* EMP is a large mana burn nuke which can hit Medusa's Mana shield with enough damage to lose even more mana.
* Deafening Blast disarms Medusa's ability to deal pseudo-AOE damage during teamfights.
* Cold Snap allows the opposing team to repeatedly stun Medusa in short succession, preventing her from successfully casting her ultimate due to its long cast time.
Additional:
* EMP allows Invoker to burn Medusa's mana to weaken Mana Shield.
* Medusa's lack of mobility makes her easy to kite with Invoker's spells.

* Cold Snap allows Invoker to interrupt Charge of Darkness and Nether Strike.
* Tornado's long range can be used to cancel Charge of Darkness.
* Deafening Blast prevents Spirit Breaker from right clicking and thus proccing his Greater Bash.

* Unlike other illusion heroes, Tempest Double won't be instantly destroyed by Stone Gaze since it is considered a clone and not an illusion.
* He can use either his own or his double's Flux to bypass the spellblock from Linken's Sphere, using the leftover Flux + Spark Wraith to slow Medusa's move speed to a crawl.
* Arc Warden has a farming advantage with double Hand of Midas, and can generally bully Medusa with other items that benefit from duplication.

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc Warden

* Mana Drain has an extremely long range and low cooldown. It can easily deplete most heroes of their entire mana pools, especially those with smaller mana pools such as Tiny or Spirit Breaker.

* Medusa lacks mobility or escape mechanisms. Earth Spike and Hex can neutralize her strong damage potential and allow for Lion's team to focus her down.
* In addition to easily breaking her commonly bought Linken's Sphere with its low cooldown, Mana Drain can quickly drain her Mana Shield, making her far less tanky.

* Medusa cannot chase Slark in any way and has no disable beyond her ultimate, making her unable to stop him getting away and regenerating before coming back to finish her off.
* Essence Shift removes 1 of every attribute, lowering Medusa's mana pool's cap and leaving her much more vulnerable in prolonged fights.
Additional:
* Medusa is especially vulnerable to Essence Shift, as both strength and intelligence contribute to her effective HP, while agility contributes to her damage.
* Dark Pact when timed right can be used to dispel Stone Gaze right after it petrifies Slark, allowing him to keep attacking Medusa throughout the duration.

* Heroes with blink or movement abilities, which are disabled by Pounce's leash: Anti-Mage, Earth Spirit, Faceless Void, Magnus, Mirana, Monkey King, Morphling, Pangolier, Phantom Assassin, Phoenix, Puck, Queen of Pain, Riki, Sand King, Spirit Breaker, Timbersaw, Tusk.

* Chakra Magic can drain her current mana, draining away her effective health in a sneaky way.
* Will-O-Wisp will keep Medusa busy after she got hit by Blinding Light.

* Heroes that punish mobile heroes: Bloodseeker, Keeper of the Light

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Durable heroes: Axe, Bristleback, Tidehunter, Wraith King

* Heroes that usually builds Linken's Sphere as a core item: Weaver, Medusa, Morphling, Queen of Pain, Storm Spirit

* Other heroes with mana burning or manipulating abilities will make Medusa much less tanky: Lion, Mirana, Weaver.

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Other heroes who has armor and slow debuffs won't allow Medusa to disengage from combat: Tidehunter, Bristleback, Slardar.

* Pit of Malice can be cast in the path of Spirit Breaker's Charge of Darkness to cancel it.
* Dark Rift provides a way to escape from a gank for Underlord and his teammates.

* In the early game, Omniknight can look like an easy target for Spirit Breaker, but with Purification and Degen Aura, what could be an opportunity could quickly turn into disaster.
* Heavenly Grace can be used to counter Charge of Darkness by minimizing the damage and lowering the stun duration with status resistance.
* Spirit Breaker's Greater Bash from all sources (Charge of Darkness or normal attacks) deals lesser damage if he is within the radius of Degen Aura.
* Due to this, Spirit Breaker's damage will always be lower when targeting Omniknight.

