* Venomancer has low health, which makes him vulnerable to Lina's heavy magic damage.
* Fiery Soul attack speed bonus removes Plague Wards easily in all stages of the game.

* Lina has very high magic burst damage to use against the low-health-pool Luna. Laguna Blade can also be upgraded with Aghanim's Scepter to bypass Luna's Black King Bar, making Lina even more of a threat.

* Lucent Beam is a solid magic nuke.
* Eclipse can cause massive damage if cast in the right time.
* Rubick has a good chance to steal Eclipse for Luna has only two cast abilities.
* Aghanim's Scepter greatly increased the effectiveness of the ability, including more damage as well as longer cast range. In addition, it allows him to cast it on another hero so Rubick doesn't have to get close to the enemy team in teamfights.

* All of Venomancer's abilities are decent choices for Rubick's Spell Steal. Stealing Plague wards makes them apply Poison sting as well.

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Devourer.

* Borrowed Time & Aphotic Shield can dispel Venomous Gale and Poison Sting.

* In the laning stage, making illusions of Venomancer will turn his Poison Sting back at him, making for an easy gank level one, and for later when your mid comes for ganks.

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

Additional:
* Demonic Purge takes off Luna's superior mobility, removing the need for chasing her and allowing your team to reposition in team fights or escape when at low HP. If Shadow Demon has Aghanim's Sceptre it will also take away glaive bounces and extra damage from Luna's passive.
* Luna's illusions created by Disruption is very valuable with their Moon Glaives. These will effectively counter her pushing attempts and are painfully effective in team fights.
* Disruption can be used to save an ally from Eclipse.

* Heroes with damage-over-time abilities will not only proc Bristleback's passive continuously, they will also do little harm to him when he is facing away from the source: Venomancer, Arc Warden

* Quill Spray and Bristleback harass Luna more efficiently than she does with Lucent Beam.
* Bristleback withstands Luna’s nukes, and gives lots of damage in return.
* Viscous Nasal Goo and Warpath are enough to outrun a speedy Luna.
* Bristleback tends to be a frequent carrier of Crimson Guard, which is good protection from bouncing glaives.
Additional:
* Multiple instances of damage from Eclipse will trigger Bristleback's passive repeatedly in a short time, dealing tremendous damage to Luna and her teammates.
* Luna's damage burst may be high, but it will not be enough for her to take down Bristleback.

* Sniper usually sits at the back and it's hard for Luna to get close to him to attack.
* Due to Sniper's Shrapnel and his long range, Luna has a hard time taking high ground despite her Moon Glaives being fantastic for taking Barracks and buildings.

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes has attack range talent can also outrange Plague Ward.

* Dark Pact can dispel Venomous Gale and Poison Sting.
* Shadow Dance allows Slark heightened regeneration when out of vision making DoTs effects less threatening.

* Shadow Dance prevents Luna from damaging Slark, and together with Shadow Blade he can kite her or escape.
* Luna has no way to escape from Pounce's leash.
Additional:
* Luna's lack of mobility and escape abilities makes her easily gankable by Slark.
* Shadow Dance will avoid all the damage from Eclipse.
* For the same reasons, Slark is a good ally for Luna when they are in the same team.

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes has attack range talent can also outrange Plague Ward.

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Devourer.

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes has attack range talent can also outrange Plague Ward.

* A couple of long-range heroes with excellent laning like Mirana, Lina, Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.

* Squishy heroes or heroes without hard disables or silences: Shadow Demon, Shadow Fiend, Venomancer, Ancient Apparition etc.

* Escape-type carries: Slark, Storm Spirit, Weaver.

* Heroes who lack escape mechanisms or disables are all easy targets for Phantom Assassin if they are not careful. Look for Luna, Venomancer and Shadow Fiend and try to catch them off guard.

* All assassin-type carries in a one against one situation: Meepo, Phantom Assassin, Riki, Ursa.

* Her Spiderlings can harass Luna in lane heavily, as Luna has no AoE abilities to clear Spiderlings.
* Broodmother can knock down towers in the early game quickly, and limit Luna's farming space.

* His highly damaging nuke spells with low cooldowns is not something Luna wants to go against.
* Thundergod's Wrath can be used before a fight to harm Luna before she activates her Black King Bar, reducing her survivability for that fight.

* One of the slowest heroes fall prey to an area nuke quickly when caught off-guard.

* Corrosive Skin means Viper can often outlast Venomancer in a battle of attrition.
* Venomancer has no mobility without items, which makes him vulnerable to constant slows.

* Because of her low range, Luna cannot easily destroy Healing Ward.
* Both Blade Fury and Omnislash are direct counters to Eclipse, offering Juggernaut spell immunity.

* Venomancer is a low health hero and low range distance attack hero easily to harass putting Ion Shell in a distance creep enemy in early game .
* Venomancer depends entirely on all his slows poison skills to keep distance or chasing enemy heroes, but Surge ignores slows, so is nearly impossible hunt or run away of Dark Seer or his surged teammates.

