aghanim's Scepter).

* Upheaval does not interrupt Slark too much, as he can just Pounce out of the area.
* Fatal Bonds and Shadow Word can be dispelled by Dark Pact.

* Warlock is a very strong hero when positioned correctly, and his long cast range helps him with this. However, some Heroes might disrupt or sneakily pass through your allies and deal with you, preventing you from doing your job. Such heroes include Chaos Knight, Spirit Breaker, Riki, and some others.

* Heroes that have superior mobility that can easily catch up with Mirana even after she used Leap to escape: Anti-Mage, Queen of Pain, Storm Spirit, Riki.

* If Slark sees the Sacred Arrow before it hits him, he can use Dark Pact to remove it a moment later.
* Pounce prevents Mirana from escaping with Leap.
* Slark can survive Mirana's Aghanim's Scepter​ combo with Shadow Dance.

* Riki is known for being a successful support killer, and not just for show. He can give you one hell of a time by constantly picking you off and/or forcing you to stick close to the rest of the team.
* Smoke Screen is particularly devastating to Shadow Shaman. With neither his various disables nor a solid health pool Shadow Shaman is usually dead. Consider a force staff if you find yourself in this scenario (to force yourself out of the cloud before shackling Riki) and buy sentry wards if you have the money.

* Nyx Assassin, Bounty Hunter and Slark can all sneak up and kill you, Nyx being particularly deadly. Watch Slark carefully, as he can break either (but not both unless you are making a mistake) of your disables, with Dark Pact and leap out of a serpent ward ring. These heroes, however, rely heavily on escape and are themselves not very durable and none of them can survive a full lockdown with Mass Serpent Ward. Having Sentry Wards can turn you from prey to predator.

* Smoke Screen prevents Storm Spirit from using his abilities once inside the radius. Riki can utilize this ability to allow his team to fight around Smoke Screen so that Storm Spirit cannot spam his spells to proc Overload.
Additional:
* Smoke Cloud prevents Storm Spirit from using any of his offensive and defensive spells, rendering him unable to effectively react to Riki's attack.

* Pounce's leash prevents Storm Spirit from using Ball Lightning, making it hard for Storm Spirit to escape a gank from Slark.
* Dark Pact can dispel Orchid Malevolence's Soul Burn.

* Heroes with invisibility: (Riki, Clinkz, Nyx Assassin

* Pounce also stops Nature's Prophet's Teleportation.

* Heroes who have a high mobility (Queen of Pain, Storm Spirit, Slark, etc.).

* Frail heroes who lacks mobility: Crystal Maiden, Enigma, Dark Willow, Vengeful Spirit.

* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Pugna
* Heroes that can quickly deal damage to her, regardless of how weak they are, can easily break through her Refraction:
* Multiple attackers thanks to summoned units or clones: Meepo, Witch Doctor, Lycan, Enigma, Shadow Shaman
* Multiple attackers thanks to illusions: Phantom Lancer, Chaos Knight, Naga Siren (bonus for her Ensnare). Also despite the visual effects, Templar Assassin does not spill damage against illusions or buildings, so she is not a really good hero to clean up illusions.
* Weak damage but high tick rate or persist in a long time: Slark, Gyrocopter, Queen of Pain, Shadow Shaman (Shackles), Pugna

Additional:
* Dark Pact rips through Refraction charges and still steals attributes during Refraction.
* Pounce and Dark Pact will still hit Templar Assassin while she is Melded. Since she cannot move, both abilities will be easy for Slark to land.

* Because Templar Assassin does not have escape potential in lane, any support hero with roaming potential and a Dust of Appearance can be great at shutting her down early game: Earth Spirit, Spirit Breaker, Tusk, Bounty Hunter, Riki, Warlock.

* Heroes with escaping and disjointing abilities can be good against Juggernaut:Anti-Mage Riki, Queen of Pain, Puck, Storm Spirit, Ember Spirit, Slark etc.

* Heroes with escaping and disjointing abilities can be good against Juggernaut:Anti-Mage Riki, Queen of Pain, Puck, Storm Spirit, Ember Spirit, Slark etc.

* Enigma is fragile, and lacks escapes, being dependent on Blink Dagger for mobility. Ganking Heroes or Heroes with burst damage will likely kill him before he can do anything. Such Heroes include: Lina, Lion, Puck, Slark, Nyx Assassin, etc.

* Frail heroes who lacks mobility: Crystal Maiden, Enigma, Dark Willow, Vengeful Spirit.

Additional:
* Riki can potentially catch an Enigma out of position and prevent him from properly blinking and initiating, thanks to Cloak and Dagger used in tandem with Smoke Screen.

