* Rage renders Lifestealer immune to the damage from Burning Spears and Life Break.
* Feast and Open Wounds makes Lifestealer one of few heroes that can outlast Huskar in a one-on-one fight.

* Mass Serpent Ward rips apart Huskar quickly due to his poor armor.
* As soon as Huskar jumps in, he will be vulnerable to Shadow Shaman's disables if he does not have Black King Bar.

* Rage protects Lifestealer nearly from all of Invoker's spells.
Additional:
* Rage grants immunity from Invoker's spells and can dispel most of the disables such as the armor loss from Forge Spirit and the constant stuns of Cold Snap.

* Heroes with long lockdowns: Shadow Shaman, Legion Commander.

* Rage ignores all of Viper's magical damage.
* Feast and Open Wounds combine to heal through Viper's physical damage.

* Viper cannot interrupt heroes with powerful channeling abilities: Bane, Enigma, Shadow Shaman, Warlock

* Rage ignores all of Gyrocopter's magical attacks.
* Open Wounds makes it hard for Gyrocopter to get away.
* Feast helps Lifestealer out-damage Gyrocopter at close range.

* Rage allows him to dispel Blinding Light from himself.
* Open Wounds allows him to slow and kill Keeper of the Light.

* Rage negates Kunkka's X Marks the Spot.
* As a strength hero with high strength gain and very little armor, as well as low agility gain, Kunkka is vulnerable to Lifestealer's Feast and Open Wounds.

* Rage provides spell immunity to Lifestealer and thus nullifies all of Lion's abilities.
* Open Wounds allows Lifestealer to easily catch Lion out and prevent him from escaping.

* Hex's instant cast time will force Brewmaster into the awkward situation of needing some form of spell immunity or block to prevent being immediately hex upon blinking in, or wait until Shaman has used all his crowd control before entering a fight.
* Brewmaster also has no defense against Shadow Shaman lockdowns.

* Feast will deal a large amount of damage to Tiny's large health pool.
* Rage protects Lifestealer from Tiny's magical burst damage.

* Rage can be used to escape from a Glimpse and to move out of Kinetic Field.
* Infest allows Lifestealer to dodge Glimpse.

* Feast deals damage and heals Lifestealer based on the target's maximum HP, which is greatly effective against naturally high HP heroes such as Doom.
* Rage allows Lifestealer to become spell immune to negate the magical damage of Infernal Blade and Scorched Earth.
* Doom has no effective means of escape from Open Wounds. This is particularly devastating in lane, where Doom may have to play a much more passive, conservative play style as a result.

* Lifestealer's Rage lets him clear Remote Mines and Proximity Mines with proper vision.
Additional:
* Rage protects Lifestealer from all of Techies' magic damage and disables and dispels Stasis Trap's debuff .
* Usually teams will have a hard time pushing high-ground against Techies, but Lifestealer can just pop Rage and walk uphill without fear of Techies.

* Feast is an effective tool against Centaur Warrunner, who generally has high health and low armor, and compensates the reflected damage of Retaliate.
* If activated, Rage protects Lifestealer from Hoof Stomp, Double Edge, and Stampede.

* Feast is good against high health strength heroes such as Alchemist.
* Rage allows Lifestealer to not be targetable by Unstable Concoction, possibly making Alchemist stun himself.

* Hex greatly reduces Timbersaw's mobility.
* The stun and damage over time from Shackles mitigates Reactive Armor's HP and armor regen.

* Rage grants Lifestealer immunity to all of Jakiro's spells. Note: magic resistance will not dispel the attack speed slow effects from Dual Breath and Liquid Fire.

* Rage protects and dispels all of Dark Willow's abilities.
Additional:
* Rage protects Lifestealer from all of Dark Willow's abilities.

* Rage protects Lifestealer from all of Lina's abilities (except an upgraded Laguna Blade).
* Open Wounds is great to keep Lina in place because she has no abilities to help her escape.