* Venomancer's damage-over-time abilities do little damage against Counterspell.
* Blink helps Anti-Mage get away from Venomancer's slows.
Additional:
* Counterspell provides magic resistance, diminishing the effectiveness of Venomancer's spells.
* Venomancer's lack of hard disable allows Anti-Mage to use Blink, circumventing the slows Venomancer depends on.

* Reflection illusion will apply Poison Sting to you if hit.
* Conjure Image and Metamorphosis will make quick work of your Plague Wards.
* While ticking down from your poison, Terrorblade can wait until the last possible moment to Sunder a target, either friend or foe.

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

* Snowball can be used to save allies or him during Venomous Gale and Poison Nova.
* Venomancer has lack of mobility and low base health can killed by Warlus Punch.

* Venomancer's damage-over-time abilities are easier to heal through with numerous Shadow Waves than other types of damage, and it's simple to time a Shallow Grave until the last possible second to save a teammate from them.

* Flesh Heap's magic resistance allows him to survive Eclipse, and Meat Hook and Dismember can disable Luna through her Black King Bar.
* However, Lucent Beam can still cancel Dismember from a safe distance, even if its damage is going to be reduced.
Additional:
* Pudge can easily survive Luna's Lucent Beam and Eclipse, and his Meat Hook and Dismember can pierce Black King Bar, making Luna one of the perfect victims for ganking.
* However, Lucent Beam can cancel Dismember, as Pudge often doesn't build Black King Bar, and if she is farmed enough, Luna might be able to fight back against Pudge.

* While Reincarnation is off cooldown, Venomancer abilities can't kill Wraith King easier.
* Vampiric Aura can out-heal the slow {tooltip:DoT|Damage over Time} from Poison Sting.

* Phantom Lancer creates many illusions to tank Luna's Eclipse.
* Doppelganger can be used to dodge a number of Lucent Beams during Eclipse.
* Phantom Lancer can chase Luna effectively regardless of her high movement speed thanks to Phantom Rush and Spirit Lance.
* Although her Moon Glaives kill his illusions quickly, Luna's low health pool is easily exploited by the sheer damage output from his illusions.

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes has attack range talent can also outrange Plague Ward.

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Devourer.

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Devourer.

* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom
* The nature of some abilities turn them into an easy target for a turnover from Spiked Carapace:
* Slow-moving projectiles: Skywrath Mage, Tinker, Necrophos
* Large area-of-effect with delay or require channeling: Enigma, Crystal Maiden, Invoker, Shadow Fiend, Pugna, Keeper of the Light
* Deals damage over time: Venomancer, Huskar, Ember Spirit, Dark Seer, Sand King, Doom

* Vulnerable spellcasters with no escape mechanisms are easy targets for Huskar: Lich, Crystal Maiden, Silencer, Keeper of the Light, Venomancer, etc.

Additional:
* Huskar can easily regenerate lost health from DoT spells through Berserker's Blood rendering them ineffective
* Venomancer has little armor and mobility, and rarely builds Linken's Sphere, so he is quite vulnerable to Life Break.

* Fortune's End and False Promise easily dispel many crippling debuffs, such as Venomancer's Venomous Gale, or Skywrath Mage's Ancient Seal.

Additional:
* Fortune's End can dispel Venomous Gale and Poison Sting from allies.
* Fate's Edict grants 100% magic resistance to target, inhibiting the damage from Venomancer abilities.

* A couple of nukers and disablers on the same lane can finish a squishy Luna efficiently despite a teammate's assistance: Sven + Shadow Shaman.

* A couple of long-range heroes with excellent laning like Mirana, Lina, Necrophos, Death Prophet. The key to success is sticking together and attacking Luna whenever she enters the range, without even giving Luna a chance to retaliate. Multiple long-range heroes is a reason to pick another hero.

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

* Escape-type carries: Slark, Storm Spirit, Weaver.

* All assassin-type carries in a one against one situation: Meepo, Phantom Assassin, Riki, Ursa.

* Every hero that can withstand or prevent Eclipse at level 7: Juggernaut, Riki, Clockwerk, Drow Ranger, Abaddon, Faceless Void, Weaver, Outworld Devourer.

* Hard-hitters who relies mostly on raw stats or good passive and therefore make a perfect target for Dark Portrait: Naga Siren, Faceless Void, Terrorblade, Luna, Anti-Mage

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

* Teleportation allows Natures Prophet to save himself from the damage over time of Venomous Gale, Poison Sting and Poison Nova.
* Plague Wards can be destroyed with Nature's Prophet's treants or Necronomicon.

* Heroes that create illusions (such as Spectre, Shadow Demon, Phantom Lancer, Naga Siren, Chaos Knight, Terrorblade) or bring other units into the fight (such as Nature's Prophet, Lone Druid, Chen, Enchantress and the aforementioned Meepo and Arc Warden) can cause Eclipse to strike the illusions/summons unintentionally. (However, in many cases Moon Glaives can resolve this issue and eliminate them before activating Eclipse).

* Any hero that can outrange Plague Ward can neutralize them without putting themselves at risk of receiving Poison Sting: Arc Warden, Chen, Clinkz, Drow Ranger, Lina, Mirana, Nature's Prophet, Pugna and Sniper.
* Special mention to heroes has attack range talent can also outrange Plague Ward.