* Without Dust of Appearance or Sentry Wards, Riki is able to silence Witch Doctor with Smoke Screen, and is likely to build a Diffusal Blade, leaving Witch Doctor without mana to cast Voodoo Restoration, as well as Skull Basher to interrupt Death Ward.

* Dark Pact can dispel Flaming Lasso if is used in anticipation, but a Blink initiation from fog can catch the Slark off guard.
* Slark can also take off any Sticky Napalm stacks with Dark Pact in lane.

* Cloak and Dagger's passive invisibility destroys Phantom's Embrace even when Riki is silenced.
* Smoke Screen prevents Grimstroke from shielding himself with Ink Swell.

* Pounce's root prevents Earth Spirit from using Rolling Boulder to escape, making it easier for Slark to shut him down especially in the laning phase.

* Heroes with abilities or items that can silence or disable Anti-Mage for long periods of time will prevent him from Blinking away: Silencer, Shadow Shaman, Grimstroke, Clinkz, Riki, Faceless Void, Skywrath Mage, Puck

Additional:
* Anti-Mage can use neither Blink nor Manta Style to escape from Smoke Cloud.
* Even if he activates a Black King Bar, his Manta Style illusions will still be blinded by Smoke Cloud.
* Riki has a very small mana pool and generally doesn't buy many items that increase it, making Mana Void ineffective.

* Pounce prevents Anti-Mage from using Blink, and lets him disengage from Anti-Mage if needed.
* Essence Shift allows Slark to permanently steal agility from Anti-Mage.
* Shadow Dance stops Anti-Mage from being able to fight back in a slippery situation.

* Heroes with damage-increasing passive abilities, such as Viper and Riki, will usually kill Silencer in a short time before he even has time to set up his abilities.

* Slark's Dark Pact allows him to dispel Silencer's debuffs.
* Against a carry Silencer, Essence Shift will lower damage from both Glaives of Wisdom and his basic attack.

* Arctic Burn and Splinter Blast debuffs are dispellable with Dark Pact. Arctic Burn is also no escape against Pounce.
* Cold Embrace just gives Slark free Essence Shift stacks. He also relies mostly on magic damage early in the game.

* Dark Pact easily purges away both slow and disarm effect from Lucky Shot.
* With Pounce now apply leash to the target, Pangolier is helpless against Slark since both his Swashbuckle and Rolling Thunder will be disabled. Pounce also help Slark to easily escape from Rolling Thunder.

* Dark Pact can dispel Venomous Gale and Poison Sting.
* Shadow Dance allows Slark heightened regeneration when out of vision making DoTs effects less threatening.

* Due to his low health and armor, Riki can easily kill Skywrath Mage.
* Smoke Screen prevents Skywrath from using all of his abilities, as he does not tend to buy Black King Bar.
* However, if Skywrath Mage can easily kill Riki if he manages to root Riki with Rod of Atos or Gleipnir, followed by Dust of Appearance, Ancient Seal and Mystic Flare.

* Dark Pact dispels debuffs from Gush, Anchor Smash and even Ravage if timed correctly.
* Kraken Shell cannot restore attributes stolen by Essence Shift or dispel the leash if he gets Pounced.

* Dark Pact dispels Ignite's slow and Fireblast's stun.
* Shadow Dance allows Slark to regenerate HP, even when he is affected by Ignite and Fireblast.

* Smoke Cloud prevents Shukuchi and Time Lapse, leaving Weaver helpless against Riki.
* The Swarm is ineffective against Riki because invisibility instantly removes the beetles.

* Chen is basically your natural prey: he has little HP, low armor and relies on his persuaded creeps to fight, which in most situations will not save Chen from you. Just be wary of {U:Centaur Conqueror}, who can stun you outside of Smoke Screen and ruin your attempt at Chen's life.

* Shadow Dance allows Slark to not be targeted by Unstable Concoction, making Alchemist stun himself and making himself vulnerable to the enemy.
* Dark Pact also allows him to just purge off the stun if timed correctly.
* Essence Shift will steal stats over long durations at a time should Alchemist lack the damage to kill Slark.

* Smoke Cloud prevents the use of Death Pact, Searing Arrows and Skeleton Walk, so Clinkz can neither defend himself against Riki nor fight back effectively.
* It's hard to gank Riki as you have to find him first.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Riki: Smoke Screen can prevent Lone Druid from using True Form and Savage Roar, additionally it cause the spirit bear to miss on attacks which reduce the chances of getting rooted from it, with diffusal Blade, he can keep Lone Druid or the Spirit Bear inside the Smoke.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Smoke Cloud prevents Queen of Pain from using any of her offensive and defensive spells, rendering her unable to effectively react to Riki's attack.
* It's easy to dodge Sonic Wave by using Blink Strike & Tricks of the Trade.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Careful not to blink into Riki's Smoke Screen or Night Stalker's Crippling Fear, as these field effects will instantly silence Earthshaker and prevent him from initiating.