* Rage will dispel Laser's blind and turns him spell immune for the duration so Tinker cannot damage him.
* Feast will quickly bring down Tinker due to being so fragile.
Additional:
* Lifestealer's Rage makes him immune to all of Tinker's damage and debuffs.
* Lifestealer can infest any mobile hero (teams usually pick one against Tinker), which ensures that Tinker will die if he is caught.

* Rage prevents Earthshaker from damaging and stunning Lifestealer.
* Feast is very effective against Earthshaker, because of him being a strength hero, allowing Lifestealer to heavily harass and kill him.
* Open Wounds prevents Earthshaker from escaping after he initiated.
* Infest gives Lifestealer an easy way to escape should he get caught out by Earthshaker.

* Lifestealer excels at killing high health heroes with Feast, and Sven is no exception.
* Rage stops Storm Hammer from hitting Lifestealer.
* Rage and Open Wounds helps Lifestealer survive against Sven's high physical damage.

* With Feast and Rage, Lifestealer is nearly impossible for Clockwerk to bring down, and is the last hero Clockwerk wants to be trapped with in Power Cogs.

* Ogre Magi has nothing against Rage and his high health pool amplifies Feast.
Additional:
* Lifestealer's Rage makes him immune to all of Ogre's magical debuffs and also dispels them.
* Ogre's as hero with great durability and high health is great target for Lifestealer in any stage of the game, thanks to Feast.

* Leshrac's high magic damage is ignored by Rage.
* Lifestealer can get in Leshrac's face with Rage and mitigate any other damage taken by Leshrac with Open Wounds.

* Rage is very useful against Zeus, as it negates magic damage and provides spell immunity. In addition, the increased attack speed can tear Zeus apart in combination with Open Wounds.
* Lifestealer can avoid Thundergod's Wrath with Infest.

* Heroes with built-in spell immunity can become immune to all of Outworld Devourer's spells: Lifestealer's Rage and Juggernaut's Blade Fury.

* In general, squishy heroes that rely on escape often struggles against the amount of disables Shadow Shaman can bring. Queen of Pain, Anti-Mage and Storm Spirit are among these.

Additional:
* Shadow Shaman has many disables to lock down Queen of Pain, preventing her from Blinking away, even through Linken's Sphere or her spell block talent.
* Mass Serpent Ward can tear through Queen of Pain's low health pool once she's locked down by Hex & Shackles.

* Any heroes with stuns or silences: Death Prophet, Lion, Shadow Shaman, Skywrath Mage

* Heroes with burst damage of their own won't be afraid to go toe to toe with Void Spirit, like Ursa, Lifestealer, or Axe.

* Heroes with spell immunity-granting spells will render Phoenix useless against them, as Phoenix has almost no spell immunity-piercing ability, other than the stun at the end of Supernova: Lifestealer, Juggernaut.

* Juggernaut and Lifestealer have abilities (Blade Fury and Rage respectively) that prevent Crystal Maiden from using her spells on them in the early game, before Black King Bar and other magical reduction is even an issue.

* In general, heroes with spell immunity abilities won't be caught inside by Pit of Malice: Juggernaut, Lifestealer.

* Lifestealer can close the distance to Sniper by using Infest on a fast or durable creep to tank Sniper's damage.
* Open Wounds will reduce Sniper's mobility heavily, and Rage's attack speed bonus helps in taking down Sniper.

* Mass Serpent Ward can kill lots of treants if played defensively.
* Mass Serpent Ward, Hex and Shackles can catch and kill a Nature's Prophet trying to use Teleportation.
Additional:
* Shadow Shaman's Mass Serpent Ward together with Ether Shock can easily kill lots of Treant if played defensively.
* Mass Serpent Ward, Hex and Shackles can disrupt Nature's Prophet's escape attempt with Teleportation. Though he can Sprout himself.
* Nature's Prophet also has no ways of canceling Shackles.