* Nether Strike can't remove Static Link and reduces Spirit Breaker's physical damage output.
* Eye of the Storm melts Spirit Breaker's armor, and makes him much less tanky.
Additional:
* Static Link drains damage bonus from Greater Bash, it cannot be removed by Nether Strike.
* Eye of the Storm melts Spirit Breaker's armor, and makes him much less tanky.

* Clockwerk can use Power Cogs to repel Spirit Breaker when he charges in with Charge of Darkness.
* Spirit Breaker's slow 0.6 second attack animation attacks do little damage against Clockwerk. It can also constantly be interrupted by Battery Assault.
* Nether Strike's 1.2 second charge time gives Clockwerk plenty of time to activate Blade Mail and for Battery Assault to cancel it.
Additional:
* Battery Assault will continuously prevent Spirit Breaker from using Nether Strike, Charge of Darkness and even right clicking because of his long attack animation.
* Charge of Darkness can be cancelled by a correctly timed Hookshot.
* Should Clockwerk or his allies be targeted by Charge of Darkness, he can stop it by casting Power Cogs in Spirit Breaker's path or around the target.

* Spirit Breaker's slow attacks cannot harm a hero shielded by Living Armor.
Additional:
* Living Armor can mitigate a large portion of Spirit Breaker's damage since his attacks are slow.
* Treant Protector can also counter initiate Spirit Breaker with Leech Seed and his bash from Nature's Guise before he manages to escape.

* Fiend's Grip provides mana drain, which can heavily damage Mana Shield and prevent Medusa from using Stone Gaze.
* Even if she does use Stone Gaze, Nightmare can buy enough time to protect allies and reset the fight.
Additional:
* His Fiend's Grip will leave Medusa defenseless after he's done, if his teammates can provide cover for him or he initiates at the right time by Spell immunity.

* Nether Ward will cause an unfriendly area for Medusa, draining her mana.

* With her passive Split Shot, Medusa can be easily interrupted by Spiked Carapace during combat, especially during her precious Stone Gaze.
* Mana Burn quickly destroys Mana Shield, especially if Medusa only increases her mana pool by bolstering intelligence (which has the added bonus of increasing Mana Burn's damage).
* Uncontrollable damage from Mystic Snake and Split Shot can trigger Spiked Carapace.
* Medusa lacks single target damage, making a Burrowed Nyx Assassin hard to kill.
Additional:
* Level 4 Mana Burn burns 38,5% of Medusa's mana every 4 seconds if Medusa only increases her mana pool with intelligence. Additionally, 60% of the Mana Burn damage gets mitigated by Mana Shield, burning even more mana.
* Due to the passive nature of Mystic Snake and Split Shot, it can possibly proc Nyx's Spiked Carapace if he's within range of Medusa's abilities and isn't invisible.
* Medusa lacks single target damage, making Nyx with Aghanim's Scepter extremely hard to deal with if Medusa is the team's main damage source.

* Due to Spirit Breaker's low attack speed, Supernova is problematic for Spirit Breaker to take down, and even more so with Fire Spirits debuff applied.
* Icarus Dive grants Phoenix capability to quickly escape to safety.

* Fissure interrupts Spirit Breaker during Charge of Darkness.

* Bramble Maze stops Charge of Darkness in its tracks. Its very long duration means it can be used as an obstacle to block off an incoming Spirit Break during teamfights.
* Shadow Realm and Bedlam can be activated when Dark Willow sees Charge of Darkness coming, preventing Spirit Breaker from using Nether Strike after the initial stun.

* Silencer burns easily through her effective hp from Mana Shield, by taking away her int.
* Arcane Curse punishes her repeatedly casting Mystic Snake to keep her mana pool high. Can force her to use Manta Style before he has cast Global Silence and Medusa usually does not want to build Black King Bar.

* Spirit Breaker's slow attack speed and moderate damage do very little to harm Dragon Knight, even if ganked with Charge of Darkness.

* Searing Chains can stop Charge of Darkness if timed correctly.
* Activate Fire Remnant can be used to escape an approaching Spirit Breaker, or lead Spirit Breaker into a bad situation.
* Activate Fire Remnant and Sleight of Fist allows Ember Spirit to dodge Charge of Darkness if timed correctly.