* Heroes with invisibility and high mobility can jump on and focus down Earthshaker before he has a chance to initiate: Clinkz, Slark, Storm Spirit

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Heroes with silence: Death Prophet, Riki, Drow Ranger.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Heroes with blind of some sort can be a bad choice for Monkey King to go on: Broodmother, Riki, Keeper of the Light.

* Heroes that can easily bypass Io's allies to get to Io: Riki, Tusk, Clinkz, Sniper

* Frail heroes who lacks mobility: Crystal Maiden, Enigma, Dark Willow, Vengeful Spirit.

Additional:
* Smoke Screen prevents Dark Willow from using her close-range bursts with Bedlam.
* Blink Strike lets Riki jump past Bramble Maze.

* Heroes with strong dispels can remove Primal Roar's stun: Abaddon, Slark, Oracle.

* Lycan cannot escape from a Pounce even if he uses Shapeshift, and has no disabling abilities to stop Slark.

* Dark Pact can be cast during the cast animation of Light Strike Array and dispel its stun.
* Pounce allows Slark to close the gap to Lina.
* Shadow Dance prevents Lina from killing Slark with her Laguna Blade when his HP gets low.

* Pounce allows Slark to close in on Lion and prevent him from escaping.
* Lion's fragile health pool makes him easy prey for Slark's high burst damage through Pounce, Dark Pact and right-clicks.
* Shadow Dance prevents Lion from casting Hex, Mana Drain, or Finger of Death on Slark.
* Dark Pact allows Slark to dispel any of Lion's disables.

* Pounce prevents Tinker from blinking away.
* Slark frequently builds Shadow Blade, which allows him to approach Tinker unnoticed. Since Tinker's farming usually covers a significant amount of area on the map, Sentry Wards may not be cost effective.
* Shadow Dance allows Slark to detect both common and unusual wards. Eliminating common ward causes Tinker trouble farming many lanes if he does not know who may be waiting to jump on him. Slark is also uniquely able to identify some of the less common wards used by Tinker, such as those placed on the cliffs at map edges which Tinker uses to give him vision over the trees he uses to hide in.
* Slark's extremely high move speed from Shadow Dance, potentially stacked with Shadow Blade, allows him to easily follow Tinker between lanes, especially if Tinker has pushed the lanes out.
* Dark Pact dispels Laser's blind.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Riki and Disruptor: Smoke Screen and Static Storm can be thrown wherever Puck used Phase Shift, making Puck an easy target if it doesn't have Blink Dagger or is on cooldown. Puck is also very susceptible to Riki's high attack damage when attacking from the back. Glimpse also prevents Puck from escaping.

* Slark's Pounce allows him to close the gap on Phantom Assassin and prevent her from escaping with Phantom Strike.
* As a hero who always goes for the Silver Edge and Abyssal Blade Slark can use it to disable Phantom Assassin and her Blur and Coup de Grace, drastically reducing her damage output and ability to evade attacks, and also preventing her from acting.
* Phantom Assassin's Coup de Grace requires Random Number Generation in order to proc, which gives Slark more than enough time to escape and recover himself.

* Heroes with dispels: Legion Commander, Oracle, Slark

* Heroes who can dispel will be able to remove Shadow Poison before Shadow Demon can build up a big stack, or remove Soul Catcher's debuff to instantly bring the health of affected heroes back to a considerable amount: Abaddon, Slark, Legion Commander, Oracle.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Shadow Dance prevents Luna from damaging Slark, and together with Shadow Blade he can kite her or escape.
* Luna has no way to escape from Pounce's leash.
Additional:
* Luna's lack of mobility and escape abilities makes her easily gankable by Slark.
* Shadow Dance will avoid all the damage from Eclipse.
* For the same reasons, Slark is a good ally for Luna when they are in the same team.

* All assassin-type carries in a one against one situation: Meepo, Phantom Assassin, Riki, Ursa.

* Dark Seer relies on Surge for most of his mobility, so he's not very vulnerable to slows, but much more to root effects and walls or pseudo-walls such as Disruptor's Kinetic Field or Slark's Pounce.

* Riki is another good hero to shutdown Death Prophet with Diffusal Blade as his core item. His Smoke Screen stops her from initiating and casting spells.

* Pounce can easily break Static Link, making it less powerful against him.
* Slark is one of the few heroes who can man fight a Razor, because of Essence Shift.
* Shadow Dance can prevent Razor from killing him and may provide an opportunity to kill Razor due to it preventing Razor from attacking Slark.