* The lifesteal of Feast scales accordingly to the health of its target, which is effective against Pudge due to his high health and further health granted by stacks of Flesh Heap.
* Lifestealer can activate Rage to completely negate magic damage, therefore rendering the damage of Rot and Dismember null.
* Pudge's plentiful health makes him an ideal target for Open Wounds.

* Shackles and Mass Serpent Ward instantly destroy Refraction

* Feast's lifesteal makes it nearly impossible for Axe to initiate and bring Lifestealer's health low enough for Culling Blade, even with many procs of Counter Helix.
* Feast's damage is calculated as a percentage of health, turning Axe's high health against him. This allow Lifestealer to hit Axe much harder than most other heroes.
Additional:
* Feast makes it impossible to put Lifestealer's health for a Culling Blade and also deals high damage to Axe due to his naturally high health.
* However, Lifestealer's Rage can be pierced by Berserker's Call.

* Can easily interrupt and disable Spirit Breaker with hex if being charged.

* Rage completely negates all of Nyx Assassin's abilities except Vendetta, while Open Wounds allow him to quickly close the gap.
* Infest combined with an ancient creep makes Nyx Assassin an easy target with Dust of Appearance or a Gem of True Sight.

* Hex can be used immediately to destroy Spectre's illusion when she Haunts.
* Shadow Shaman can use Shackles to lock down Spectre for his team.
* Shadow Shaman's Mass Serpent Ward and Ether Shock help him push lanes and end the game early before Spectre can come online and take over the late game.

* Heroes with spell immunity or pseudo-blinks which provide invulnerability: Lifestealer, Juggernaut, Omniknight, Huskar , and Tusk have spells which allow them to easily escape Dream Coil.

* Heroes with channeling spells because Shadow Fiend has nothing to cancel channeling: Bane, Enigma, Pudge, Shadow Shaman.

* Shadow Shaman's many disables can lock down Weaver. Even with Linken's Sphere, Weaver might not be able to escape should Shadow Shaman uses Shackles quickly enough following Hex.
* Mass Serpent Ward can make short work of Weaver once he is locked down.

* Lifestealer's Rage negates Sand King's spells which do magical damage.

* Heroes with long or multiple disables will prevent Legion Commander from winning Duels: Shadow Shaman, Lion

* All of Shadow Shaman's abilities totally ruin Terrorblade: Ether Shock destroys his illusions, Hex prevents him from using Sunder or Manta Style in bad situations, Shackles not only that prevent him from using Sunder, but he has no way to cancel it and Mass Serpent Ward can help Shadow Shaman push faster than Terrorblade even in Metamorphosis.
Additional:
* Ether Shock can destroy Terrorblade's illusions.
* Hex prevents Terrorblade from using Sunder or Manta Style in bad situations. Hex can also destroy one of his illusions.
* Shackles prevents Terrorblade from using his skills and items, whether to fight, survive, or dispel it in any way. In addition, Terrorblade has no solutions to cancel it.

* Heroes with abilities or items that can silence or disable Anti-Mage for long periods of time will prevent him from Blinking away: Silencer, Shadow Shaman, Drow Ranger, Clinkz, Riki, Broodmother, Skywrath Mage, Puck

* Lifestealer is not affected by Earthbind or Poof during Rage, making him a difficult target to work around.

* Lifestealer with Rage and Infest
* Heroes that can remove the Track debuff with their skills:
* Abaddon with Aphotic Shield and Borrowed Time
* Huskar with Life Break
* Juggernaut with Blade Fury
* Legion Commander with Press the Attack
* Lifestealer with Rage and Infest
* Naga Siren with Mirror Image
* Omniknight with Heavenly Grace
* Oracle with Fortune's End and False Promise
* Phantom Lancer with Doppelganger
* Slark with Dark Pact
* Ursa with Enrage
* Weaver with Time Lapse
* Tidehunter with Kraken Shell when damage received reaches the threshold.

* Slark, Lifestealer, Morphling and such with a good escape mechanism are a nuisance to deal with in the early-game.