* Outworld Destroyer's pure and magical damage is particularly effective against Axe.
* Astral Imprisonment is an excellent way to defend against an initiating Axe.
* Sanity's Eclipse deals high damage to Axe due to his low mana pool.
Additional:
* Berserker's Call bonus armor doesn't block Arcane Orb's pure damage.
* Astral Imprisonment can be used to prevent an ally or Outworld Devourer himself from an Axe initiation.
* Axe's low mana means he's susceptible to a powerful Sanity's Eclipse.

* Dispersion makes Spectre very durable, making it much less likely for Axe to bring her low enough for Culling Blade.
* Spectre can simply use Spectral Dagger to escape against an Axe gank.

* Outworld Destroyer's pure and magical damage is particularly effective against Earthshaker.
* Astral Imprisonment catches Earthshaker while he blinks in, preventing him from executing his combo.
* Earthshaker has mana troubles, and Outworld Destroyer's abilities can press this by stealing intelligence comes from Arcane Orb, therefore depleting his mana pool and mana regeneration.
* Sanity's Eclipse deals high damage to Earthshaker, due to his low intelligence and mana pool.

* Spectral Dagger can be used to traverse past Fissure.
* Haunt will usually disable Earthshaker's Blink Dagger prior to a teamfight, preventing him from initiating.
* On the other hand, Haunt will amplify damage done from Echo Slam. Use this to your advantage.
Additional:
* Spectre can use Haunt to intercept and disrupt Earthshaker's initiation attempts.
* Spectral Dagger can be used to traverse past Fissure.
* Earthshaker often travels alone when he is trying to initiate, so Desolate can be very effective against him.
* Beware that the Haunt illusions amplify the damage done from Echo Slam, which can prove fatal for Spectre's own team.

* Spectral Dagger hinders Sven's low movement speed, and can be an easy tool to escape against his high damage.
* Dispersion makes it harder for Sven to burst down Spectre in one on one fights, and can reflect Sven's high damage back to him or his nearby teammates.
* Haunt and Radiance disables Sven's Blink Dagger.
* Desolate's pure damage ignores Sven's high armor.
* Spectre should not attempt to stand up to a full slotted Sven, since she will get shredded.

* Tanky melee heroes that can easily be kited, which allows Outworld Devourer to deal heavy damage with Arcane Orb from a distance: Sven, Underlord, Bristleback.

* Black King Bar is useless, since all of the Spectre's abilities go through spell immunity,
* Phantom Assassin's Blur cannot evade Desolate because its damage is a separate damage instance and is applied before the attack hits.
* Spectre's high durability provided by Dispersion and damage block items makes her one of the hardest carries to take down.
Additional:
* Dispersion makes it hard for Phantom Assassin to burst down Spectre while also reflecting back Phantom Assassin's high burst damage against herself.
* Desolate ignores the evasion from Blur.
* Black King Bar is useless against Spectre as all of her skills pierce spell immunity.

* Any heroes with low mana pools will die quickly or even instantly to Sanity's Eclipse: Doom, Phantom Assassin, Troll Warlord.

* Spectre's entire ability set is designed to get to and destroy heroes that stay in the backlines, both carries (like the aforementioned Drow Ranger and Sniper) and supports (like Dazzle and Shadow Shaman).

* Astral Imprisonment is a versatile nuisance:
* If it is cast on a low-enough-health unit at least 1 second into Shallow Grave's duration, the Shallow Grave will end during the imprisonment, and the target will take lethal damage when released.
* It can be used remove Dazzle from the fight at a time he could have saved someone.
* It lets himself or an ally dodge all of Poison Touch's effects, for long enough to recover their Blink Dagger.

* Outworld Destroyer's pure damage from Arcane Orb is very effective at killing Troll Warlord quickly.
* Astral Imprisonment removes Troll Warlord from a fight for four seconds, minimizing his contribution to a teamfight, and potentially wasting over half of Battle Trance's duration.
* Troll Warlord gains a measly 1 intelligence point per level, meaning Sanity's Eclipse is especially effective, often instantly killing him.

* Heroes that rely on evasion are slightly countered by Desolate: Phantom Assassin, Troll Warlord.

* Spectral Dagger give vision over Slark, slows strong with the talent, can not be dispelled and can not be missed if targeted. With the cooldown reduction talent, Spectre can keep constant vision over Slark, so he has to use his Shadow Dance to disengage so he can't be targeted by the dagger, which can still latch on to him when ground targeted.
* Spectre deals a lot of AOE damage in teamfights which goes through Shadow dance.

* Arcane Orb deals pure damage, which ignores armor granted from permanent agility stacks.
* Astral Imprisonment can disrupt any Pounce attempt by banishing the leashed ally.
* Slark's low intelligence and therefore mana pool makes him more susceptible to Sanity's Eclipse.

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Destroyer.

