* Mana Shield makes Medusa very hard to take down in Duels.
* Stone Gaze stops Legion Commander from Dueling altogether, regardless of who she targets.

* With armor items like Solar Crest or Assault Cuirass combined with Bash of the Deep, Slardar can easily tank the Duel, If not dueled himself, he can drop Legion Commander's armor during duel and/or buff his teammate and save them, leaving her only the choice of dueling supports which can also be saved with fast Blink into Slithereen Crush.

* Heroes with high physical damage can damage Lifestealer more than he can heal: Bristleback, Clinkz, Luna,Shadow Fiend, Slardar

* Lifestealer's low mobility makes him easy to kite.
* Stone Gaze pierces Rage, wasting its cooldown and making Lifestealer unable to fight.

* Summoned gargoyles will give Medusa free target practice.
* Mana Shield will resist Soul Assumption instances without effort.

* Heroes with armor reducing abilities greatly hinder Visage's defense like Slardar and Dazzle.

* Enchantress often has a small army of neutral creeps, allowing Medusa to hit her with a later bounce of her Mystic Snake.
* Untouchable is ignored by secondary attacks from Split Shot.

* Corrosive Haze grants vision of Monkey King, even when he is in the trees.

* Corrosive Haze helps counteract Tiny's bonus armor from Grow, as well as giving true sight, countering Shadow Blade as a common item on Tiny.

* Corrosive Haze lowers armor and reveals Pudge's location, making it hard to use Meat Hook on Slardar's teammates or Slardar himself.
* Because Corrosive Haze also reduces armor, it amplifies Bash of the Deep's damage.
* Slithereen Crush interrupts Pudge during Dismember at close range.
* Guardian Sprint allows Slardar to avoid Meat Hook.
Additional:
* While Slardar has Guardian Sprint activated, Rot cannot slow him and Meat Hook is easier to avoid.
* Slithereen Crush allows Slardar to interrupt Dismember at close range (when Slardar is not a target).
* Corrosive Haze reveals Pudge's location, making it very difficult for him to land hooks from the fog.

* Split Shot will keep attacking Pangolier even when he is rolling around.
* Stone Gaze stuns Pangolier during Rolling Thunder, or forces him to roll away.

* Doom does not disable Mana Shield. As such, Doom's damage is largely mitigated by her mana shield. Additionally, Medusa is not reliant on her abilities to be effective during a teamfight, making Medusa an unproductive hero to target.
* Medusa is an ideal Linken's Sphere carrier. Should one be purchased, and without any additional disables, Doom may find that few opportunities exist to effectively lockdown, disable, and kill Medusa.

* Shadow Fiend, a normal Shadow Blade builder often relies on its invisibility to escape fights. Corrosive Haze reveals Shadow Fiend and also weakens his already low armor.

* Mystic Snake can harass Axe in lane and drain his small mana pool.
* Mana Shield reduces the effectiveness of Counter Helix.
* Stone Gaze makes it very difficult for Axe to pursue.

* Slardar's Corrosive Haze provides True Sight on its target, thus exposing Bounty Hunter's position regardless of Shadow Walk. In addition, Slardar's Guardian Sprint gives a very high movement speed bonus allowing him to chase Bounty Hunter even if Slardar is tracked.
Additional:
* Bounty Hunter's Shadow Walk is rendered useless with Corrosive Haze and makes Bounty Hunter an easy target for Slardar and his team.

* If Medusa activates Stone Gaze, the charge will inevitably fail.
* Mana Shield and overall tankiness allows Medusa to easily survive Spirit Breaker's initiation.

* Corrosive Haze and Bash of the Deep will make short work of Huskar's low armor, even if Slardar is alone.

* Her Mana Shield is too tough for Lycan to break in.
* Mystic Snake can hit for a massive damage once it spread between his summons.
Additional:
* Can be easily petrified despite his speed.
* Summoned wolves will be targeted by Split Shot or Mystic Snake

* Corrosive Haze followed by Slithereen Crush takes advantage of Alchemist's main weakness, being physical damage before he has the change to improve his surviability with items.
* Bash of the Deep will deal lots of damage during the laning phase.
Additional:
* Alchemist has a low starting armor and a low agility growth, which translates to a low armor growth . And since it is very uncommon for Alchemist to get straight to Assault Cuirass, or Shiva's Guard, Corrosive Haze makes him too vulnerable to physical damage, even with the hp regeneration of Chemical Rage

* Stone Gaze allows Medusa to easily kite and kill Sven.
* Mystic Snake eats away at Sven's small mana pool.
* Mana Shield negates much of Sven's burst damage.

* Split Shot can destroy Tombstone Zombies and Tombstone itself while still damaging heroes.
* Mana Shield reduces the impact of Decay and Flesh Golem's Plague Aura.

* Medusa's Split Shot can make quick work of Enigma's Eidolons and take advantage of their considerable bounty.
* If Medusa activates Stone Gaze at the start of a fight, it can make initiating — and landing an effective Black Hole exceedingly difficult.
* Mystic Snake can be potentially detrimental to Enigma's initiation. Getting hit by the latter high-damage bounces (from standing behind his Eidolons or his teammates) can hinder his mana pool, preventing him from executing a strong initiation.
Additional:
* Mana Shield makes Medusa harder to kill with Enigma's Black Hole and Pulse combo.
* Medusa's Split Shot can kill Demonic Conversion creeps easier and Mystic Snake bounces off from them.
* Stone Gaze makes it hard for Enigma to approach Medusa for a Black Hole.