* Because of her need to get status items early to tank it up, Rubick can greatly reduce her damage early with Fade Bolt
* Her stationary nature and the slow cast time of her spells makes it easier for Rubick to steal Stone Gaze or Mystic Snake
* Aghanim's Scepter's Mystic Snake is often better used by Rubick than by Medusa

* Medusa's tankiness doesn't help her very much against Fury Swipes in long teamfights.
* With no escape mechanism and a slow movement speed, getting jumped on by Ursa usually spells a quick end for Medusa in the early game.
Additional:
* Ursa's status resistance from Enrage will ignore Medusa's gaze.
* Ursa can stack damage with Fury Swipes easily against her Mana Shield in a prolonged team match.

* Astral Imprisonment can be used to protect allies by imprisoning either them or Spirit Breaker.
* Arcane Orb will heavily drain Spirit Breaker's intelligence, rendering him almost useless and unable to cast spells. Spirit Breaker's low intelligence also means Sanity's Eclipse will deal a lot of damage to him.

* Heroes that have a weak laning stage: Spectre, Nyx Assassin, Clockwerk, Spirit Breaker, Omniknight, Pudge.

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Heroes that can cancel Charge of Darkness: Ogre Magi, Earthshaker.

* Heroes with mobility spells like Queen of Pain, Anti-Mage, Riki, Puck, and Spirit Breaker that are cancelled by Frostbite can suffer greatly from the presence of Crystal Maiden. It is absolutely critical, however, to have followup from teammates, as all of the above heroes can make quick work of the squishy Crystal Maiden after they are released from her grip.

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc Warden

* Heroes who continue dealing damage while being stunned: Luna, Razor, Axe, Bristleback, Leshrac,

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc Warden

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Heroes who take a long time to become strong are in for a rough mid game, such as Outworld Devourer, Magnus, Medusa, and Anti-Mage.

* Heroes that build Diffusal Blade or can fit it well into their item build will also make Medusa much less tanky: Riki, Naga Siren, Terrorblade, Juggernaut, Spectre, Slark,Drow Ranger.

* Heroes that usually builds Linken's Sphere as a core item: Weaver, Medusa, Morphling, Queen of Pain, Storm Spirit

* Heroes with ways to protect themselves or allies from Spirit Breaker's initiation: Shadow Demon

* Heroes that can slow Charge of Darkness by a huge amount: Venomancer, Viper, Dazzle, Arc Warden

* Durable heroes: Axe, Bristleback, Tidehunter, Wraith King

* Heroes that usually builds Linken's Sphere as a core item: Weaver, Medusa, Morphling, Queen of Pain, Storm Spirit

* Webbed areas can be used to hit and run, covering distance hastily weakening her on the way and initiating ganks.
* Even though Medusa can hunt down Spiderlings easily when given enough range, after an Incapacitating Bite she will get her swarmed in no time.
* Medusa usual do not build a BKB to benefit from Mana Shield fully while Broodmother can fit a Diffusal Blade to burn away mana.
Additional:
* Incapacitating Bite will give Medusa a dire time to clear horde of small spiderlings or retaliate Broodmother herself.
* Spin Web will allow broodmother to pick her own fights and sometimes slip away to ambush Medusa.

* He won't be around waiting for Medusa to Stone Gaze and pin him until she bears a true sight.
* With Smoke Screen, Riki will silence and catch Medusa in a surprise with high miss chance flushing her from positions easily in team fights.
* He can still deal huge amount of damage through Cloak and Dagger via backstabs, drying out Medusa's protection in a whim at random occassions.

* Can easily interrupt and disable Spirit Breaker with hex if being charged.

* Phantom Lancer with Diffusal Blade will very quickly burn Medusa's mana, making Mana Shield significantly less effective.
* Doppelganger's 1 second invulnerability can be used to dodge Medusa's petrification from Stone Gaze, as well as Mystic Snake.
* Phantom Lancer's illusions outnumber Medusa's targets from Split Shot, likely shielding your team in the process.