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

* Nature's Prophet can literally do nothing against Spectre, because she can chase him from anywhere with Haunt.
* Spectre, just like Naga Siren, loves buying Radiance, which can kill Nature's Prophet's treants, and grant her farm simultaneously.
Additional:
* Spectre can get to him anywhere on the map with Haunt.
* Spectre can pass through his trees with Spectral Dagger.
* Desolate's damage will melt him quickly, as he's alone most of the time.

* Spectre can use Haunt to intercept and disrupt Magnus's initiation attempts.
* Spectral Dagger can severely slow down Magnus after he uses Skewer.
* Magnus often travels alone when he is trying to initiate, so Desolate can be very effective against him.
Additional:
* Spectre disables Magnus' Blink Dagger using her ultimate, and later into the game can usually outlive Reverse Polarity's duration.

* Sanity's Eclipse only triggers Bristleback's passive once, and deals high damage against Bristleback's low intelligence.

* Spectral Dagger and Haunt allow Spectre to get close to Lina.
* Desolate is very strong against Lina, who's usually a bit isolated in fights because of her high attack and cast range.
* Dispersion can mitigate a good portion of Lina's burst damage, allowing Spectre to turn on her afterwards.
Additional:
* Spectre can very easily close the distance on Lina with Haunt and Spectral Dagger, and due to Lina's abysmal mobility without a Blink Dagger and terrible health pool and armor, Lina easily gets slaughtered due Desolate.
* Dispersion can mitigate a good portion of Lina's burst damage, allowing Spectre to turn against her afterwards.

* Arcane Orb deals heavy damage to both Lone Druid and the Spirit Bear.
* Astral Imprisonment can prevent the Spirit Bear from attacking, which is Lone Druid's main damage output.
* Sanity's Eclipse deals heavy damage to Lone Druid.

* Arcane Orb deals pure damage, effectively bypassing Morphling's high armor from Attribute Shift (Agility Gain).
* Sanity's Eclipse is more effective against a low health and mana pool Morphling, enabling Outworld Destroyer to burst Morphling down before he can shift to Strength.
Additional:
* Arcane Orb deals high damage regardless of Morphling's high armor from Attribute Shift (Agility Gain).
* Because of Morphling's very low intelligence gain and base intelligence, Sanity's Eclipse will almost always be effective against Morphling.

* The pure damage provided by Arcane Orb is a great addition for killing Ember Spirit.
* Astral Imprisonment fully negates all magic damage of Flame Guard and Searing Chains and will temporarily save himself from Sleight of Fist's physical damage, and Ember Spirit is not a hero that can counter these skills.

* Arcane Orb's constant pure damage output is devastating to Dragon Knight.
* Dragon Knight's relatively low mana pool leads to heavy damage from Sanity's Eclipse, which also bypasses his armor.

* Arcane Orb deals constant pure damage, which bypasses Timbersaw's Reactive Armor.
* Sanity's Eclipse can hit targets inside Astral Imprisonment, which helps Outworld Destroyer finish off Timbersaw before he escapes with Timber Chain. It can also drain his mana, limiting his ability to escape should he survive.
Additional:
* Arcane Orb's pure damage ignores Timbersaw's Reactive Armor.
* Astral Imprisonment, if timed correctly, can interrupt Timber Chain, preventing him from escaping.

* Astral Imprisonment protects an ally for much of Rolling Thunder's duration, especially at the lower levels. As Rolling Thunder has a considerable cast animation, an Outworld Destroyer with Blink Dagger can initiate on him and destroy his timing.

* Outworld Destroyer's pure damage will mop up Primal Split's units very quickly.

* Astral Imprisonment can be used to protect allies by imprisoning either them or Spirit Breaker.
* Arcane Orb will heavily drain Spirit Breaker's intelligence, rendering him almost useless and unable to cast spells. Spirit Breaker's low intelligence also means Sanity's Eclipse will deal a lot of damage to him.

* Oracle's burst damage is ineffective against Dispersion.
* Disarm provided by Fate's Edict is not as significant debilitation for Spectre as it might be for other carries since She can do damage even without landing attacks.

* Sanity's Eclipse does massive damage to Wraith King who naturally has a low mana pool and typically doesn't build items to increase it.
* Wraithfire Blast's slow projectile speed makes it easy to avoid using Astral Imprisonment.

* Spectre can instantly escape Focus Fire or hunt a Windranger with Haunt.
* Spectre can catch up to her with Spectral Dagger, even if she uses Windrun.
* Desolate allows Spectre to hit Windranger through Windrun.
* Dispersion makes Spectre tanky and also reflects some damage back to Windranger.
Additional:
* Spectre can catch up to her with Spectral Dagger, even if she uses Windrun.
* Spectre can instantly reach a ratting Windranger with Haunt.
* Windrun's miss chance is countered by Desolate.
* Dispersion can reflect some of her damage, especially from her Focus Fire.