* Corrosive Haze will reveal Treant Protector even when he is under the effects of Nature's Guise.

* Mana Shield tanks most of the damage from Reaper's Scythe; with sufficient mana, the kill threshold drops to 15%/17%/19% health (before reductions).
* Heartstopper Aura does not chip away at Medusa's mana, this makes it not a threat as it deals damage based on current health.
* Necrophos has a movement speed equal to Medusa, and is easy to chase down with a slowing item in Medusa's inventory.

* Stone Gaze negates Dispersion's damage reduction and allows Medusa to kite Spectre.
* Spectre's small mana pool is depleted quickly by Mystic Snake.
* Split Shot can clear Haunt illusions quickly.

* Slardar's Slithereen Crush allows him to stun Spectre and illusions, and Corrosive Haze prevents her from juking with Spectral Dagger.

* Clinkz survivability depends entirely on Skeleton Walk. Corrosive Haze not only makes its invisibility useless, but also makes Clinkz even more vulnerable to physical damage.
Additional:
* Slardar can reveal Clinkz with Corrosive Haze and make him easy to kill, and his Bash of the Deep also hits hard against Clinkz's naturally low health pool.
* Slardar's Guardian Sprint can catch up with Clinkz's Skeleton Walk.
* The stun and slow from Slardar's Slithereen Crush can hold Clinkz in place.

* Heroes with detection: Bounty Hunter, Disruptor, Razor, Slardar, Spectre, Spirit Breaker

* Heroes who can stun multiple units at once: Dark Willow, Spirit Breaker, Slardar, Invoker, and Tidehunter.

* Poof won't damage Medusa and he can Gaze an entire flock of Meepos.
* Mystic Snake will easily become the bane of Meepo early game.

* Slardar can chase Dragon Knight down with Guardian Sprint and stun him with both Slithereen Crush and his passive Bash of the Deep. He can also use Corrosive Haze to whittle Dragon Knight's armor.

* Heroes with cleave abilities and area of effect damage can make quick work of Chen's converted creeps and at same time gain farm: Magnus, Jakiro, Shadow Fiend, Kunkka, Luna, Dragon Knight, Medusa, Alchemist.

* Medusa's Stone Gaze forces Mars to choose between getting petrified, or turning his vulnerable back on Medusa.

* Heroes who can provide True Sight are always credible threats: Slardar, Bounty Hunter, especially Zeus since his Lightning Bolt provides True Sight without the need to detect her beforehand to apply the debuff. So even a late-coming Zeus can easily scout a large area to reveal her, and she cannot purge herself from his sight with the dispel talent.

* Heroes with Linken's Sphere as core item: Weaver, Morphling, Medusa.

* Crystal Maiden's already low armor and easily interruptible ultimate, Freezing Field can make Slardar her worst nightmare. Crystal Maiden also often builds Glimmer Cape which is revealed by Corrosive Haze.

* Slardar can attack through Plague Wards and gaining Bash of the Deep charges.

* Guardian Sprint allows Slardar to outrun Bristleback, even when slowed by Viscous Nasal Goo.
* Corrosive Haze's armor reduction makes Bristleback much less tanky.

* Weaver relies on Shukuchi to escape and kite enemy heroes. Slardar's Corrosive Haze lowers armor and reveals Weaver, who is already a very frail target.
* Weaver usually builds Linken's Sphere, Corrosive Haze can be used to "pop" the spell block of Linken's Sphere, additionally the level 25 undispellable talent will prevent Weaver from removing Corrosive Haze with Time Lapse, allowing allied heroes to use their abilities on Weaver.
Additional:
* Corrosive Haze lowers armor and reveals Weaver during Shukuchi, who is already a frail target. In addition, Weaver usually builds Linken's Sphere, and Corrosive Haze can be used to "pop" the spell block. His level 25 talent can also make Corrosive Haze undispellable by Time Lapse, which puts Weaver in an even worse situation.
* Guardian Sprint can dodge Weaver's bugs with the movement speed bonus.

* The brutal physical damage of Slithereen Crush and Bash of the Deep can quickly remove Void Spirit's shield and stun him for a while.
* Corrosive Haze provides vision of Void Spirit while he is running away and Guardian Sprint allows Slardar to quickly close the gap

* Mana Shield makes it very difficult for Bloodseeker to gain his Thirst bonuses.
* Rupture rarely kills Medusa through Mana Shield.

* Slardar can use Guardian Sprint with Blink Dagger or Shadow Blade to get close, and Slithereen Crush will stun Sniper, making him vulnerable to Slardar's teammates.
* Corrosive Haze lowers Sniper's armor and makes Sniper's Shadow Blade useless, easily killing him with a few attacks.

* Slithereen Crush and Bash of the Deep prevent Anti-Mage from using Blink, the latter even if Anti-Mage activates Black King Bar.
* Corrosive Haze allows allies to take down Anti-Mage before he has a chance to Blink, and maintains vision over him even if he does Blink away.

* Heroes with spells that negate invisibility such as Bounty Hunter, Zeus and Slardar prevent her from saving her allies with Moonlight Shadow.

* Corrosive Haze works much like Track, giving the enemy team vision over Riki. While it doesn't give a movement speed bonus, it instead melts Riki's armor and Slardar can use Guardian Sprint to catch up to him.
Additional:
* Corrosive Haze makes Riki completely vulnerable to Slardar and his allies, as Riki has no easy way of dispelling it.
* Slardar's physical damage with Slithereen Crush and Bash of the Deep amplified by Corrosive Haze can easily kill Riki.