* Arcane Orb 's pure damage can do great damage to Underlord.
* Sanity's Eclipse can tear down Underlord's health by a large amount, since his mana pool is very low compare to OD's high mana pool.

* Astral Imprisonment wastes Borrowed Time's duration.
* Outworld Destroyer's Sanity's Eclipse can kill Abaddon before Borrowed Time triggers.

* As Ancient Apparition likes to stay far away from the fight to get full effectiveness from Ice Blast, he is a very good target for a Haunt gank.
* Ancient Apparition also has no hard disables and escape spells, making him an easy kill for Spectre.

* Sanity's Eclipse will likely instantly kill all illusions.

* Spectre can instantly reveal Bounty Hunter's position on the activation of her ultimate Haunt. She can also semi-reveal( visible but not target-able) Bounty Hunter by hitting him with Spectral Dagger.

* Outworld Destroyer doesn't care if Razor steals his damage because he does most of his damage through Arcane Orb.
* Astral Imprisonment can prevent Razor from using the stolen damage from Static Link or chasing with Eye of the Storm.
* Sanity's Eclipse will do a ton of damage to Razor due to his low mana pool.

* Haunt can ruin Enigma's initiation with Blink Dagger, no matter where he is on the map.
* Dispersion reflects the damage of Midnight Pulse and Black Hole inflicted back to Enigma.

* Any hero that can nullify effects of Chronosphere: (Omniknight, Keeper of the Light with Aghanim's Scepter during daytime, Winter Wyvern), banishing him or Faceless Void (Outworld Destroyer, Shadow Demon, Earth Spirit with Aghanim's Scepter) or protecting him in other ways (Dazzle, Oracle, Abaddon) can greatly limit Chronosphere's potential.

* Shadow Demon, Outworld Destroyer and Tusk can all save a Lasso'd teammate with their defensive spells.

* Heroes who can hide the Dueled target (Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter etc).

Additional:
* Outworld Devourer can save an ally hero caught by Duel with Astral Imprisonment, and he can inflict heavy damage on Legion Commander with Arcane Orb to aid his ally. However, if he gets caught, he is unlikely to survive the duel, due to his lack of durability.

* Heroes that can protect or dispel stunned allies such as Legion Commander, Outworld Destroyer, Shadow Demon and Oracle can reduce the effectiveness of Sacred Arrow.

* Ursa struggles against heroes with strong (and especially undispellable) disables (Disruptor, Puck, Shadow Demon, Outworld Destroyer and etc).

* Illusion based heroes (like Chaos Knight and Terrorblade) can't use their illusion beneficially against Sanity's Eclipse's high AoE burst damage.

* Squishy heroes without good escape mechanism: Crystal Maiden, Chen.

* Heroes with pure damage can kill Huskar when he inevitably gets low on health: Outworld Destroyer, Silencer.

Additional:
* Outworld Devourer can dodge Life Break with Astral Imprisonment, leaving him unharmed while Huskar loses HP.
* Sanity's Eclipse can deal massive damage to Huskar before he builds up his Berserker's Blood stacks due to Huskar's low mana pool.

* Spectre can easily close the distance on Drow Ranger with Haunt and stick on her with Spectral Dagger, negating the bonus agility from Marksmanship.

* As Crystal Maiden is squishy with very bad movement speed, Spectre can easily stay on Crystal Maiden with Haunt and Spectral Dagger.
* Late game, with enough farm, Spectre can withstand an entire Freezing Field, possibly even causing Crystal Maiden to kill herself from Dispersion.

* Astral Imprisonment allows Outworld Destroyer to save himself or ally from Invoker's combo, or remove Invoker from a fight temporarily.
* Arcane Orb's pure damage will deal a lot of damage against Invoker's mediocre strength gain.
* EMP is useless against Outworld Destroyer by activating Equilibrium.
* However, be aware that Sanity's Eclipse will most likely not deal any damage at all, due to Invoker's high intelligence gain compared to Outworld Destroyer's.

* Spectre can instantly escape Burning Army or hunt Clinkz with Haunt.
* Spectre can catch up to him with Spectral Dagger, even if he uses Skeleton Walk.
* Desolate allows Spectre to hit Clinkz through Skeleton Walk.
* Dispersion makes Spectre tanky and also reflects some damage back to Clinkz.
Additional:
* Spectre can catch Clinkz with Spectral Dagger, even if he uses Skeleton Walk.
* Spectre can instantly reach a ratting Clinkz with Haunt.
* Desolate's damage will melt him quickly, as he's alone most of the time.

* His global teleportation with Boots of Travel and Rearm is easily countered with Haunt, and Spectre can reach him anywhere on the map.
* He is squishy, and if alone Desolate will kill him very fast.
* Laser's blind isn't reliable, since Desolate cannot miss.

* Heroes who possess abilities that can save targets from being killed by Reaper's Scythe: Abaddon, Bane, Outworld Destroyer, Shadow Demon, Omniknight, etc.

* Enemies that possess high defenses through magic resistance, damage reduction, or high regeneration will make it difficult to whittle their health down to get to Reaper's Scythe's threshold. Such heroes include Bristleback (although only from behind), Spectre, Ursa, and Dragon Knight.

* Astral Imprisonment can allow Outworld Destroyer to save himself or allies from Kunkka's full kit.
* Sanity's Eclipse deal a large amount of damage, as Kunkka's mana pool is much smaller than Outworld Destroyer's.
* Arcane Orb deals pure damage, shredding through Kunkka and his team even with Ghostship's buff.

* None of Spectre's spells are very good for Rubick to Spell Steal.

* Arcane Orb deals pure damage against the real Terrorblade, bypassing his high base armor.
* Arcane Orb and Sanity's Eclipse will make very short work of Terrorblade and his illusions.

* Arcane Orb and Sanity's Eclipse quickly drains Pudge's limited mana pool, making him unable to use Meat Hook or Dismember and also bypasses Flesh Heap.
* Outworld Destroyer can save allies or himself caught by Dismember or Meat Hook with Astral Imprisonment.

* Zeus can deal a huge amount of damage, but he lacks defensive abilities, such as good mobility or resistance. Due to that, he doesn't like to be touched by any means. Heroes with higher damage output and good mobility will often get easily near Zeus and trade damage (eventually causing Zeus's downfall). Such Heroes include: Lycan, Slark, Storm Spirit, Spectre and others.

* Arcane Orb's pure damage penetrates Guardian Angel's defense.
* Outworld Destroyer's intelligence steal is also devastating to Omniknight's already low mana pool.

* Arcane Orb's pure damage ignores Mars' Bulwark.
* Astral Imprisonment can be used to stop Mars from being disruptive or save allies from his abilities.
* Sanity's Eclipse deals high damage to Mars, due to his low intelligence.

* Spectral Dagger follows Riki even after he goes invisible and stays on him through Tricks of the Trade, revealing his location.
* Desolate grants Spectre the ability to damage Riki with right clicks regardless of Smoke Screen's blind.
* Riki relies on his high damage to kill is opponents, which is countered by Dispersion.
* Haunt can find Riki globally at any time, negating much of his ganking potential.

* Arcane Orb's pure damage goes through Counterspell, and deals splash damage to illusions spawned from Manta Style.
* Sanity's Eclipse hits Anti-Mage while he is disabled with Astral Imprisonment, and forces him to take heavy damage due to his low intelligence.
* Essence Flux keeps Outworld Destroyer at high mana, thus greatly reducing the damage from Mana Void.
Additional:
* Counterspell doesn't work versus Arcane Orb because it does pure damage.
* Anti-Mage cannot burn all of Outworld Devourer's mana without disables due to Essence Flux.
* Anti-Mage's Manta Style illusions are quickly destroyed by Arcane Orb.
* However, if the enemy has multiple means of removing mana, Mana Void becomes a threat to Outworld Devourer, Anti-Mage has better mobility than Outworld Devourer with Blink, and Counterspell blocks a large portion of the damage from Sanity's Eclipse.

* Haunt instantly allows her to get up and close with Sniper, and Spectral Dagger makes it difficult to escape from her.
* Spectre outcarries Sniper in the late game, so Sniper must try to end the game early before Spectre comes online.
Additional:
* Spectre can reach him easily in the backlines with Spectral Dagger or teleport to him with Haunt.
* He is usually a fair distance away from his allies, so Desolate will quickly tear Sniper down.

* Outworld Devourer's pure damage from Arcane Orb can go through Cold Embrace.
* Outworld Devourer can negate the healing from Cold Embrace using Astral Imprisonment, and steal mana while doing so.
* Outworld Devourer's damage during Winter's Curse is reduced due to Arcane Orb being unable to target allies.
Additional:
* Winter Wyvern must never put her allies in Cold Embrace against Outworld Destroyer as Arcane Orb will continue to steal Intelligence and deal damage to the defenseless hero.
* Arcane Orb does not hit his allies when he is taunted by Winter's Curse, making it weak against allies, but strong versus enemies.
* Astral Imprisonment can protect a target inflicted with Winter's Curse.

* Spectral Dagger maintains vision on Monkey King, and allows Spectre to chase Monkey King into the trees.
* Haunt will still spawn an illusion next to Monkey King while under the effects of Mischief, removing the disguise.
* Monkey King attack range is exactly 300. The best range for Dispersion buff.

* Heroes with hiding abilities can protect disabled allies: Outworld Destroyer, Shadow Demon, Tusk, Phoenix with Aghanim's Scepter